0. DOCID:11184 SCORE: 0.00412642516244434
DOCNO: 7079145
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: therapy
QUALIFIER: administration & dosage
AUTHOR: G Richer G
AUTHOR: F K Jansen FK
AUTHOR: P Gros P
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse m├ędicale.
COUNTRY: FRANCE
TITLE: [Immunotoxins (author's transl)]
PUBDATE: 19820401
Immunotoxins are hybrid molecules made up of an antibody and of the toxic subunit of a polypeptidic toxin. They act on the principle that the antibody binds the molecule to a cellular antigen which it specifically recognizes, so that the cytotoxic component only kills those cells that bear the antigen. Cell hybridizations obtained by fusion now produce monoclonal antibodies specific enough to bind the antigens present on certain malignant cells. In vitro experiments have demonstrated the high specific activity of immunotoxins against malignant cells, and this seems to be confirmed by in vivo experiments in mice. Such experimental results suggest that immunotoxins may eventually be used in the treatment of cancer as well as for other pharmacological purposes.


1. DOCID:10315 SCORE: 0.00347350528737929
DOCNO: 6857286
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: R A Saavedra RA
AUTHOR: G R Anderson GR
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: A cancer-associated lactate dehydrogenase is expressed in normal retina.
PUBDATE: 19830701
An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase k, is found in high concentrations in cultured cells transformed by the Kirsten murine sarcoma virus and in many human cancer tissues. In experiments described here high levels of a lactate dehydrogenase k activity were detected in extracts of normal rodent retina. This activity had the same key properties as the human tumor isozyme, namely, a highly cathodic electrophoretic mobility and inhibition of enzymatic activity by oxygen and 5',5'-dipurinenucleoside tetraphosphates. Expression of this activity in the retina may be related to the high aerobic glycolysis characteristic of the retina, a metabolic feature shared with many tumors.


2. DOCID:13322 SCORE: 0.00320684827297891
DOCNO: 2659583
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diagnostic Imaging
DESCRIPTOR: Technetium Compounds
QUALIFIER: diagnosis
AUTHOR: W Gordenne W
AUTHOR: E Bauduin E
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal belge de radiologie.
COUNTRY: BELGIUM
TITLE: Diagnostic accuracy of new imaging techniques in breast diseases.
PUBDATE: 19890201
During the last decade, the hypothetical carcinogenic effects of mammography have lead to new technical developments in X-ray diagnosis and to the use of other imaging techniques such as ultrasonography (US), transillumination, magnetic resonance imaging (MRI). Many preliminary studies were published but few clinical trials are really convincing. According to the definition of a diagnostic tool, none of these new modalities is supposed to supplant mammography in the diagnosis of breast cancer. Improvements are expected by digital mammography in the near future.


3. DOCID:13360 SCORE: 0.0032068471706367
DOCNO: 3951093
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: C Hogstedt C
AUTHOR: L Aringer L
AUTHOR: A Gustavsson A
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Epidemiologic support for ethylene oxide as a cancer-causing agent.
PUBDATE: 19860301
The mortality and incidence of cancer in three groups of workers with occupational exposure to ethylene oxide have been assessed. Eight cases of leukemia have occurred among 733 ethylene oxide-exposed workers compared with an expected 0.8 cases. Six cases of stomach cancer have been reported compared with 0.65 cases expected. These epidemiologic results provide support for an increased risk of malignancy in individuals with extended and intermittent exposure to low concentrations of ethylene oxide.


4. DOCID:14944 SCORE: 0.00320052926678202
DOCNO: 3606015
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: blood
AUTHOR: A J Taylor AJ
AUTHOR: H I Pandov HI
AUTHOR: N Lawson N
PUBTYPE: Journal Article
JOURNALTITLE: Annals of clinical biochemistry.
COUNTRY: ENGLAND
TITLE: Determination of erythrocyte fatty acids by capillary gas liquid chromatography.
PUBDATE: 19870501
A capillary gas liquid chromatography method was established for the routine determination of fatty acid profiles from washed erythrocyte membranes. Only the five major fatty acids found in erythrocytes (palmitic, stearic, oleic, linoleic and arachidonic acids) had acceptable precision (CVs less than 10.0%) for use in establishing quantitative differences between groups of individuals. Reference values were established for the relative amounts of these five fatty acids in adults. Significant alterations in the relative concentrations of oleic and arachidonic acids were found after storage at +4 degrees C for 24 h, which has important implications in the study of changes in erythrocyte fatty acids in cancer and diabetes.


5. DOCID:10374 SCORE: 0.00285777172642671
DOCNO: 6305855
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Transformation, Viral
QUALIFIER: biosynthesis
QUALIFIER: metabolism
QUALIFIER: genetics
AUTHOR: J R Schlehofer JR
AUTHOR: L Gissmann L
AUTHOR: B Matz B
AUTHOR: H zur Hausen H
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Herpes simplex virus-induced amplification of SV40 sequences in transformed Chinese hamster embryo cells.
PUBDATE: 19830701
Infection with Herpes simplex viruses (HSV) induces amplification of SV40 sequences in SV40-transformed Chinese hamster embryo cells (CO631). This is shown by in situ hybridization of the infected cells with cloned 32P-labelled SV40 DNA. The HSV-mediated synthesis of SV40 DNA is more pronounced than after treatment with chemical carcinogens. This initiator-like effect of HSV may, in concert with the previously reported mutagenic activity of this virus (Schlehofer and zur Hausen, 1982), point to a possible mechanism of HSV infection in human genital cancer.


6. DOCID:15932 SCORE: 0.0026078207281146
DOCNO: 3458227
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: R R Weichselbaum RR
AUTHOR: W Dahlberg W
AUTHOR: M Beckett M
AUTHOR: T Karrison T
AUTHOR: D Miller D
AUTHOR: J Clark J
AUTHOR: T J Ervin TJ
PUBTYPE: Journal Article
JOURNALTITLE: Proceedings of the National Academy of Sciences of the United States of America.
COUNTRY: UNITED STATES
TITLE: Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
PUBDATE: 19860401
Inherent cellular radioresistance and repair of x-ray damage was studied in 19 early-passage squamous cell carcinoma lines derived from head- and neck-cancer patients with known clinical results following radiotherapy. Human tumor cells that were radioresistant and/or proficient in accumulation/repair of x-ray damage were cultured from patients unsuccessfully treated with radiotherapy. Thus, the presence of radiation-resistant and repair-proficient tumor cells was associated with clinical radiation failure, suggesting the possibility of a predictive assay based on in vitro radiobiological parameters.


7. DOCID:10109 SCORE: 0.0022960555855742
DOCNO: 6612933
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: V A Gerasin VA
AUTHOR: V A Kartavova VA
AUTHOR: G F Palamarchuk GF
PUBTYPE: Journal Article
JOURNALTITLE: Vestnik khirurgii imeni I. I. Grekova.
COUNTRY: USSR
TITLE: [Current bronchological methods of diagnosis of lung cancer]
PUBDATE: 19830601
On the basis of an analysis of results of studying 541 patients with lung cancer the authors consider that bronchoscopy can diagnose the central lung cancer practically in all the patients including the early stages of the disease before the development of changes in the lungs on roentgenograms. The histological verification of the peripheral lung cancer of the root and median zones is ensured in 77% of patients by bronchofibroscopy under local anesthesia with the transbronchial peripheral forcepts and brush biopsy under the roentgen and TV control. Bronchological diagnosis of cancer of the subpleural zone still remains less effective.


8. DOCID:9276 SCORE: 0.00229599551746626
DOCNO: 6886023
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: M G Wood MG
AUTHOR: C Bates C
AUTHOR: R C Brown RC
AUTHOR: M S Losowsky MS
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical pathology.
COUNTRY: ENGLAND
TITLE: Intramucosal carcinoma of the gastric antrum complicating Menetrier's disease.
PUBDATE: 19830901
A 48-year-old man presented with haematemesis and was found to have Menetrier's disease. Three and a half years later early gastric cancer was detected at routine follow-up endoscopy. This is the first report of the development of early gastric cancer during follow-up in a case of Menetrier's disease. It is probable that patients with Menetrier's disease are at increased risk of gastric cancer, and should have regular endoscopic follow-up with gastric biopsy.


9. DOCID:13629 SCORE: 0.00201514795055082
DOCNO: 3388698
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cytotoxicity, Immunologic
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A A Red'ko AA
AUTHOR: A M Malygin AM
AUTHOR: N A Dvaladze NA
AUTHOR: V A Pleskach VA
AUTHOR: F Kh Kutushev FKh
PUBTYPE: Journal Article
JOURNALTITLE: Vestnik khirurgii imeni I. I. Grekova.
COUNTRY: USSR
TITLE: [Natural killer activity and sensitization of the lymphocytes to tissue antigens in lung cancer]
PUBDATE: 19880201
A decreased natural killer activity was observed in patients with lung cancer as the disease progressed. Surgical intervention results in its elevation at the IIId stage, while the application of cytostatics or irradiation are efficient at the IIId and IInd stages. Pronounced sensibilization of the peripheral blood lymphocytes in cancer patients to normal and cancer tissue antigens was demonstrated with the help of the leukocyte adhesion inhibition test.


10. DOCID:11660 SCORE: 0.00170732524939668
DOCNO: 3859696
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: African Continental Ancestry Group
DESCRIPTOR: European Continental Ancestry Group
QUALIFIER: epidemiology
AUTHOR: H E Ownby HE
AUTHOR: J Frederick J
AUTHOR: J Russo J
AUTHOR: S C Brooks SC
AUTHOR: G M Swanson GM
AUTHOR: G H Heppner GH
AUTHOR: M J Brennan MJ
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Racial differences in breast cancer patients.
PUBDATE: 19850701
One thousand seventy-eight patients diagnosed with primary breast cancer were examined for racial differences in histopathologic and clinical parameters. There were no observed differences in tumor histopathologic type or tumor endocrine status between races. There were no differences with respect to time to breast tumor recurrence observed between black and white patients. However, differences were observed in factors that contributed to tumor stage at diagnosis and to tumor grade. Survival differences observed in univariant analysis of blacks vs. whites were explainable by the presence of more severe skin involvement, tumor grade, and tumor size at diagnosis in the black patients.


11. DOCID:9044 SCORE: 0.001706964004668
DOCNO: 6390918
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: D G Skinner DG
AUTHOR: G Lieskovsky G
AUTHOR: S D Boyd SD
PUBTYPE: Journal Article
JOURNALTITLE: The Urologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Technique of creation of a continent internal ileal reservoir (Kock pouch) for urinary diversion.
PUBDATE: 19841101
Kock and associates have made a major contribution to the urologic surgical armamentarium by developing a method to create a continent internal urinary reservoir out of ileum. This innovative procedure now offers patients requiring cystectomy for bladder cancer or cutaneous urinary diversion for any reason a real alternative to the standard ileal conduit, which requires wearing an external appliance. Operative technique, including some modifications developed by the authors, is presented.


12. DOCID:11671 SCORE: 0.001674837736564
DOCNO: 3855275
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, 21-22 and Y
DESCRIPTOR: Inversion, Chromosome
DESCRIPTOR: Translocation, Genetic
QUALIFIER: genetics
AUTHOR: R Morgan R
AUTHOR: R D Stebbins RD
AUTHOR: F Hecht F
AUTHOR: A A Sandberg AA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: The Philadelphia (Ph) chromosome in leukemia. III. Complex Ph translocation plus inversion in chronic myelocytic leukemia.
PUBDATE: 19850101
Remarkable chromosome abnormalities were observed in bone marrow cells from a woman with chronic myelocytic leukemia and atypical tuberculosis due to Mycobacterium avium-intracellulare infection. Four chromosome breaks occurred at bands 1p13, 1q32, 11p15, and 22q11. These breaks resulted in a complex Philadelphia (Ph) translocation between chromosomes #1, #11, and #22 and in an inversion of chromosome #1. Oncogenes on these chromosomes include N-ras and c-sk on chromosome #1, c-H-ras on chromosome #11, and c-sis on chromosome #22. Complex chromosome rearrangements may facilitate multiple oncogene changes, thereby permitting several steps in cancer development to occur simultaneously.


13. DOCID:9473 SCORE: 0.00165505581703966
DOCNO: 7129670
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: L A Mahmoud LA
AUTHOR: W A Robinson WA
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Vitamin A levels in human bladder cancer.
PUBDATE: 19820801
The following studies were undertaken to determine the levels of serum carotene and vitamin A (retinol) in Egyptian patients with intestinal, urinary, hepatosplenic schistosomiasis, and bladder cancer. These studies have shown that both serum carotene and serum retinol levels are significantly reduced in patients with bladder cancer when compared to controls. These data, when viewed in light of previous animal studies noted, raise the question as to whether vitamin A administration can be beneficial in the prevention and/or treatment of human bladder cancer, particularly that associated with schistosomiasis.


14. DOCID:15643 SCORE: 0.00142214747259182
DOCNO: 3560451
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Rectal Neoplasms
QUALIFIER: secondary
QUALIFIER: secondary
AUTHOR: A Ishikura A
AUTHOR: N Hunaki N
AUTHOR: K Watanabe K
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Brain metastases of colorectal cancer--a case report]
PUBDATE: 19870201
Metastatic brain tumors from colorectal cancers are relatively rate. In previous reports, the incidence, ranged from 1.9 to 3.5 percent of all metastatic brain tumors. We reported 2 cases of metastatic brain tumors from colorectal cancers. Metastasis to the lung and liver were not found in 2 cases at the time of the diagnosis of the single brain metastasis. The CEA levels in the serum were highly elevated in these 2 cases. On a contrast-enhanced CT scan, tumors were equally demonstrated as high density and cystic, with a ring-like mass with surrounding brain edema. Brain metastases of colorectal cancer were discussed with a review of the literature.