0. DOCID:22554 SCORE: 0.0049090874355458
DOCNO: 8984148
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: isolation & purification
QUALIFIER: pharmacology
QUALIFIER: isolation & purification
QUALIFIER: pharmacology
AUTHOR: J H Sheu JH
AUTHOR: S Y Huang SY
AUTHOR: C Y Duh CY
AFFILIATION: Department of Marine Resources, National Sun Yat-Sen University, Taiwan, Republic of China.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: UNITED STATES
TITLE: Cytotoxic oxygenated desmosterols of the red alga Galaxaura marginata.
PUBDATE: 19960101
Desmosterol (1), 24,25-epoxycholesterol (2), 24-hydroperoxycholesta-5,25-dien-3 beta-ol (3), 25-hydroperoxycholesta-5,23(E)-dien-3 beta-ol (4), cholesta-5,25-diene-3 beta,24-diol (5), and 24,25-epoxy-6 beta-hydroxycholest-4-en-3-one (7) were isolated from the marine red alga Galaxaura marginata; sterols 3, 4, and 7 were isolated for the first time from a natural source. Sterols 3-7 exhibited significant cytotoxicity toward several cancer cell lines.


1. DOCID:22600 SCORE: 0.00490908556665496
DOCNO: 9157516
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
AUTHOR: P Moullier P
AUTHOR: N Ferry N
AUTHOR: J M Heard JM
AFFILIATION: Laboratoire de thérapie génique, CHU Hötel-Dieu, Nantes.
PUBTYPE: Journal Article
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Principles and stakes of gene therapy]
PUBDATE: 19970101
As the human genome sequencing expands and the molecular bases of diseases are better understood, the tools that allow gene packaging and transfer are available. Transferring a therapeutical gene becomes a reality and indeed more than 100 clinical protocols are currently exploring a variety of applications, from the inherited genetic diseases such as cystic fibrosis to the acquired ones such as cancer. Herein, we describe the different gene transfer strategies applied to animals and humans and we present the advantages and limitations of the currently available vectors which, today, represent the limiting factor for efficient gene therapy.


2. DOCID:22134 SCORE: 0.00355432527794318
DOCNO: 10153735
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: legislation & jurisprudence
QUALIFIER: legislation & jurisprudence
QUALIFIER: economics
AUTHOR: E Brown E
PUBTYPE: Journal Article
JOURNALTITLE: Physician executive.
COUNTRY: UNITED STATES
TITLE: The medical device payment controversy rages on.
PUBDATE: 19951101
Who will pay for investigational research? This seemingly endless debate assumes different guises as different aspects of the health care industry come under scrutiny. The latest wrinkle in the debate involves reimbursement for devices that are not FDA approved. My September column discussed the issue of funding investigational cancer therapies, specifically high-dose therapy and bone marrow transplant, as treatments for various malignancies. That controversy was centered on the use of FDA-approved drugs in settings beyond the labeled indications. However, the issue with medical devices is different. It involves implantable devices that the FDA says have not proven to be safe and effective.


3. DOCID:20511 SCORE: 0.00341465989667457
DOCNO: 9460335
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: T J Powles TJ
AFFILIATION: Royal Marsden Hospital, Sutton, Surrey.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer care.
COUNTRY: ENGLAND
TITLE: Evolving clinical strategies: innovative approaches to the use of mitoxantrone--introduction.
PUBDATE: 19971201
New clinical strategies and innovative approaches to the use of mitoxantrone include high-dose treatment, new combinations such as 5-fluorouracil with leucovorin (NFL), and neoadjuvant therapy for metastatic and primary breast cancer. Its use in other malignancies such as acute leukaemia and low-grade non-Hodgkin's lymphoma are also areas of significant development.


4. DOCID:23169 SCORE: 0.0031829421732717
DOCNO: 7501534
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude to Health
QUALIFIER: psychology
QUALIFIER: psychology
QUALIFIER: psychology
QUALIFIER: surgery
AUTHOR: J Watt-Watson J
AUTHOR: J Graydon J
AFFILIATION: Faculty of Nursing, University of Toronto, Ontario, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: The Nursing clinics of North America.
COUNTRY: UNITED STATES
TITLE: Impact of surgery on head and neck cancer patients and their caregivers.
PUBDATE: 19951201
Little information has been gathered about the experiences of head and neck cancer patients at the time of their initial surgery and about the ramifications of the surgery for patients and their caregivers. The authors discuss the pain experience of patients, the relationship of pain to their fatigue and negative mood, and the concerns of both patients and caregivers. Family caregivers are expected to take responsibility for the patients, and it is important for nurses to recognize the concerns of both patients and caregivers at the time of discharge into the home setting.


5. DOCID:22431 SCORE: 0.0030787614776549
DOCNO: 9224590
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: surgery
AUTHOR: R J Gimpelson RJ
AFFILIATION: Department of Obstetrics and Gynecology, St. Louis University School of Medicine, St. Louis, Missouri, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of the American Association of Gynecologic Laparoscopists.
COUNTRY: UNITED STATES
TITLE: Not so benign endometrial hyperplasia: endometrial cancer after endometrial ablation.
PUBDATE: 19970801
The masking or development of endometrial cancer after endometrial ablation is a concern often alluded to in discussions of complications of endometrial ablation. It is necessary to look for a common factor when this complication occurs. Six cases published in peer-reviewed literature were collected to establish a link between the development of endometrial cancer and endometrial ablation. Preexisting endometrial hyperplasia seems to be the common denominator, and should be considered a contraindication to endometrial ablation until more data are collected.


6. DOCID:20660 SCORE: 0.00301984610436676
DOCNO: 7538092
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Terminal Care
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: A Adunsky A
AUTHOR: M Berkowitz M
AUTHOR: A Waller A
AFFILIATION: Geriatrics Dept. and Tel Hashomer Hospice, Chaim Sheba Medical Center, Tel Hashomer.
PUBTYPE: Journal Article
JOURNALTITLE: Harefuah.
COUNTRY: ISRAEL
TITLE: [Corticosteroids in terminal cancer]
PUBDATE: 19950301
Corticosteroids are frequently prescribed in terminal cancer. They were prescribed in more than 50% of 100 consecutive patients of our hospice for palliation of anorexia, weakness, symptoms of cerebral metastases and of hypercalcemia, and other problems. There was objective and/or subjective improvement in most, though usually of short duration. If there is no improvement after a few days, corticosteroids should be discontinued.


7. DOCID:22808 SCORE: 0.00298087591966821
DOCNO: 8683174
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: etiology
QUALIFIER: drug therapy
QUALIFIER: adverse effects
AUTHOR: S Nishiuchi S
AUTHOR: T Okazaki T
AUTHOR: M Shinkai M
AUTHOR: H Fuziwara H
AUTHOR: M Nasu M
AUTHOR: T Shomura T
AFFILIATION: Department of Thoracic Surgery, Kobe City General Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: [Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai.
COUNTRY: JAPAN
TITLE: [A case of cardiac herniation following intrapericardial pneumonectomy after induction chemoradiotherapy]
PUBDATE: 19960101
A case of cardiac herniation following left intrapericardial pneumonectomy after induction chemoradiotherapy has been presented. Curative resection after induction chemoradiotherapy for central bronchogenic cancer may require intrapericardial pneumonectomy. Cardiac herniation through the pericardial defect is a fatal complication after a pneumonectomy unless pericardial repair should be done immediately. Closure of the pericardial defect with prosthetic patch, regardless of defect size, is always necessary for the prevention of the cardiac herniation following intrapericardial pneumonectomy after induction chemoradiotherapy.


8. DOCID:21190 SCORE: 0.0029044295919246
DOCNO: 7600034
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: adverse effects
QUALIFIER: drug therapy
QUALIFIER: chemically induced
AUTHOR: E Dajczman E
AUTHOR: H Srolovitz H
AUTHOR: H Kreisman H
AUTHOR: H Frank H
AFFILIATION: Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Lung cancer (Amsterdam, Netherlands)
COUNTRY: IRELAND
TITLE: Fatal pulmonary toxicity following oral etoposide therapy.
PUBDATE: 19950301
Oral etoposide has considerable activity in small cell lung cancer and the low risk of toxicity has resulted in the frequent prescription of this agent in elderly or infirmed patients. We describe a case of fatal pulmonary toxicity following the administration of oral etoposide. This is the first report of biopsy-proven pulmonary toxicity associated with this agent.


9. DOCID:23443 SCORE: 0.00267502224586643
DOCNO: 7480655
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: history
QUALIFIER: history
QUALIFIER: standards
QUALIFIER: history
AUTHOR: F Houn F
AUTHOR: M L Elliott ML
AUTHOR: J L McCrohan JL
AFFILIATION: Division of Mammography Quality and Radiation Programs, Food and Drug Administration, Rockville, Maryland, USA.
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Radiologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: The Mammography Quality Standards Act of 1992. History and philosophy.
PUBDATE: 19951101
The Mammography Quality Standards Act (MQSA) of 1992 established a precedent in the practice of mammography by creating federal quality standards for all parts of the mammography system. Heralded by some as crucial so all US women can reap the full benefits of early detection of breast cancer, MQSA implementation was delegated to the Food and Drug Administration (FDA) on June 2, 1993. In this article the major historical forces that surrounded MQSA's enactment as well as the FDA's philosophy on regulation development, inspections, and compliance under MQSA is summarized.


10. DOCID:23771 SCORE: 0.00267474938493637
DOCNO: 7842999
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: J Zhang J
AUTHOR: Y Z Yi YZ
AUTHOR: G G Fen GG
AFFILIATION: Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou.
PUBTYPE: Journal Article
JOURNALTITLE: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology.
COUNTRY: CHINA
TITLE: [An analytic study of metastatic carcinoma to the uvea]
PUBDATE: 19940501
The authors analyzed 107 cases of metastatic carcinoma to the uvea, 21 cases from their hospital and 86 cases from Chinese literature, to find no predilection for either eye and that the tumor originated from the lung in 45 cases (42.1%) and from the breast in 14 cases (13.1%). Among 43 cases of lung cancer with records, 33 cases reported visual symptoms as their first complaints while none of the 14 cases of breast cancer so did. This could have been due to the higher incidence of lung carcinoma which was also less readily detected.


11. DOCID:23414 SCORE: 0.00266279041722347
DOCNO: 8939849
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle
QUALIFIER: pathology
AUTHOR: C J Sherr CJ
AFFILIATION: Howard Hughes Medical Institute, Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA. sherr@stjude.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Cancer cell cycles.
PUBDATE: 19961201
Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16(INK4a) and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RB) and control exit from the G1 phase of the cell cycle, are so frequent in human cancers that inactivation of this pathway may well be necessary for tumor development. Like the tumor suppressor protein p53, components of this "RB pathway," although not essential for the cell cycle per se, may participate in checkpoint functions that regulate homeostatic tissue renewal throughout life.


12. DOCID:23849 SCORE: 0.00256090813773272
DOCNO: 10155129
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: methods
AUTHOR: L I Grossweiner LI
AFFILIATION: Physics Department, Illinois Institute of Technology, Chicago 60616, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of laser applications.
COUNTRY: UNITED STATES
TITLE: Photodynamic therapy.
PUBDATE: 19950301
Photodynamic therapy (PDT) is a new treatment for solid tumors utilizing the combined action of light and a photosensitizing drug. Laser-fiber optic delivery systems make it practical to treat superficial and interstitial cancers, including malignancies of the skin, head and neck, esophagus, endobronchial tract, stomach, urinary bladder, female genital tract, and other sites. The putative action mechanism in PDT involves photochemical destruction of tumor tissue membranes mediated by singlet molecular oxygen. Light dosimetry modeling based on tissue optics is applicable for treatment planning. Related research areas include non-invasive optical diagnosis and imaging, development of new PDT drugs and light sources, and the extension of PDT methods to treatment of atherosclerotic vascular disease and blood detoxification.


13. DOCID:23658 SCORE: 0.00253019939754276
DOCNO: 7567724
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mastectomy, Radical
DESCRIPTOR: Mastectomy, Segmental
QUALIFIER: surgery
AUTHOR: L A Porterfield LA
AUTHOR: N Love N
AFFILIATION: Center for Breast Care/Lynn Regional Cancer Center, Boca Raton Community Hospital, Florida, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Local and regional therapy for primary breast tumors. Answers to major questions.
PUBDATE: 19951001
Because all primary care physicians see patients with breast cancer, it is imperative that they maintain an up-to-date working knowledge of its diagnosis and treatment. The diagnosis of breast cancer requires awareness and diligence on the part of both physician and patient, and surgical consultation is most appropriate before any invasive diagnostic procedures are done. The ultimate treatment plan evolves from consideration of tumor- and patient-related factors. Of these, the ratio of tumor size to breast size, the invasiveness and distribution of the tumor, and the individual patient's attitude and concerns are most important.


14. DOCID:22927 SCORE: 0.00250099344843728
DOCNO: 7728736
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: metabolism
AUTHOR: M Verma M
AFFILIATION: Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, Washington, D.C. 20007, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer biochemistry biophysics.
COUNTRY: ENGLAND
TITLE: Carcinoma associated mucins: molecular biology and clinical applications.
PUBDATE: 19941001
Mucin is a viscous secretion of glycoproteins secreted by epithelial cells of normal and cancerous tissues. Excessive and abnormal mucin synthesis has been observed in a number of cancers. The conformation and configuration of the surface carbohydrates play a key role in generating multiple forms of mucins in different cancers. The epitopes on the surface of mucin are recognized by antibodies present in different cancer cells. The primary structure of some of the cancer-associated mucins has been determined by molecular cloning of their complementary DNAs. The detection methods for cancer-associated mucins and their clinical applications are discussed.