0. DOCID:7343 SCORE: 0.00726736526493298
DOCNO: 7289916
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Genetic
QUALIFIER: genetics
AUTHOR: P R Fain PR
AUTHOR: H T Lynch HT
AUTHOR: W A Albano WA
AUTHOR: T A Ruma TA
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Sex differences in lung cancer incidence: a genetic model.
PUBDATE: 19810801
Family histories pertaining to cancer of all anatomic sites were ascertained on 88 Caucasian patients (61 males, 27 females) with histologically verified lung cancer. Lifetable analysis revealed that relatives of female probands had a significantly higher risk for cancer (all sites) at younger age (p less than .04) compared to relatives of male probands. This trend was peculiar to nonsmoking-associated cancer sites, and was not apparent for smoking-associated cancer sites. We hypothesize that certain components of genetic liability to lung cancer are common to nonsmoking-associated malignant neoplasms, and that females who develop lung cancer are more extreme with respect to genotype than are males who develop lung cancer. Our hypothesis accounts for the lower incidence of lung cancer among females, as well as the apparent increased susceptibility to cancer among their relatives.


1. DOCID:7404 SCORE: 0.0055685549083676
DOCNO: 7245351
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: G Cardona G
AUTHOR: S Ciatto S
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Criteria of clinical and radiological diagnosis in nonpuerperal acute phlogistic-like processes of the breast: considerations on 97 consecutive cases.
PUBDATE: 19810201
The authors report a series of 97 cases of phlogistic-like process of the breast. Clinical and radiological signs and criteria of differential diagnosis between benign phlogosis and cancer are investigated. The location in the areolar/periareolar region, the presence of fever, and the radiological evidence of limited skin thickening were the features more significantly correlated with benign phlogosis, while cancer should be suspected in the case of lesions located in the upper-outer quadrant and in presence of a diffuse skin thickening at radiological examination. These diagnostic criteria seem particularly useful since the typical clinical or radiological signs of cancer are present only in 50% of cancer cases. The cytological examination of nipple discharge or needle aspiration fluid is of particular help: no false positive or negative cases were observed in a series of 42 examined patients.


2. DOCID:7499 SCORE: 0.00436765232056081
DOCNO: 435624
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammary Glands, Animal
QUALIFIER: veterinary
AUTHOR: A E Khaĭsman AE
AUTHOR: I P Tereschenko IP
AUTHOR: A S Iagubov AS
PUBTYPE: Journal Article
JOURNALTITLE: Biulleten' eksperimental'noĭ biologii i meditsiny.
COUNTRY: USSR
TITLE: [Relation of the ultrastructural organization of mouse mammary gland cancer to its ability to metastasize]
PUBDATE: 19790401
A quantitative ultrastructural investigation of cancer in mice mammary glands and of its metastases to the lungs was carried out. It was established that in tumors showing no metastatic spreading in experiment the area of membrane surface of the endoplasmic reticulum and the number of bound ribosomes are greater than those in tumor spreading metastases. At the same time the number of ribosomes organized into polysomes is higher in the metastasized tumors. The comparison of the tumors with their metastases revealed differences in the structure of the mitochondrial apparatus: the surface area of cristae is larger in the metastatic foci. The evidence obtained shows that tumors spreading metastases have a lower level of cellular differentiation. The primary and metastatic foci do not exhibit any difference in the level of differentiation.


3. DOCID:7447 SCORE: 0.00436764968983077
DOCNO: 7212797
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Enzyme Tests
DESCRIPTOR: Rectal Neoplasms
QUALIFIER: blood
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: P I Tartter PI
AUTHOR: G Slater G
AUTHOR: I Gelernt I
AUTHOR: A H Aufses AH
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Screening for liver metastases from colorectal cancer with carcinoembryonic antigen and alkaline phosphatase.
PUBDATE: 19810301
A sensitive and economic method of screening for liver metastases in patients with colorectal cancer was developed using serum alkaline phosphatase and carcinoembryonic antigen. The upper limit of normal for alkaline phosphatase and carcinoembryonic antigen did not represent the optimal levels for use in predicting liver metastases. However, with alkaline phosphatase greater than 135 I.U., and/or carcinoembryonic antigen greater than 10 ng/ml, sensitivity was 88%: 23 of 26 patients with liver metastases fulfilled either or both criteria. The false-positive rate was 12%. Liver scanning, alone, demonstrated metastases in only 69% of 35 patients with liver metastases. The combination of alkaline phosphatase and carcinoembryonic antigen can be used economically to screen for liver metastases, and to determine which patients should undergo a liver scan.


4. DOCID:7526 SCORE: 0.00413538831100231
DOCNO: 7351004
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: P A Pizzo PA
AUTHOR: S Ladisch S
AUTHOR: K Ribichaud K
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Treatment of gram-positive septicemia in cancer patients.
PUBDATE: 19800101
Seventy-eight pediatric cancer patients were treated for gram-positive bacterial septicemia during a 10-year period (1968-1977). Sixty-one (78%) of the patients were granulocytopenic (PMNs less than 500/mm3) at the onset of the septic episode. All the patients whose granulocytopenia resolved (PMNs greater than 500/mm3) within one week of therapy recovered without sequelae. However, 7 of 15 patients (47%) who remained granulocytopenic for more than 7 days and who were treated with a single antibiotic developed a second sepsis with a gram-negative organism. In contrast, second infections were not observed in 24 patients with PMNs less than 500/mm3 for more than 7 days who were treated with broad spectrum antibiotics (p less than 0.002), suggesting that a broad-spectrum antibiotic regimen may be preferable when a cancer patient has prolonged granulocytopenia.


5. DOCID:7212 SCORE: 0.00381148727967482
DOCNO: 7357548
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: drug effects
QUALIFIER: drug effects
AUTHOR: K Morimoto K
AUTHOR: S Wolff S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Increase of sister chromatid exchanges and perturbations of cell division kinetics in human lymphocytes by benzene metabolites.
PUBDATE: 19800401
Benzene, which has been associated with human cancers, is metabolized to produce several major metabolites that could be responsible for the biological effects. Tests have now been carried out on human lymphocytes in culture to determine if benzene or its metabolites, phenol, catechol, and hydroquinone, induce cytogenetic changes and affect the cell cycle. The results indicate that benzene itself does not induce sister chromatid exchanges or affect cell cycle kinetics over a wide range of doses. Phenol has an effect only at very high doses. On the other hand, catechol is a potent compound that induces sister chromatid exchanges and delays cell division very readily. Hydroquinone is also potent, but less so than catechol. Thus, the formation of catechol and hydroquinone is the most likely cause of benzene toxicity.


6. DOCID:5349 SCORE: 0.00359087933808326
DOCNO: 349973
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: isolation & purification
QUALIFIER: prevention & control
AUTHOR: D Hoffman D
AUTHOR: E L Wynder EL
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, präventive Medizin.
COUNTRY: GERMANY, WEST
TITLE: Identification and reduction of carcinogens in the respiratory environment.
PUBDATE: 19780301
Epidemiological studies have implicated three factors in the overall increase of lung cancer--tobacco, especially cigarette smoking, urban pollution and, to a lesser extent, certain industrial respiratory environments. Some data were discussed on carcinogenic industrial inhalants, and on the possible effect of urban pollution. The reduction of pollution and that of specific environmental agents is stressed. Laboratory studies on the identification of carcinogens in cigarette smoke and their reduction toward the "less harmful cigarette" represent a part of this aspect.


7. DOCID:7693 SCORE: 0.00355700689809634
DOCNO: 28178
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Transformation, Neoplastic
DESCRIPTOR: Chromosome Aberrations
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: metabolism
AUTHOR: W F Benedict WF
AUTHOR: A Banerjee A
AUTHOR: N Venkatesan N
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Cyclophosphamide-induced oncogenic transformation, chromosomal breakage, and sister chromatid exchange following microsomal activation.
PUBDATE: 19780901
Cyclophosphamide, an extensively used cancer chemotherapeutic agent, requires metabolic activation through a mixed-function oxygenase system. The capacity of this agent to produce oncogenic transformation and chromosomal damage, including increases in sister chromatid exchanges, was investigated in cell culture with or without an exogenous liver metabolic activation system. No oncogenic transformation or chromosomal aberrations were produced by cyclophosphamide in the absence of metabolic activation, whereas significant transformation, chromosomal breaks, and increases in sister chromatid exchanges were observed when the activation system was incorporated into the assays. The oncogenic transformation and chromosomal changes were completely eliminated by removing glucose 6-phosphate and nicotinamide adenine dinucleotide phosphate from the metabolic generating system. These studies emphasize the necessity to incorporate some activation procedure into short-term assays used for evaluating the mutagenic and/or oncogenic potential of various chemicals.


8. DOCID:5409 SCORE: 0.00341153472339005
DOCNO: 532178
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: diagnosis
AUTHOR: K Brezina K
AUTHOR: P Proszowski P
PUBTYPE: Journal Article
JOURNALTITLE: Wiener medizinische Wochenschrift (1946)
COUNTRY: AUSTRIA
TITLE: [Importance of x-ray examination to endoscopic diagnosis of carcinoma of the stomach (author's transl)]
PUBDATE: 19790901
Radiologic and endoscopic examinations were performed in 166 histologically verified carcinomas of the stomach. 71% of the carcinomas were diagnosed at the first examination by X-ray and/or endoscopy. By a second examination of the radiologically but not endoscopically suspected the percentage of diagnosed carcinomas was increased to 83%. Though the results of endoscopy on an average are somewhat better due to the practicability of biopsy, X-ray examination cannot be renounced. In early cancer the most reliable diagnosis is to be realized by endoscopy on the basis of X-ray findings.


9. DOCID:7023 SCORE: 0.00337850408158136
DOCNO: 354770
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A I Kanbour AI
AUTHOR: R J Stock RJ
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Squamous cell carcinoma in situ of the endometrium and fallopian tube as superficial extension of invasive cervical carcinoma.
PUBDATE: 19780801
Five cases of squamous cell carcinoma of the cervix associated with widespread squamous cell carcinoma in situ of the endometrial surface are reported. In one case, carcinoma in situ was also found in one fallopian tube in continuity with the cervicoendometrial lesion. A survey of the literature reveals only 20 cases with similar surface endometrial involvement by cervical squamous cell carcinoma. Of these, the fallopian tubes were involved by an identical lesion in six cases only. Pyometra and cervical stenosis were reported in about 66% of the cases. This rare form of upward cervical cancer extension was present in five of 680 cases (0.7%) of squamous cell carcinoma of the cervix in the file of the Tumor Registry of Magee-Womens Hospital.


10. DOCID:6809 SCORE: 0.00334384191066641
DOCNO: 452201
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J Lanesky J
AUTHOR: M I Opipari MI
AUTHOR: M McKenzie M
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Multiple primary prostate cancer.
PUBDATE: 19790601
Although increasing reports are noted of apparent endometrial carcinoma of prostatic origin, the controversy is present of the actual existence of such an entity. The association of papillary prostatic cancer (endometrial or ductal) with the typical microacinar variety has also been previously presented. This report is an account of 2 cases of multiple prostatic primary tumors. The first case is the twelfth reported case of endometrial (utricular) carcinoma not only simultaneously associated with microacinar type carcinoma, but also with a previous transitional carcinoma of the urinary bladder. The second case is a papillary carcinoma and associated microacinar type with the papillary component responding dramatically to chemotherapy. Significant aspects of interest in this case include the site of papillary metastasis to the lungs, elevated estrogen levels with normalization after treatment, and finally response to chemotherapy.


11. DOCID:5679 SCORE: 0.00334282420116878
DOCNO: 7357890
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J A Zalla JA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cutis; cutaneous medicine for the practitioner.
COUNTRY: UNITED STATES
TITLE: Werner's syndrome.
PUBDATE: 19800301
A typical patient with this uncommon premature aging syndrome was followed over a period of four and a half years until his death. He presented the characteristic clinical features, as well as the complications, of Werner's syndrome. About one hundred forty cases of this recessively inherited syndrome have been reported. Most patients become recognizable in their thirties by their short stature, typical facies, premature graying, hair loss, cataracts, atrophy of skin and subcutaneous tissue, and acral sclerosis. Advanced peripheral vascular disease occurs early; angina, skin cancer, diabetes mellitus, and internal malignancy are common. Most patients die before the age of fifty years either from complications of anteriosclerotic vascular disease or malignancy.


12. DOCID:6162 SCORE: 0.00320657902744651
DOCNO: 734430
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: E Nagel-Studer E
AUTHOR: J J Staub JJ
AUTHOR: G A Nagel GA
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Biology of breast cancer: current approaches to new treatment modalities]
PUBDATE: 19781201
After years of progress, there appear to be few new developments in the treatment of breast cancer at the present time. Aspects of breast cancer are discussed which might offer new therapeutic possibilities. The rather schematic management of the patient with breast cancer is less than well matched with the variable biology and the multitude of factors influencing risk and prognosis. Epidemiological, hereditary, and environmental, as well as endocrinological, immunological, and psychoneurological variables are believed to determine the spontaneous course of the disease and the therapeutic results. One way of improving treatment results is better evaluation of such biological factors in a given patient and variation of treatment plans according to individual needs.


13. DOCID:5422 SCORE: 0.00316192926763587
DOCNO: 675731
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography
QUALIFIER: diagnosis
AUTHOR: K Schulze K
AUTHOR: R Meudt R
AUTHOR: U F Benz UF
PUBTYPE: Journal Article
JOURNALTITLE: Strahlentherapie.
COUNTRY: GERMANY, WEST
TITLE: [Ultrasonic diagnostics in the scope of clarification and prognosis of oncologic cases (author's transl)]
PUBDATE: 19780701
By means of ultrasonic diagnosis it is possible to represent neoplasms in the abdomen, retroperitoneum and small pelvis. The real-time scanner is utilized in tumor localization and search for metastases, whereas an exact measurement of the tumor, possible of a representative metastasis, and also the treatment planning, are performed with the cross-sectional images from the storage compound scanner. Controls during cancer therapy will give information about the therapeutic results. Recurrences or newly spread metastases may easily be detected by this method in the course of follow-up of the tumor patients.


14. DOCID:7188 SCORE: 0.00310125645657891
DOCNO: 728881
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: N Nakissa N
AUTHOR: N B Hornback NB
AUTHOR: H Shidnia H
AUTHOR: E Sayoc E
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Carcinoma of the floor of the mouth.
PUBDATE: 19781201
Records of all patients with carcinoma of the floor of mouth seen at the Indiana School of Medicine University Hospital between March 1965 and March 1975 were reviewed. 126 patients with these tumors were seen during this ten-year period. This study included patient's age, sex, race, family history for cancer, type of treatment received, treatment results and complications. The complications and duration of hospital stay were also studied. 18 of the 126 patients received surgery alone and 108 patients received either preoperative, postoperative or curative radiation therapy. Long-term disease control rates in the early stages of carcinoma of the floor of mouth treated by radiation therapy alone were equivalent or superior to results obtained by surgery alone and patients experienced considerably less complications. In more advanced cases, radiation therapy played an important adjunctive and palliative role.