0. DOCID:7313 SCORE: 0.00629936914972148
DOCNO: 7427908
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: F P Smith FP
AUTHOR: D F Hoth DF
AUTHOR: B Levin B
AUTHOR: D A Karlin DA
AUTHOR: J S MacDonald JS
AUTHOR: P V Woolley PV
AUTHOR: P S Schein PS
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: 5-fluorouracil, Adriamycin, and mitomycin-C (FAM) chemotherapy for advanced adenocarcinoma of the pancreas.
PUBDATE: 19801101
Thirty-nine patients with advanced metastatic adenocarcinoma of the pancreas were treated with a combination of 5-fluorouracil, Adriamycin, and mitomycin-C (FAM). Twenty-seven of these patients had measurable disease, and ten (37%) achieved a partial response. An additional three patients had evidence of disease stabilization. The median survival period of responding patients was 12 months, compared with 3.5 months for nonresponders (P < 0.01). The median survival period for all patients was 6 months. Moderate myelosuppression constituted the treatment-limiting toxicity. The FAM combination is an active and well-tolerated regimen for pancreatic cancer and may have an application in the management of patients with less advanced disease.


1. DOCID:7929 SCORE: 0.00589635878212896
DOCNO: 103610
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: M Perloff M
AUTHOR: R D Hart RD
AUTHOR: J F Holland JF
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Vinblastine, adriamycin, thiotepa, and halotestin (VATH): therapy for advanced breast cancer refractory to prior chemotherapy.
PUBDATE: 19781201
Nineteen postmenopausal patients with metastatic breast cancer refractory to conventional combination chemotherapy were treated with monthly cycles with the combinations of vinblastine, adriamycin, thiotepa and halotestin. Ten patients (52%) responded with a greater than 50% regression of measurable tumor. The median duration of response was 11.5 months, with 5/10 patients still responding at a mean follow-up of 10 months. Only 2/10 responders have died with a mean follow-up of 13.8 months. In contrast, 8/9 nonresponders have died (median survival 6.0 months). Response to therapy was neither influenced by site of disease, time interval from diagnosis to primary chemotherapy nor duration of response to primary chemotherapy. No patient was hospitalized because of drug induced toxicity. This combination of drugs is a tolerable effective regimen for patients relapsing after adjuvant chemotherapy or after primary combination chemotherapy for grossly metastatic disease.


2. DOCID:6770 SCORE: 0.00499852991981668
DOCNO: 6245096
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Protons
QUALIFIER: methods
AUTHOR: H D Suit HD
AUTHOR: M Goitein M
AUTHOR: J E Munzenrider JE
AUTHOR: L Verhey L
AUTHOR: E Gragoudas E
AUTHOR: A M Koehler AM
AUTHOR: M Urano M
AUTHOR: W U Shipley WU
AUTHOR: R M Linggood RM
AUTHOR: C Friedberg C
AUTHOR: M Wagner M
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Canadian Association of Radiologists.
COUNTRY: CANADA
TITLE: Clinical experience with proton beam radiation therapy.
PUBDATE: 19800301
Our experience with modulated energy proton beams in the definitive treatment of cancer patients indicates that, for the patients accepted, treatment volumes have been smaller and total doses higher than would have obtained for photon techniques alone used in our institution. The reactions of normal tissue have, with very few exceptions, been readily acceptable. The higher radiation doses employed should yield higher tumor control frequencies. Clearly, we cannot assess the efficacy of this modality because of the small number of patients followed for short periods. However, the results are judged by use to warrant intensive evaluation of this modality.


3. DOCID:5249 SCORE: 0.00474004251147637
DOCNO: 209161
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: F P Li FP
AUTHOR: M H Myers MH
AUTHOR: H W Heise HW
AUTHOR: N Jaffe N
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of pediatrics.
COUNTRY: UNITED STATES
TITLE: The course of five-year survivors of cancer in childhood.
PUBDATE: 19780801
A follow-up study was made of two independent series of 1,807 and 425 children who were alive five years after diagnosis of a malignant neoplasm. Over the subsequent 20 years (5 to 24 years after initial diagnosis), actuarial survival rates for the cohorts were 83% and 79%, respectively, compared to 97% for matched control subjects in the general population (P less than 0.01). Cure was achieved in a large majority of the 5-year relapse-free survivors of cancer in this study.


4. DOCID:7478 SCORE: 0.00462279153071926
DOCNO: 222425
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: biosynthesis
QUALIFIER: metabolism
AUTHOR: M Hattori M
AUTHOR: H Imura H
AUTHOR: S Matsukura S
AUTHOR: Y Yoshimoto Y
AUTHOR: K Sekita K
AUTHOR: T Tomomatsu T
AUTHOR: M Kyogoku M
AUTHOR: T Kameya T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Multiple-hormone producing lung carcinoma.
PUBDATE: 19790601
Endocrine and immunohistochemical studies were performed in a patient with lung cancer associated with gynecomastia. Elevated level of human chorionic gonadotropin (hCG) in plasma and mild hyperadrenocorticism were demonstrated by hormone assays. Postmortem examination proved the existence of anaplastic small cell carcinoma of the lung mixed with a feature of chorioepithelioma. The presence of significant amounts of adrenocorticotropic hormone (ACTH), beta-melanocyte stimulating hormone (beta-MSH), calcitonin, gastrin, hCG, hCG-alpha, hCG-beta and human chorionic somatomammotropin (hCS) in tumor tissues was demonstrated by radioimmunoassays, bioassay and immunohistochemical techniques. We present here a unique case of multiple hormones producing tumor elaborating both hormones of amine precursor uptake and decarboxylation (APUD) series (ACTH, beta-MSH, calcitonin and gastrin) and of placental origin (hCG, hCG-alpha, hCG-beta and hCS).


5. DOCID:5827 SCORE: 0.00392000065951831
DOCNO: 7334976
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: cytology
QUALIFIER: diagnosis
AUTHOR: C D Holman CD
AUTHOR: A J McCartney AJ
AUTHOR: K L Hyde KL
AUTHOR: B K Armstrong BK
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: Cervical cytology histories of 100 women with invasive carcinoma of the cervix.
PUBDATE: 19811101
We reviewed the cytological histories of 100 women diagnosed as having invasive carcinoma of the cervix in Western Australia in 1977-80. Sixty-one women had never had a cervical smear test before the diagnosis of cancer. Among the remaining 39 patients, nine had one or more dyskaryotic cervical smears taken, up to eight years before the diagnosis of invasive cancer was made. Another patient had two smears, suspicious of malignancy, taken 15 years before diagnosis. Wider use of colposcopy and selective biopsy in the management of patients with abnormal smear test results is recommended.


6. DOCID:6722 SCORE: 0.00371455289769737
DOCNO: 393609
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Enzyme Tests
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: N A Romas NA
AUTHOR: N R Rose NR
AUTHOR: M Tannenbaum M
PUBTYPE: Journal Article
JOURNALTITLE: Human pathology.
COUNTRY: UNITED STATES
TITLE: Acid phosphatase: new developments.
PUBDATE: 19790901
Acid phosphatase was the first "tumor marker" to be measured in the blood, and over 40 years have passed since an elevation of the serum acid phosphatase level was observed in patients with prostatic carcinoma. However, significant elevations in the level of this enzyme have been observed in other diseases, as well as elevations of other tissue phosphatases. Many improvements in the colorimetric technique have been introduced, but none has been used successfully to detect the tissue origin of this ubiquitous enzyme. The finding that prostatic acid phosphatase is antigenically distinct from acid phosphatase of other tissues opened a new horizon in the measurement of acid phosphatase in prostatic cancer. On the basis of this immunochemical specificity, several immunoassays have been employed for determining the prostatic acid phosphatase level.


7. DOCID:6606 SCORE: 0.00361750439572207
DOCNO: 435064
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pancreatectomy
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: A R Moossa AR
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Reoperation for pancreatic cancer.
PUBDATE: 19790401
Over an eight-year period, 24 patients were referred following laparotomy at various community hospitals where their conditions had been diagnosed as "incurable pancreatic cancer." Seventeen of these patients' conditions were reevaluated and they underwent exploratory surgery again. In two patients, no cancer was found in spite of multiple biopsies. Nine patients underwent total pancreatectomy with no operative deaths, and two of them had localized primary ampullary cancer. Eleven of these 17 patients have survived 1 1/2 to six years. We conclude that reoperation in selected cases in which the condition was diagnosed as "inoperable pancreatic cancer" can have an appreciable salvage rate. We suggest that pancreatic exploration with a view to resection should be performed only in specialty centers where there is interest and expertise in the problem.


8. DOCID:7840 SCORE: 0.0035432057331428
DOCNO: 6971869
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: B Andreoni B
AUTHOR: P Salvini P
AUTHOR: B Gridelli B
AUTHOR: M Balestri M
AUTHOR: L Strada L
AUTHOR: L Tognini L
AUTHOR: C Ghezzi C
AUTHOR: G Bevilacqua G
PUBTYPE: Journal Article
JOURNALTITLE: Journal de chirurgie.
COUNTRY: FRANCE
TITLE: [Early diagnosis of stomach cancer: report on 23 cases including 15 patients with an acute hemorrhage or perforation (author's transl)]
PUBDATE: 19810401
Early gastric cancer was detected in 23 patients, 15 of whom had acute complications of either hemorrhage or perforation. Cases with acute complications often have a more favorable prognosis as a carcinoma may be identified while still in its pre-invasive stage. The gravity of the complication should not result in the employ of limited diagnostic procedures (e.g. endoscopy without multiple biopsies) or the use of incomplete therapeutic measures (e.g. simple suture of a perforated ulcer). The treatment of hemorrhagic gastric ulcers and perforated ulcers is discussed in greater detail. The need for a continuous follow-up of these patients with gastric ulcers is emphasized. This should include periodic endoscopy examination and multiple biopsies, even when a gastric ulcer has been apparently cured by medical treatment.


9. DOCID:7934 SCORE: 0.00349096060221044
DOCNO: 628297
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: K J Rothman KJ
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Epidemiology of head and neck cancer.
PUBDATE: 19780301
The epidemiology of head and neck cancer can be accounted for largely in terms of known carcinogens introduced into the body through the mouth. Though there are many environmental exposures--such as asbestos, radon, nickel and arsenic--which have strong carcinogenic effects, most of these have only a small impact on the general population because exposure is limited, usually to small occupational groups. Two prevalent exposures, however, tobacco and alcohol, are strong risk factors for nearly all sites in the head and neck, and together account for about 80%-90% of all cancers of the head and neck. There is evidence for biologic interaction between some occupational exposures and cigarette smoking for cancer of the lung, and tobacco and alcohol for cancer of the mouth. Based on this evidence for biologic interaction and the prevalence of smoking, it seems likely that tobacco is related to about 80% of all cancers of the head and neck in the United States.


10. DOCID:6629 SCORE: 0.00348920567542704
DOCNO: 7272917
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography
QUALIFIER: diagnosis
AUTHOR: D Pollock D
AUTHOR: K J Taylor KJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Ultrasound scanning in patients with clinical suspicion of pancreatic cancer: a retrospective study.
PUBDATE: 19810301
A retrospective study was performed on all patients with clinical suspicion of a pancreatic cancer over a seven-month period. Diagnostic scans of the pancreas were obtained in 87% of the patients. Of 112 patients with a successful ultrasound study, 97 had adequate clinical or surgical follow up. The ultrasound examination was abnormal in 16 of 17 pancreatic cancer patients, yielding a positive predictive value of 84%. Most patients had distant spread at this time. The negative predictive value was 99%, sensitivity was 94%, specificity 96%. This study does nt suggest that ultrasound leads to an earlier diagnosis of pancreatic cancer. However, because the symptoms of the disease are common in the elderly, ultrasound allows reliable exclusion of this disease in a noninvasive way.


11. DOCID:7599 SCORE: 0.00348523207120508
DOCNO: 7324484
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: methods
AUTHOR: R Hawliczek R
AUTHOR: H D Kogelnik HD
AUTHOR: K H Kärcher KH
AUTHOR: W Binder W
AUTHOR: T Szepesi T
PUBTYPE: Journal Article
JOURNALTITLE: Wiener klinische Wochenschrift.
COUNTRY: AUSTRIA
TITLE: [The moving-strip technique in the treatment of ovarian cancer (author's transl)]
PUBDATE: 19811101
A critical analysis of the latest results in the treatment of epithelial ovarian carcinomas indicates significant progress. Postoperative radiotherapy using the moving-strip technique is the treatment of choice in stages I a (grade 2 and 3 lesions and/or tumour rupture), Ib, II and III (asymptomatic) with residual tumours less than 2 cm in size. In the stages Ic, IIc and III (symptomatic) with residual tumours larger than 2 cm, radiotherapy may be curative following successful initial combination chemotherapy. This combined modality treatment is being investigated in our department in a prospective trial. The importance of prognostically significant factors (completeness of operation, age, histology, histological grade and adequate treatment) is discussed. The moving-strip technique is described in particular with regard to its practical application as basis of the modern therapeutic regimen for ovarian cancer.


12. DOCID:7608 SCORE: 0.00347115133090798
DOCNO: 7262675
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: A Kuten A
AUTHOR: L Lev L
AUTHOR: J Mohaliver J
AUTHOR: E Robinson E
PUBTYPE: Journal Article
JOURNALTITLE: Harefuah.
COUNTRY: ISRAEL
TITLE: [Combination chemotherapy in metastatic breast cancer]
PUBDATE: 19810201
Combination chemotherapy was administered to 62 patients with metastatic breast cancer in the years 1977-9. The combination consisted of cyclophosphamide, methotrexate and 5-fluorouracil. The average age was 52.5 years, and the range from 27-76. Complete or partial remission for a period of 11.5 months (median) was achieved in 56.5%. Among 23 cases of lung metastases 48% had partial or complete remissions, among 16 cases of lymph node metastases 81%, and among 32 cases of bone metastases, 37.5%. Of six cases of local recurrence, 33.3% had partial remissions. Among four cases of liver metastases, 50% had objective responses. Among five cases of miscellaneous metastases, all had complete or partial responses. The median survival of the complete responders was 17 months, while that of the nonresponders was only 11 months. Side effected were tolerable and no deaths were attributed to the treatment.


13. DOCID:5659 SCORE: 0.00345279541318873
DOCNO: 6791280
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Staplers
QUALIFIER: prevention & control
QUALIFIER: surgery
AUTHOR: J M Anderson JM
PUBTYPE: Journal Article
JOURNALTITLE: Scottish medical journal.
COUNTRY: SCOTLAND
TITLE: Chemoradiotherapeutic prevention of local recurrence after stapled anastomoses in rectal cancer.
PUBDATE: 19810101
Continuity of bowel was restored after resection of twelve midrectal cancers (6 Dukes' B, 4 Dukes' C and 2 metastatic to liver) by stapling with the SPTU suture gun, following pre-operative radiotherapy and intraoperative topical chemotherapy with 5-flourouracil and mercuric perchloride. Postoperative contrast radiographs revealed one of the 12 anastomoses to be leaking. Three patients died 18 to 10 months after resection and nine have been followed for two to six years. No clinical, endoscopic or biochemical evidence of local recurrence has emerged. Comparative trials of this type of chemoradiotherapeutic prophylaxis of local recurrence after restorative operations for low rectal cancers are advocated.


14. DOCID:5962 SCORE: 0.00338314243719184
DOCNO: 7440045
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: J Faivre J
AUTHOR: C Milan C
AUTHOR: M C Hillon MC
AUTHOR: F Martin F
AUTHOR: C Klepping C
PUBTYPE: Journal Article
JOURNALTITLE: International journal of epidemiology.
COUNTRY: ENGLAND
TITLE: Incidence of digestive tract cancers in a well defined population in France.
PUBDATE: 19800901
A systematic registration of mortality and morbidity from digestive tract cancers was started in January 1976 in the French department of Cote d'Or (population 455,727). In the course of 3 years 1356 newly diagnosed cases were recorded. In males cancer of the rectum is the most common digestive tract cancer, coming before cancer of the stomach and cancer of the colon. In females cancer of the colon prevails over cancer of the rectum and cancer of the stomach. The survey allows comparison with the incidence rate of digestive cancers in other countries. Results of treatment underline the lateness of diagnosis.