0. DOCID:25917 SCORE: 0.00643209196377112
DOCNO: 10553409
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: T Kubota T
AFFILIATION: Dept. of Surgery, School of Medicine, Keio University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Theoretical basis for low-dose CDDP/5-FU therapy]
PUBDATE: 19991001
The theoretical basis for low-dose cisplatin (CDDP)/5-fluorouracil (5-FU) therapy is rather clear. CDDP can inhibit methionine-uptake into tumor cells and cause depletion of folate cofactors including 5-CH3FH4 and FH4, which are essential for the formation of a ternary complex with thymidylate synthetase and 5-fluorodeoxyuridine, an active metabolite of 5-FU. The literature on this mechanism are reviewed herein, and the methionine-dependency of human cancer xenografts and the modulation of 5-FU-cytotoxicity through methionine-depletion are reported.


1. DOCID:23965 SCORE: 0.00574833575553586
DOCNO: 9234358
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: immunology
QUALIFIER: chemistry
QUALIFIER: diagnostic use
QUALIFIER: instrumentation
QUALIFIER: chemistry
AUTHOR: G Ferro-Flores G
AUTHOR: J Lezama-Carrasco J
AFFILIATION: Department of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Mexico.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Nuclear medicine and biology.
COUNTRY: ENGLAND
TITLE: A freeze dried kit formulation for the preparation of 99mTc-EHDP-MoAb-IOR CEA1 complex.
PUBDATE: 19941001
A freeze dried kit formulation for the preparation of 99mTc-labelled IOR-CEA1, a monoclonal antibody (MoAb) against a human colorectal cancer, was developed. Methods of analysis were also established permitting identification of radiochemical impurities which may be present in radiopharmaceutical solution. 99mTc-EHDP-MoAb-IOR CEA1 prepared by the kit method was evaluated in human volunteers to apply the radioimmunodetection of human colon cancer. Data demonstrated that the complex formed after kit-reconstitution shows excellent stability and tumor seeking properties. Colon carcinoma in patients was successfully detected 6-8 and 20-28 h post administration.


2. DOCID:19769 SCORE: 0.00505739905744972
DOCNO: 8483604
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prostheses and Implants
QUALIFIER: surgery
QUALIFIER: radiotherapy
QUALIFIER: surgery
AUTHOR: G Granström G
AUTHOR: A Tjellström A
AUTHOR: P I Brånemark PI
AUTHOR: J Fornander J
AFFILIATION: Department of Otolaryngology-Head and Neck Surgery, Ostra Hospital, University of Gothenburg, Sweden.
PUBTYPE: Journal Article
JOURNALTITLE: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.
COUNTRY: UNITED STATES
TITLE: Bone-anchored reconstruction of the irradiated head and neck cancer patient.
PUBDATE: 19930401
Titanium implants in facial bones for retention of epitheses or dental bridges were used for reconstruction in cancer patients after tumor surgery. Even heavily irradiated bones could integrate the implants and bear the load from the epithesis. No major complications, such as wound infection, fistulation, or osteoradionecrosis, occurred after implant surgery. There was, however, an increased loss of implants with time after irradiation, especially in the orbital region. When hyperbaric oxygen was used as adjunctive treatment, implant losses were reduced.


3. DOCID:26082 SCORE: 0.00500332748170083
DOCNO: 10228355
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: M Malerba M
AUTHOR: S Cavaliere S
AUTHOR: A Marengoni A
AUTHOR: A Politi A
AUTHOR: A Radaeli A
AUTHOR: V Grassi V
AFFILIATION: Cattedra di Medicina Interna I, Università, Brescia. medresp@master.cci.unibs.it
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Recenti progressi in medicina.
COUNTRY: ITALY
TITLE: [Tracheal stenosis due to metastatic adenopathic compression from breast carcinoma]
PUBDATE: 19990301
Paratracheal lymph-nodal metastases secondary of breast cancer aren't frequent in this kind of cancer. Here is described the case of a 76-years-old woman come to our note for ingravescent dyspnoea caused by metastatic adenopathy compression of the tracheal lumen. After excluding other treatments, a tracheal stent is put on. The obstruction gets better right away, the initial severe respiratory symptoms are improved and the ventilation is almost normal.


4. DOCID:18560 SCORE: 0.00460490342165036
DOCNO: 1323751
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: physiopathology
QUALIFIER: etiology
QUALIFIER: physiology
AUTHOR: B E Smith BE
AFFILIATION: Mayo Medical School, Scottsdale, Arizona.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Neurologic clinics.
COUNTRY: UNITED STATES
TITLE: Inflammatory sensory polyganglionopathies.
PUBDATE: 19920801
The inflammatory sensory polyganglionopathies are a group of uncommon neurologic disorders primarily affecting dorsal root ganglion cells and their processes. Subdivided into malignant and nonmalignant inflammatory sensory polyganglionopathy, these conditions are important in the differential diagnosis of sensory neuropathy. The clinical significance of malignant inflammatory sensory polyganglionopathy, a paraneoplastic syndrome, rests in the discovery of subclinical cancer, which may produce antineuronal nuclear antibodies directed against the dorsal root ganglion cell and other neurons resulting in characteristic neurologic deficits. Prompt recognition of these distinctive signs and symptoms may result in early diagnosis and improved patient survival and lead to a better understanding of immune-mediated neurologic disease.


5. DOCID:23508 SCORE: 0.00441959023437234
DOCNO: 9134529
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: immunology
AUTHOR: H L Chen HL
AUTHOR: D P Carbone DP
AFFILIATION: Division of Medical Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Molecular medicine today.
COUNTRY: ENGLAND
TITLE: p53 as a target for anti-cancer immunotherapy.
PUBDATE: 19970401
The key to specific and non-toxic cancer therapy is likely to be identification and targeting of processes that are absolutely unique to the tumor. One such approach is to target cells expressing mutations in the oncoproteins that led to the development of the cancer, such as p53. In animal model systems, highly mutant p53-specific cytotoxic T cells can be induced, but it remains to be seen whether this can be translated into clinical practice, and what proportion of tumors will respond. In this review, the potential and problems of immunological targeting of mutant p53 in solid tumors are discussed.


6. DOCID:23478 SCORE: 0.00441301696646127
DOCNO: 8133759
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Spectroscopy
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: N V Pederson NV
AUTHOR: J A Zanghi JA
AUTHOR: W M Miller WM
AUTHOR: R H Knop RH
AFFILIATION: Chemical Engineering Department, Northwestern University, Evanston, Illinois.
PUBTYPE: Journal Article
JOURNALTITLE: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine.
COUNTRY: UNITED STATES
TITLE: Discrimination of fluorinated uridine metabolites in N-417 small cell lung cancer cell extracts via 19F- and 31P-NMR.
PUBDATE: 19940201
31P-NMR extract spectra of N-417 Small Cell Lung Cancer (SCLC) cells cultured with fluorouridine (FUrd) reveal new peaks with chemical shifts in the diphosphodiester and nucleoside triphosphate regions. These peaks were identified as FUTP, FUDP, FUDP-glucose, FUDP-glucuronate, FUDP-GlcNAc, and FUDP-GalNAc via enzymatic conversion and 19F- and 31P-NMR analysis. Distinct 19F chemical shifts were assigned for FUTP, FUDP, and the FUDP-sugars.


7. DOCID:30701 SCORE: 0.00439186965148416
DOCNO: 16050939
OWNER: NLM
STATUS: In-Process
AUTHOR: Susan G Lakoski SG
AUTHOR: David M Herrington DM
AFFILIATION: Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Diabetes, obesity & metabolism.
COUNTRY: England
TITLE: Effects of oestrogen receptor-active compounds on lipid metabolism.
PUBDATE: 20050901
Selective estrogen receptor modulators (SERMs) have been used successfully in the treatment of breast cancer and osteoporosis while Tibolone has been used extensively in Europe for the treatment of menopausal symptoms. Limited data is available on the effect of these agents on the cardiovascular system. Traditional and novel lipid markers are valuable in determining patients at increased cardiovascular risk. The purpose of this article is to discuss the mechanism of action of Tamoxifen, Raloxifene and Tibolone and their effects on lipid metabolism.


8. DOCID:22207 SCORE: 0.00428149897829284
DOCNO: 8611983
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: transplantation
QUALIFIER: surgery
AUTHOR: C Acar C
AUTHOR: A Berrebi A
AUTHOR: M Tolan M
AUTHOR: J C Chachqués JC
AFFILIATION: Department of Cardiovascular Surgery, Hospital Bichat, Paris, France.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of heart valve disease.
COUNTRY: ENGLAND
TITLE: Partial mitral homograft: a new technique for mitral valve repair.
PUBDATE: 19951101
Partial mitral homograft was used in 22 patients with localized lesions contraindicating a conventional valve repair. The etiologies of valve disease were: calcified rheumatic stenosis (n=14) and acute bacterial endocarditis (n=8). One patient died three months after surgery from cancer. Another patient required reoperation for residual stenosis 14 months postoperatively. All other patients had an excellent functional result with 19 patients in sinus rhythm. In this series, partial homograft replacement of the mitral valve significantly extended the possibilities of reconstructive surgery.


9. DOCID:23403 SCORE: 0.00424974943335454
DOCNO: 9111642
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Androgen Antagonists
DESCRIPTOR: Imidazoles
DESCRIPTOR: Imidazolidines
QUALIFIER: drug therapy
AUTHOR: S D Huan SD
AUTHOR: R G Gerridzen RG
AUTHOR: J C Yau JC
AUTHOR: D J Stewart DJ
AFFILIATION: Division of Medical Oncology, Ottawa Regional Cancer Centre, Ontario, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Antiandrogen withdrawal syndrome with nilutamide.
PUBDATE: 19970401
Antiandrogens are combined with medical or surgical castration to achieve total androgen blockade in metastatic prostate cancer. Discontinuation of antiandrogens at disease progression has been associated with prostate-specific antigen (PSA) decrease, symptom improvement, and occasionally objective tumor regression. Two cases of metastatic prostate cancer demonstrating decrease in PSA of 92% and 56% on discontinuation of nilutamide therapy are reported. Improvement in urinary symptoms, bone pain and, in one, disappearance of para-aortic lymphadenopathy paralleled the PSA decrease. The duration of the withdrawal response of 6 months was comparable to those reported with discontinuation of flutamide.


10. DOCID:22989 SCORE: 0.0041895157030139
DOCNO: 8528480
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mesothelioma
DESCRIPTOR: Pleural Neoplasms
AUTHOR: J S Donington JS
AUTHOR: D J Mew DJ
AUTHOR: H I Pass HI
AFFILIATION: Thoracic Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology.
COUNTRY: ENGLAND
TITLE: Malignant pleural mesothelioma: newer aspects of carcinogenesis, molecular genetics, and prospects for future therapies.
PUBDATE: 19950801
Malignant pleural mesothelioma (MPM) is an asbestos-related disease which, although rare, is having a major social impact, and is, for the majority of cases, an incurable illness. There has been a surge of information regarding data on mesothelial transformation, mesothelioma molecular genetics and somatic gene therapy for this disease. This report summarizes the most recent investigations attempting to characterize the behaviour, on a cellular and molecular level, of MPM, with an emphasis on data from investigations performed at the National Cancer Institute with our collaborators.


11. DOCID:26389 SCORE: 0.00410638193822204
DOCNO: 11189780
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: organization & administration
QUALIFIER: rehabilitation
QUALIFIER: organization & administration
QUALIFIER: organization & administration
QUALIFIER: organization & administration
AUTHOR: H H Bartsch HH
AUTHOR: H Delbrück H
AUTHOR: P Kruck P
AUTHOR: L Schmid L
AFFILIATION: Klinik für Tumorbiologie an der Universität Freiburg. baha@tumorbio.uni-freiburg.de
PUBTYPE: Journal Article
JOURNALTITLE: Die Rehabilitation.
COUNTRY: Germany
TITLE: [Process quality in oncologic rehabilitation. Viewpoint of the Professional Committee of Rehabilitation, After-care and Social Medicine of the German Cancer Society]
PUBDATE: 20001201
The article concerns itself with the issue of process quality in inpatient institutions for oncological rehabilitation and expresses the viewpoint of the German Cancer Society's Section for Rehabilitation, Aftercare and Social Medicine (ARNS). Standards for the organization of patients' access to the rehabilitation clinic, for the design of oncological-rehabilitational diagnostics, for the formation of therapeutic strategies and the rehabilitative services offered will be described.


12. DOCID:21963 SCORE: 0.00403773417861595
DOCNO: 7858571
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: B Duquesnoy B
AUTHOR: R M Flipo RM
AFFILIATION: Service de Rhumatologie, Hôpital B, CH et U, Lille.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue du rhumatisme (Ed. française : 1993)
COUNTRY: FRANCE
TITLE: [Rheumatoid arthritis and neoplasms]
PUBDATE: 19941201
The relationships between rheumatoid arthritis and malignant disease have been a focus of controversy for many years. The body of available data supports a relative decrease in the overall rate of occurrence of cancer, in particular of the colon, with no significant impact on mortality. However, increases have been demonstrated in the relative risks of lymphoma and, to a lesser degree, leukemia. The concomitant occurrence of rheumatoid arthritis and multiple myeloma seems fortuitous, with a relative risk of approximately 2. The effect of treatments, including methotrexate, remains unproven to date.


13. DOCID:23314 SCORE: 0.00402166457834576
DOCNO: 9276605
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: virology
QUALIFIER: virology
QUALIFIER: complications
QUALIFIER: virology
AUTHOR: P Widrick P
AUTHOR: A Boguniewicz A
AUTHOR: T Nazeer T
AUTHOR: S C Remick SC
AFFILIATION: Division of Medical Oncology, Albany Medical College, New York, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Mayo Clinic proceedings. Mayo Clinic.
COUNTRY: UNITED STATES
TITLE: Breast cancer in a man with human immunodeficiency virus infection.
PUBDATE: 19970801
Non-acquired immunodeficiency syndrome (AIDS)-defining neoplasms are being increasingly recognized in patients infected with the human immunodeficiency virus (HIV). The incidence of Hodgkin's disease and seminoma has recently been reported to be increasing in these patients. This article describes the second case of breast cancer in an HIV-infected male patient. A total of 11 cases of coincident breast cancer and HIV infection have previously been reported. It may be prudent to consider breast cancer in the differential diagnosis of an axillary mass in an HIV-infected patient.


14. DOCID:23382 SCORE: 0.00402166254282573
DOCNO: 8646605
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: K Ishikawa K
AUTHOR: H Nakano H
AUTHOR: T Fujioka T
AUTHOR: I Nagakubo I
AFFILIATION: Department of Urology, Tachikawa Mutualaid Hospital, Tokyo, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: Testicular cancer in father and son.
PUBDATE: 19960101
The occurrence of testicular tumors in closely related family members is rare. We report a case of testicular cancers in a father and son. The father had pure seminoma, and his son developed a mixed nonseminomatous germ cell tumor. The peripheral blood lymphocytes in both patients were tested for 52 HLA specificities, and the patients were found to have six in common. The son was homozygous for HLA A24. The association between certain HLA antigens, other genetic factors, and testicular cancer requires further study to improve the care and counseling of patients and their families.