0. DOCID:31170 SCORE: 0.00459085286649682
DOCNO: 15766656
AUTHOR: Pablo Rodriguez-Viciana P
AUTHOR: Frank McCormick F
AFFILIATION: University of California, San Francisco, Cancer Research Institute, 2340 Sutter Street, San Francisco, California, 94115, USA.
PUBTYPE: Comment
PUBTYPE: Journal Article
JOURNALTITLE: Cancer cell.
COUNTRY: United States
TITLE: RalGDS comes of age.
PUBDATE: 20050301
Ras proteins send signals through multiple effector pathways. The Raf/MEK/MAPK and PI 3' kinase pathways are well-validated Ras effectors in human cancers, but many other candidate pathways could be equally important. RalGDS is such a candidate: in a new paper from Chris Marshall's group, an important role for RalGDS in Ras transformation in vivo has been established for the first time. Mice lacking RalGDS are defective in tumor formation, possibly because of increased apoptosis in Ras-driven tumors. The hunt for a clear role for RalGDS activation in human cancer is on.

1. DOCID:29803 SCORE: 0.00373645526778999
DOCNO: 15218734
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
AUTHOR: M Nagy M
AFFILIATION: Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava. nagy@fpharm.uniba.sk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti.
COUNTRY: Czech Republic
TITLE: [Ricin--a plant toxin with potential therapeutic use]
PUBDATE: 20040501
Ricin is a very toxic RIP II type lectin. As no effective antidote is known, its toxicity could be misused in terrorist actions. The mechanism of the toxic action is currently studied for the preparation of selective immunotoxins, which could be used in the therapy of various cancer diseases or HIV infection. There are promising in vitro results, but some adverse in vivo effects limit the use of these preparations in real therapy.

2. DOCID:30482 SCORE: 0.0034958375416116
DOCNO: 16266566
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: Mette Nørgaard M
AUTHOR: Lene Hjerrild Iversen LH
AUTHOR: Henrik Toft Sørensen HT
AFFILIATION: Arhus Universitetshospital, Aalborg Sygehus, Klinisk Epidemiologisk Afdeling, Aalborg. uxmeno@aas.nja.dk
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Colorectal cancer. Incidence and risk factors]
PUBDATE: 20051001
Colorectal cancer (CRC) is a common cancer in the more developed Western countries. This paper aims to give a review of the established or suspected and potentially modifiable risk factors for CRC. Increased BMI, physical inactivity, tobacco smoking and high alcohol consumption are strongly implicated factors. The precise dietary patterns associated with increased risk are less clear. Use of NSAIDs as well as postmenopausal hormones seems to be associated with a substantially reduced risk of CRC. Altogether, the evidence indicates that primary prevention of CRC is feasible.

3. DOCID:31051 SCORE: 0.00343956512275331
DOCNO: 15984224
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: organization & administration
QUALIFIER: organization & administration
QUALIFIER: organization & administration
QUALIFIER: organization & administration
AUTHOR: Peter A Mackereth PA
AUTHOR: Jacqui Stringer J
AFFILIATION: Clinical Leads, Complementary Therapy Service, Rehabilitation Unit, Christie Hospital, Manchester, UK. peter.a.mackereth@virgin.net
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Complementary therapies in clinical practice.
COUNTRY: England
TITLE: CAM and cancer care: champions for integration.
PUBDATE: 20050201
The paper reviews challenges and developments in the integration of complementary therapies in cancer care. These issues are examined by reflecting on papers published in CTNM in the last 10 years by champions of CAM in cancer care. Given the aim of the journal to encourage an inclusive readership, multidisciplinary and user perspectives are included. The paper argues for better information, improved service provision and CAM choices in public healthcare, leadership support, funded research and audit, and user and non-users views.

4. DOCID:29349 SCORE: 0.00312360528977663
DOCNO: 15700040
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Choice Behavior
DESCRIPTOR: Socioeconomic Factors
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: N C Henley NC
AUTHOR: D J Hole DJ
AUTHOR: E Kesson E
AUTHOR: H J G Burns HJ
AUTHOR: W D George WD
AUTHOR: T G Cooke TG
AFFILIATION: University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK. nhenley@doctors.org.uk
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: Does deprivation affect breast cancer management?
PUBDATE: 20050201
We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of which retained significance on multivariate analysis, except deprivation. Pathological characteristics and surgical decision-making determined choice of operation not deprivation.

5. DOCID:31128 SCORE: 0.00306985763506361
DOCNO: 11790552
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Transformation, Neoplastic
QUALIFIER: metabolism
QUALIFIER: physiology
AUTHOR: Margaret C Frame MC
AUTHOR: Valerie G Brunton VG
AFFILIATION: The Beatson Institute for Cancer Research and Institute of Biomedical and Life Sciences, Cancer Research Campaign Beatson Laboratories, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: England
TITLE: Advances in Rho-dependent actin regulation and oncogenic transformation.
PUBDATE: 20020201
Cellular movement is central to invasion. The Rho family of small GTPases co-ordinate the cytoskeletal and adhesion modelling within cells that is crucial for normal migratory responses. Consequently, Rho proteins, and their regulators and effectors, are targets for subversion during oncogenic transformation and tumour development. Recent findings have thrown light on how actin regulators may be linked to oncogenesis and the development of cancer.

6. DOCID:31065 SCORE: 0.00306985682539949
DOCNO: 15541962
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: blood
AUTHOR: M Gion M
AUTHOR: M G Daidone MG
AFFILIATION: Associazione ABO, c/o Centro Regionale Indicatori Biochimici di Tumore, Ospedale Civile, Venice 30122, Italy. cnabo@provincia.venezia.it
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer (Oxford, England : 1990)
COUNTRY: England
TITLE: Circulating biomarkers from tumour bulk to tumour machinery: promises and pitfalls.
PUBDATE: 20041101
In this paper, we provide a working classification for circulating biomarkers according to their potential clinical application. We broadly divided biomarkers into four groups: (i) biomarkers of cancer risk, (ii) biomarkers of tumour-host interactions, (iii) biomarker of tumour burden, and (iv) function-related biomarkers. We hope this classification will provide a framework to which the results of future studies can be added. We also discuss the promises and pitfalls in the optional use of biomarkers in oncology.

7. DOCID:30673 SCORE: 0.00291928092735298
DOCNO: 12028305
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: Takahiro Inoue T
AUTHOR: Takuichi Hioki T
AUTHOR: Yasuaki Arai Y
AUTHOR: Yoshitaka Inaba Y
AUTHOR: Yoshiki Sugimura Y
AFFILIATION: Department of Urology, Aichi Cancer Center Hospital, Nagoya, Japan. takahi@kuhp.kyoto-u.ac.jp
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: Australia
TITLE: Ureteroarterial fistula controlled by intraluminal ureteral occlusion.
PUBDATE: 20020201
A 73-year-old woman underwent a pelvic exenteration for transitional cell carcinoma of the bladder and radiation-induced rectovaginal fistula. The patient had undergone radical hysterectomy and radiotherapy for cervical cancer 30 years earlier. Fifteen months after the operation, she suffered from ureteroaortic fistula, which was controlled by intraluminal ureteral occlusion using Gianturco coils. During 53 months of follow up, she has been free of hemorrhagic episodes.

8. DOCID:30668 SCORE: 0.00291927914619578
DOCNO: 12001437
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Congresses
AUTHOR: Celia Chao C
AUTHOR: R Craig DeWeese RC
AUTHOR: Gregory L Juhl GL
AUTHOR: Kelly M McMasters KM
AUTHOR: Michael J Edwards MJ
AFFILIATION: Department of Surgery, University of Louisville, Louisville, KY 40292, USA.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of the Kentucky Medical Association.
COUNTRY: United States
TITLE: State-of-the-art breast care: Multidisciplinary Breast Conference.
PUBDATE: 20020401
State-of-the-art breast care has become highly sophisticated over the past 20 years. Dialogue among participating breast imagers, pathologists, surgeons, medical oncologists, radiation oncologists, plastic and reconstructive surgeons, as well as genetic counselors, can only complement and enhance the care of the breast cancer patient. In an ongoing effort to offer an open forum to such breast care experts, the Multidisciplinary Breast Conference was launched in December 2000.

9. DOCID:31496 SCORE: 0.00288562524205771
DOCNO: 15991629
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: Khalil Zaman K
AUTHOR: Nicholas Ketterer N
AUTHOR: Diane Vulliémoz D
AUTHOR: Roger Stupp R
AUTHOR: Serge Leyvraz S
AFFILIATION: Fondation du Centre pluridisciplinaire d'oncologie, CHUV, 1011 Lausanne. Khalil.Zaman@hospvd.ch
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue médicale suisse.
COUNTRY: Switzerland
TITLE: [New systemic therapies in oncology]
PUBDATE: 20050501
These last decades showed important progress in cancer systemic therapies. A better understanding of the differences between cancer cells and normal cells lead to the emergence of targeted therapies. These treatments interfere with different specific molecules playing a critical role in tumour growth or progression. On the other side, thanks to the development of new therapeutic substances, new modes of administration and to the improvement of supportive care, conventional chemotherapy is more effective and less toxic. The following review summarizes current progress with clinical impact observed these last years.

10. DOCID:29033 SCORE: 0.0027991379251458
DOCNO: 16555991
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Continental Population Groups
DESCRIPTOR: Mutation
DESCRIPTOR: Sex Factors
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: antagonists & inhibitors
AUTHOR: Antonio Jimeno A
AFFILIATION: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Drug Development Program, Oncology Department, The Bunting-Blaustein Cancer Research Building, Room 162A, 1650 Orleans Street, Baltimore, MD 21231-1000, USA. ajimeno1@jhmi.edu
PUBTYPE: Journal Article
JOURNALTITLE: Future oncology (London, England)
COUNTRY: England
TITLE: Race, gender and mutations in the prediction of anti-EGFR activity.
PUBDATE: 20050401
Evaluation of: Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T: Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res. 64(24), 8919-8923 (2004).

11. DOCID:28782 SCORE: 0.00279913356076213
DOCNO: 16395659
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: toxicity
QUALIFIER: toxicity
QUALIFIER: toxicity
AUTHOR: Maurizio Bruno M
AUTHOR: Sergio Rosselli S
AUTHOR: Antonella Maggio A
AUTHOR: Rosa Angela Raccuglia RA
AUTHOR: Kenneth F Bastow KF
AUTHOR: Chin-Chung Wu CC
AUTHOR: Kuo-Hsiung Lee KH
AFFILIATION: Dipartimento di Chimica Organica, Università di Palermo, Palermo, Italy. bruno@dicpm.unipa.it
PUBTYPE: Journal Article
JOURNALTITLE: Planta medica.
COUNTRY: Germany
TITLE: Cytotoxic activity of some natural and synthetic sesquiterpene lactones.
PUBDATE: 20051201
Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane, heliangolane and their hydroxy analogues 9 and 10, all containing an alpha,beta-unsaturated aldehyde substituent, were the most potent compounds.

12. DOCID:28427 SCORE: 0.00279912344799905
DOCNO: 16149079
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: physiopathology
AUTHOR: M J Goblirsch MJ
AUTHOR: P Zwolak P
AUTHOR: D R Clohisy DR
AFFILIATION: University of Minnesota, Minneapolis, Minnesota, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of cellular biochemistry.
COUNTRY: United States
TITLE: Advances in understanding bone cancer pain.
PUBDATE: 20051101
Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment.

13. DOCID:29594 SCORE: 0.00261140831884547
DOCNO: 11906612
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Liver Transplantation
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: Burckhardt Ringe B
AFFILIATION: Klinik für Transplantationschirurgie, Georg-August Universität Göttingen, Göttingen, Germany. bringe@med.uni-gottingen.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Liver.
COUNTRY: Denmark
TITLE: Transplantation for liver tumors: current status.
PUBDATE: 20020201
The question of liver transplantation for hepatobiliary malignancy has continued to generate controversial discussion. As shown by single-center studies and large databases, there is a clear indication for total hepatectomy and liver replacement under the premises of appropriate selection of suitable patients as well as of favorable type and stage of tumors. Future improvement of tumor-free patient survival can be expected from better understanding of tumor biology, including prevention and earlier detection of cancer, and effective multimodality treatment strategies.

14. DOCID:29396 SCORE: 0.00261140810328989
DOCNO: 16595067
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: chemically induced
AUTHOR: Gerald M Higa GM
AUTHOR: Rodney F Kovach RF
AUTHOR: Jame Abraham J
AFFILIATION: Department of Medicine, Section of Hematology/Oncology, West Virginia University, Morgantown, USA. ghiga@hsc.wvu.edu
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
COUNTRY: England
TITLE: Actinic keratosis and capecitabine therapy.
PUBDATE: 20051201
Topical application of 5-fluorouracil (5-FU) is one of the most effective clinical strategies available to treat actinic keratosis (AK). During treatment, an apparent toxic skin reaction occurs before dermal quiescence ensues. We report a case of a typical flare of AK in a woman treated with capecitabine for advanced breast cancer.