0. DOCID:30487 SCORE: 0.0015603064886632
DOCNO: 16009521
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: pharmacology
QUALIFIER: chemistry
AUTHOR: Gordon M Cragg GM
AUTHOR: David J Newman DJ
AFFILIATION: Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, P.O. Box B, Frederick, MD 21702-1201, USA. cragg@mail.nih.gov
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of ethnopharmacology.
COUNTRY: Ireland
TITLE: Plants as a source of anti-cancer agents.
PUBDATE: 20050801
Plant-derived compounds have been an important source of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, derived from epipodophyllotoxin, and paclitaxel (taxol A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest.


1. DOCID:29255 SCORE: 0.00154327627376209
DOCNO: 14606062
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: trends
QUALIFIER: therapy
AUTHOR: Chao Zhang C
AUTHOR: Zhan-Kui Liu ZK
AFFILIATION: Department of General Surgery, Southwest Hospital, Third Military Medical University, Gaotan Yan, Chongqing 400038, China. meizhang6688@yahoo.com.cn
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: World journal of gastroenterology : WJG.
COUNTRY: China
TITLE: Gene therapy for gastric cancer: a review.
PUBDATE: 20031101
Gastric cancer is common in China, and its early diagnosis and treatment are difficult. In recent years great progress has been achieved in gene therapy, and a wide array of gene therapy systems for gastric cancer has been investigated. The present article deals with the general principles of gene therapy and then focuses on how these principles may be applied to gastric cancer.


2. DOCID:29757 SCORE: 0.00129127066947615
DOCNO: 11985563
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: standards
AUTHOR: J H F Smith JH
AFFILIATION: Department of Histopathology, Royal Hallamshire Hospital, Sheffield, UK. John.Smith@sth.nhs.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cytopathology : official journal of the British Society for Clinical Cytology.
COUNTRY: England
TITLE: Bethesda 2001.
PUBDATE: 20020201
The Bethesda system (TBS) for reporting cervical/vaginal cytological diagnoses was originally developed in 1988 at a National Cancer Institute (NCI) workshop convened to consider the benefits of increased standardization in the diagnostic reports provided by cytology laboratories. It rapidly gained acceptance in laboratory practice in the USA and beyond and three years later the NCI sponsored another workshop to assess the use of TBS in practice and consider areas for improvement. Subsequently an illustrated guide was published.


3. DOCID:29415 SCORE: 0.00129123916659974
DOCNO: 15919587
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: Duncan M Baird DM
AFFILIATION: Department of Pathology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. bairddm@cardiff.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Experimental gerontology.
COUNTRY: England
TITLE: New developments in telomere length analysis.
PUBDATE: 20050501
Telomeres provide an essential 'capping' function, which prevents the natural end of a chromosome from being recognised as a simple dsDNA break. The biology of human telomeres is inextricably linked with both cancer and ageing. As such there is considerable interest in determining the length of these essential and dynamic structures. Here I review, from the standpoint of ageing research in humans, the current situation with regards to technologies available to determine telomere length in human cells and tissues.


4. DOCID:29591 SCORE: 0.00127447807144525
DOCNO: 12063681
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Profiling
DESCRIPTOR: Oligonucleotide Array Sequence Analysis
QUALIFIER: genetics
AUTHOR: Jonathan R Pollack JR
AUTHOR: Matt Van de Rijn M
AUTHOR: David Botstein D
AFFILIATION: Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: United States
TITLE: Challenges in developing a molecular characterization of cancer.
PUBDATE: 20020601
DNA microarrays are widely used to measure gene expression across thousands of genes in parallel. Recently, considerable efforts have been made to utilize this technology to improve our understanding of cancer and to identify novel diagnostic markers and therapeutic targets. Here, we detail some of the challenges in developing a molecular characterization of cancer and in translating these new discoveries towards clinical utility.


5. DOCID:31145 SCORE: 0.00103486305529043
DOCNO: 16340841
OWNER: NLM
STATUS: In-Process
AUTHOR: J-P Sculier JP
AFFILIATION: Service des Soins Intensifs & Oncologie Thoracique, Institut Jules Bordet, Bruxelles, Belgique. sculier@bordet.de
PUBTYPE: Journal Article
JOURNALTITLE: Revue des maladies respiratoires.
COUNTRY: France
TITLE: [Treatment of thoracic malignancy--results of meta-analyses]
PUBDATE: 20051201
Meta-analyses dealing with the treatment of thoracic malignancy (non-small cell lung cancer, small cell lung cancer and mesothelioma) were reviewed including isolated ones, based on individual data from clinical trials, or conducted in the context of a systematic review of the literature Their results have changed clinical practice, notably by validating radiochemotherapy for patients with unresectable limited diseases, adjuvant chemotherapy for resectable non-small cell lung cancer and by identifying the most active drugs. However it is important to understand the limits of their methodology in order to avoid inappropriate interpretations.


6. DOCID:31336 SCORE: 0.00103486304824227
DOCNO: 12914763
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Intercellular Signaling Peptides and Proteins
QUALIFIER: etiology
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: Ginette Serrero G
AFFILIATION: A&G Pharmaceutical Inc., Columbia, MD 21045, USA. gserrero@agrx.net
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: United States
TITLE: Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis.
PUBDATE: 20030801
PC-cell derived growth factor (PCDGF), also known as granulin precursor or progranulin, is the largest member of a family of growth modulators characterized by a unique cysteine-rich motif. Biological and pathological studies point out to the importance of this growth factor in breast cancer and other human cancers, where it stimulates proliferation and survival, and promotes metastasis. These studies suggest that PCDGF is a suitable therapeutic and diagnostic target for the development of novel cancer therapy and diagnosis.


7. DOCID:31341 SCORE: 0.00103486304767734
DOCNO: 16422370
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: microbiology
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Soraya Fenniche S
AUTHOR: Leila El Fékih L
AUTHOR: Selma Attia S
AUTHOR: Lilia Ben Fatma L
AUTHOR: Héla Hassène H
AUTHOR: Khaoula Ben Miled K
AUTHOR: Faou El Mezni F
AUTHOR: Dalenda Belhabib D
AUTHOR: Mohamed Lamine Megdiche ML
AFFILIATION: Service Ibn Nafiss, Hôpital Abderrahmen Mami, Ariana.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: La Tunisie médicale.
COUNTRY: Tunisia
TITLE: [Pseudo tumoral bronchial tuberculosis]
PUBDATE: 20051101
Bronchial lesion is a rare site for tuberculosis. It can mimic lung cancer especially when sputum- smear is negative, and this be a cause of a delay in diagnosis, that can be made later on by a culture of Koch bacillus or after a bronchial biopsy. Through these 4 cases reports, the authors recall the ethiopathogenic hypotheses of this lesion and review the radiologic, clinical and prognostic features of these unusual forms of TB.


8. DOCID:29947 SCORE: 0.00103219038366799
DOCNO: 16292460
OWNER: NLM
STATUS: In-Process
AUTHOR: G Geiges G
AUTHOR: A Böhle A
AUTHOR: H Rexer H
AFFILIATION: Urologische Praxis, Berlin.
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: Germany
TITLE: [Study participation in urological practices]
PUBDATE: 20051201
In the past, participation of practicing urologists in clinical trials has been very rare. The reasons for this have been influenced in different ways over the last 10 years, so that the situation has now changed. In this paper, the current motivation for the participation of practicing urologists in research studies is discussed. Moreover, we discuss the ways in which the Association of Urological Oncology (AUO) of the German Cancer Association promotes the participation of colleagues in AUO studies and how the AUO meets the needs of urologists in practice.


9. DOCID:30018 SCORE: 0.00103219037460223
DOCNO: 16201982
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Calices
DESCRIPTOR: Tissue Adhesives
QUALIFIER: methods
QUALIFIER: analogs & derivatives
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: Güven Aslan G
AUTHOR: Süleyman Men S
AUTHOR: Aytaç Gülcü A
AUTHOR: Aykut Kefi A
AUTHOR: Adil Esen A
AFFILIATION: Department of Urology, School of Medicine, Dokuz Eylul University, Izmir, Turkey. aslang@deu.edu.tr
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: Australia
TITLE: Percutaneous embolization of persistent urinary fistula after partial nephrectomy using N-butyl-2-cyanoacrylate.
PUBDATE: 20050901
Percutaneous closure of a calyceal fistula following partial nephrectomy for kidney cancer was achieved with fistula embolization with n-butyl-2-cyanoacrylate. Previous attempts at closure by conservative and endoscopic means were unsuccessful. Tissue adhesives are useful in the management of persistent urinary leakage after partial nephrectomy.


10. DOCID:29857 SCORE: 0.00103219036973308
DOCNO: 16278140
OWNER: NLM
STATUS: In-Process
AUTHOR: Siwan Thomas-Gibson S
AUTHOR: Christopher B Williams CB
AFFILIATION: Wolfson Unit for Endoscopy, St. Mark's Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK. siwan@doctors.org.uk
PUBTYPE: Journal Article
JOURNALTITLE: Gastrointestinal endoscopy clinics of North America.
COUNTRY: United States
TITLE: Colonoscopy training--new approaches, old problems.
PUBDATE: 20051001
Colonoscopy traditionally has been taught using the apprenticeship approach. Assessment of competence has been, at best, informal and based largely on the number of procedures trainees have performed. The advent of colorectal cancer screening has demanded formalization of training and assessment using structured teaching and state-of-the-art training tools, such as computer simulation. New-generation approaches and technology have the ability to raise the standard of coloscopy provided by competent practitioners.


11. DOCID:30019 SCORE: 0.00103219035612098
DOCNO: 16205900
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Bonkhoff H
AFFILIATION: Praxis für Pathologie, Berlin. bonkhoff@prostapath.de
PUBTYPE: Journal Article
JOURNALTITLE: Der Pathologe.
COUNTRY: Germany
TITLE: [Prognostic factors in prostate cancer]
PUBDATE: 20051101
Since several therapeutic options are currently available for clinically organ-confined prostate cancer, morphological parameters have rapidly emerged as prognostic factors to stratify patients into different therapeutic modalities. In addition to the PSA value, pathologic stage, as defined by the TNM system, Gleason grade and the surgical margin status, other markers have prognostic implications. This includes the percent pattern 4/5 cancer, tumor volume, intraductal spread, large volume perineural invasion and molecular markers. This review discusses the methods of sampling and reporting in prostate pathology with an emphasis on well established and new prognostic factors.


12. DOCID:30024 SCORE: 0.00103219033624087
DOCNO: 12894249
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: therapy
AUTHOR: David Kerr D
AFFILIATION: National Translational Cancer Research Network, Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK. david.kerr@clinpharm.ox.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Clinical development of gene therapy for colorectal cancer.
PUBDATE: 20030801
Colorectal cancer (CRC) is the second most common type of malignancy in Western nations. Improvements in surgical and radiotherapeutic techniques and the increased availability of new cytotoxic drugs have improved outcome, but 50% of patients still die from recurrent or metastatic disease. Several features of its natural history render CRC a good candidate for gene therapy. Techniques include gene replacement, virus-directed enzyme-prodrug therapy, immune manipulation and virotherapy, all of which have entered clinical trials.


13. DOCID:30660 SCORE: 0.00102228070614942
DOCNO: 12436225
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: complications
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: Declan Walsh D
AUTHOR: Pamela S Tropiano PS
AFFILIATION: The Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA. walsht@ccf.org
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
COUNTRY: Germany
TITLE: Long-term rectal administration of high-dose sustained-release morphine tablets.
PUBDATE: 20021101
Two proprietary sustained-release morphine tablets for oral administration are available in the USA, and the authors have found that rectal administration of these provide excellent analgesia although their use by this route is not approved by the United States Food and Drug Administration. An illustrative case in a 72-year-old patient with prostate cancer is reported.


14. DOCID:29851 SCORE: 0.00102218795084391
DOCNO: 16308096
OWNER: NLM
STATUS: MEDLINE
AUTHOR: William Chesnut Dooley WC
AFFILIATION: Oklahoma University Breast Institute, Cade Cancer Center, Oklahoma City, OK 73104, USA. william-dooley@ouhsc.edu
PUBTYPE: Journal Article
JOURNALTITLE: Clinics in laboratory medicine.
COUNTRY: United States
TITLE: The future prospect: ductoscopy-directed brushing and biopsy.
PUBDATE: 20051201
The intraductal approach to breast cancer and premalignant lesions has now developed to yield substantial cytologic samples of exfoliated cells. Standard cytology is still inadequate in sensitivity and specificity to accurately interpret the majority of samples. As techniques evolve using ductoscopic biopsy and molecular marker panels to increase accuracy of cytologic interpretation, these tools will be able to unravel the breast carcinogenesis pathways. They will also offer considerable benefit in screening for premalignant changes and developing effective chemoprevention strategies.