0. DOCID:25897 SCORE: 0.00515750118238086
DOCNO: 10783788
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Statistical
AUTHOR: S W Thurston SW
AUTHOR: M P Wand MP
AUTHOR: J K Wiencke JK
AFFILIATION: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA. sthursto@hsph.harvard.edu
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: Negative binomial additive models.
PUBDATE: 20000301
The generalized additive model is extended to handle negative binomial responses. The extension is complicated by the fact that the negative binomial distribution has two parameters and is not in the exponential family. The methodology is applied to data involving DNA adduct counts and smoking variables among ex-smokers with lung cancer. A more detailed investigation is made of the parametric relationship between the number of adducts and years since quitting while retaining a smooth relationship between adducts and the other covariates.

1. DOCID:27572 SCORE: 0.00427694466635792
DOCNO: 10833762
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Projective Techniques
QUALIFIER: psychology
AUTHOR: G J Smith GJ
AUTHOR: A Lilja A
AFFILIATION: Department of Psychology and Clinical Neuroscience, Lund University, Sweden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Perceptual and motor skills.
COUNTRY: UNITED STATES
TITLE: Aggression: destructive and constructive aspects.
PUBDATE: 20000401
The concept of aggression was long relegated to the shadow of the libido in psychoanalytic theory, placed among the negative affects by some theoreticians, denied the role of a primary drive among leading writers in clinical psychology, brought to the fore as an adaptive force in ethology, and proved to be a decisive factor in the development of psychosomatic ailments. The second part of the paper reviews experiments using projective techniques, showing that highly creative subjects as opposed to ones low in creativity seem inclined to accept their aggressive impulses. A total denial of these impulses has been typical of women with breast cancer.

2. DOCID:25404 SCORE: 0.00411231016027233
DOCNO: 10943042
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: R Klimek R
AUTHOR: M Mazanek-Mościcka M
AUTHOR: J Stettner J
AUTHOR: R Wójcik R
AFFILIATION: Katedry i Kliniki Endokrynologii i Płodności Zespołu Katedr Ginekologii i Połoznictwa Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
PUBTYPE: Journal Article
JOURNALTITLE: Ginekologia polska.
COUNTRY: POLAND
TITLE: [Prognostic factors in treatment of neoplasms as the dissipative structures]
PUBDATE: 20000501
The aim of the study is to define the systemic prognostic factors in the neoplasm according to thermodynamic theory of cancer a the self-organising dissipative structure. As the local, so called "specific" factors seem to be not adequate one should look for more general ones. It is shown, that such general factors as hormonal state of women' organism, preterm births, lactation, infertility treatment are important.

3. DOCID:26947 SCORE: 0.00396583501867622
DOCNO: 10726706
AUTHOR: G P Digoy GP
AUTHOR: F Tibayan F
AUTHOR: H Young H
AUTHOR: P Edelstein P
AFFILIATION: Cornell University Medical College, New York City, NY USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pediatric surgery.
COUNTRY: UNITED STATES
TITLE: Adenocarcinoma of the rectum with associated colorectal adenomatous polyps in tuberous sclerosis: a case report.
PUBDATE: 20000301
The authors present the case of a 17-year-old girl with tuberous sclerosis (TS) who presented with symptoms of intussusception. Although endoscopically diagnosed with multiple colonic polyps, presumed to be hamartomas, and an invasive rectal adenocarcinoma, postoperative pathology findings confirmed the rectal cancer and showed multiple colonic adenomas. Multiple colonic adenomatous polyps in a young girl with tuberous sclerosis is extremely rare. Furthermore, we believe that this is the first report of an invasive adenocarcinoma of the large intestine occurring in a patient with TS.

4. DOCID:27346 SCORE: 0.0036760638469597
DOCNO: 11281137
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: S J Rowland SJ
AUTHOR: S T Belt ST
AUTHOR: E J Wraige EJ
AUTHOR: G Massé G
AUTHOR: C Roussakis C
AUTHOR: J M Robert JM
AFFILIATION: Department of Environmental Sciences, University of Plymouth, UK. s.rowland@plymouth.ac.uk
PUBTYPE: Journal Article
JOURNALTITLE: Phytochemistry.
COUNTRY: United States
TITLE: Effects of temperature on polyunsaturation in cytostatic lipids of Haslea ostrearia.
PUBDATE: 20010301
Unusual chemicals produced by the-'blue oyster' diatom, Haslea ostrearia, include the water-soluble blue pigment marennine and numerous polyunsaturated sesterterpene oils or haslenes. Aqueous extracts of the alga exhibit in vitro and in vivo activities against human lung cancer cells and anti-HIV effects. Here we report that three haslenes also demonstrate in vitro cytostatic action against a human lung cancer cell line. The most active haslene is the most unsaturated and unsaturation in the haslenes increases with increasing algal growth temperature.

5. DOCID:26946 SCORE: 0.00363749640301805
DOCNO: 10820796
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
AUTHOR: C L Zani CL
AUTHOR: T M Alves TM
AUTHOR: R Queiróz R
AUTHOR: E S Fontes ES
AUTHOR: Y G Shin YG
AUTHOR: G A Cordell GA
AFFILIATION: Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou-FIOCRUZ, Belo Horizonte, MG, Brazil.
PUBTYPE: Journal Article
JOURNALTITLE: Phytochemistry.
COUNTRY: UNITED STATES
TITLE: A cytotoxic diterpene from Alomia myriadenia.
PUBDATE: 20000401
An extract of the aerial parts from Alomia myriadenia Schultz-Bip. ex Baker (Asteraceae) showed significant cytotoxicity against a panel of human cancer cell lines in a screening of extracts from Brazilian Atlantic Forest plant species. Employing a bioassay-linked HPLC-electrospray/MS method, followed by semi-preparative HPLC, the active component was isolated and characterized as a mixture of epimers of the labdane diterpene 12S,16-dihydroxy-ent-labda-7,13-dien-15,16-olide.

6. DOCID:26722 SCORE: 0.00346945857626531
DOCNO: 10612836
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA-Binding Proteins
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: G Isidro G
AUTHOR: I Veiga I
AUTHOR: P Matos P
AUTHOR: S Almeida S
AUTHOR: S Bizarro S
AUTHOR: B Marshall B
AUTHOR: M Baptista M
AUTHOR: J Leite J
AUTHOR: F Regateiro F
AUTHOR: J Soares J
AUTHOR: S Castedo S
AUTHOR: M G Boavida MG
AFFILIATION: Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal. cgh@insarj.pt
PUBTYPE: Journal Article
JOURNALTITLE: Human mutation.
COUNTRY: UNITED STATES
TITLE: Four novel MSH2 / MLH1 gene mutations in portuguese HNPCC families.
PUBDATE: 20000101
Hereditary non-polyposis colorectal cancer (HNPCC) is considered to be determined by germline mutations in the mismatch repair (MMR) genes, especially MSH2 and MLH1. While screening for mutations in these two genes in HNPCC portuguese families, 3 previously unreported MSH2 and 1 MLH1 mutations have been identified in families meeting strict Amsterdam criteria. Hum Mutat 15:116, 2000.

7. DOCID:26983 SCORE: 0.00308787347849486
DOCNO: 9832252
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
AUTHOR: C T Bedford CT
AFFILIATION: Department of Biotechnology, University of Westminister, London, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of chromatography. B, Biomedical sciences and applications.
COUNTRY: NETHERLANDS
TITLE: Glucuronic acid conjugates.
PUBDATE: 19981001
The methods of assay in body fluids of 1-beta-alkyl, 1-beta-phenyl and 1-beta-acyl glucuronic acids ("glucuronide conjugates") have been reviewed. Most of the 78 references cited (from the literature of the period 1990-1997) concern the glucuronide conjugates of drug metabolites, and these have been considered, for reasons of accessibility, within sections of individual drug classes such as analgesics, anti-cancer agents and opioids. Other glucuronide conjugates are considered under "miscellaneous compounds". A few gas chromatography and capillary electrophoresis methods are described, but the major technique of assay (62 citations) is reversed-phase high-performance liquid chromatography.

8. DOCID:25034 SCORE: 0.00305742485886578
DOCNO: 10528906
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: diagnosis
AUTHOR: L H Schwartz LH
AFFILIATION: Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Advances in cross-sectional imaging of colorectal cancer.
PUBDATE: 19991001
Imaging of colorectal cancer is primarily accomplished with computed tomography (CT) and magnetic resonance imaging (MRI). These two modalities have been used for more than a decade in imaging both primary and metastatic colorectal cancer. Recent advances in the CT and MRI technologies are redefining the precise role of these imaging modalities in the work-up and evaluation of patients with colorectal cancer.

9. DOCID:27569 SCORE: 0.00305240094977341
DOCNO: 10946927
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: utilization
QUALIFIER: statistics & numerical data
QUALIFIER: statistics & numerical data
AUTHOR: A P Polednak AP
AFFILIATION: Connecticut Tumor Registry, Connecticut Department of Public Health, Hartford 06134-0308, USA. anthonypolednak@po.state.ct.us
PUBTYPE: Journal Article
JOURNALTITLE: Plastic and reconstructive surgery.
COUNTRY: UNITED STATES
TITLE: Geographic variation in postmastectomy breast reconstruction rates.
PUBDATE: 20000801
Data on postmastectomy breast reconstructive surgery were examined for 52,357 female breast cancers that were treated with mastectomy and diagnosed in geographic areas covered by the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. The proportion of cancers that involved reconstruction varied in these geographic areas in each age group (under age 70 years) by a factor of about four or five, even after adjustment for stage at diagnosis, marital status, and poverty rate of county of residence at diagnosis. Studies are needed to explain the large differences in reconstruction rates by geographic area.

10. DOCID:27579 SCORE: 0.00302730414321748
DOCNO: 10674986
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: T Kikuchi T
AUTHOR: J Arai J
AUTHOR: H Shibuki H
AUTHOR: H Kawashima H
AUTHOR: N Yoshimura N
AFFILIATION: Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of neuroimmunology.
COUNTRY: NETHERLANDS
TITLE: Tubby-like protein 1 as an autoantigen in cancer-associated retinopathy.
PUBDATE: 20000201
Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome that is characterized by retinal degeneration. Two cDNA clones, recoverin and tubby-like protein 1 (TULP1), were isolated from a human retinal cDNA library by using serum from a CAR patient as the probe. Both recoverin and TULP1 are retina-specific protein, and TULP1 is a member of tubby gene family. A determination of the recognized amino acid sequence of TULP1 by the patient serum and immunohistochemical studies on the distribution of TULP1 in the retina were done in this study.

11. DOCID:26399 SCORE: 0.00300356756977471
DOCNO: 10895163
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymph Node Excision
DESCRIPTOR: Mastectomy, Segmental
QUALIFIER: surgery
AUTHOR: R M Nambiar RM
AFFILIATION: Tan Tock Seng Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: Breast conservation therapy--surgical aspects.
PUBDATE: 20000501
Breast conservation therapy is now accepted as an alternative to mastectomy for early stage breast cancer. In 1991 the NIH recommended a regime consisting of the excision of a primary tumour with a 1 cm-margin of breast tissue around and an axillary node dissection followed by postoperative administration of 45-50 Gy irradiation. Although this regime is popular in most centres, several issues remain controversial. These are (1) selection of cases, (2) surgical technique, (3) histopathology and radiology, and (4) adjutant therapy. In this presentation I shall deal mainly with the surgical aspects of breast conservation.

12. DOCID:25582 SCORE: 0.00295315514742443
DOCNO: 11577168
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: blood
AUTHOR: W Zumkeller W
AFFILIATION: Department of Paediatrics, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097 Halle/Saale, Germany. walter.zumkeller@medizin.uni-halle.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Molecular pathology : MP.
COUNTRY: England
TITLE: IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?
PUBDATE: 20011001
Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysregulation of the IGF system is a frequent pattern in malignancy, IGFs/IGFBPs might represent novel tumour markers that could be useful both for diagnosis and surveillance.

13. DOCID:26135 SCORE: 0.00279650605148611
DOCNO: 11104561
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: K Laake K
AUTHOR: P Vu P
AUTHOR: T I Andersen TI
AUTHOR: B Erikstein B
AUTHOR: R Kåresen R
AUTHOR: P E Lonning PE
AUTHOR: E Skovlund E
AUTHOR: A L Børresen-Dale AL
AFFILIATION: Department of Genetics, The Norwegian Radium Hospital, Montebello, Oslo, 0310.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: SCOTLAND
TITLE: Screening breast cancer patients for Norwegian ATM mutations.
PUBDATE: 20001201
483 Norwegian breast cancer patients were screened for six different ataxia telangiectasia mutated (ATM) mutations previously found to account for 83% of the disease alleles in Norwegian ataxia telangiectasia (AT) patients. Only one carrier was found. These results provide no evidence in favour of an excess risk of breast cancer associated with heterozygosity for classical AT mutations, but remain consistent with a maximum 2.4-fold increased risk.

14. DOCID:26180 SCORE: 0.00279650049031508
DOCNO: 9675677
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cryopreservation
DESCRIPTOR: Cryosurgery
DESCRIPTOR: Ice
QUALIFIER: physiology
QUALIFIER: pathology
AUTHOR: K Tatsutani K
AUTHOR: B Rubinsky B
AFFILIATION: Department of Mechanical Engineering, University of California at Berkeley 94720, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of biomechanical engineering.
COUNTRY: UNITED STATES
TITLE: A method to study intracellular ice nucleation.
PUBDATE: 19980201
The thermodynamics of intracellular ice nucleation are important in low-temperature biology for understanding and controlling the process of cell destruction by freezing. We have developed a new apparatus and technique for studying the physics of intracellular ice nucleation. Employing the principle of directional solidification in conjunction with light microscopy, we can generate information on the temperature at which ice nucleates intracellularly as a function of the thermal history the cells experience. The methodology is introduced, and results with primary prostatic cancer cells are described.