0. DOCID:25917 SCORE: 0.00643209196377112
DOCNO: 10553409
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: T Kubota T
AFFILIATION: Dept. of Surgery, School of Medicine, Keio University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Theoretical basis for low-dose CDDP/5-FU therapy]
PUBDATE: 19991001
The theoretical basis for low-dose cisplatin (CDDP)/5-fluorouracil (5-FU) therapy is rather clear. CDDP can inhibit methionine-uptake into tumor cells and cause depletion of folate cofactors including 5-CH3FH4 and FH4, which are essential for the formation of a ternary complex with thymidylate synthetase and 5-fluorodeoxyuridine, an active metabolite of 5-FU. The literature on this mechanism are reviewed herein, and the methionine-dependency of human cancer xenografts and the modulation of 5-FU-cytotoxicity through methionine-depletion are reported.


1. DOCID:26082 SCORE: 0.00500332748170083
DOCNO: 10228355
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: M Malerba M
AUTHOR: S Cavaliere S
AUTHOR: A Marengoni A
AUTHOR: A Politi A
AUTHOR: A Radaeli A
AUTHOR: V Grassi V
AFFILIATION: Cattedra di Medicina Interna I, Università, Brescia. medresp@master.cci.unibs.it
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Recenti progressi in medicina.
COUNTRY: ITALY
TITLE: [Tracheal stenosis due to metastatic adenopathic compression from breast carcinoma]
PUBDATE: 19990301
Paratracheal lymph-nodal metastases secondary of breast cancer aren't frequent in this kind of cancer. Here is described the case of a 76-years-old woman come to our note for ingravescent dyspnoea caused by metastatic adenopathy compression of the tracheal lumen. After excluding other treatments, a tracheal stent is put on. The obstruction gets better right away, the initial severe respiratory symptoms are improved and the ventilation is almost normal.


2. DOCID:26389 SCORE: 0.00410638193822204
DOCNO: 11189780
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: organization & administration
QUALIFIER: rehabilitation
QUALIFIER: organization & administration
QUALIFIER: organization & administration
QUALIFIER: organization & administration
AUTHOR: H H Bartsch HH
AUTHOR: H Delbrück H
AUTHOR: P Kruck P
AUTHOR: L Schmid L
AFFILIATION: Klinik für Tumorbiologie an der Universität Freiburg. baha@tumorbio.uni-freiburg.de
PUBTYPE: Journal Article
JOURNALTITLE: Die Rehabilitation.
COUNTRY: Germany
TITLE: [Process quality in oncologic rehabilitation. Viewpoint of the Professional Committee of Rehabilitation, After-care and Social Medicine of the German Cancer Society]
PUBDATE: 20001201
The article concerns itself with the issue of process quality in inpatient institutions for oncological rehabilitation and expresses the viewpoint of the German Cancer Society's Section for Rehabilitation, Aftercare and Social Medicine (ARNS). Standards for the organization of patients' access to the rehabilitation clinic, for the design of oncological-rehabilitational diagnostics, for the formation of therapeutic strategies and the rehabilitative services offered will be described.


3. DOCID:27504 SCORE: 0.00364734543053272
DOCNO: 9750487
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
QUALIFIER: pathology
QUALIFIER: classification
QUALIFIER: pathology
AUTHOR: A Sakamoto A
AUTHOR: Y Terado Y
AFFILIATION: Department of Pathology, School of Medicine, Kyorin University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Histological classification of prostatic cancer]
PUBDATE: 19980801
Histological classification of prostatic cancer with a special focus on adenocarcinoma was reviewed according to "General Rule for Clinical and Pathological Studies on Prostatic Cancer (The 2nd Edition, 1992) published by Japanese Urological Association and The Japanese Society of Pathology. The points of the classification are as follows; (1) adenocarcinoma is separated into 3 categories, namely, well, moderately and poorly differentiated types, by structural features. (2) nuclear grading does not commit for making a subclassification of prostatic adenocarcinoma. The other types of primary malignancies are rare in the prostate. Prostatic intraepithelial neoplasia should be discussed in the further revision of the classification.


4. DOCID:24182 SCORE: 0.00348814230076061
DOCNO: 14731833
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: J C Litherland JC
AFFILIATION: West of Scotland Breast Screening Service and Glasgow Royal Infirmary, Glasgow.
PUBTYPE: Journal Article
JOURNALTITLE: Breast (Edinburgh, Scotland)
COUNTRY: Scotland
TITLE: The effects of HRT on screening mammography.
PUBDATE: 20000601
The effects of hormone replacement therapy on screening for breast cancer by mammography are reviewed. There is a decline in specificity in screen mammography for women over the age of 50 taking oral preparations, The use of HRT also reduces the sensitivity of breast screening by regular mammography.


5. DOCID:27386 SCORE: 0.00347736407770712
DOCNO: 10669049
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: metabolism
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: K Takao K
AUTHOR: S Takai S
AUTHOR: T Ishihara T
AUTHOR: S Mita S
AUTHOR: M Miyazaki M
AFFILIATION: Department of Pharmacology, Osaka Medical College, Takatsuki, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of pharmacology.
COUNTRY: JAPAN
TITLE: Inhibition of human chymase by suramin.
PUBDATE: 19991201
Chymase is a chymotrypsin-like protease localized in mast cells in complexes with heparin. In the present study, we demonstrated that suramin, a hexasulfonated naphthylurea used as an anti-cancer drug, inhibits the activity of purified human chymase in vitro. The inhibition was ionic-strength-dependent. It was observed that suramin competed with heparin-Sepharose gel for binding to chymase and the inhibition of chymase activity by suramin was partially impaired by heparin. Our results show that suramin may become a prototype of a new type of chymase inhibitor because of its unique character.


6. DOCID:27411 SCORE: 0.00330798590716117
DOCNO: 10938655
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: H R Metelmann HR
AFFILIATION: Klinik für Mund-, Kiefer- und Gesichtschirurgie/Plastische Operationen, Greifswald, Deutschland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Mund-, Kiefer- und Gesichtschirurgie : MKG.
COUNTRY: GERMANY
TITLE: [Chemotherapy and radiochemotherapy in tumors of the head-neck area]
PUBDATE: 20000501
Standard curative therapy in head and neck cancer, especially in oral cavity carcinoma, consists, so far, of surgery. Until today, chemotherapy using standard drugs has failed to be effective beyond controlling cancer manifestations and palliation of symptoms. The introduction of chemotherapy and radiotherapy as adjuvant treatment, however, may improve overall survival and curative options. A multicentric randomized trial, initiated by DOSAK, has compared results after radical surgery alone with results of combined preoperative radio-chemotherapy followed by radical surgery. The life table analysis substantiated improved survival rates in the group of patients whose treatment included chemotherapy and radiation.


7. DOCID:27218 SCORE: 0.00330785630544737
DOCNO: 9563228
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ampulla of Vater
DESCRIPTOR: Common Bile Duct Neoplasms
DESCRIPTOR: Cystadenoma, Mucinous
DESCRIPTOR: Neoplasms, Multiple Primary
DESCRIPTOR: Ovarian Neoplasms
DESCRIPTOR: Pregnancy Complications, Neoplastic
AUTHOR: T K Choudhury TK
AUTHOR: A Sen A
AFFILIATION: Department of General Surgery, Institute of Post Graduate Medical Education and Research, Calcutta.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.
COUNTRY: INDIA
TITLE: Periampullary carcinoma with bilateral ovarian cystadenoma in pregnancy.
PUBDATE: 19980401
We report a 30-year-old woman with periampullary cancer and a large left ovarian cystadenoma presenting during pregnancy with features of duodenal obstruction. She had a right benign ovarian tumor removed a year back. She delivered an intrauterine-growth-retarded live baby. Laparotomy in the postpartum period revealed an unresectable periampullary growth with hepatic metastasis and a left ovarian cystadenoma. The ovarian tumor was removed and a palliative gastrojejunostomy performed.


8. DOCID:26674 SCORE: 0.00307960646583854
DOCNO: 10702326
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: mortality
QUALIFIER: analysis
AUTHOR: C Y Yang CY
AUTHOR: M F Cheng MF
AUTHOR: S S Tsai SS
AUTHOR: C F Hung CF
AFFILIATION: School of Public Health, Kaohsiung Medical College, Kaohsiung, 80708, Taiwan.
PUBTYPE: Journal Article
JOURNALTITLE: Environmental research.
COUNTRY: UNITED STATES
TITLE: Fluoride in drinking water and cancer mortality in Taiwan.
PUBDATE: 20000301
The possibility that cancer risk is associated with naturally fluoridated water in Taiwan is examined. The 1982-1991 age-adjusted mortality rates for cancer for 10 municipalities whose water supplies contained the highest naturally occurring fluoride concentrations in Taiwan were compared to those rates for 10 matched municipalities with unfluoridated water. The two groups had similar urbanization levels and sociodemographic characteristics. Our study does not support the suggestion that fluoridation of water supplies is associated with an increase in cancer mortality in Taiwan.


9. DOCID:26869 SCORE: 0.00306146055967389
DOCNO: 10079659
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Services for the Aged
DESCRIPTOR: Patient Care Team
QUALIFIER: therapy
AUTHOR: F Ashkanani F
AUTHOR: S D Heys SD
AUTHOR: O Eremin O
AFFILIATION: Department of Surgery, University Medical Buildings, Foresterhill, Aberdeen, Scotland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the Royal College of Surgeons of Edinburgh.
COUNTRY: SCOTLAND
TITLE: The management of cancer in the elderly.
PUBDATE: 19990201
The treatment of elderly patients with cancer requires a multidisciplinary approach if optimal locoregional control of disease and survival are to be achieved. Wherever possible, the surgical, radiotherapeutic and chemotherapeutic regimens given to elderly patients with cancer should be comparable with those currently used for the treatment of younger patients with cancer. However, the morbidity (physical and psychological) of therapy must be evaluated against the likely benefits to ensure that elderly patients with cancer receive both optimal management and quality of life.


10. DOCID:25286 SCORE: 0.00298551640086582
DOCNO: 11473438
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: isolation & purification
AUTHOR: B W Yu BW
AUTHOR: L H Meng LH
AUTHOR: J Y Chen JY
AUTHOR: T X Zhou TX
AUTHOR: K F Cheng KF
AUTHOR: J Ding J
AUTHOR: G W Qin GW
AFFILIATION: Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, People's Republic of China.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: Cytotoxic oxoisoaporphine alkaloids from Menispermum dauricum.
PUBDATE: 20010701
Four new oxoisoaporphine alkaloids, daurioxoisoporphines A-D (1-4), were isolated from the rhizomes of Menispermum dauricum. The structures of these alkaloids were established by spectroscopic methods. The cytotoxic evaluation of 1 and 2 is reported against four cancer cell lines.


11. DOCID:26254 SCORE: 0.00298086127658832
DOCNO: 9695575
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: L R Vorobĭova LR
PUBTYPE: Journal Article
JOURNALTITLE: Likars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny.
COUNTRY: UKRAINE
TITLE: [The morphogenesis of cancer of the prostate (immunohistochemical research)]
PUBDATE: 19980501
With the purpose of establishing morphogenetic features of precancer and early cancer of the prostate gland a comparative immunomorphological evaluation was done of the prostate tumor markers (PAP, PSA, PCNA, and 34 beta E12). Due emphasis is given to the part the basal cell dysplasia plays in morphogenesis of prostatic cancer. The precancer lesions of the prostate include atypical adenomatous hyperplasia, grade I and II prostatic intraepithelial neoplasia (PIN). Grade III prostatic intraepithelial neoplasm is cancer in situ, or uninfiltrative (unpalpable) cancer of the prostate. PIN patients are at high risk for subsequent development of invasive prostatic carcinoma.


12. DOCID:27733 SCORE: 0.00278243034615387
DOCNO: 9712386
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: therapeutic use
AUTHOR: M Carlisle M
AUTHOR: A Cortés A
AUTHOR: I R McDougall IR
AFFILIATION: Division of Nuclear Medicine, Stanford Health Services, California 94305, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical nuclear medicine.
COUNTRY: UNITED STATES
TITLE: Uptake of I-131 in the biliary tract: a potential cause of a false-positive result of scintiscan.
PUBDATE: 19980801
Focal uptake of I-131 in the region of the liver was seen on whole-body scans in a 22-year-old asymptomatic woman who had invasive papillary cancer. Hepatic metastases were unlikely because of the clinical risk factors, and a CT scan of the liver was normal. By superimposing the I-131 scintiscan and a hepatobiliary scan, the site of the uptake was shown to be in the biliary tract, and it had migrated to the gallbladder on more delayed images. No pathologic cause was found.


13. DOCID:27175 SCORE: 0.00266579477640592
DOCNO: 10475836
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Life Expectancy
DESCRIPTOR: Women's Health
QUALIFIER: physiology
QUALIFIER: trends
AUTHOR: H Kesteloot H
AFFILIATION: Ecole de Santé Publique, Universitaire Ziekenhuis Sint Rafaël, Leuven.
PUBTYPE: Journal Article
JOURNALTITLE: Revue médicale de Liège.
COUNTRY: BELGIUM
TITLE: [Female mortality: lessons from geopathological comparisons]
PUBDATE: 19990401
Worldwide a highly significant correlation exists between male and female mortality, particularly for all-cause, cardiovascular and cerebrovascular mortality, but to a lesser degree for cancer. This shows that the same factors are the major determinants of mortality in both sexes. Mortality from all causes over the age range 35-84 years can adequately be expressed by Gompertz equations (log mortality versus age), of which the intercepts are lower and the slopes higher in women compared to men. The demonstrates that ageing progresses more slowly in women. Maximum life expectancy is slightly higher in women. The various causes of mortality are competitive.


14. DOCID:25913 SCORE: 0.0026599704624957
DOCNO: 10584600
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
DESCRIPTOR: Population Surveillance
QUALIFIER: diagnosis
QUALIFIER: prevention & control
AUTHOR: J F Helm JF
AUTHOR: R S Sandler RS
AFFILIATION: Department of Medicine, University of South Florida, Tampa, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Medical clinics of North America.
COUNTRY: UNITED STATES
TITLE: Colorectal cancer screening.
PUBDATE: 19991101
Colorectal cancer is an important problem in the United States, with over 130,000 new cases and 55,000 deaths each year. There is now strong evidence that screening for colorectal cancer with fecal occult blood testing can decrease mortality, and additional evidence that removing benign adenomas can decrease cancer incidence. Evidence-based screening guidelines depend on colorectal cancer risk. Individuals at higher risk because of a personal or family history deserve more intensive screening than asymptomatic individuals over age 50.