0. DOCID:7197 SCORE: 0.00338970262926924
DOCNO: 7304598
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Maternal Age
QUALIFIER: etiology
AUTHOR: C Bain C
AUTHOR: W Willett W
AUTHOR: B Rosner B
AUTHOR: F E Speizer FE
AUTHOR: C Belanger C
AUTHOR: C H Hennekens CH
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Early age at first birth and decreased risk of breast cancer.
PUBDATE: 19811101
The relationship between age at birth of a first child and breast cancer was evaluated for 1159 affected women and 11,590 women without cancer in data collected in 1976 among married female registered nurses residing in 11 states in the United States. A positive trend of increasing risk of breast cancer with later ages at first birth was found (chi 2(1) for trend in proportions = 30.9, p less than 0.01). Adjustment for potential confounding variables by multiple logistic regression did not affect this trend. The presence of this relationship using non-hospitalized controls of similar social status to cases supports the reality of this association, which has recently been challenged as an artifact due to inappropriate choice of hospitalized controls.

1. DOCID:6523 SCORE: 0.00312280185110921
DOCNO: 6172161
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: D Franco D
AUTHOR: J Morin J
AUTHOR: A M Szekely AM
AUTHOR: H Bismuth H
PUBTYPE: Journal Article
JOURNALTITLE: Biomedicine / [publiée pour l'A.A.I.C.I.G.].
COUNTRY: FRANCE
TITLE: Enhancement of Aflatoxin B1 induced liver carcinogenesis by portal diversion in the rat.
PUBDATE: 19811001
Conflicting results have been reported on the influence of portacaval anastomosis on liver carcinogenesis. The purpose of this investigation was to study the effect of portal diversion on liver carcinogenesis induced in the rat by a potent chemical liver carcinogen, Aflatoxin B1 (AFB1). Liver tumors appeared earlier and were significantly bigger in rats with shunts than in sham-operated controls. Portal diversion also induced in rats fed AFB1 a splenic atrophy with nearly complete disappearance of Malpighian corpuscles suggesting a profound immunodepression. This might be responsible for the enhancement of liver cancer by portacaval anastomosis in the rats fed AFB1. Thus, the influence of portal diversion on liver cancers appears to be multifactorial.

2. DOCID:5078 SCORE: 0.0031228005605278
DOCNO: 11643610
OWNER: KIE
STATUS: MEDLINE
DESCRIPTOR: Death
DESCRIPTOR: Mass Media
DESCRIPTOR: Terminal Care
DESCRIPTOR: Terminally Ill
AUTHOR: Bernard Towers B
PUBTYPE: Journal Article
JOURNALTITLE: Journal of medical ethics.
COUNTRY: United States
TITLE: A television triumph about death and dying.
PUBDATE: 19800601
Towers reviews Joan Robinson: One Woman's Story, an American documentary film about a terminal cancer patient that was first broadcast by the Public Broadcasting Service on 21 January 1980. The film was made at the instigation of Robinson, a writer and editor, and covers the last twenty-two months of her life from the diagnosis of incurable ovarian cancer to her graveside funeral service. Towers praises the film-makers for their empathetic and sensitive handling of a difficult subject, and recommends that the film be made available for teaching purposes.

3. DOCID:7757 SCORE: 0.00288592737792189
DOCNO: 6939415
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: A O Langlands AO
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: The evaluation of the results of cancer therapy treatment utility.
PUBDATE: 19810201
The results of cancer management are frequently presented in a way such that the only comparison that can be made between treatments is that of fixed term survival. Very few reports attempt to include an analysis of the effect of second line therapy or a comparison of the different morbidities of different treatments. Techniques now exist (one of these is the concept of treatment utility) which take into account not only the probability of the outcome of a treatment but also the quality of that outcome. To expand this concept requires research in cancer management to be directed to the production of numerical values for treatment toxicity, pain, disability and mutilation, in addition to the conventional survival rates. This paper examines the concept of treatment utility when a comparison is made between two treatments which produce differences in survival but only one of which is associated with significant permanent disability.

4. DOCID:5876 SCORE: 0.00263023813494662
DOCNO: 7468583
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: epidemiology
AUTHOR: A Linos A
AUTHOR: R A Kyle RA
AUTHOR: W M O'Fallon WM
AUTHOR: L T Kurland LT
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Leukemia and prior malignant and hematologic diseases: a case-control study.
PUBDATE: 19810301
Records of 138 patients with leukemia diagnosed between 1955-1974 in Olmsted County, Minnesota, and 276 controls were examined for the occurrence of prior malignancies and hematologic diseases. No significant excess of malignancy was observed when all types of malignancy and all types of leukemia combined were considered. When they were analyzed separately, however, a fivefold increase in the risk of prior skin cancer was found in patients with chronic lymphocytic leukemia. Because of the relatively small numbers, this difference is of borderline statistical significance. The presence of prior hematologic disorders was also examined, and the findings are discussed.

5. DOCID:6010 SCORE: 0.00254447310773559
DOCNO: 6931248
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: E C Krishnan EC
AUTHOR: C D Menon CD
AUTHOR: L Krishnan L
AUTHOR: W R Jewell WR
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Deficiency in maturation process of macrophages in human cancer.
PUBDATE: 19800801
Peripheral blood mononuclear cells were cultured from normal individuals and patients with cancer. The analysis of these results indicated a lower number of macrophage precursors (monocytes) in patients with cancer as compared to the number in normal individuals. The macrophage yield was 1.9 +/- 1.1 X 10(4)/ml of blood in patients with cancer versus 7.2 +/- 2.0 X 10(4)/ml of blood in normal individuals. This low yield of macrophages in patients with cancer was not associated with serum factors. Furthermore, a study of the adherent cell population suggests in intrinsic defect in the maturation process in vitro in patients with cancer.

6. DOCID:5973 SCORE: 0.00254446450225961
DOCNO: 7355227
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: P K Leichner PK
AUTHOR: N B Rosenshein NB
AUTHOR: S A Leibel SA
AUTHOR: S E Order SE
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Distribution and tissue dose of intraperitoneally administered radioactive chromic phosphate (32P) in New Zealand white rabbits.
PUBDATE: 19800301
Radiophosphorus (32P) has become the preferred radioisotope for intraperitoneal radiotherapy in the adjuvant treatment of ovarian cancer. In a study of the distribution and tissue dose of intraperitoneally administered 32P in rabbits, effective half-lives of 32P and the radiation dose absorbed by intra-abdominal tissues were determined. Results show that 32P is not uniformly distributed over the peritoneal surfaces and that many areas are minimally irradiated. It is concluded that a significant fraction of the 32P distribution is systemic and that the beta-ray dose for intra-abdominal tissues is much lower than suggested by theoretical models.

7. DOCID:7842 SCORE: 0.00225528473373561
DOCNO: 6162550
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: pharmacology
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
AUTHOR: S W Rosen SW
AUTHOR: I Calvert I
AUTHOR: B D Weintraub BD
AUTHOR: J S Tseng JS
AUTHOR: A S Rabson AS
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Stimulation of N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate of ectopic production of the free beta subunit of chorionic gonadotropin by a human brain tumor cell line.
PUBDATE: 19801101
Previous studies have favored a basic difference in the regulation of specialized protein production by cells derived from the usual tissue of origin (eutopic) and cancer cells derived from a tissue not normally producing the protein (ectopic). Thus N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate was believed to stimulate only eutopic (but not ectopic) chorionic gonadotropin production, and butyrate to stimulate only ectopic (but not eutopic). However, in CBT, a human brain tumor cell line, we find that N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate, but not butyrate, stimulated ectopic production of the beta subunit of chorionic gonadotropin. We conclude that neither butyrate nor cyclic adenosine 3':5'-monophosphate derivatives reliably discriminate ectopic from eutopic regulation.

8. DOCID:4882 SCORE: 0.00224948492292722
DOCNO: 79865
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mutagens
DESCRIPTOR: Plants, Toxic
DESCRIPTOR: Tobacco
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: complications
AUTHOR: T Hewer T
AUTHOR: E Rose E
AUTHOR: P Ghadirian P
AUTHOR: M Castegnaro M
AUTHOR: C Malaveille C
AUTHOR: H Bartsch H
AUTHOR: N Day N
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Ingested mutagens from opium and tobacco pyrolysis products and cancer of the oesophagus.
PUBDATE: 19780901
Substances which are commonly sucked or chewed in two areas where the incidence of oesophageal cancer is high, the Transkei and north-east Iran, were tested in bacterial mutagenicity assays. Pyrolysed substances, opium dross in north-east Iran and tobacco pipe residues in the Transkei, displayed mutagenic activity in Salmonella typhimurium strains TA98 and TA100 in the presence of rat liver microsomes.

9. DOCID:7635 SCORE: 0.00196615910616438
DOCNO: 748802
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: A E Bogden AE
AUTHOR: H J Esber HJ
PUBTYPE: Journal Article
JOURNALTITLE: National Cancer Institute monograph.
COUNTRY: UNITED STATES
TITLE: Influence of surgery, irradiation, chemotherapy, and immunotherapy on growth of a metastasizing rat mammary adenocarcinoma.
PUBDATE: 19781201
Based upon the hypothesis that a factor most pertinent to the absence of an effective immune response in cancer is the inadequacy of the antigenic stimulus provided by the neoplasm, either in terms of weak immunogenicity of the tumor antigen or of the necessary antigen mass available to the reticuloendothelial tissues at any one time for effective sensitization, the host immune response capabilities were stimulated within a time frame synchronous with a greater release of tumor antigens. In the treatment of a metastasizing, solid tumor model syngeneic with F344 rats, immunotherapy was most effectively applied in combinations with chemotherapy and/or localized radiotherapy, therapeutic modalities that induced a degree of oncolysis and tumor resorption. Surgery combined with chemotherapy permitted evaluation of therapeutic effects against metastases. The methanol-soluble fraction of Mycobacterium butyricum was used as the nonspecific immunologic adjuvant.

10. DOCID:4924 SCORE: 0.00167703693614272
DOCNO: 7445298
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: P C Ho PC
AUTHOR: L B Talner LB
AUTHOR: C L Parsons CL
AUTHOR: J D Schmidt JD
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Percutaneous nephrostomy: experience in 107 kidneys.
PUBDATE: 19801101
We were successful using percutaneous nephrostomy to relieve upper urinary obstruction in 98 of 107 kidneys. In two thirds of our patients obstruction was due to neoplasm, with prostatic cancer the leading cause. Percutaneous nephrostomy proved to be ideally suited for drainage of pyonephrosis and in azotemic patients. Its use can obviate surgical nephrostomy and prolonged ureteral catheter drainage. We also are encouraged by our early experience with extensions of percutaneous nephrostomy, including percutaneous ureteral stenting, renal stone dissolution, and percutaneous pyelolithotomy.

11. DOCID:4516 SCORE: 0.00167702150713859
DOCNO: 7016103
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: etiology
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: I F Young IF
AUTHOR: I C Roberts-Thomson IC
AUTHOR: J R Sullivan JR
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Histiocytic lymphoma presenting with extrahepatic biliary obstruction: a report of three cases.
PUBDATE: 19810401
Three patients with histiocytic lymphoma presented with jaundice due to extrahepatic biliary obstruction. Two had widespread disease, but one had a primary lymphoma of the head of the pancreas simulating pancreatic cancer. Biliary bypass surgery was avoided in two patients, both of whom showed resolution of jaundice following treatment with cytotoxic chemotherapeutic drugs.

12. DOCID:7559 SCORE: 0.00167681074332504
DOCNO: 7296482
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: P C Nasca PC
AUTHOR: P Greenwald P
AUTHOR: W S Burnett WS
AUTHOR: S Chorost S
AUTHOR: W Schmidt W
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Cancer among the foreign-born in New York State.
PUBDATE: 19811101
Cancer deaths among white, foreign-born residents of New York State (exclusive of New York City) during the years 1969 through 1971 were analyzed according to country of birth. The largest numbers of immigrants came from Great Britain, Ireland, Germany, Austria, Poland, Italy, USSR, and Canada. Several distinctive features emerged from these data: Irish immigrants have an increased risk of dying from oropharyngeal, gastrointestinal, lung, and prostate cancers. Among all migrant groups studied, contrasting mortality patterns observed for carcinomas of the stomach, colon, and rectum provide further support for the concept that these neoplasms result from different etiologic processes. For the leukemias, lymphomas, and carcinomas of the breast and colon, each of the migrant groups acquired the higher risk common to others in the host country. This rise in risk suggests a major environmental component for cancers of these sites.

13. DOCID:6227 SCORE: 0.00167561419705631
DOCNO: 7248915
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Registries
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: L E Dougan LE
AUTHOR: M L Matthews ML
AUTHOR: B K Armstrong BK
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The effect of diagnostic review on the estimated incidence of lymphatic and hematopoietic neoplasms in Western Australia.
PUBDATE: 19810801
Diagnoses of 1443 patients from a population-based leukemia and allied disorders registry in Western Australia were subjected to diagnostic review, resulting in 235 deletions, 120 changes in diagnosis, and 23 undecided diagnoses. Deletions occurred mainly in lymphoma registrations, most of these being reclassified as other cancers. Among the patients whose names were deleted, 196 deaths occurred of whom 67 had leukemia or an allied disorder as the certified cause of death. Lymphoma incidence rates in Western Australia were lower than those reported from another Australian registry. Quality control of registration and special interests in diagnosis or classification of particular tumors may affect their reported incidence rates.

14. DOCID:6057 SCORE: 0.00138790139551259
DOCNO: 6157337
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
AUTHOR: S L Warren SL
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of allergy.
COUNTRY: UNITED STATES
TITLE: A practitioner's guide to interferon.
PUBDATE: 19800701
The discovery and subsequent development of interferon as an anti-viral, ant-cancer therapeutic agent may well be a major milestone in the history of medical therapeutics. The results of the limited clinical trials available offer great promise for this biological agent. Only time, with large scale clinical trials, will serve to evaluate the true benefit of this modality of therapy. In the interim it is most desirable that the prcticing allergist-immunologist maintain an awareness of the use and mens of production of interferon so that he has available at his descretion a therapeutic modality for possible use in cases that have drastic, very poor or no therapeutic alternatives, remembering that each case add to the compendium of clinical knowledge.