0. DOCID:2958 SCORE: 0.00542164372503239
DOCNO: 328139
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: R J Johnson RJ
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Gastrointestinal cancer--colon (surgery-radiotherapy). The role of radiation therapy in the management of rectosigmoid cancer.
PUBDATE: 19770701
The lack of an improvement in the gross survival statistics for colorectal cancer during the last decade and the negative results of randomized trials, suggests that 5-FU used as an adjuvant treatment has not increased survival. Current chemotherapeutic drug combinations, however, may prove effective in the adjuvant situation. The adjuvant use of preoperative radiation has shown improved survival in one randomized study and no change in the second study. Current preoperative radiotherapy studies using a more effective radiation dose will confirm the effect of preoperative radiation both on the primary tumor control and on metastases. Current postoperative adjuvant trials incorporating radiation, chemotherapy or a combination of the two, when completed, will provide clear indications for the physician as to the optimum treatment of Duke's B and C cancer of the colorectum. Three national randomized studies for inoperable, recurrent or residual carcinoma of the colorectum are testing the effect of radiation alone or in combination with chemotherapy or chemotherapy followed by immunotherapy.


1. DOCID:2882 SCORE: 0.00187579879835622
DOCNO: 1133845
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: A L Dellon AL
AUTHOR: G N Rogentine GN
AUTHOR: P B chretien PB
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Prolonged survival in bronchogenic carcinoma associated with HL-A antigens W-19 and HL-A5: a preliminary report.
PUBDATE: 19750601
The HL-A antigens were determined retrospectively in a group of 14 surgically cured bronchogenic carcinoma patients and prospectively in another group of 100 untreated patients. In the retrospective group, the frequencies of antigens W-19 and HL-A5 were significantly increased when compared with the noncancer control and the prospective lung cancer populations. In the latter group, 60% of the patients with W-19 and 58% with HL-A5 survived without evidence of tumor for at least 1 year after treatment compared with 15% of patients with neither of these antigens, P less than 0.01 and 0.005, respectively. These comparisons were for adenocarcinoma and squamous carcinoma. The patient groups for oat cell and undifferentiated carcinoma were too small for valid statistical comparisons. This preliminary study suggests that the presence of HL-A antigens W-19 and HL-A5 confers resistance to dissemination of bronchogenic carcinoma.


2. DOCID:169 SCORE: 0.0018732712468495
DOCNO: 1135726
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ethnic Groups
QUALIFIER: mortality
AUTHOR: E Bradshaw E
AUTHOR: J S Harington JS
PUBTYPE: Journal Article
JOURNALTITLE: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
COUNTRY: SOUTH AFRICA
TITLE: The changing pattern of cancer mortality in South Africa, 1949-1969.
PUBDATE: 19750501
Cancer mortality rates for Whites, Coloureds and Asians for the period of 1949 - 1969 have been analysed, and a changing pattern has been found. Some comparisons with other countries have been made, and the risk for each race group has been delineated for cancers at the commonest sites.


3. DOCID:1139 SCORE: 0.00173290494200514
DOCNO: 1267497
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Axilla
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: R Ashikari R
AUTHOR: P P Rosen PP
AUTHOR: J A Urban JA
AUTHOR: T Senoo T
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Breast cancer presenting as an axillary mass.
PUBDATE: 19760401
Experience with breast cancer presenting as an axillary mass in 42 patients has been reviewed according to initial clinical findings, treatment and survival. In the absence of an obvious inflammatory lesion, an axillary node may prove to be the first sign of breast cancer. It has been demonstrated that such a node should be biopsied and if positive for adenocarcinoma, a radical mastectomy performed presuming other primary sites have been ruled out. The survival rate after surgery in this group of patients is better than in those who present with a palpable breast mass and have axillary metastases.


4. DOCID:2265 SCORE: 0.00150490579970461
DOCNO: 409481
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: B S Schoenberg BS
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Multiple primary neoplasms and the nervous system.
PUBDATE: 19771001
Studies of multiple primary neoplasms and their relation to the nervous system should consider two important principles: 1) neoplasms of the nervous system have certain unusual features that distinguish them from tumors occurring elsewhere in the body; and 2) there is good evidence that the various histologic types of nervous system tumors should be regarded as separate diseases. The association of nervous system neoplasms and tumors of other sites may occur in patients with phacomatoses or particular genetic syndromes. In addition, certain nervous system neoplasms may be multicentric in origin. Retinoblastoma and osteosarcoma occur together in the same patient more often than expected by chance, as do meningioma and breast cancer. These relationships are important in that they serve to identify the high risk patient, may provide etiologic clues, may point to the presence of genetic syndromes, and may highlight sites in which subsequent tumors are most likely to develop.


5. DOCID:217 SCORE: 0.00132781821723841
DOCNO: 1263319
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Seminal Vesicles
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: C K Carris CK
AUTHOR: A P McLaughlin AP
AUTHOR: R F Gittes RF
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Amyloidosis of the lower genitourinary tract.
PUBDATE: 19760401
Three patients with amyloidosis of the lower genitourinary tract are described. In the cases of primary localized amyloidosis of the urethra and primary systemic amyloidosis involving the prostate the clinical presentation mimicked cancer of the respective sites. In the case of secondary localized amyloidosis of the seminal vesicles chronic perineal pain suggested seminal vesiculitis.


6. DOCID:3730 SCORE: 0.0013224952840103
DOCNO: 12308163
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Contraception
DESCRIPTOR: Family Planning Services
PUBTYPE: Journal Article
JOURNALTITLE: IPPF/WHR news service. International Planned Parenthood Federation. Western Hemisphere Region.
COUNTRY: United States
TITLE: Ecuadorian Health Ministry publishes fertility regulation handbook.
PUBDATE: 19761001
A manual on technical and medical norms for family planning and cancer detection programs has been published by the National Development Division of Ecuador's Ministry of Public Health. The manual will be distributed to all public and private health centers, hospitals, and doctors' offices in Ecuador. Near the end of the writing of the manual a 3-day meeting was held, with representatives of governmental and private organizations attending. The publication contains: 1) medical protocols to be observed in prescribing oral contraceptives and the IUD, 2) a description of the rhythm method and other temporary methods such as the condom and spermicidal foam, 3) a detailed summary of medical procedures to be observed in establishing services for the detection of cervical cancer, and 4) a section devoted to the study and treatment of infertility. The manual also offers organizational strategies to incorporate these services into the existing health structure. The objectives of the Ministry's National Program of Maternal and Child Health and Family Well-Being are: 1) to make contraceptive services available to all couples who choose them; 2) to give family planning information and education to all clients; and 3) to make contraceptive, infertility, and cancer prevention services available to all qualified woman who choose to use them.


7. DOCID:3229 SCORE: 0.00132234873937126
DOCNO: 1160465
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neck Dissection
QUALIFIER: surgery
AUTHOR: J Conley J
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Radical neck dissection.
PUBDATE: 19750801
Radical neck dissection has evolved into a standard surgical technique over the past century. It has been the most effective method of attempting to control suspected or gross metastasis to the cervical region. The technique embraces the en masse removal of all tissue elements in the space between the subdermis and the fascia colli. The perimeters of the dissection extend from the midline anteriorly to the anterior border of the trapezius muscle posteriorly, and from the clavicle to the mandible. The essential portion of this large mass of tissue is the cervical lymph system with its lymph nodes and afferent and efferent connecting vessels. Controllability of the cancer process is in direct proportion to the number of nodes involved, their size and their position in the neck. Complications in the routine radical neck dissection are minimal. Cure rates are influenced by the type, size and site of the primary cancer, the possibilities for the adjunctive treatment such as radiotherapy and chemotherapy, and the, as yet, little understood immunological factors. The radical neck dissection has proven itself to be an essential tool in the management of cancer in the head and neck.


8. DOCID:3031 SCORE: 0.00132232663653721
DOCNO: 194494
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: T G Frazier TG
AUTHOR: E M Copeland EM
AUTHOR: H S Gallager HS
AUTHOR: D D Paulus DD
AUTHOR: E C White EC
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Prognosis and treatment in minimal breast cancer.
PUBDATE: 19770601
Of 176 patients with minimal breast cancer, 138 had intraductal carcinoma in situ, 21 minimally invasive carcinoma, and 17 lobular carcinoma in situ. Various modalities of treatment were used including radical, modified radical, and simple mastectomy with and without radiation therapy. Long-term postoperative follow-up was available in all but five patients and ranged from one year to twenty-one years. Actuarial analysis projected a twenty year survival of 93.2 per cent for the entire group. Analysis of survival figures based on each of the several treatment modalities showed no definite advantage of one form of treatment over another. The data suggest that minimal breast cancer is a prognostically favorable diagnosis, provided invasive carcinoma is not present or does not develop in the opposite breast. It is also indicated that breast cancer is potentially a bilateral disease and that follow-up and treatment of the opposite breast must be of major concern in the care of these patients.


9. DOCID:3712 SCORE: 0.00107924876965947
DOCNO: 1068480
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: E Cameron E
AUTHOR: L Pauling L
PUBTYPE: Journal Article
JOURNALTITLE: Proceedings of the National Academy of Sciences of the United States of America.
COUNTRY: UNITED STATES
TITLE: Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.
PUBDATE: 19761001
Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease. Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization of this substance to potentiate these various host resistance factors. The results of a clinical trial are presented in which 100 terminal cancer patients were given supplemental ascorbate as part of their routine management. Their progress is compared to that of 1000 similar patients treated identically, but who received no supplemental ascorbate. The mean survival time is more than 4.2 times as great for the ascorbate subjects (more than 210 days) as for the controls (50 days). Analysis of the survival-time curves indicates that deaths occur for about 90% of the ascorbate-treated patients at one-third the rate for the controls and that the other 10% have a much greater survival time, averaging more than 20 times that for the controls. The results clearly indicate that this simple and safe form of medication is of definite value in the treatment of patients with acvanced cancer.


10. DOCID:3341 SCORE: 0.00105427816477187
DOCNO: 1088947
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aging
DESCRIPTOR: Models, Biological
AUTHOR: L Hayflick L
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Federation proceedings.
COUNTRY: UNITED STATES
TITLE: Current theories of biological aging.
PUBDATE: 19750101
Several lines of evidence have led to the notion that biological aging occurs as a result of changes in the information-containing molecules either at the genetic or epigenetic level. The error theory, the redundant message theory, the codon restriction theory, and the transcriptional event theory represent the major current conceptualizations of biological aging as held by most gerontologists. The finding that cultured normal human and animal cells undergo a finite number of population doublings in vitro has provided new insights into age changes at the cellular level. The number of mitotic events that cultured normal animal cells can undergo appears to be inversely related to the age of the donor. A direct proportionality exists, however, between the mean maximum life-span of a species and the number of population doublings that their cultured embryonic cells will undergo. The several biochemical decrements known to occur prior to the cessation of mitotic activity in vitro are thought to herald those manifestations of senescence seen in the whole animal. Yet to be explained is how those cell classes such as the germ plasm and continuously propagable cancer cells escape from the inevitability of biological aging.


11. DOCID:3334 SCORE: 0.00105427816350466
DOCNO: 1160970
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: B R Henderson BR
AUTHOR: V Gerkins V
AUTHOR: I Rosario I
AUTHOR: J Casagrande J
AUTHOR: M C Pike MC
PUBTYPE: Journal Article
JOURNALTITLE: The New England journal of medicine.
COUNTRY: UNITED STATES
TITLE: Elevated serum levels of estrogen and prolactin in daughters of patients with breast cancer.
PUBDATE: 19751001
Demographic risk factors in sisters and daughters of 150 patients with breast cancer were compared to those of controls. Plasma hormone levels in 36 teen-age daughters of patients and 31 controls were also studied to ascertain whether an "abnormal" hormone pattern underlies these risk factors. The patients' sisters had, on the average, menarche four months earlier and first full-term pregnancy 12 months later than the controls. The patients' daughters did not show these differences -- apparently owing to low fertility in the patients with early menarche. The patients' daughters had higher 22d-day estradiol-plus-estrone levels than controls (24.4 vs. 19.1 ng per 100 ml, P less than 0.05). Sixth-day prolactin was also elevated (19.0 vs. 14.2 ng per 100 ml, P less than 0.05). About half the patients' daughters could clearly be distinguished from the controls' daughters by means of the sixth-day information on both estrogens and prolactin. Hypersecretion of these hormones may be important factors in breast cancer.


12. DOCID:2143 SCORE: 0.00105137803382246
DOCNO: 848523
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: prevention & control
AUTHOR: S E Brown SE
AUTHOR: H H Allen HH
AUTHOR: R N Robins RN
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: The use of delayed primary wound closure in preventing wound infections.
PUBDATE: 19770401
Delayed primary wound closure was performed in 146 patients considered at risk of developing wound infection according to established criteria. These patients were matched individually for age, weight, diagnosis, and the use of prophylactic antibiotics with 146 patients undergoing immediate wound closure during the same time period. The matched pairs were subdivided into five categories depending on the indication for delayed closure; obesity, cancer, "above and below" procedure, infection, and opened bowel. In all categories the incidence of wound infection was significantly lower in the patients with delayed closure. The over-all infection rate was reduced from 23.3% in the control group to 2.1% in the study group. Hospital stay was unaffected. Delayed primary wound closure provides a safe, simple, effective means of reducing the incidence of wound infection.


13. DOCID:3526 SCORE: 0.00104682633999693
DOCNO: 68678
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: R L Peters RL
AUTHOR: A P Afroudakis AP
AUTHOR: D Tatter D
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical pathology.
COUNTRY: UNITED STATES
TITLE: The changing incidence of association of hepatitis B with hepatocellular carcinoma in California.
PUBDATE: 19770701
Two hundred seventy-nine patients who died of hepatocellular carcinoma were autopsied at Los Angeles County--USC Medical Center and the John Wesley--USC Liver Unit from 1949 through 1974, and tissues from 168 of these cases were available for staining for hepatitis B surface antigen (HBSAg). Twenty-one per cent of the livers had stainable HBSAg. There were prominent increases both in total numbers of hepatic cancers and in the percentages that were HBSAg-positive beginning about 1970, but the numbers of hepatocellular carcinomas arising in noncirrhotic livers also increased. From 1969 to 1974, 73% of those who had hepatocellular carcinomas arising to nonalcoholic but cirrhotic livers were HBSAg-positive. Racial differences in the incidences of cirrhosis, the incidences of hepatocellular carcinomas associated with HBSAg were found. The incidences of cirrhosis were: Caucasian 11%; Mexican 12.2%; Negro 5.7:; Oriental 10%. Hepatocellular carcinomas arose in 3.2% of Caucasians who had cirrhosis; 3.6% of Mexicans; 8.3% of Negroes; 47% or Orientals. Ten per cent of Caucasians who had hepatocellular carcinomas in cirrhotic livers were HBSAg-positive; 25% of Negroes; 12% of Mexicans; 47% of Orientals.


14. DOCID:3477 SCORE: 0.00104682251346966
DOCNO: 922745
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Circadian Rhythm
QUALIFIER: physiopathology
QUALIFIER: blood
AUTHOR: W B Malarkey WB
AUTHOR: L L Schroeder LL
AUTHOR: V C Stevens VC
AUTHOR: A G James AG
AUTHOR: R R Lanese RR
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Disordered nocturnal prolactin regulation in women with breast cancer.
PUBDATE: 19771201
Mean 24-hr prolactin concentrations were determined in 25 female control subjects, 16 women with benign breast masses, and 23 subjects with breast cancer. This evaluation performed before breast surgery revealed significantly decreased (p less than 0.02) nocturnal (12 a.m. to 7 a.m.) prolactin concentrations in 12 postmenopausal breast cancer subjects that contrasted with significantly increased (p less than 0.05) nocturnal prolactin levels in five luteal-phase premenopausal women with breast cancers. Prolactin concentrations in patients with benign breast disease were not significantly different from control subjects. Two of the premenopausal breast cancer patients had marked preoperative elevations in their mean 24-hr prolactin levels, and they were two of the three subjects who have since expired. Nocturnal prolactin secretion was significantly decreased (p less than 0.03) in four premenopausal breast cancer patients when they were studied 1 year after surgery; however, it remained the same in the eight postmenopausal breast cancer patients similarly evaluated. Although disordered prolactin regulation has been found in these women with breast cancer, its role in the etiology and progression of human cancer is still uncertain.