0. DOCID:25897 SCORE: 0.00515750118238086
DOCNO: 10783788
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Statistical
AUTHOR: S W Thurston SW
AUTHOR: M P Wand MP
AUTHOR: J K Wiencke JK
AFFILIATION: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA. sthursto@hsph.harvard.edu
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: Negative binomial additive models.
PUBDATE: 20000301
The generalized additive model is extended to handle negative binomial responses. The extension is complicated by the fact that the negative binomial distribution has two parameters and is not in the exponential family. The methodology is applied to data involving DNA adduct counts and smoking variables among ex-smokers with lung cancer. A more detailed investigation is made of the parametric relationship between the number of adducts and years since quitting while retaining a smooth relationship between adducts and the other covariates.


1. DOCID:31170 SCORE: 0.00459085286649682
DOCNO: 15766656
AUTHOR: Pablo Rodriguez-Viciana P
AUTHOR: Frank McCormick F
AFFILIATION: University of California, San Francisco, Cancer Research Institute, 2340 Sutter Street, San Francisco, California, 94115, USA.
PUBTYPE: Comment
PUBTYPE: Journal Article
JOURNALTITLE: Cancer cell.
COUNTRY: United States
TITLE: RalGDS comes of age.
PUBDATE: 20050301
Ras proteins send signals through multiple effector pathways. The Raf/MEK/MAPK and PI 3' kinase pathways are well-validated Ras effectors in human cancers, but many other candidate pathways could be equally important. RalGDS is such a candidate: in a new paper from Chris Marshall's group, an important role for RalGDS in Ras transformation in vivo has been established for the first time. Mice lacking RalGDS are defective in tumor formation, possibly because of increased apoptosis in Ras-driven tumors. The hunt for a clear role for RalGDS activation in human cancer is on.


2. DOCID:27572 SCORE: 0.00427694466635792
DOCNO: 10833762
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Projective Techniques
QUALIFIER: psychology
AUTHOR: G J Smith GJ
AUTHOR: A Lilja A
AFFILIATION: Department of Psychology and Clinical Neuroscience, Lund University, Sweden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Perceptual and motor skills.
COUNTRY: UNITED STATES
TITLE: Aggression: destructive and constructive aspects.
PUBDATE: 20000401
The concept of aggression was long relegated to the shadow of the libido in psychoanalytic theory, placed among the negative affects by some theoreticians, denied the role of a primary drive among leading writers in clinical psychology, brought to the fore as an adaptive force in ethology, and proved to be a decisive factor in the development of psychosomatic ailments. The second part of the paper reviews experiments using projective techniques, showing that highly creative subjects as opposed to ones low in creativity seem inclined to accept their aggressive impulses. A total denial of these impulses has been typical of women with breast cancer.


3. DOCID:25404 SCORE: 0.00411231016027233
DOCNO: 10943042
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: R Klimek R
AUTHOR: M Mazanek-Mościcka M
AUTHOR: J Stettner J
AUTHOR: R Wójcik R
AFFILIATION: Katedry i Kliniki Endokrynologii i Płodności Zespołu Katedr Ginekologii i Połoznictwa Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
PUBTYPE: Journal Article
JOURNALTITLE: Ginekologia polska.
COUNTRY: POLAND
TITLE: [Prognostic factors in treatment of neoplasms as the dissipative structures]
PUBDATE: 20000501
The aim of the study is to define the systemic prognostic factors in the neoplasm according to thermodynamic theory of cancer a the self-organising dissipative structure. As the local, so called "specific" factors seem to be not adequate one should look for more general ones. It is shown, that such general factors as hormonal state of women' organism, preterm births, lactation, infertility treatment are important.


4. DOCID:26947 SCORE: 0.00396583501867622
DOCNO: 10726706
AUTHOR: G P Digoy GP
AUTHOR: F Tibayan F
AUTHOR: H Young H
AUTHOR: P Edelstein P
AFFILIATION: Cornell University Medical College, New York City, NY USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pediatric surgery.
COUNTRY: UNITED STATES
TITLE: Adenocarcinoma of the rectum with associated colorectal adenomatous polyps in tuberous sclerosis: a case report.
PUBDATE: 20000301
The authors present the case of a 17-year-old girl with tuberous sclerosis (TS) who presented with symptoms of intussusception. Although endoscopically diagnosed with multiple colonic polyps, presumed to be hamartomas, and an invasive rectal adenocarcinoma, postoperative pathology findings confirmed the rectal cancer and showed multiple colonic adenomas. Multiple colonic adenomatous polyps in a young girl with tuberous sclerosis is extremely rare. Furthermore, we believe that this is the first report of an invasive adenocarcinoma of the large intestine occurring in a patient with TS.


5. DOCID:29803 SCORE: 0.00373645526778999
DOCNO: 15218734
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
AUTHOR: M Nagy M
AFFILIATION: Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava. nagy@fpharm.uniba.sk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti.
COUNTRY: Czech Republic
TITLE: [Ricin--a plant toxin with potential therapeutic use]
PUBDATE: 20040501
Ricin is a very toxic RIP II type lectin. As no effective antidote is known, its toxicity could be misused in terrorist actions. The mechanism of the toxic action is currently studied for the preparation of selective immunotoxins, which could be used in the therapy of various cancer diseases or HIV infection. There are promising in vitro results, but some adverse in vivo effects limit the use of these preparations in real therapy.


6. DOCID:27346 SCORE: 0.0036760638469597
DOCNO: 11281137
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: S J Rowland SJ
AUTHOR: S T Belt ST
AUTHOR: E J Wraige EJ
AUTHOR: G Massé G
AUTHOR: C Roussakis C
AUTHOR: J M Robert JM
AFFILIATION: Department of Environmental Sciences, University of Plymouth, UK. s.rowland@plymouth.ac.uk
PUBTYPE: Journal Article
JOURNALTITLE: Phytochemistry.
COUNTRY: United States
TITLE: Effects of temperature on polyunsaturation in cytostatic lipids of Haslea ostrearia.
PUBDATE: 20010301
Unusual chemicals produced by the-'blue oyster' diatom, Haslea ostrearia, include the water-soluble blue pigment marennine and numerous polyunsaturated sesterterpene oils or haslenes. Aqueous extracts of the alga exhibit in vitro and in vivo activities against human lung cancer cells and anti-HIV effects. Here we report that three haslenes also demonstrate in vitro cytostatic action against a human lung cancer cell line. The most active haslene is the most unsaturated and unsaturation in the haslenes increases with increasing algal growth temperature.


7. DOCID:26946 SCORE: 0.00363749640301805
DOCNO: 10820796
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
AUTHOR: C L Zani CL
AUTHOR: T M Alves TM
AUTHOR: R Queiróz R
AUTHOR: E S Fontes ES
AUTHOR: Y G Shin YG
AUTHOR: G A Cordell GA
AFFILIATION: Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou-FIOCRUZ, Belo Horizonte, MG, Brazil.
PUBTYPE: Journal Article
JOURNALTITLE: Phytochemistry.
COUNTRY: UNITED STATES
TITLE: A cytotoxic diterpene from Alomia myriadenia.
PUBDATE: 20000401
An extract of the aerial parts from Alomia myriadenia Schultz-Bip. ex Baker (Asteraceae) showed significant cytotoxicity against a panel of human cancer cell lines in a screening of extracts from Brazilian Atlantic Forest plant species. Employing a bioassay-linked HPLC-electrospray/MS method, followed by semi-preparative HPLC, the active component was isolated and characterized as a mixture of epimers of the labdane diterpene 12S,16-dihydroxy-ent-labda-7,13-dien-15,16-olide.


8. DOCID:30482 SCORE: 0.0034958375416116
DOCNO: 16266566
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: Mette Nørgaard M
AUTHOR: Lene Hjerrild Iversen LH
AUTHOR: Henrik Toft Sørensen HT
AFFILIATION: Arhus Universitetshospital, Aalborg Sygehus, Klinisk Epidemiologisk Afdeling, Aalborg. uxmeno@aas.nja.dk
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Colorectal cancer. Incidence and risk factors]
PUBDATE: 20051001
Colorectal cancer (CRC) is a common cancer in the more developed Western countries. This paper aims to give a review of the established or suspected and potentially modifiable risk factors for CRC. Increased BMI, physical inactivity, tobacco smoking and high alcohol consumption are strongly implicated factors. The precise dietary patterns associated with increased risk are less clear. Use of NSAIDs as well as postmenopausal hormones seems to be associated with a substantially reduced risk of CRC. Altogether, the evidence indicates that primary prevention of CRC is feasible.


9. DOCID:26722 SCORE: 0.00346945857626531
DOCNO: 10612836
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA-Binding Proteins
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: G Isidro G
AUTHOR: I Veiga I
AUTHOR: P Matos P
AUTHOR: S Almeida S
AUTHOR: S Bizarro S
AUTHOR: B Marshall B
AUTHOR: M Baptista M
AUTHOR: J Leite J
AUTHOR: F Regateiro F
AUTHOR: J Soares J
AUTHOR: S Castedo S
AUTHOR: M G Boavida MG
AFFILIATION: Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal. cgh@insarj.pt
PUBTYPE: Journal Article
JOURNALTITLE: Human mutation.
COUNTRY: UNITED STATES
TITLE: Four novel MSH2 / MLH1 gene mutations in portuguese HNPCC families.
PUBDATE: 20000101
Hereditary non-polyposis colorectal cancer (HNPCC) is considered to be determined by germline mutations in the mismatch repair (MMR) genes, especially MSH2 and MLH1. While screening for mutations in these two genes in HNPCC portuguese families, 3 previously unreported MSH2 and 1 MLH1 mutations have been identified in families meeting strict Amsterdam criteria. Hum Mutat 15:116, 2000.


10. DOCID:31051 SCORE: 0.00343956512275331
DOCNO: 15984224
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: organization & administration
QUALIFIER: organization & administration
QUALIFIER: organization & administration
QUALIFIER: organization & administration
AUTHOR: Peter A Mackereth PA
AUTHOR: Jacqui Stringer J
AFFILIATION: Clinical Leads, Complementary Therapy Service, Rehabilitation Unit, Christie Hospital, Manchester, UK. peter.a.mackereth@virgin.net
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Complementary therapies in clinical practice.
COUNTRY: England
TITLE: CAM and cancer care: champions for integration.
PUBDATE: 20050201
The paper reviews challenges and developments in the integration of complementary therapies in cancer care. These issues are examined by reflecting on papers published in CTNM in the last 10 years by champions of CAM in cancer care. Given the aim of the journal to encourage an inclusive readership, multidisciplinary and user perspectives are included. The paper argues for better information, improved service provision and CAM choices in public healthcare, leadership support, funded research and audit, and user and non-users views.


11. DOCID:29349 SCORE: 0.00312360528977663
DOCNO: 15700040
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Choice Behavior
DESCRIPTOR: Socioeconomic Factors
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: N C Henley NC
AUTHOR: D J Hole DJ
AUTHOR: E Kesson E
AUTHOR: H J G Burns HJ
AUTHOR: W D George WD
AUTHOR: T G Cooke TG
AFFILIATION: University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK. nhenley@doctors.org.uk
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: Does deprivation affect breast cancer management?
PUBDATE: 20050201
We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of which retained significance on multivariate analysis, except deprivation. Pathological characteristics and surgical decision-making determined choice of operation not deprivation.


12. DOCID:26983 SCORE: 0.00308787347849486
DOCNO: 9832252
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
AUTHOR: C T Bedford CT
AFFILIATION: Department of Biotechnology, University of Westminister, London, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of chromatography. B, Biomedical sciences and applications.
COUNTRY: NETHERLANDS
TITLE: Glucuronic acid conjugates.
PUBDATE: 19981001
The methods of assay in body fluids of 1-beta-alkyl, 1-beta-phenyl and 1-beta-acyl glucuronic acids ("glucuronide conjugates") have been reviewed. Most of the 78 references cited (from the literature of the period 1990-1997) concern the glucuronide conjugates of drug metabolites, and these have been considered, for reasons of accessibility, within sections of individual drug classes such as analgesics, anti-cancer agents and opioids. Other glucuronide conjugates are considered under "miscellaneous compounds". A few gas chromatography and capillary electrophoresis methods are described, but the major technique of assay (62 citations) is reversed-phase high-performance liquid chromatography.


13. DOCID:31128 SCORE: 0.00306985763506361
DOCNO: 11790552
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Transformation, Neoplastic
QUALIFIER: metabolism
QUALIFIER: physiology
AUTHOR: Margaret C Frame MC
AUTHOR: Valerie G Brunton VG
AFFILIATION: The Beatson Institute for Cancer Research and Institute of Biomedical and Life Sciences, Cancer Research Campaign Beatson Laboratories, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: England
TITLE: Advances in Rho-dependent actin regulation and oncogenic transformation.
PUBDATE: 20020201
Cellular movement is central to invasion. The Rho family of small GTPases co-ordinate the cytoskeletal and adhesion modelling within cells that is crucial for normal migratory responses. Consequently, Rho proteins, and their regulators and effectors, are targets for subversion during oncogenic transformation and tumour development. Recent findings have thrown light on how actin regulators may be linked to oncogenesis and the development of cancer.


14. DOCID:31065 SCORE: 0.00306985682539949
DOCNO: 15541962
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: blood
AUTHOR: M Gion M
AUTHOR: M G Daidone MG
AFFILIATION: Associazione ABO, c/o Centro Regionale Indicatori Biochimici di Tumore, Ospedale Civile, Venice 30122, Italy. cnabo@provincia.venezia.it
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer (Oxford, England : 1990)
COUNTRY: England
TITLE: Circulating biomarkers from tumour bulk to tumour machinery: promises and pitfalls.
PUBDATE: 20041101
In this paper, we provide a working classification for circulating biomarkers according to their potential clinical application. We broadly divided biomarkers into four groups: (i) biomarkers of cancer risk, (ii) biomarkers of tumour-host interactions, (iii) biomarker of tumour burden, and (iv) function-related biomarkers. We hope this classification will provide a framework to which the results of future studies can be added. We also discuss the promises and pitfalls in the optional use of biomarkers in oncology.