0. DOCID:18744 SCORE: 0.00167784977014748
DOCNO: 2047875
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genetic Vectors
DESCRIPTOR: Vaccines, Synthetic
DESCRIPTOR: Vaccinia virus
AUTHOR: B Moss B
AFFILIATION: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Vaccinia virus: a tool for research and vaccine development.
PUBDATE: 19910601
Vaccinia virus is no longer needed for smallpox immunization, but now serves as a useful vector for expressing genes within the cytoplasm of eukaryotic cells. As a research tool, recombinant vaccinia viruses are used to synthesize biologically active proteins and analyze structure-function relations, determine the targets of humoral- and cell-mediated immunity, and investigate the immune responses needed for protection against specific infectious diseases. When more data on safety and efficacy are available, recombinant vaccinia and related poxviruses may be candidates for live vaccines and for cancer immunotherapy.


1. DOCID:18067 SCORE: 0.00159871895656821
DOCNO: 1370589
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: W Weber W
AFFILIATION: FMH Innere Medizin, speziell Onkologie-Hämatologie, Heuberg, Basel.
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis.
COUNTRY: SWITZERLAND
TITLE: [Respiratory problems in cancer--causes and treatment]
PUBDATE: 19920101
Half of the patients with advanced cancer suffer from shortness of breath. This may be due to the cancer itself, result from its treatment or arise from concurrent conditions. Careful assessment should precede any intervention. Treatment should be directed toward altering the underlying pathological process as far as possible (e.g. tumour reduction or pleural puncture). The relieve of symptoms by reassuring presence and morphine application are the mainstay, when it is not possible to reverse the cause of dyspnea, and can also successfully complement specific therapy.


2. DOCID:18341 SCORE: 0.00159855715562237
DOCNO: 1836053
AUTHOR: P B Lockhart PB
AUTHOR: M J Kutcher MJ
AFFILIATION: Department of Dentistry, Carolinas Medical Center, Charlotte.
PUBTYPE: Journal Article
JOURNALTITLE: North Carolina medical journal.
COUNTRY: UNITED STATES
TITLE: Oral considerations for the cancer patient.
PUBDATE: 19911101
An increasing number of patients are undergoing cancer chemotherapy and/or radiotherapy and are experiencing side effects in their mouths. A thorough oral examination is important in the overall pretherapy evaluation of these patients, and, along with a consideration for the patient's disease, treatment, prognosis and laboratory values, allows for realistic planning for dental management prior to, during and following cancer therapy. The early establishment of a good working relationship with the patient and those caring for him or her, and an understanding of the importance of compliance with oral hygiene will eliminate needless therapy-induced morbidity and mortality.


3. DOCID:18065 SCORE: 0.00132288823187179
DOCNO: 1843060
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: T Rowan T
PUBTYPE: Journal Article
JOURNALTITLE: Wisconsin medical journal.
COUNTRY: UNITED STATES
TITLE: Breast cancer: pathologic and prognostic evaluation.
PUBDATE: 19911201
Breast cancer presentation is changing, with more tumors detected at an early stage. This makes choosing the most appropriate tests for evaluation of a particular tumor more difficult. Mammography with biopsy of suspicious areas reveals an increasing incidence of microscopic cancers, with a corresponding reduction in larger palpable cancers. Coincidentally, a number of tests for evaluating these cancers, which may affect treatment, have been developed. These includes immunohistochemical evaluation of estrogen receptor and progesterone receptor status and a number of tests still listed as investigational. This paper reviews the diagnosis, evaluation, and prognosis of breast cancers, and suggests an optimal way for handling these tumors.


4. DOCID:19703 SCORE: 0.00132283420880692
DOCNO: 1878383
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tibia
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: diagnosis
AUTHOR: J Sciuk J
AUTHOR: B Kirchner B
AFFILIATION: Klinik und Poliklinik für Nuklearmedizin, Westfälische Wilhelms-Universität Münster.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Aktuelle Radiologie.
COUNTRY: GERMANY
TITLE: [Atypical bone metastases in prostate cancer]
PUBDATE: 19910501
Two cases of prostatic cancer with single bone metastasis in the tibia are discussed. The intense uniform involvement of a solitary limb bone with high perfusion and blood pool activity in the 3-phase bone scan and the positive white blood cell scan (observed in one case) were not typical for a metastatic bone lesion. Conventional radiomorphology--lamellar, periosteal reaction, disseminated medullar sclerosis, no localized lesion--also led to other differential considerations such as osteomyelitis and malignant lymphoma, which could not be specified by CT and MRI. Even if there is no typical morphology in scintigraphic and radiologic imaging, biopsy should be performed to exclude bone metastasis in prostatic cancer.


5. DOCID:16702 SCORE: 0.00129114811632004
DOCNO: 8137083
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Biological Assay
QUALIFIER: chemically induced
QUALIFIER: chemically induced
AUTHOR: N Takihi N
AUTHOR: H S Rosenkranz HS
AUTHOR: G Klopman G
AFFILIATION: Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
PUBTYPE: Journal Article
JOURNALTITLE: Quality assurance (San Diego, Calif.)
COUNTRY: UNITED STATES
TITLE: Identification of chemicals for testing in the rodent cancer bioassay.
PUBDATE: 19930901
A recently developed method was used to identify the structural moieties that are not represented among the chemicals tested in the U.S. National Toxicology Program rodent cancer bioassay. Inclusion of those chemicals in the bioassay would increase the informational content of rodent cancer assay data base.


6. DOCID:19417 SCORE: 0.00129052990887027
DOCNO: 1678623
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Procedures, Operative
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: immunology
AUTHOR: L Athlin L
AUTHOR: S B Holmberg SB
AUTHOR: L Hafström L
AFFILIATION: Department of Surgery, University Hospital, Umeå, Sweden.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The European journal of surgery = Acta chirurgica.
COUNTRY: SWEDEN
TITLE: Macrophage function and surgery. A clinical review with special reference to phagocytosis.
PUBDATE: 19910301
Present knowledge of macrophage phagocytosis in the context of surgical trauma is reviewed. The historical and morphologic background of the reticuloendothelial system and the mononuclear phagocyte system is surveyed. The physiology of the phagocytic process and methods of measurement are summarized and the influence on phagocytosis of shock, sepsis, cancer, parenteral nutrition and surgical procedures such as liver resection and splenectomy is discussed. Conclusions are that multiple factors may depress macrophage phagocytosis during surgery and that, in order to maintain immune defence balance, traumatic manipulation of tissue and abdominal organs must be minimized.


7. DOCID:19355 SCORE: 0.0010630401022291
DOCNO: 1437539
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: methods
AUTHOR: Y Kajiya Y
AUTHOR: K Ikeda K
AUTHOR: Y Kajiya Y
AUTHOR: H Inoue H
AUTHOR: N Miyazono N
AUTHOR: I Kanetsuki I
AUTHOR: T Takeshita T
AUTHOR: M Nakajo M
AUTHOR: N Fukushima N
AFFILIATION: Department of Radiology, Kagoshima University School of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica.
COUNTRY: JAPAN
TITLE: [MR imaging during arterio-portography (MR-AP) in the detection of hepatic cancer]
PUBDATE: 19920901
Magnetic resonance imaging during arterio-portography (MR-AP) was performed in 2 patients of hepatic cancer. Low dose of meglumine gadopentetate (4 ml of a 0.5 mmol/L solution) was injected into a superior mesenteric artery during acquisition of a Turbo-FLASH sequence. An increase in liver to lesion contrast was obtained with MR-AP and it is also useful in the late phase to distinguish a flow defect lesion due to portal obstruction from the tumor.


8. DOCID:18348 SCORE: 0.00104775485526154
DOCNO: 1653689
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: J A Rui JA
AFFILIATION: Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [Right trisegmentectomy for primary liver cancer--a report of 4 cases with review of literature]
PUBDATE: 19910101
From April 1987 to May 1988, right trisegmentectomy was done in 4 primary liver cancer patients under normothermic interruption of porta hepatis. This interruption lasted 22-26 minutes. Two of the 4 cases were associated with mild cirrhosis. No operative complication and mortality occurred. Two patients died of recurrence 5 and 14 months after operation. The other two patients are still alive free of tumor for 14 and 24 months. Detailed technical description and discussion with review of literature are presented.


9. DOCID:19300 SCORE: 0.00104767211430935
DOCNO: 8094712
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Amplification
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: therapeutic use
AUTHOR: U Lönn U
AUTHOR: S Lönn S
AUTHOR: B Stenkvist B
AFFILIATION: Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: UNITED STATES
TITLE: Reduced occurrence of mdr-1 amplification in stage-IV breast-cancer patients treated with tamoxifen compared with other endocrine treatments.
PUBDATE: 19930201
Amplification of mdr-1 occurs in breast cancer patients receiving endocrine treatment. We have compared a group of patients receiving tamoxifen and a group receiving second-line endocrine treatment after failure of tamoxifen treatment. Chronological tumor samples were obtained by fine-needle biopsies from the same tumor lesion of each patient and PCR was used to detect the appearance of gene amplification. Three of 20 patients receiving tamoxifen developed amplified mdr-1 whereas 7 of 17 patients receiving second-line endocrine treatment developed mdr-1 amplification.


10. DOCID:19663 SCORE: 0.00104742316845163
DOCNO: 8460881
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: R E Parnes RE
AUTHOR: S H Goldberg SH
AUTHOR: J W Sassani JW
AFFILIATION: Department of Ophthalmology, Penn State University College of Medicine, Hershey 17033.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annals of ophthalmology.
COUNTRY: UNITED STATES
TITLE: Renal cell carcinoma metastatic to the orbit: a clinicopathologic report.
PUBDATE: 19930301
Renal cell carcinoma (RCC) is a tumor of middle-aged men that metastasizes to the lung, liver, and bone. Few cases of RCC metastatic to the orbit have been reported. When this tumor spreads to the orbit, the orbital metastasis is likely to be the first indication of the cancer. We report the case of a 53-year-old man with widespread metastatic RCC whose first sign of disease was a metastatic orbital tumor. External and ocular examination and computed tomographic and histopathologic findings are described. The clinical characteristics, treatment, and prognosis of metastatic RCC are discussed.


11. DOCID:16230 SCORE: 0.00104731405574846
DOCNO: 2234468
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: M Vitale M
AUTHOR: A Coda A
AUTHOR: S Comoglio S
AFFILIATION: Istituto di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi di Torino.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Anatomo-clinical considerations on early gastric cancer]
PUBDATE: 19901001
The morphological features of early gastric carcinoma and its differences with respect to advanced gastric cancer are discussed on the basis of reported data. In particular, prognostic morphological implications and therapeutic possibilities are discussed. Study of recurrences suggest factors to improve prognostic productivity.


12. DOCID:16975 SCORE: 0.00104731244270048
DOCNO: 1621002
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: drug effects
QUALIFIER: therapeutic use
AUTHOR: M B Maxwell MB
AUTHOR: K E Maher KE
AFFILIATION: Department of Nursing, VA Medical Center, Portland, OR 97207.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: UNITED STATES
TITLE: Chemotherapy-induced myelosuppression.
PUBDATE: 19920501
Chemotherapy-induced myelosuppression is the most common dose-limiting and potentially fatal complication of cancer treatment. Prior attempts to lessen chemotherapy-induced myelosuppression have been minimally effective. The new hematopoietic growth factors show promise, especially for patients requiring intensely myelotoxic chemotherapy. However, a cautious approach should be used with growth factors because their clinical uses and how best to apply each use needs to be defined.


13. DOCID:17110 SCORE: 0.00104731055189528
DOCNO: 1523370
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: rehabilitation
AUTHOR: S J Mellette SJ
AUTHOR: G G Parker GG
AFFILIATION: Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: UNITED STATES
TITLE: Future directions in cancer rehabilitation.
PUBDATE: 19920801
Many of the current and future directions in cancer rehabilitation have been briefly discussed; and some of the important areas for development are outlined in Table 1. Implementation of rehabilitation measures may be facilitated by organized and creative multidisciplinary rehabilitation programs. Advances are also dependent on health care policy, particularly in reimbursement for rehabilitation services and in the funding of rehabilitation research. Much progress can be expected in the years ahead.


14. DOCID:18367 SCORE: 0.00104727937277792
DOCNO: 2262188
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
QUALIFIER: therapeutic use
AUTHOR: S Niesert S
AFFILIATION: Frauenklinik im Krankenhaus Oststadt, Medizinischen Hochschule Hannover.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Fortschritte der Medizin.
COUNTRY: GERMANY
TITLE: [GnRH analogs in gynecology. Possibilities for therapeutic use]
PUBDATE: 19900901
Gonadotropin releasing hormone (GnRH) agonists are synthetic peptide analogues of the natural gonadotropin releasing hormone with a stronger and more prolonged effect than the natural GnRH. Repeated administration of GnRH agonists induces pituitary desensitization followed by a decrease in gonadotropin secretion and estradiol synthesis. Thus reversible hypogonadotropic hypogonadism is produced. Consequently, estrogen-dependent diseases can be treated successfully with GnRH analogues. The therapeutic results obtained in patients with endometriosis, leiomyoma, pubertas praecox, and metastatic breast cancer are discussed. Furthermore the contraceptive properties of GnRH analogues, and combination treatment with HMG to induce ovulation is reviewed.