0. DOCID:23965 SCORE: 0.00574833575553586
DOCNO: 9234358
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: immunology
QUALIFIER: chemistry
QUALIFIER: diagnostic use
QUALIFIER: instrumentation
QUALIFIER: chemistry
AUTHOR: G Ferro-Flores G
AUTHOR: J Lezama-Carrasco J
AFFILIATION: Department of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Mexico.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Nuclear medicine and biology.
COUNTRY: ENGLAND
TITLE: A freeze dried kit formulation for the preparation of 99mTc-EHDP-MoAb-IOR CEA1 complex.
PUBDATE: 19941001
A freeze dried kit formulation for the preparation of 99mTc-labelled IOR-CEA1, a monoclonal antibody (MoAb) against a human colorectal cancer, was developed. Methods of analysis were also established permitting identification of radiochemical impurities which may be present in radiopharmaceutical solution. 99mTc-EHDP-MoAb-IOR CEA1 prepared by the kit method was evaluated in human volunteers to apply the radioimmunodetection of human colon cancer. Data demonstrated that the complex formed after kit-reconstitution shows excellent stability and tumor seeking properties. Colon carcinoma in patients was successfully detected 6-8 and 20-28 h post administration.


1. DOCID:23508 SCORE: 0.00441959023437234
DOCNO: 9134529
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: immunology
AUTHOR: H L Chen HL
AUTHOR: D P Carbone DP
AFFILIATION: Division of Medical Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Molecular medicine today.
COUNTRY: ENGLAND
TITLE: p53 as a target for anti-cancer immunotherapy.
PUBDATE: 19970401
The key to specific and non-toxic cancer therapy is likely to be identification and targeting of processes that are absolutely unique to the tumor. One such approach is to target cells expressing mutations in the oncoproteins that led to the development of the cancer, such as p53. In animal model systems, highly mutant p53-specific cytotoxic T cells can be induced, but it remains to be seen whether this can be translated into clinical practice, and what proportion of tumors will respond. In this review, the potential and problems of immunological targeting of mutant p53 in solid tumors are discussed.


2. DOCID:23478 SCORE: 0.00441301696646127
DOCNO: 8133759
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Spectroscopy
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: N V Pederson NV
AUTHOR: J A Zanghi JA
AUTHOR: W M Miller WM
AUTHOR: R H Knop RH
AFFILIATION: Chemical Engineering Department, Northwestern University, Evanston, Illinois.
PUBTYPE: Journal Article
JOURNALTITLE: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine.
COUNTRY: UNITED STATES
TITLE: Discrimination of fluorinated uridine metabolites in N-417 small cell lung cancer cell extracts via 19F- and 31P-NMR.
PUBDATE: 19940201
31P-NMR extract spectra of N-417 Small Cell Lung Cancer (SCLC) cells cultured with fluorouridine (FUrd) reveal new peaks with chemical shifts in the diphosphodiester and nucleoside triphosphate regions. These peaks were identified as FUTP, FUDP, FUDP-glucose, FUDP-glucuronate, FUDP-GlcNAc, and FUDP-GalNAc via enzymatic conversion and 19F- and 31P-NMR analysis. Distinct 19F chemical shifts were assigned for FUTP, FUDP, and the FUDP-sugars.


3. DOCID:22207 SCORE: 0.00428149897829284
DOCNO: 8611983
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: transplantation
QUALIFIER: surgery
AUTHOR: C Acar C
AUTHOR: A Berrebi A
AUTHOR: M Tolan M
AUTHOR: J C Chachqués JC
AFFILIATION: Department of Cardiovascular Surgery, Hospital Bichat, Paris, France.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of heart valve disease.
COUNTRY: ENGLAND
TITLE: Partial mitral homograft: a new technique for mitral valve repair.
PUBDATE: 19951101
Partial mitral homograft was used in 22 patients with localized lesions contraindicating a conventional valve repair. The etiologies of valve disease were: calcified rheumatic stenosis (n=14) and acute bacterial endocarditis (n=8). One patient died three months after surgery from cancer. Another patient required reoperation for residual stenosis 14 months postoperatively. All other patients had an excellent functional result with 19 patients in sinus rhythm. In this series, partial homograft replacement of the mitral valve significantly extended the possibilities of reconstructive surgery.


4. DOCID:23403 SCORE: 0.00424974943335454
DOCNO: 9111642
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Androgen Antagonists
DESCRIPTOR: Imidazoles
DESCRIPTOR: Imidazolidines
QUALIFIER: drug therapy
AUTHOR: S D Huan SD
AUTHOR: R G Gerridzen RG
AUTHOR: J C Yau JC
AUTHOR: D J Stewart DJ
AFFILIATION: Division of Medical Oncology, Ottawa Regional Cancer Centre, Ontario, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Antiandrogen withdrawal syndrome with nilutamide.
PUBDATE: 19970401
Antiandrogens are combined with medical or surgical castration to achieve total androgen blockade in metastatic prostate cancer. Discontinuation of antiandrogens at disease progression has been associated with prostate-specific antigen (PSA) decrease, symptom improvement, and occasionally objective tumor regression. Two cases of metastatic prostate cancer demonstrating decrease in PSA of 92% and 56% on discontinuation of nilutamide therapy are reported. Improvement in urinary symptoms, bone pain and, in one, disappearance of para-aortic lymphadenopathy paralleled the PSA decrease. The duration of the withdrawal response of 6 months was comparable to those reported with discontinuation of flutamide.


5. DOCID:22989 SCORE: 0.0041895157030139
DOCNO: 8528480
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mesothelioma
DESCRIPTOR: Pleural Neoplasms
AUTHOR: J S Donington JS
AUTHOR: D J Mew DJ
AUTHOR: H I Pass HI
AFFILIATION: Thoracic Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology.
COUNTRY: ENGLAND
TITLE: Malignant pleural mesothelioma: newer aspects of carcinogenesis, molecular genetics, and prospects for future therapies.
PUBDATE: 19950801
Malignant pleural mesothelioma (MPM) is an asbestos-related disease which, although rare, is having a major social impact, and is, for the majority of cases, an incurable illness. There has been a surge of information regarding data on mesothelial transformation, mesothelioma molecular genetics and somatic gene therapy for this disease. This report summarizes the most recent investigations attempting to characterize the behaviour, on a cellular and molecular level, of MPM, with an emphasis on data from investigations performed at the National Cancer Institute with our collaborators.


6. DOCID:21963 SCORE: 0.00403773417861595
DOCNO: 7858571
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: B Duquesnoy B
AUTHOR: R M Flipo RM
AFFILIATION: Service de Rhumatologie, Hôpital B, CH et U, Lille.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue du rhumatisme (Ed. française : 1993)
COUNTRY: FRANCE
TITLE: [Rheumatoid arthritis and neoplasms]
PUBDATE: 19941201
The relationships between rheumatoid arthritis and malignant disease have been a focus of controversy for many years. The body of available data supports a relative decrease in the overall rate of occurrence of cancer, in particular of the colon, with no significant impact on mortality. However, increases have been demonstrated in the relative risks of lymphoma and, to a lesser degree, leukemia. The concomitant occurrence of rheumatoid arthritis and multiple myeloma seems fortuitous, with a relative risk of approximately 2. The effect of treatments, including methotrexate, remains unproven to date.


7. DOCID:23314 SCORE: 0.00402166457834576
DOCNO: 9276605
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: virology
QUALIFIER: virology
QUALIFIER: complications
QUALIFIER: virology
AUTHOR: P Widrick P
AUTHOR: A Boguniewicz A
AUTHOR: T Nazeer T
AUTHOR: S C Remick SC
AFFILIATION: Division of Medical Oncology, Albany Medical College, New York, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Mayo Clinic proceedings. Mayo Clinic.
COUNTRY: UNITED STATES
TITLE: Breast cancer in a man with human immunodeficiency virus infection.
PUBDATE: 19970801
Non-acquired immunodeficiency syndrome (AIDS)-defining neoplasms are being increasingly recognized in patients infected with the human immunodeficiency virus (HIV). The incidence of Hodgkin's disease and seminoma has recently been reported to be increasing in these patients. This article describes the second case of breast cancer in an HIV-infected male patient. A total of 11 cases of coincident breast cancer and HIV infection have previously been reported. It may be prudent to consider breast cancer in the differential diagnosis of an axillary mass in an HIV-infected patient.


8. DOCID:23382 SCORE: 0.00402166254282573
DOCNO: 8646605
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: K Ishikawa K
AUTHOR: H Nakano H
AUTHOR: T Fujioka T
AUTHOR: I Nagakubo I
AFFILIATION: Department of Urology, Tachikawa Mutualaid Hospital, Tokyo, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: Testicular cancer in father and son.
PUBDATE: 19960101
The occurrence of testicular tumors in closely related family members is rare. We report a case of testicular cancers in a father and son. The father had pure seminoma, and his son developed a mixed nonseminomatous germ cell tumor. The peripheral blood lymphocytes in both patients were tested for 52 HLA specificities, and the patients were found to have six in common. The son was homozygous for HLA A24. The association between certain HLA antigens, other genetic factors, and testicular cancer requires further study to improve the care and counseling of patients and their families.


9. DOCID:22902 SCORE: 0.00398251292142109
DOCNO: 10157739
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Practice Guidelines
QUALIFIER: therapeutic use
QUALIFIER: standards
AUTHOR: C M Murphy CM
AUTHOR: J Jackson J
AUTHOR: L Worrall L
AFFILIATION: Oncology Nursing Society, Pittsburgh, PA 15220, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Pharmacy practice management quarterly.
COUNTRY: UNITED STATES
TITLE: Oncology Nursing Society: development and implementation of practice guidelines.
PUBDATE: 19960401
With more than 25,000 professional nurse members, the Oncology Nursing Society (ONS) is the largest oncology membership organization in the world. Now in its 20th year, one way that ONS supports its mission of promoting excellence in oncology nursing is through the development and dissemination of patient care standards and guidelines. The first guidelines to be developed by ONS were the Cancer Chemotherapy Guidelines. Now in their third edition, the historical development and revision of these guidelines is detailed in this article, along with the evaluation and refinement of the process utilized by ONS.


10. DOCID:23999 SCORE: 0.0031863695247362
DOCNO: 7935315
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
PUBTYPE: Journal Article
JOURNALTITLE: MMWR. Morbidity and mortality weekly report.
COUNTRY: UNITED STATES
TITLE: Cigarette smoking among women of reproductive age--United States, 1987-1992.
PUBDATE: 19941101
Women who smoke cigarettes are at increased risk for lung cancer, chronic obstructive pulmonary disease, and complications of oral contraceptive use. During pregnancy, cigarette smoking increases the risks for a low birthweight infant and infant mortality. A national health objective for the year 2000 is to reduce cigarette smoking among women of reproductive age (i.e., 18-44 years) to a prevalence of no more than 12% (objective 3.4h)(1). This goal is substantially lower than the estimated baseline prevalence of 29% measured by CDC's 1987 National Health Interview Survey (NHIS). To characterize recent trends in cigarette smoking and monitor progress toward the year 2000 objective, data from the NHIS for 1987 through 1992 were analyzed for women aged 18-44 years.


11. DOCID:22286 SCORE: 0.00288618897683261
DOCNO: 8927266
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: S Gentilli S
AUTHOR: C M Fronticelli CM
AUTHOR: A Ferrero A
AUTHOR: F Quiriconi F
AUTHOR: R Corradino R
AFFILIATION: VI Divisione Universitaria di Chirurgia Generale, Ospedale San Giovanni Battista, Torino.
PUBTYPE: Journal Article
JOURNALTITLE: Minerva chirurgica.
COUNTRY: ITALY
TITLE: [Gallbladder carcinoma. Our experience]
PUBDATE: 19960401
The authors report their experience of 18 patients with primary cancer of the gallbladder. On 10 patients at stage IV, 9 had a preoperative diagnosis, while at stage 0-1 and 2 the diagnosis was intraoperative or histologic. Every patient had a cholelithiasis at the same time. The authors discuss prophylactic cholecystectomy, even without specific symptoms, and emphasize the need for a better morphological and radiomorphological classification. In the light of the new microinvasive surgical techniques, they briefly discuss laparoscopic cholecystectomy and histologic diagnosis of carcinoma of the gallbladder.


12. DOCID:23176 SCORE: 0.00285138302845175
DOCNO: 7655520
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: P Graziotti P
AUTHOR: A Losa A
AUTHOR: R Hurle R
AUTHOR: A Lembo A
AFFILIATION: Divisione Urologia, Ospedali Riuniti Bergamo.
PUBTYPE: Journal Article
JOURNALTITLE: Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia.
COUNTRY: ITALY
TITLE: [Our current indications for radical prostatectomy]
PUBDATE: 19950601
Radical prostatectomy is the golden standard for localized prostate cancer. The identification of patients with intraprostatic disease who can be cured and will live long enough to benefit from a surgical therapy represents the primary goal of the authors. Target of this article is underlining the importance of an accurate preoperative staging through ultrasound-guided biopsy of seminal vesicles and periprostatic spaces. The positivity of the surgical margin after radical prostatectomy is also taken into account as it represents, according to the authors, an extremely important but often overlooked parameter.


13. DOCID:22395 SCORE: 0.00278434232539126
DOCNO: 7983764
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: metabolism
QUALIFIER: therapeutic use
AUTHOR: R Selvakumar R
AUTHOR: L A Borenstein LA
AUTHOR: Y L Lin YL
AUTHOR: R Ahmed R
AUTHOR: F O Wettstein FO
AFFILIATION: Department of Microbiology and Immunology, School of Medicine, University of California, Los Angeles 90024-1747.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of virology.
COUNTRY: UNITED STATES
TITLE: Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas.
PUBDATE: 19950101
Cottontail rabbit papillomavirus is the major animal model for cancer-associated papillomaviruses. Here we show that vaccination with the nonstructural proteins E1 and E2 induces the regression of virus-induced papillomas and that vaccination is equally effective when proteins are given with and without adjuvant. There was no correlation between antibody levels and regression, suggesting that tumor regression may be due to a cell-mediated response.


14. DOCID:22944 SCORE: 0.00253131174070224
DOCNO: 7513895
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: ultrasonography
AUTHOR: P G Hammerer PG
AFFILIATION: Abteilung für Urologie, Stanford Universität.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Der Radiologe.
COUNTRY: GERMANY
TITLE: [Sonographic diagnosis of prostatic cancer]
PUBDATE: 19940301
In 75-80% of all clinically significant prostate cancer, the peripheral zone appears to be hypoechoic on transrectal ultrasound (TRUS). However, examination by TRUS alone in a screening program is not recommended due to its low sensitivity. The combination of prostate-specific antigen, digital rectal examination, and TRUS increases the detection rate of prostate cancer. In prostate cancer arising from the transition zone, TRUS findings are often nonspecific. Even prostate biopsies might be negative due to the location of this tumor. Anterior biopsies of the transition zone will identify these prostate cancers. Color Doppler ultrasound of the prostate has little additional value over TRUS alone in the diagnosis of prostate cancer.