0. DOCID:2958 SCORE: 0.00542164372503239
DOCNO: 328139
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: R J Johnson RJ
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Gastrointestinal cancer--colon (surgery-radiotherapy). The role of radiation therapy in the management of rectosigmoid cancer.
PUBDATE: 19770701
The lack of an improvement in the gross survival statistics for colorectal cancer during the last decade and the negative results of randomized trials, suggests that 5-FU used as an adjuvant treatment has not increased survival. Current chemotherapeutic drug combinations, however, may prove effective in the adjuvant situation. The adjuvant use of preoperative radiation has shown improved survival in one randomized study and no change in the second study. Current preoperative radiotherapy studies using a more effective radiation dose will confirm the effect of preoperative radiation both on the primary tumor control and on metastases. Current postoperative adjuvant trials incorporating radiation, chemotherapy or a combination of the two, when completed, will provide clear indications for the physician as to the optimum treatment of Duke's B and C cancer of the colorectum. Three national randomized studies for inoperable, recurrent or residual carcinoma of the colorectum are testing the effect of radiation alone or in combination with chemotherapy or chemotherapy followed by immunotherapy.


1. DOCID:2882 SCORE: 0.00187579879835622
DOCNO: 1133845
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: A L Dellon AL
AUTHOR: G N Rogentine GN
AUTHOR: P B chretien PB
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Prolonged survival in bronchogenic carcinoma associated with HL-A antigens W-19 and HL-A5: a preliminary report.
PUBDATE: 19750601
The HL-A antigens were determined retrospectively in a group of 14 surgically cured bronchogenic carcinoma patients and prospectively in another group of 100 untreated patients. In the retrospective group, the frequencies of antigens W-19 and HL-A5 were significantly increased when compared with the noncancer control and the prospective lung cancer populations. In the latter group, 60% of the patients with W-19 and 58% with HL-A5 survived without evidence of tumor for at least 1 year after treatment compared with 15% of patients with neither of these antigens, P less than 0.01 and 0.005, respectively. These comparisons were for adenocarcinoma and squamous carcinoma. The patient groups for oat cell and undifferentiated carcinoma were too small for valid statistical comparisons. This preliminary study suggests that the presence of HL-A antigens W-19 and HL-A5 confers resistance to dissemination of bronchogenic carcinoma.


2. DOCID:169 SCORE: 0.0018732712468495
DOCNO: 1135726
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ethnic Groups
QUALIFIER: mortality
AUTHOR: E Bradshaw E
AUTHOR: J S Harington JS
PUBTYPE: Journal Article
JOURNALTITLE: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
COUNTRY: SOUTH AFRICA
TITLE: The changing pattern of cancer mortality in South Africa, 1949-1969.
PUBDATE: 19750501
Cancer mortality rates for Whites, Coloureds and Asians for the period of 1949 - 1969 have been analysed, and a changing pattern has been found. Some comparisons with other countries have been made, and the risk for each race group has been delineated for cancers at the commonest sites.


3. DOCID:1139 SCORE: 0.00173290494200514
DOCNO: 1267497
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Axilla
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: R Ashikari R
AUTHOR: P P Rosen PP
AUTHOR: J A Urban JA
AUTHOR: T Senoo T
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Breast cancer presenting as an axillary mass.
PUBDATE: 19760401
Experience with breast cancer presenting as an axillary mass in 42 patients has been reviewed according to initial clinical findings, treatment and survival. In the absence of an obvious inflammatory lesion, an axillary node may prove to be the first sign of breast cancer. It has been demonstrated that such a node should be biopsied and if positive for adenocarcinoma, a radical mastectomy performed presuming other primary sites have been ruled out. The survival rate after surgery in this group of patients is better than in those who present with a palpable breast mass and have axillary metastases.


4. DOCID:2265 SCORE: 0.00150490579970461
DOCNO: 409481
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: B S Schoenberg BS
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Multiple primary neoplasms and the nervous system.
PUBDATE: 19771001
Studies of multiple primary neoplasms and their relation to the nervous system should consider two important principles: 1) neoplasms of the nervous system have certain unusual features that distinguish them from tumors occurring elsewhere in the body; and 2) there is good evidence that the various histologic types of nervous system tumors should be regarded as separate diseases. The association of nervous system neoplasms and tumors of other sites may occur in patients with phacomatoses or particular genetic syndromes. In addition, certain nervous system neoplasms may be multicentric in origin. Retinoblastoma and osteosarcoma occur together in the same patient more often than expected by chance, as do meningioma and breast cancer. These relationships are important in that they serve to identify the high risk patient, may provide etiologic clues, may point to the presence of genetic syndromes, and may highlight sites in which subsequent tumors are most likely to develop.


5. DOCID:7193 SCORE: 0.00143461071480198
DOCNO: 203902
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: E P Fazzini EP
PUBTYPE: Journal Article
JOURNALTITLE: Postgraduate medicine.
COUNTRY: UNITED STATES
TITLE: Lung cancer: the pathologist's role in management.
PUBDATE: 19780201
The prognosis of lung cancer is poor, although there is hope for improvement based on early detection through cytologic screening and the use of newer treatment protocols. Although there are difficulties inherent in classifying tumors by type on the basis of very small samples of lesions that are not necessarily homogeneous, the pathologist should use a standard classification that sets forth definite criteria for the differentiated types. Among the common tumors, a small, well-differentiated epidermoid carcinoma with no evidence of lymph node involvement has the most favorable prognosis, and a small-cell anaplastic or oat cell carcinoma the worst. Results of therapy for tumors of other types show much variation. Future studies of lung cancer should include careful clinical staging and, when resection is done, pathologic staging. More study of the immunomorphology of lymph nodes is needed, as this may provide highly useful prognostic information.


6. DOCID:7772 SCORE: 0.00136147878087502
DOCNO: 534827
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: H M Spence HM
AUTHOR: W W Hoffman WW
AUTHOR: G P Fosmire GP
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: Tumour of the colon as a late complication of ureterosigmoidostomy for exstrophy of the bladder.
PUBDATE: 19791201
Two cases of cancer of the colon have occurred recently in our series of 38 patients with exstrophy of the bladder treated by ureterosigmoidostomy. Twenty-six and 14 years elapsed between the original operation and the diagnosis of malignancy. Since 1929 the literature contains reports of 55 patients who have developed bowel neoplasms as a late complication of this form of diversion. The operation was performed for exstrophy in 35 of these, in whom the resulting tumour at the anastomotic site was malignant in 28 and benign in 7 patients. The shortest interval between ureterosigmoidostomy and recognition of the growth was 10 years with a mean latent period of 25 years. The aetiology remains uncertain but it is clear that long-term survivors after ureterosigmoidostomy should have diagnostic large bowel studies included in the follow-up.


7. DOCID:7698 SCORE: 0.00136112455365395
DOCNO: 6173052
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hypophysectomy
DESCRIPTOR: Hypophysectomy, Chemical
DESCRIPTOR: Palliative Care
QUALIFIER: secondary
QUALIFIER: therapy
AUTHOR: J W Lloyd JW
AUTHOR: W A Rawlinson WA
AUTHOR: P J Evans PJ
PUBTYPE: Journal Article
JOURNALTITLE: British journal of anaesthesia.
COUNTRY: ENGLAND
TITLE: Selective hypophysectomy for metastatic pain. A review of ethyl alcohol ablation of the anterior pituitary in a Regional Pain Relief Unit.
PUBDATE: 19811101
Selective adenohypophysectomy, by the injection of up to 1 ml of absolute alcohol to the pituitary gland, was used to produce pain relief in 25 patients suffering from metastatic cancer. Thirty-five treatments were given and good analgesia was obtained in 74%. The median duration of pain relief was 6-7 weeks, although some treatments produced relief for up to 20 months. The procedure was most successful in relieving bone pain in patients with advanced carcinoma of the breast or prostate. The use of a fine-gauge needle for the intranasal trans-sphenoidal approach to the gland and the injection of alcohol to the anterior part (pars distalis) of the gland reduced the frequency of the major complications diabetes insipidus (17%) and prolonged visual disturbance (3%).


8. DOCID:4834 SCORE: 0.00134107210320401
DOCNO: 7356527
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: M R Greenberg MR
AUTHOR: J Caruana J
AUTHOR: B Holcomb B
AUTHOR: G Greenberg G
AUTHOR: R Parker R
AUTHOR: J Louis J
AUTHOR: P White P
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: High cancer mortality rates from childhood leukemia and young adult Hodgkin's disease and lymphoma in the New Jersey-New York-Philadelphia Metropolitan Corridor, 1950 to 1969.
PUBDATE: 19800201
In comparison to the United States as a whole and to their total population age-adjusted rates, the New Jersey-New York-Philadelphia Metropolitan Region was found to have excessively high childhood leukemia and high young adult Hodgkin's disease and lymphoma cancer mortality rates in the period from 1950 to 1969.


9. DOCID:217 SCORE: 0.00132781821723841
DOCNO: 1263319
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Seminal Vesicles
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: C K Carris CK
AUTHOR: A P McLaughlin AP
AUTHOR: R F Gittes RF
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Amyloidosis of the lower genitourinary tract.
PUBDATE: 19760401
Three patients with amyloidosis of the lower genitourinary tract are described. In the cases of primary localized amyloidosis of the urethra and primary systemic amyloidosis involving the prostate the clinical presentation mimicked cancer of the respective sites. In the case of secondary localized amyloidosis of the seminal vesicles chronic perineal pain suggested seminal vesiculitis.


10. DOCID:3730 SCORE: 0.0013224952840103
DOCNO: 12308163
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Contraception
DESCRIPTOR: Family Planning Services
PUBTYPE: Journal Article
JOURNALTITLE: IPPF/WHR news service. International Planned Parenthood Federation. Western Hemisphere Region.
COUNTRY: United States
TITLE: Ecuadorian Health Ministry publishes fertility regulation handbook.
PUBDATE: 19761001
A manual on technical and medical norms for family planning and cancer detection programs has been published by the National Development Division of Ecuador's Ministry of Public Health. The manual will be distributed to all public and private health centers, hospitals, and doctors' offices in Ecuador. Near the end of the writing of the manual a 3-day meeting was held, with representatives of governmental and private organizations attending. The publication contains: 1) medical protocols to be observed in prescribing oral contraceptives and the IUD, 2) a description of the rhythm method and other temporary methods such as the condom and spermicidal foam, 3) a detailed summary of medical procedures to be observed in establishing services for the detection of cervical cancer, and 4) a section devoted to the study and treatment of infertility. The manual also offers organizational strategies to incorporate these services into the existing health structure. The objectives of the Ministry's National Program of Maternal and Child Health and Family Well-Being are: 1) to make contraceptive services available to all couples who choose them; 2) to give family planning information and education to all clients; and 3) to make contraceptive, infertility, and cancer prevention services available to all qualified woman who choose to use them.


11. DOCID:3229 SCORE: 0.00132234873937126
DOCNO: 1160465
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neck Dissection
QUALIFIER: surgery
AUTHOR: J Conley J
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Radical neck dissection.
PUBDATE: 19750801
Radical neck dissection has evolved into a standard surgical technique over the past century. It has been the most effective method of attempting to control suspected or gross metastasis to the cervical region. The technique embraces the en masse removal of all tissue elements in the space between the subdermis and the fascia colli. The perimeters of the dissection extend from the midline anteriorly to the anterior border of the trapezius muscle posteriorly, and from the clavicle to the mandible. The essential portion of this large mass of tissue is the cervical lymph system with its lymph nodes and afferent and efferent connecting vessels. Controllability of the cancer process is in direct proportion to the number of nodes involved, their size and their position in the neck. Complications in the routine radical neck dissection are minimal. Cure rates are influenced by the type, size and site of the primary cancer, the possibilities for the adjunctive treatment such as radiotherapy and chemotherapy, and the, as yet, little understood immunological factors. The radical neck dissection has proven itself to be an essential tool in the management of cancer in the head and neck.


12. DOCID:3031 SCORE: 0.00132232663653721
DOCNO: 194494
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: T G Frazier TG
AUTHOR: E M Copeland EM
AUTHOR: H S Gallager HS
AUTHOR: D D Paulus DD
AUTHOR: E C White EC
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Prognosis and treatment in minimal breast cancer.
PUBDATE: 19770601
Of 176 patients with minimal breast cancer, 138 had intraductal carcinoma in situ, 21 minimally invasive carcinoma, and 17 lobular carcinoma in situ. Various modalities of treatment were used including radical, modified radical, and simple mastectomy with and without radiation therapy. Long-term postoperative follow-up was available in all but five patients and ranged from one year to twenty-one years. Actuarial analysis projected a twenty year survival of 93.2 per cent for the entire group. Analysis of survival figures based on each of the several treatment modalities showed no definite advantage of one form of treatment over another. The data suggest that minimal breast cancer is a prognostically favorable diagnosis, provided invasive carcinoma is not present or does not develop in the opposite breast. It is also indicated that breast cancer is potentially a bilateral disease and that follow-up and treatment of the opposite breast must be of major concern in the care of these patients.


13. DOCID:6480 SCORE: 0.00113806841139841
DOCNO: 6269241
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: J P Minton JP
AUTHOR: H Abou-Issa H
AUTHOR: J B Elliot JB
AUTHOR: M K Foecking MK
AUTHOR: J M Roseman JM
AUTHOR: R H Matthews RH
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: Biochemical subgrouping of benign breast disease to define premalignant potential.
PUBDATE: 19811001
To determine which subgroups of benign breast disease are likely to progress to malignant degeneration, a biochemical analysis of 3'5' cyclic adenosine monophosphate (cAMP) was run on several samples of breast tissue. cAMP is elevated in a progressive fashion from normal breast tissue to fibrosis, cystic mastitis, ductular hyperplasias, and finally to carcinoma. Correlation of cAMP levels in breast lesions with histopathologic grading of increasing epithelial proliferation confirmed the concept that there are subgroups within those lesions that have greater malignant potential. Benign breast lesions with significantly higher cAMP levels, although still lower than those of cancer, must be considered at higher risk for eventual malignant change.


14. DOCID:3712 SCORE: 0.00107924876965947
DOCNO: 1068480
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: E Cameron E
AUTHOR: L Pauling L
PUBTYPE: Journal Article
JOURNALTITLE: Proceedings of the National Academy of Sciences of the United States of America.
COUNTRY: UNITED STATES
TITLE: Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.
PUBDATE: 19761001
Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease. Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization of this substance to potentiate these various host resistance factors. The results of a clinical trial are presented in which 100 terminal cancer patients were given supplemental ascorbate as part of their routine management. Their progress is compared to that of 1000 similar patients treated identically, but who received no supplemental ascorbate. The mean survival time is more than 4.2 times as great for the ascorbate subjects (more than 210 days) as for the controls (50 days). Analysis of the survival-time curves indicates that deaths occur for about 90% of the ascorbate-treated patients at one-third the rate for the controls and that the other 10% have a much greater survival time, averaging more than 20 times that for the controls. The results clearly indicate that this simple and safe form of medication is of definite value in the treatment of patients with acvanced cancer.