0. DOCID:2958 SCORE: 0.00542164372503239
DOCNO: 328139
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: R J Johnson RJ
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Gastrointestinal cancer--colon (surgery-radiotherapy). The role of radiation therapy in the management of rectosigmoid cancer.
PUBDATE: 19770701
The lack of an improvement in the gross survival statistics for colorectal cancer during the last decade and the negative results of randomized trials, suggests that 5-FU used as an adjuvant treatment has not increased survival. Current chemotherapeutic drug combinations, however, may prove effective in the adjuvant situation. The adjuvant use of preoperative radiation has shown improved survival in one randomized study and no change in the second study. Current preoperative radiotherapy studies using a more effective radiation dose will confirm the effect of preoperative radiation both on the primary tumor control and on metastases. Current postoperative adjuvant trials incorporating radiation, chemotherapy or a combination of the two, when completed, will provide clear indications for the physician as to the optimum treatment of Duke's B and C cancer of the colorectum. Three national randomized studies for inoperable, recurrent or residual carcinoma of the colorectum are testing the effect of radiation alone or in combination with chemotherapy or chemotherapy followed by immunotherapy.


1. DOCID:25581 SCORE: 0.00236567493147002
DOCNO: 11577673
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: prevention & control
QUALIFIER: prevention & control
AUTHOR: B F Barker BF
AUTHOR: G J Barker GJ
AFFILIATION: Department of Oral and Maxillofacial Pathology, University of Missouri-Kansas City School of Dentistry, USA. barkerb@umkc.edu
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the California Dental Association.
COUNTRY: United States
TITLE: Oral management of the patient with cancer in the head and neck region.
PUBDATE: 20010801
Cancer therapies--including surgery, radiation, and chemotherapy--may unfavorably affect the oral/dental health of patients. Existing dental problems can also result in serious complications that may be prevented by dental intervention prior to cancer therapy. This paper will be limited to a discussion of the detrimental effects of radiation therapy on the oral cavity and salivary glands and appropriate dental management.


2. DOCID:21567 SCORE: 0.00236285522807981
DOCNO: 10143480
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
QUALIFIER: supply & distribution
AUTHOR: S Paryani S
AUTHOR: W Scott W
AUTHOR: J Wells J
AUTHOR: D Johnson D
AUTHOR: R Chobe R
AUTHOR: S Schoeppel S
AUTHOR: A Kuruvilla A
AUTHOR: A Deshmukh A
AFFILIATION: Williams Cancer Center, Bapitist Medical Center, Jacksonville, FL, USA.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of ambulatory care management.
COUNTRY: UNITED STATES
TITLE: The "revolution" in outpatient care.
PUBDATE: 19950701
Although the concept of outpatient care is not a new one, the growth in ambulatory facilities has revolutionized medical care in the United States. The growth in ambulatory surgery centers, imaging centers, and cancer centers in Florida is explored in detail. With the many changes forthcoming in health care, ambulatory care will play an increasing role in delivering good health care at a reasonable cost.


3. DOCID:26461 SCORE: 0.00207746634095906
DOCNO: 12013537
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: G W Sledge GW
AFFILIATION: Indiana University School of Medicine, Indianapolis, USA. gsledge@iupui.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of mammary gland biology and neoplasia.
COUNTRY: United States
TITLE: Breast cancer in the clinic: treatments past, treatments future.
PUBDATE: 20011001
Therapeutic options for the patient with systemic breast cancer were long limited to either chemotherapy and hormonal therapy. While these therapies provide palliation for many patients with advanced disease, and occasionally cure the patient with micrometastatic disease, they are not optimal either with regard to toxicity or efficacy. This paper reviews the past of systemic therapy (chemotherapy and hormonal therapy), then discusses developing treatment strategies. These strategies include the recently introduced anti-HER-2 antibody trastuzumab, novel agents targeting other aspects of tumor growth mechanisms, as well as agents blocking angiogenesis.


4. DOCID:2882 SCORE: 0.00187579879835622
DOCNO: 1133845
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: A L Dellon AL
AUTHOR: G N Rogentine GN
AUTHOR: P B chretien PB
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Prolonged survival in bronchogenic carcinoma associated with HL-A antigens W-19 and HL-A5: a preliminary report.
PUBDATE: 19750601
The HL-A antigens were determined retrospectively in a group of 14 surgically cured bronchogenic carcinoma patients and prospectively in another group of 100 untreated patients. In the retrospective group, the frequencies of antigens W-19 and HL-A5 were significantly increased when compared with the noncancer control and the prospective lung cancer populations. In the latter group, 60% of the patients with W-19 and 58% with HL-A5 survived without evidence of tumor for at least 1 year after treatment compared with 15% of patients with neither of these antigens, P less than 0.01 and 0.005, respectively. These comparisons were for adenocarcinoma and squamous carcinoma. The patient groups for oat cell and undifferentiated carcinoma were too small for valid statistical comparisons. This preliminary study suggests that the presence of HL-A antigens W-19 and HL-A5 confers resistance to dissemination of bronchogenic carcinoma.


5. DOCID:169 SCORE: 0.0018732712468495
DOCNO: 1135726
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ethnic Groups
QUALIFIER: mortality
AUTHOR: E Bradshaw E
AUTHOR: J S Harington JS
PUBTYPE: Journal Article
JOURNALTITLE: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
COUNTRY: SOUTH AFRICA
TITLE: The changing pattern of cancer mortality in South Africa, 1949-1969.
PUBDATE: 19750501
Cancer mortality rates for Whites, Coloureds and Asians for the period of 1949 - 1969 have been analysed, and a changing pattern has been found. Some comparisons with other countries have been made, and the risk for each race group has been delineated for cancers at the commonest sites.


6. DOCID:27513 SCORE: 0.00182801215060964
DOCNO: 9528237
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: transplantation
QUALIFIER: surgery
AUTHOR: T Kaneko T
AUTHOR: S Uemura S
AUTHOR: H Harada H
AUTHOR: S Sugihara S
AUTHOR: T Egami T
AFFILIATION: Department of Surgery, Shimonoseki Kousei Hospital, Yamaguchi, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Kyobu geka. The Japanese journal of thoracic surgery.
COUNTRY: JAPAN
TITLE: [A case of acute empyema who underwent omentopexy and was found to have gastric cancer during operation]
PUBDATE: 19980301
A 76-year-old man had undergone omentopexy for empyema. He was found to have gastric cancer and revealed Borrmann III by gastroendoscopy intraoperative period. Segmental gastrectomy was performed without dissection of lymph nodes, because his general condition was poor. After operation, the patient showed septic shock, ARDS and hepato-renal failure but his condition was getting improved by conservative therapy. After 5 years later, he was examined gastro-endoscopy, abdominal and chest CT and revealed no recurrence sign.


7. DOCID:1139 SCORE: 0.00173290494200514
DOCNO: 1267497
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Axilla
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: R Ashikari R
AUTHOR: P P Rosen PP
AUTHOR: J A Urban JA
AUTHOR: T Senoo T
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Breast cancer presenting as an axillary mass.
PUBDATE: 19760401
Experience with breast cancer presenting as an axillary mass in 42 patients has been reviewed according to initial clinical findings, treatment and survival. In the absence of an obvious inflammatory lesion, an axillary node may prove to be the first sign of breast cancer. It has been demonstrated that such a node should be biopsied and if positive for adenocarcinoma, a radical mastectomy performed presuming other primary sites have been ruled out. The survival rate after surgery in this group of patients is better than in those who present with a palpable breast mass and have axillary metastases.


8. DOCID:18744 SCORE: 0.00167784977014748
DOCNO: 2047875
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genetic Vectors
DESCRIPTOR: Vaccines, Synthetic
DESCRIPTOR: Vaccinia virus
AUTHOR: B Moss B
AFFILIATION: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Vaccinia virus: a tool for research and vaccine development.
PUBDATE: 19910601
Vaccinia virus is no longer needed for smallpox immunization, but now serves as a useful vector for expressing genes within the cytoplasm of eukaryotic cells. As a research tool, recombinant vaccinia viruses are used to synthesize biologically active proteins and analyze structure-function relations, determine the targets of humoral- and cell-mediated immunity, and investigate the immune responses needed for protection against specific infectious diseases. When more data on safety and efficacy are available, recombinant vaccinia and related poxviruses may be candidates for live vaccines and for cancer immunotherapy.


9. DOCID:8689 SCORE: 0.0016276491801707
DOCNO: 3913993
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: G Gardellin G
AUTHOR: B Perin B
AUTHOR: F Lunghi F
AUTHOR: P Frasson P
AUTHOR: D Celi D
PUBTYPE: Journal Article
JOURNALTITLE: La Radiologia medica.
COUNTRY: ITALY
TITLE: [Preoperative ultrasonic diagnosis of metastasis to the cervical lymph nodes from otorhinolaryngeal neoplasms]
PUBDATE: 19851201
The results of a study on 30 patients with ear, nose and throat cancers are discussed; a comparison of clinical, ultrasound and histological findings for the preoperatory evaluation of the cervical lymph nodes has been carried out. Ultrasound technique is an excellent method of investigation for the staging "N" of such neoplasms; its contribution is very important for the following therapeutic program.


10. DOCID:18067 SCORE: 0.00159871895656821
DOCNO: 1370589
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: W Weber W
AFFILIATION: FMH Innere Medizin, speziell Onkologie-Hämatologie, Heuberg, Basel.
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis.
COUNTRY: SWITZERLAND
TITLE: [Respiratory problems in cancer--causes and treatment]
PUBDATE: 19920101
Half of the patients with advanced cancer suffer from shortness of breath. This may be due to the cancer itself, result from its treatment or arise from concurrent conditions. Careful assessment should precede any intervention. Treatment should be directed toward altering the underlying pathological process as far as possible (e.g. tumour reduction or pleural puncture). The relieve of symptoms by reassuring presence and morphine application are the mainstay, when it is not possible to reverse the cause of dyspnea, and can also successfully complement specific therapy.


11. DOCID:18341 SCORE: 0.00159855715562237
DOCNO: 1836053
AUTHOR: P B Lockhart PB
AUTHOR: M J Kutcher MJ
AFFILIATION: Department of Dentistry, Carolinas Medical Center, Charlotte.
PUBTYPE: Journal Article
JOURNALTITLE: North Carolina medical journal.
COUNTRY: UNITED STATES
TITLE: Oral considerations for the cancer patient.
PUBDATE: 19911101
An increasing number of patients are undergoing cancer chemotherapy and/or radiotherapy and are experiencing side effects in their mouths. A thorough oral examination is important in the overall pretherapy evaluation of these patients, and, along with a consideration for the patient's disease, treatment, prognosis and laboratory values, allows for realistic planning for dental management prior to, during and following cancer therapy. The early establishment of a good working relationship with the patient and those caring for him or her, and an understanding of the importance of compliance with oral hygiene will eliminate needless therapy-induced morbidity and mortality.


12. DOCID:21691 SCORE: 0.00156558294937955
DOCNO: 8535902
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Comorbidity
QUALIFIER: secondary
QUALIFIER: therapy
AUTHOR: T A Graves TA
AUTHOR: K I Bland KI
AFFILIATION: Brown University School of Medicine, Providence, Rhode Island, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Comorbidity risk parameters associated with advanced breast cancer and systemic disease. Management of nonbreast disease.
PUBDATE: 19951001
The comorbidity risks associated with advanced breast cancer and systemic disease have been outlined under three broad categories: the local or regional consequences of advanced local breast cancer and its management, systemic sequelae of adjuvant chemotherapy and radiotherapy, and systemic sequelae of metastatic breast disease. Awareness of the potential risks, early detection, and active intervention may diminish the adverse consequences of comorbidities in breast cancer and improve the patient's quality of life.


13. DOCID:21428 SCORE: 0.00156557788436984
DOCNO: 9257149
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: B R Stotland BR
AUTHOR: E S Siegelman ES
AUTHOR: J B Morris JB
AUTHOR: M L Kochman ML
AFFILIATION: Department of Medicine, University of Pennsylvania Health System, Philadelphia, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Preoperative and postoperative imaging for colorectal cancer.
PUBDATE: 19970801
Management and survival in colorectal cancer are dictated by the extent of the disease at the initial diagnosis. Technological advances over the past 25 years have improved the ability to accurately preoperatively stage these lesions and detect recurrence. This article reviews the focus on the utility of computerized tomography, magnetic resonance, endoscopic ultrasound, and newer imaging methods including PET scan and monoclonal antibodies in the management of colorectal carcinoma.


14. DOCID:23940 SCORE: 0.00156557621331775
DOCNO: 8593169
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, src
DESCRIPTOR: Multigene Family
QUALIFIER: genetics
QUALIFIER: physiology
AUTHOR: S J Taylor SJ
AUTHOR: D Shalloway D
AFFILIATION: Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14851, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: BioEssays : news and reviews in molecular, cellular and developmental biology.
COUNTRY: ENGLAND
TITLE: Src and the control of cell division.
PUBDATE: 19960101
The finely tuned mechanisms that control cell cycle progression go awry in cancer, pointing to proto-oncogene products as important players in cell-cycle regulation. One such proto-oncoprotein, c-Src, has previously been directly implicated, based on its requirement for growth factor-stimulated DNA synthesis. Roche et al. have now shown that c-Src or its close relatives are also required for cell division to occur. The demonstration of essential functions for the Src family at multiple points in the cell cycle raises important questions about the normal and transforming activities of these and other proto-oncoproteins.