0. DOCID:31319 SCORE: 0.00311012224593751
DOCNO: 12087457
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Air Pollution, Indoor
DESCRIPTOR: Environmental Exposure
DESCRIPTOR: Gamma Rays
DESCRIPTOR: Housing
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: British journal of cancer.
COUNTRY: Scotland
TITLE: The United Kingdom Childhood Cancer Study of exposure to domestic sources of ionising radiation: 2: gamma radiation.
PUBDATE: 20020601
This article reports measurements of household levels of gamma and cosmic rays at the addresses of children with cancer at the time of diagnosis and six months before, and of similar data at the addresses of control children. There is no indication of increased risk with increasing dose rates either in matched or unmatched analyses, with or without adjustment for deprivation. Sub-division by diagnostic group did not reveal any association with any specific types of malignancy. Studies of the relationship between household gamma rays and radon concentration show no evidence of any interactions.


1. DOCID:30385 SCORE: 0.00168274290784681
DOCNO: 15024383
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: Hirofumi Tachibana H
AUTHOR: Kiyoshi Koga K
AUTHOR: Yoshinori Fujimura Y
AUTHOR: Koji Yamada K
AFFILIATION: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6-10-1, Fukuoka, 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp
PUBTYPE: Journal Article
JOURNALTITLE: Nature structural & molecular biology.
COUNTRY: United States
TITLE: A receptor for green tea polyphenol EGCG.
PUBDATE: 20040401
The major polyphenol in green tea, (-)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K (d) value.


2. DOCID:29269 SCORE: 0.00139316388380331
DOCNO: 11940467
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
AUTHOR: Mario Campone M
AUTHOR: Pierre Fumoleau P
AFFILIATION: Service d'oncologie, Centre René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain Cedex.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Weekly administration of paclitaxel in the treatment of metastatic breast cancer: from rational to practice]
PUBDATE: 20020301
Clinical studies showed that paclitaxel is active as single agent and in combination chemotherapy for the management of metastatic breast cancer. A variety of doses and administration schedules have been evaluated in phase II and III trials. Weekly administration of paclitaxel which is generally well tolerated increases the therapeutic index (efficacy/safety) resulting from anti-angiogenic and pro-apoptotic effects.


3. DOCID:29423 SCORE: 0.00139283350556052
DOCNO: 15533503
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
QUALIFIER: surgery
QUALIFIER: injuries
QUALIFIER: surgery
QUALIFIER: adverse effects
QUALIFIER: surgery
AUTHOR: Massimiliano Spaliviero M
AUTHOR: Andrew P Steinberg AP
AUTHOR: Jihad H Kaouk JH
AUTHOR: Mihir M Desai MM
AUTHOR: Warren C Hammert WC
AUTHOR: Inderbir S Gill IS
AFFILIATION: Section of Laparoscopic and Minimally Invasive Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: United States
TITLE: Laparoscopic injury and repair of obturator nerve during radical prostatectomy.
PUBDATE: 20041101
A 61-year-old man with bilateral Gleason score 7 (3+4) clinical Stage T1c prostate cancer was treated with laparoscopic bilateral pelvic lymphadenectomy and radical prostatectomy. The left obturator nerve was inadvertently transected during left obturator lymph node dissection and repaired by laparoscopic reapproximation.


4. DOCID:29695 SCORE: 0.00139281365226014
DOCNO: 16124750
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: Ismael León I
AUTHOR: Raúl G Enríquez RG
AUTHOR: David A Nieto DA
AUTHOR: Daniel Alonso D
AUTHOR: William F Reynolds WF
AUTHOR: Eduardo Aranda E
AUTHOR: Josué Villa J
AFFILIATION: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62210 Cuernavaca, Morelos, México. ismaelr@ciq.uaem.mx
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: Pentasaccharide glycosides from the roots of Ipomoea murucoides.
PUBDATE: 20050801
Five pentasaccharide glycosides, murucins 1-5 (1-5), were isolated from the roots of the arboreal species Ipomoea murucoides, and their structures were elucidated by spectroscopic and chemical methods. Compounds 1-5 were evaluated for cytotoxicity against a small panel of cancer cell lines.


5. DOCID:29485 SCORE: 0.00139281242000713
DOCNO: 15270644
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: immunology
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: Benjamin Levy B
AUTHOR: Dennis Panicalli D
AUTHOR: John Marshall J
AFFILIATION: Lombardi Comprehensive Cancer Center, 3800 Reservoir Rd NW, Washington, DC 20007, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert review of vaccines.
COUNTRY: England
TITLE: TRICOM: enhanced vaccines as anticancer therapy.
PUBDATE: 20040801
Renewed interest in immune therapies for the treatment of cancer has sparked a number of different immune stimulation approaches. These include antibody based, dendritic cell-based and vaccine-based therapies. The poxvirus-based vaccines incorporating a TRIad of COstimulatory Molecules (TRICOM) will be reviewed here. Through stimulation of cancer-specific T-cell responses, researchers have demonstrated interesting clinical efficacy in addition to the high safety profile in clinical trials.


6. DOCID:30092 SCORE: 0.00139280328802752
DOCNO: 12654256
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: metabolism
QUALIFIER: physiology
AUTHOR: Boris Zhivotovsky B
AUTHOR: Sten Orrenius S
AFFILIATION: Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden. boris.zhivotovsky@imm.ki.se
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: United States
TITLE: Defects in the apoptotic machinery of cancer cells: role in drug resistance.
PUBDATE: 20030401
The therapeutic goal in cancer treatment is to trigger tumor-selective cell death. Since many antineoplastic agents induce an apoptotic type of death in susceptible cells, it is likely that dysfunction of the apoptotic machinery might be an important determinant of resistance to anticancer drugs. Here we review known differences in the apoptotic machinery in cancer cells, and how this knowledge can be used to increase the efficiency of tumor treatment.


7. DOCID:30270 SCORE: 0.00139270780864481
DOCNO: 15354226
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Design
QUALIFIER: chemistry
QUALIFIER: pharmacology
AUTHOR: Shuang Liu S
AFFILIATION: Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA. lius@pharmacy.purdue.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Chemical Society reviews.
COUNTRY: England
TITLE: The role of coordination chemistry in the development of target-specific radiopharmaceuticals.
PUBDATE: 20040901
There is a great current interest in developing target-specific radiopharmaceuticals for early detection of diseases and radiotherapy of cancers. This critical review will focus on the role of coordination chemistry in the development of target-specific radiopharmaceuticals. It will also discuss the recent development in technetium, copper, gallium, indium, yttrium and lanthanide chemistry, as well as analytical tools for quality control and characterization of radiolabeled small biomolecules (159 references).


8. DOCID:28753 SCORE: 0.00115010820603014
DOCNO: 16097458
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Total Quality Management
DESCRIPTOR: Waiting Lists
QUALIFIER: economics
QUALIFIER: organization & administration
AUTHOR: Rebecca Coombes R
PUBTYPE: Journal Article
JOURNALTITLE: The Health service journal.
COUNTRY: England
TITLE: A year in Bristol. Back from the red.
PUBDATE: 20050701
United Bristol Healthcare trust has pulled back from a predicted 3.5m pounds sterling deficit to achieve zero balance. It faces a raft of new challenges, ranging from tough cancer targets to censure over waiting-list breaches. The trust has cut the use of nursing agencies drastically, with 95 per cent of nurses now bank staff. Non-clinical issues such as litter, food and the appearance of buildings are also being tackled.


9. DOCID:30076 SCORE: 0.00114716138047968
DOCNO: 14601044
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: physiology
AUTHOR: Renato Baserga R
AUTHOR: Francesca Peruzzi F
AUTHOR: Krysztof Reiss K
AFFILIATION: Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, 624 BLSB, Philadelphia, PA 19107, USA. b_lupo@mail.jci.tju.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: United States
TITLE: The IGF-1 receptor in cancer biology.
PUBDATE: 20031201
The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.


10. DOCID:31369 SCORE: 0.00110260801906182
DOCNO: 16010982
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: metabolism
AUTHOR: G Vani G
AUTHOR: C S Shyamala Devi CS
AFFILIATION: Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India. vangan@yahoo.com
PUBTYPE: Journal Article
JOURNALTITLE: Molecular and cellular biochemistry.
COUNTRY: Netherlands
TITLE: Effect of histone H1 on estrogen receptor status of human breast cancer MCF 7 cells.
PUBDATE: 20050401
The effects of exogenous histone H1 on estrogen receptor status of human breast cancer MCF 7 cells were investigated in presence and absence of estrogen. Exogenous histone H1 was significantly cytotoxic in a dose- and time-dependent manner. Cell cycle analysis revealed a significant increase in the percentage of cell accumulation in G0/G1 phase. In histone H1-treated cells, a significant decrease in the estrogen receptor content and an increase in the dissociation constant (KD) of ER was observed compared to control.


11. DOCID:28850 SCORE: 0.00110260789109508
DOCNO: 12691452
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clothing
DESCRIPTOR: Radiation Protection
QUALIFIER: adverse effects
QUALIFIER: administration & dosage
AUTHOR: Raymond Ramirez R
AUTHOR: Jeffrey Schneider J
AFFILIATION: University of California, San Francisco, Comprehensive Cancer Center, Melanoma Clinic, Box 1706, San Francisco, CA 94143-1706, USA.
PUBTYPE: Journal Article
JOURNALTITLE: The Surgical clinics of North America.
COUNTRY: United States
TITLE: Practical guide to sun protection.
PUBDATE: 20030201
Sun exposure is the major cause of accelerated skin aging and skin cancer. Proper sun protection includes: (1) Limiting time in the midday sun, (2) Checking the Ultraviolet (UV) index, (3) Using shade wisely, (4) Wearing protective clothing especially broad hats and eyewear, (5) Using sunscreen properly, (6) Avoiding sunlamps and tanning beds.


12. DOCID:31299 SCORE: 0.00110260481400269
DOCNO: 12648714
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: methods
QUALIFIER: radiotherapy
AUTHOR: A Belliere A
AUTHOR: O Chapet O
AUTHOR: R Coquard R
AUTHOR: P Romestaing P
AUTHOR: J M Ardiet JM
AUTHOR: J P Gérard JP
AFFILIATION: Service de radiothérapie, CH Lyon-Sud, 69495 cedex, Pierre-Bénite, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer radiothérapie : journal de la Société française de radiothérapie oncologique.
COUNTRY: France
TITLE: [Brachytherapy in carcinomas of anal canal and rectum: techniques and results]
PUBDATE: 20030201
Conservative treatment of small anal canal and low rectal cancers is a valid alternative to radical surgery through combinated strategies including external beam and/or intracavitary irradiation, concomitant chemotherapy and 192 iridium implantation as a booster dose. Feasibility, tolerance and results are effective. Local control of the disease and the quality of the anal functions are good. The treatment requires great care in patient selection and follow-up.


13. DOCID:31442 SCORE: 0.00110253669820442
DOCNO: 12242108
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nuclear Proteins
DESCRIPTOR: Saccharomyces cerevisiae Proteins
QUALIFIER: chemistry
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: Kristen E Neely KE
AUTHOR: Jerry L Workman JL
AFFILIATION: Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 306 Althouse Laboratory, University Park, PA 16802, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: Netherlands
TITLE: The complexity of chromatin remodeling and its links to cancer.
PUBDATE: 20021001
The relief of chromatin-mediated repression by ATP-dependent chromatin-remodeling complexes is an important step in the proper transcriptional regulation of many genes. This review gives an organized summary of this large group of complexes that exist in yeast, flies, and humans. Their subunit composition and brief overview of their functional properties will be discussed. Also, current links between human chromatin-remodeling complexes and cell growth and cancer will be presented.


14. DOCID:31464 SCORE: 0.00110203161178298
DOCNO: 16361195
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Estrogen Antagonists
DESCRIPTOR: Lactic Acid
DESCRIPTOR: Microspheres
DESCRIPTOR: Polyglycolic Acid
DESCRIPTOR: Polymers
DESCRIPTOR: Tamoxifen
AUTHOR: S Sehra S
AUTHOR: A S Dhake AS
AFFILIATION: Department of Pharmaceutical Sciences, Guru Jambheshwar Univeristy, Hisar, Haryana, India.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of microencapsulation.
COUNTRY: England
TITLE: Formulation and evaluation of sustained release microspheres of poly-lactide-co-glycolide containing tamoxifen citrate.
PUBDATE: 20050801
Tamoxifen citrate, a non-steroidal anti-oestrogen has potential applications in treatment of breast cancer. Biodegradable microspheres of' PLGA 65:35 were prepared by o/w emulsification solvent evaporation method. In this study, different batches of varying concentration of drug, polymer, polyvinyl alcohol and solvent were prepared. All the batches prepared were characterized by particle size distribution, encapsulation efficiency and in vitro release behaviour. Drug, polymer and PVA concentrations were varied to obtain optimum release profile for sustaining the action of drug.