0. DOCID:7343 SCORE: 0.00726736526493298
DOCNO: 7289916
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Genetic
QUALIFIER: genetics
AUTHOR: P R Fain PR
AUTHOR: H T Lynch HT
AUTHOR: W A Albano WA
AUTHOR: T A Ruma TA
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Sex differences in lung cancer incidence: a genetic model.
PUBDATE: 19810801
Family histories pertaining to cancer of all anatomic sites were ascertained on 88 Caucasian patients (61 males, 27 females) with histologically verified lung cancer. Lifetable analysis revealed that relatives of female probands had a significantly higher risk for cancer (all sites) at younger age (p less than .04) compared to relatives of male probands. This trend was peculiar to nonsmoking-associated cancer sites, and was not apparent for smoking-associated cancer sites. We hypothesize that certain components of genetic liability to lung cancer are common to nonsmoking-associated malignant neoplasms, and that females who develop lung cancer are more extreme with respect to genotype than are males who develop lung cancer. Our hypothesis accounts for the lower incidence of lung cancer among females, as well as the apparent increased susceptibility to cancer among their relatives.


1. DOCID:3191 SCORE: 0.0061678835705766
DOCNO: 169989
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: T Nakashima T
AUTHOR: K Okuda K
AUTHOR: M Kojiro M
AUTHOR: K Sakamoto K
AUTHOR: Y Kubo Y
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Primary liver cancer coincident with Schistosomiasis japonica. A study of 24 necropsies.
PUBDATE: 19751001
The etiologic relationship of parasitic liver disease to primary liver cancer has long been debated. For this reason, a review of 4611 necropsies was carried out to determine the frequency with which hepatocellular carcinoma occurred in association with schistosomiasis. Of 227 cases of hepatocellular carcinoma, 24 (10.6%) were associated with schistosomiasis japonica. This was significantly higher than the incidence of this carcinoma without schistosomiasis (2.78%). The majority of the 24 cases exhibited the features of a mixed macronodular and micronodular cirrhosis (Gall's posthepatitic cirrhosis); this was super-imposed upon and caused a masking of schistosomiasis fibrosis. By radioimmunoassay hepatitis B antigen was positive in 27% of these cases. A review of the literature indicated that chronic schistosomiasis, on its own, is unlikely to be the cause of primary liver cell carcinoma. Histologic features resembling post-hepatitic cirrhosis combined with a high frequency of hepatitis B antigen suggest that viral hepatitis rather than S. japonicum is the more likely etiologic factor involved, or has a synergistic effect on carcinogenesis.


2. DOCID:10517 SCORE: 0.00600749954935269
DOCNO: 6806472
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neutrons
QUALIFIER: radiotherapy
QUALIFIER: methods
AUTHOR: L Cohen L
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Royal Society of Medicine.
COUNTRY: ENGLAND
TITLE: Expanding options in radiation oncology: neutron beam therapy.
PUBDATE: 19820601
Twelve years' experience with neutron beam therapy in Britain, the USA, Europe and Japan shows that local control is achievable in late-stage epidermoid cancer somewhat more frequently than with conventional radiotherapy. Tumours reputed to be radioresistant (salivary gland, bladder, rectosigmoid, melanoma, bone and soft-tissue sarcomas) have proved to be particularly responsive to neutrons. Pilot studies in brain and pancreatic tumours suggest promising new approaches to management of cancer in these sites. The availability of neutron therapy in the clinical environment opens new prospects for irradiation of 'radioresistant' tumours, permits more conservative cancer surgery, expands the use of elective chemotherapy and provides a wider range of options for cancer patients.


3. DOCID:7404 SCORE: 0.0055685549083676
DOCNO: 7245351
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: G Cardona G
AUTHOR: S Ciatto S
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Criteria of clinical and radiological diagnosis in nonpuerperal acute phlogistic-like processes of the breast: considerations on 97 consecutive cases.
PUBDATE: 19810201
The authors report a series of 97 cases of phlogistic-like process of the breast. Clinical and radiological signs and criteria of differential diagnosis between benign phlogosis and cancer are investigated. The location in the areolar/periareolar region, the presence of fever, and the radiological evidence of limited skin thickening were the features more significantly correlated with benign phlogosis, while cancer should be suspected in the case of lesions located in the upper-outer quadrant and in presence of a diffuse skin thickening at radiological examination. These diagnostic criteria seem particularly useful since the typical clinical or radiological signs of cancer are present only in 50% of cancer cases. The cytological examination of nipple discharge or needle aspiration fluid is of particular help: no false positive or negative cases were observed in a series of 42 examined patients.


4. DOCID:3868 SCORE: 0.00554960590539212
DOCNO: 877854
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pancreatic Ducts
QUALIFIER: secretion
QUALIFIER: secretion
QUALIFIER: physiopathology
AUTHOR: H A Reber HA
AUTHOR: F E Johnson FE
AUTHOR: C Montgomery C
AUTHOR: W R Carl WR
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: Pancreatic secretion in hamsters with pancreatic cancer.
PUBDATE: 19770701
Pancreatic secretory abnormalities develop in most persons with pancreatic cancer and have been attributed to ductal obstruction. These experiments investigated whether abnormal secretion results instead from carcinogen-induced changes in the secreting cells. Fifty male Syrian Golden hamsters (40 to 100 grams) received weekly injections of di-isopropyl-nitrosamine (250 mg/kg, subcutaneously), and survivors and age-matched controls were studied after 3.5 to 6.5 months of treatment. Pancreatic secretion was stimulated by secretin or cholecystokinin (2 units/kg, intravenously, as a bolus). After each stimulus four 15-minute collections of pancreatic juice were analyzed for HCO3- and Cl- or total protein, amylase, trypsin, and chymotrypsin. The organs were examined histologically. Pancreatic ductal adenocarcinoma developed in 30% of the animals at 5 months, 56% at 5.5 months, and 100% at 6.5 months. The animals without cancer either had hyperplasia of the duct epithelium or were histologically normal. The histologic appearance of acinar tissue and protein secretion were normal in all groups. The tumors did not obstruct the major ducts. In all treated animals the pancreatic secretory response to secretin was of low volume, low maximal [HCO3-] and HCO3- output, and low [Cl- + HCO3-]; these changes progressed with time. The secretory abnormalities antedated the appearance of the neoplasms and were not caused by obstruction.


5. DOCID:2926 SCORE: 0.00483874837723853
DOCNO: 1228259
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymph Node Excision
DESCRIPTOR: Mastectomy
QUALIFIER: surgery
AUTHOR: K Esato K
AUTHOR: R Kaku R
AUTHOR: R Yamaki R
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: Reevaluation of parasternal lymph node dissection in the treatment of mammary cancer.
PUBDATE: 19750901
One hundred and forty one patients with mammary cancer underwent the extended radical mastectomy with parasternal lymph nodes dissection between January, 1966 and December, 1974. From the basis of the present report involvement of parasternaly lymph node chain was evaluated retrospectively with respect to the stage, location, size, histological type of cancer, metastasis to axillary and subclavicular lymph nodes, and the five-year survival rate. The parasternal as well as subclavicular and axillary lymph node involvements were not found in non-infiltrating cancer. The more the stage of cancer advanced, the more frequently the parasternal lymph nodes were involved regardless of the location of cancer in the breast. The parasternal lymph node chain alone was rarely involved, but frequently affected along with the axillary lymph nodes. When the parasternal lymph nodes were involved, the five-year survival rate was extremely poor, even after their surgical removal. Subsequently, addition of parasternal lymph node dissection does not seem to be beneficial.


6. DOCID:10243 SCORE: 0.00472975743587724
DOCNO: 6821874
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: D C Chacko DC
AUTHOR: F R Hendrickson FR
AUTHOR: A Fisher A
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Definitive irradiation of T1-T4N0 larynx cancer.
PUBDATE: 19830301
The use of definitive irradiation in T1-T4N0 larynx cancer was reviewed in 236 patients at Rush-Presbyterian-St. Luke's Medical Center in Chicago. Recurrence-free survival for all stages was 86% at five years. Ultimate recurrence-free survival, including successful surgical salvage, was 91% at five years. The data described herein and the literature reviewed support the recommendation for definitive radiation therapy for T1 and T2N0 larynx cancer of any site. T3 lesions may also be reasonably treated with radiation therapy initially, reserving surgery for salvage. However, more data are needed to accurately identify the T3 larynx cancer patients most suited for radiation therapy.


7. DOCID:15864 SCORE: 0.004586783146417
DOCNO: 2687307
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: history
AUTHOR: O Vesterberg O
AFFILIATION: Division of Medical Chemistry, National Institute of Occupational Health, Solna, Sweden.
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chromatography.
COUNTRY: NETHERLANDS
TITLE: History of electrophoretic methods.
PUBDATE: 19891001
Electrophoresis is the migration of electrically charged particles or ions in solutions due to an applied electric field. The ability to separate very similar substances including different proteins for analytical and preparative purposes has increased, especially since 1950, owing to the introduction of zone electrophoresis in paper and later in gels of polyacrylamide or agarose. After 1960, disc and displacement electrophoresis (isotachophoresis) and isoelectric focusing offered much increased resolution. Electrophoretic methods nowadays promote advances in biochemistry and molecular biology and will continue to be very important in science and for numerous applications in genetics, gene technology, sequencing of nucleic acids and proteins, studies of diseases and malfunctions including cancer, and in the identification of species and individuals, e.g., in forensic medicine.


8. DOCID:7499 SCORE: 0.00436765232056081
DOCNO: 435624
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammary Glands, Animal
QUALIFIER: veterinary
AUTHOR: A E Khaĭsman AE
AUTHOR: I P Tereschenko IP
AUTHOR: A S Iagubov AS
PUBTYPE: Journal Article
JOURNALTITLE: Biulleten' eksperimental'noĭ biologii i meditsiny.
COUNTRY: USSR
TITLE: [Relation of the ultrastructural organization of mouse mammary gland cancer to its ability to metastasize]
PUBDATE: 19790401
A quantitative ultrastructural investigation of cancer in mice mammary glands and of its metastases to the lungs was carried out. It was established that in tumors showing no metastatic spreading in experiment the area of membrane surface of the endoplasmic reticulum and the number of bound ribosomes are greater than those in tumor spreading metastases. At the same time the number of ribosomes organized into polysomes is higher in the metastasized tumors. The comparison of the tumors with their metastases revealed differences in the structure of the mitochondrial apparatus: the surface area of cristae is larger in the metastatic foci. The evidence obtained shows that tumors spreading metastases have a lower level of cellular differentiation. The primary and metastatic foci do not exhibit any difference in the level of differentiation.


9. DOCID:7447 SCORE: 0.00436764968983077
DOCNO: 7212797
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Enzyme Tests
DESCRIPTOR: Rectal Neoplasms
QUALIFIER: blood
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: P I Tartter PI
AUTHOR: G Slater G
AUTHOR: I Gelernt I
AUTHOR: A H Aufses AH
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Screening for liver metastases from colorectal cancer with carcinoembryonic antigen and alkaline phosphatase.
PUBDATE: 19810301
A sensitive and economic method of screening for liver metastases in patients with colorectal cancer was developed using serum alkaline phosphatase and carcinoembryonic antigen. The upper limit of normal for alkaline phosphatase and carcinoembryonic antigen did not represent the optimal levels for use in predicting liver metastases. However, with alkaline phosphatase greater than 135 I.U., and/or carcinoembryonic antigen greater than 10 ng/ml, sensitivity was 88%: 23 of 26 patients with liver metastases fulfilled either or both criteria. The false-positive rate was 12%. Liver scanning, alone, demonstrated metastases in only 69% of 35 patients with liver metastases. The combination of alkaline phosphatase and carcinoembryonic antigen can be used economically to screen for liver metastases, and to determine which patients should undergo a liver scan.


10. DOCID:11865 SCORE: 0.00420674105128596
DOCNO: 6181268
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hemoperfusion
DESCRIPTOR: Infusions, Intra-Arterial
QUALIFIER: administration & dosage
QUALIFIER: therapy
AUTHOR: T Harada T
AUTHOR: H Ohmura H
AUTHOR: O Nishizawa O
AUTHOR: S Tsuchida S
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Efficacy and side effects of the regional arterial infusion of anti-cancer drugs combined with direct hemoperfusion in malignancies of the urinary tract.
PUBDATE: 19820901
Regional arterial infusion of high doses of anti-cancer drugs combined with direct hemoperfusion was done in 12 patients with malignancies of the urinary tract. The perfuser contained 130 gm. activated charcoal, which was coated with cellulose. General toxicity caused by escape of the drug from the tumor area was prevented by adsorption within activated charcoal. The capacity of activated charcoal to adsorb doxorubicin hydrochloride was excellent, as determined by measurements of plasma concentration. With this method, objective tumor reduction was noted in 84 per cent of the patients with prostatic or bladder carcinoma, although results were disappointing in patients with renal cell carcinoma.


11. DOCID:7526 SCORE: 0.00413538831100231
DOCNO: 7351004
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: P A Pizzo PA
AUTHOR: S Ladisch S
AUTHOR: K Ribichaud K
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Treatment of gram-positive septicemia in cancer patients.
PUBDATE: 19800101
Seventy-eight pediatric cancer patients were treated for gram-positive bacterial septicemia during a 10-year period (1968-1977). Sixty-one (78%) of the patients were granulocytopenic (PMNs less than 500/mm3) at the onset of the septic episode. All the patients whose granulocytopenia resolved (PMNs greater than 500/mm3) within one week of therapy recovered without sequelae. However, 7 of 15 patients (47%) who remained granulocytopenic for more than 7 days and who were treated with a single antibiotic developed a second sepsis with a gram-negative organism. In contrast, second infections were not observed in 24 patients with PMNs less than 500/mm3 for more than 7 days who were treated with broad spectrum antibiotics (p less than 0.002), suggesting that a broad-spectrum antibiotic regimen may be preferable when a cancer patient has prolonged granulocytopenia.


12. DOCID:1844 SCORE: 0.0041180778778512
DOCNO: 203233
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T G Peters TG
AUTHOR: W L Donegan WL
AUTHOR: E A Burg EA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Minimal breast cancer: a clinical appraisal.
PUBDATE: 19771201
Eighty-five patients with a diagnosis of minimal breast cancer were evaluated. The predominant lesion was intraductal carcinoma, and axillary metastases occurred in association with minimal breast cancer in seven of 96 cases. One death occurred due to minimal breast cancer. Bilateral mammary carcinoma was evident in 24% and bilateral minimal breast cancer in 13% of the patients. The component lesions of minimal breast cancer have varied biologic activity, but prognosis is good with a variety of operations. The multifocal nature of minimal breast cancer and the potential for metastases should be recognized. Therapy should include removal of the entire mammary parenchyma and low axillary nodes. The high incidence of bilateral malignancy supports elective contralateral biopsy at the time of therapy for minimal breast cancer.


13. DOCID:12948 SCORE: 0.004091008329791
DOCNO: 3947604
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: S Hayasaka S
AUTHOR: K Mizuno K
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of ophthalmology.
COUNTRY: ENGLAND
TITLE: Malignant melanoma of the choroid in a mother and retinoblastoma in her son.
PUBDATE: 19860201
A 31-year-old woman was diagnosed as having a malignant melanoma of the choroid in the right eye. Twenty months later her 7-year-old son was diagnosed as having retinoblastoma in the right eye. Both diagnoses were confirmed histopathologically after enucleation. A chromosomal study revealed normal karyotypes in the son. The family history was positive for cancer of the stomach. The implications of this rare association are discussed.


14. DOCID:15536 SCORE: 0.0040888707235585
DOCNO: 3039618
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: rehabilitation
AUTHOR: G Schwidurski-Maib G
AUTHOR: K A Jochheim KA
PUBTYPE: Journal Article
JOURNALTITLE: Die Rehabilitation.
COUNTRY: GERMANY, WEST
TITLE: [Current status of after-care cures in oncologic patients]
PUBDATE: 19870501
Some 40 accredited aftercare clinics are available for inpatient cancer aftercare, since 1981 also for immediately post-acute treatment courses. These clinics are used for both, the frequent physical treatment aftermath from oncological diseases in the otological or gynaecological field, and for psychic stabilization when psychosocial problems arise. Participation in autogeneous relaxation training, yoga, and/or psychotherapeutic services are found to entail improved disease coping. Concrete patient care expectancies primarily center around movement therapy, lymphatic drainage (in breast carcinoma), speech therapy (in laryngectomees), pain control, but are also directed at psychosocial care in terms of achieving" inner calmness and relaxation". Given the age distribution seen, increasing the quality of life takes priority over restoration of the working capacity.