0. DOCID:10517 SCORE: 0.00600749954935269
DOCNO: 6806472
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neutrons
QUALIFIER: radiotherapy
QUALIFIER: methods
AUTHOR: L Cohen L
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Royal Society of Medicine.
COUNTRY: ENGLAND
TITLE: Expanding options in radiation oncology: neutron beam therapy.
PUBDATE: 19820601
Twelve years' experience with neutron beam therapy in Britain, the USA, Europe and Japan shows that local control is achievable in late-stage epidermoid cancer somewhat more frequently than with conventional radiotherapy. Tumours reputed to be radioresistant (salivary gland, bladder, rectosigmoid, melanoma, bone and soft-tissue sarcomas) have proved to be particularly responsive to neutrons. Pilot studies in brain and pancreatic tumours suggest promising new approaches to management of cancer in these sites. The availability of neutron therapy in the clinical environment opens new prospects for irradiation of 'radioresistant' tumours, permits more conservative cancer surgery, expands the use of elective chemotherapy and provides a wider range of options for cancer patients.

1. DOCID:10243 SCORE: 0.00472975743587724
DOCNO: 6821874
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: D C Chacko DC
AUTHOR: F R Hendrickson FR
AUTHOR: A Fisher A
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Definitive irradiation of T1-T4N0 larynx cancer.
PUBDATE: 19830301
The use of definitive irradiation in T1-T4N0 larynx cancer was reviewed in 236 patients at Rush-Presbyterian-St. Luke's Medical Center in Chicago. Recurrence-free survival for all stages was 86% at five years. Ultimate recurrence-free survival, including successful surgical salvage, was 91% at five years. The data described herein and the literature reviewed support the recommendation for definitive radiation therapy for T1 and T2N0 larynx cancer of any site. T3 lesions may also be reasonably treated with radiation therapy initially, reserving surgery for salvage. However, more data are needed to accurately identify the T3 larynx cancer patients most suited for radiation therapy.

2. DOCID:15864 SCORE: 0.004586783146417
DOCNO: 2687307
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: history
AUTHOR: O Vesterberg O
AFFILIATION: Division of Medical Chemistry, National Institute of Occupational Health, Solna, Sweden.
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chromatography.
COUNTRY: NETHERLANDS
TITLE: History of electrophoretic methods.
PUBDATE: 19891001
Electrophoresis is the migration of electrically charged particles or ions in solutions due to an applied electric field. The ability to separate very similar substances including different proteins for analytical and preparative purposes has increased, especially since 1950, owing to the introduction of zone electrophoresis in paper and later in gels of polyacrylamide or agarose. After 1960, disc and displacement electrophoresis (isotachophoresis) and isoelectric focusing offered much increased resolution. Electrophoretic methods nowadays promote advances in biochemistry and molecular biology and will continue to be very important in science and for numerous applications in genetics, gene technology, sequencing of nucleic acids and proteins, studies of diseases and malfunctions including cancer, and in the identification of species and individuals, e.g., in forensic medicine.

3. DOCID:11865 SCORE: 0.00420674105128596
DOCNO: 6181268
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hemoperfusion
DESCRIPTOR: Infusions, Intra-Arterial
QUALIFIER: administration & dosage
QUALIFIER: therapy
AUTHOR: T Harada T
AUTHOR: H Ohmura H
AUTHOR: O Nishizawa O
AUTHOR: S Tsuchida S
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Efficacy and side effects of the regional arterial infusion of anti-cancer drugs combined with direct hemoperfusion in malignancies of the urinary tract.
PUBDATE: 19820901
Regional arterial infusion of high doses of anti-cancer drugs combined with direct hemoperfusion was done in 12 patients with malignancies of the urinary tract. The perfuser contained 130 gm. activated charcoal, which was coated with cellulose. General toxicity caused by escape of the drug from the tumor area was prevented by adsorption within activated charcoal. The capacity of activated charcoal to adsorb doxorubicin hydrochloride was excellent, as determined by measurements of plasma concentration. With this method, objective tumor reduction was noted in 84 per cent of the patients with prostatic or bladder carcinoma, although results were disappointing in patients with renal cell carcinoma.

4. DOCID:12948 SCORE: 0.004091008329791
DOCNO: 3947604
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: S Hayasaka S
AUTHOR: K Mizuno K
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of ophthalmology.
COUNTRY: ENGLAND
TITLE: Malignant melanoma of the choroid in a mother and retinoblastoma in her son.
PUBDATE: 19860201
A 31-year-old woman was diagnosed as having a malignant melanoma of the choroid in the right eye. Twenty months later her 7-year-old son was diagnosed as having retinoblastoma in the right eye. Both diagnoses were confirmed histopathologically after enucleation. A chromosomal study revealed normal karyotypes in the son. The family history was positive for cancer of the stomach. The implications of this rare association are discussed.

5. DOCID:15536 SCORE: 0.0040888707235585
DOCNO: 3039618
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: rehabilitation
AUTHOR: G Schwidurski-Maib G
AUTHOR: K A Jochheim KA
PUBTYPE: Journal Article
JOURNALTITLE: Die Rehabilitation.
COUNTRY: GERMANY, WEST
TITLE: [Current status of after-care cures in oncologic patients]
PUBDATE: 19870501
Some 40 accredited aftercare clinics are available for inpatient cancer aftercare, since 1981 also for immediately post-acute treatment courses. These clinics are used for both, the frequent physical treatment aftermath from oncological diseases in the otological or gynaecological field, and for psychic stabilization when psychosocial problems arise. Participation in autogeneous relaxation training, yoga, and/or psychotherapeutic services are found to entail improved disease coping. Concrete patient care expectancies primarily center around movement therapy, lymphatic drainage (in breast carcinoma), speech therapy (in laryngectomees), pain control, but are also directed at psychosocial care in terms of achieving" inner calmness and relaxation". Given the age distribution seen, increasing the quality of life takes priority over restoration of the working capacity.

6. DOCID:14389 SCORE: 0.00381445324761142
DOCNO: 3470632
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: blood
AUTHOR: M Rapellino M
AUTHOR: F Pecchio F
AUTHOR: S Baldi S
AUTHOR: R Obert R
AUTHOR: A Bevilacqua Rapellino A
AUTHOR: D Libertucci D
AUTHOR: F Coni F
AUTHOR: A Oliaro A
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Usefulness of the determination of CEA and Ca 19-9 in the diagnosis and staging of bronchial carcinoma]
PUBDATE: 19870301
The value of CEA and Ca 19-9 assays in the diagnosis and staging of lung cancer is examined. The particular sensitivity of CEA especially in extensive or metastasised tumours is demonstrated. The minimal sensitivity of Ca 19-9 is pointed out but also its absolute specificity in high risk control groups (smokers and BPCO). It is therefore concluded that Ca 19-9 might be used together with CEA in the diagnosis and staging of lung cancer.

7. DOCID:13564 SCORE: 0.00377001480029602
DOCNO: 3079317
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: radiotherapy
AUTHOR: A S Glicksman AS
AUTHOR: J T Leith JT
AFFILIATION: Dept. of Radiation Medicine, Brown University, Providence, RI.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Radiobiological considerations of brachytherapy.
PUBDATE: 19880101
The special radiobiological effects of low dose-rate radiation on tumors and normal tissue are in large part responsible for the effectiveness of brachytherapy. There is good reason to believe that improvement in local tumor control can be expected by the addition of chemotherapeutic agents, specifically designed radiation sensitizers, and differentiation-inducing agents, as well as by the manipulation of dose rates and dose distributions. This can be an important contribution to cancer management in the future and is an exciting area for further study.

8. DOCID:11071 SCORE: 0.00375150393112164
DOCNO: 2408591
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Esophagus
QUALIFIER: therapy
QUALIFIER: complications
QUALIFIER: instrumentation
AUTHOR: P Y Wang PY
AUTHOR: T J Yeh TJ
AUTHOR: C L Chen CL
AUTHOR: C Y Chen CY
PUBTYPE: Journal Article
JOURNALTITLE: The Annals of thoracic surgery.
COUNTRY: UNITED STATES
TITLE: A spiral-grooved endoesophageal tube for management of malignant esophageal obstruction.
PUBDATE: 19850601
Dysphagia is common in patients with cancer of the esophagus or cardia. The rate of resectability of the lesion is low, and the majority of patients require palliation to relieve the dysphagia. Esophageal intubation is a simple, safe method at present. However, migration of the tube is a frequently reported complication. To prevent dislodgment of the tube, an esophageal tube with spiral grooves and a distal ring has been devised and used in 334 patients in the Veterans General Hospital, Taipei, Taiwan. There have been no operative deaths. The postoperative complication rate was 15%; migration of the tube comprised only 2.7% of that figure.

9. DOCID:15141 SCORE: 0.00372594898257248
DOCNO: 3011256
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: drug therapy
QUALIFIER: chemically induced
AUTHOR: D J Stewart DJ
AUTHOR: J A Maroun JA
AUTHOR: B Lefebvre B
AUTHOR: R Heringer R
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Neurotoxicity and efficacy of combined vinca alkaloids in breast cancer.
PUBDATE: 19860501
We treated 17 patients with metastatic breast cancer with the four-drug combination of vincristine (0.5-1.0 mg), vinblastine (4 mg/m2), doxorubicin (40 mg/m2), and cyclophosphamide (400 mg/m2). The two vinca alkaloids appeared to be synergistic in causing acute, reversible neurotoxicity, manifested primarily as diffuse pains involving one or more of jaws, limbs (particularly joints), chest, and abdomen. The response rate of 70% was no higher than that noted previously with a regimen identical to this one except for the exclusion of vincristine. Further studies of combined vinca alkaloids are not recommended in the treatment of breast cancer.

10. DOCID:10984 SCORE: 0.00372399115423269
DOCNO: 6979179
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: M Moskowitz M
AUTHOR: P S Gartside PS
PUBTYPE: Journal Article
JOURNALTITLE: AJR. American journal of roentgenology.
COUNTRY: UNITED STATES
TITLE: Evidence of breast cancer mortality reduction: aggressive screening in women under age 50.
PUBDATE: 19820501
Five year follow-up data for breast cancer screening of 10,531 self-selected women are presented. The data are compared with the Health Insurance Plan of New York population and it appears that the magnitude of the mortality reduction in these two populations is similar. However, contrary to the New York findings, the data demonstrate that the benefit to screening this population was maximal in women under age 50. No breast cancer deaths have been recorded in 5 years of follow-up in this younger population (6,030 individuals). Interpretation of the data is that aggressive screening for breast cancer can favorably alter breast cancer mortality, particularly in younger women.

11. DOCID:10546 SCORE: 0.00364249868843253
DOCNO: 6149439
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prenatal Exposure Delayed Effects
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: L M Kinnier Wilson LM
AUTHOR: J A Waterhouse JA
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Obstetric ultrasound and childhood malignancies.
PUBDATE: 19841101
The mothers of 1731 children who died of cancer in the United Kingdom between 1972 and 1981, together with the mothers of 1731 matched controls, were asked about exposure to diagnostic ultrasound during the relevant pregnancy. The claims of 103 case mothers and 103 control mothers were verified by hospital records. Exposure to ultrasound in utero did not differ between cancer and control children. It is concluded that ultrasound is safe as regards the risk of cancer and leukaemia. The observed difference between cases and controls exposed during the earlier years of ultrasound use may be due to the selective application of this technique to abnormal pregnancies at that time.

12. DOCID:11287 SCORE: 0.00364043992825988
DOCNO: 6538708
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
AUTHOR: M De Lena M
AUTHOR: V Lorusso V
AUTHOR: U Iacobellis U
AUTHOR: F Marzullo F
AUTHOR: E Maiello E
AUTHOR: A Cramarossa A
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Cis-diamminedichloroplatinum activity in bidimensionally measurable metastatic lesions of bladder carcinoma.
PUBDATE: 19840201
Cis-diamminedichloroplatinum (CDDP) was administered i.v., at the dosage of 20 mg/m2 for 5 consecutive days and recycled every 3 weeks, to 11 patients with bidimensionally measurable metastatic lesions from bladder cancer previously untreated with antineoplastic drugs. Eight patients (6 men and 2 women) were evaluated for clinical response and 9 for toxicity. No complete regression was observed, and partial regression was obtained only in 3 patients (37.5%). Severe leukopenia and thrombocytopenia occurred only occasionally; moderate nausea and vomiting were observed in 5 cases. Nephrotoxicity was noted in 4 of the 9 patients evaluable for toxicity, and 2 of them, with ureteral obstruction, died of renal failure.

13. DOCID:11357 SCORE: 0.00361601981053661
DOCNO: 6494841
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Environmental Exposure
QUALIFIER: mortality
AUTHOR: M J Gardner MJ
AUTHOR: P D Winter PD
PUBTYPE: Journal Article
JOURNALTITLE: Scandinavian journal of work, environment & health.
COUNTRY: FINLAND
TITLE: Extensions to a technique for relating mortality and environment--exemplified by nasal cancer and industry.
PUBDATE: 19840801
The use of geographic data to interrelate mortality rates and environmental variables is an important approach to determining reasons for the variations in disease frequency. An alternative methodology to standard regression analysis was recently suggested, which is particularly useful when there are a large number of geographic areas and relatively few deaths. An extension of this technique is described, which includes a modified regression approach using areas aggregated according to their level of the environmental factor. An example is given relating nasal cancer mortality to the distribution of industry in England and Wales. The known hazards in the furniture and leather industries are indicated and other potential risk industries, including tailoring, are suggested.

14. DOCID:11458 SCORE: 0.00356852901362288
DOCNO: 6200221
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: G Blackledge G
AUTHOR: F Lawton F
AUTHOR: H Buckley H
AUTHOR: D Crowther D
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Phase II evaluation of bleomycin in patients with advanced epithelial ovarian cancer.
PUBDATE: 19840301
Twenty-four patients received bleomycin twice weekly im. Treatment was given for 3 weeks initially, and if there was no evidence of disease progression treatment was given for another 3 weeks. Four patients had partial responses of 2, 4, 4, and 5 months' duration. Three patients had stable disease which did not progress for at least 4 months. There were ten patients with ascites; three of these showed a significant reduction in the amount of ascites present during treatment. There was a partial reduction of tumor in one of these patients. Toxicity was minimal with this regimen, and bleomycin deserves further study in the treatment of ovarian cancer.