0. DOCID:3466 SCORE: 0.00545840022442393
DOCNO: 888102
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hypersensitivity, Delayed
DESCRIPTOR: Postoperative Complications
QUALIFIER: immunology
AUTHOR: J B Pietsch JB
AUTHOR: J L Meakins JL
AUTHOR: L D MacLean LD
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: The delayed hypersensitivity response: application in clinical surgery.
PUBDATE: 19770901
Delayed hypersensitivity skin testing was performed on 520 surgical patients. Significantly higher incidences of sepsis and mortality (p less than 0.001) were found in the abnormal patients as compared to normal responders in the preoperative (322 patients), postoperative and post-trauma (115 patients), and nonoperative (83 patients) groups. Sequential testing in individual patients was of even greater prognostic value. Of the 177 patients who either remained normal or whose responses became normal, the sepsis rate was 10.1%, and the mortality rate was 8.4%. However, a sepsis rate of 57.6% and a 78% mortality rate were found in those patients who developed abnormal responses or whose responses did not improve. Cancer and increased age (older than 80 years) did not account for the incidence of anergy and relative anergy. The mortality rate was higher in the cancer group. Anergy and relative anergy were found to be associated with malnutrition, sepsis, shock, and trauma. In the clinical setting, effective treatment of these associated conditions, especially the maintenance of body cell mass by the use of total parenteral nutrition, was associated with reversal of the anergic state and an improved prognosis.


1. DOCID:2988 SCORE: 0.00508319224344904
DOCNO: 402201
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: J G Pearson JG
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The present status and future potential of radiotherapy in the management of esophageal cancer.
PUBDATE: 19770201
The management of 2032 patients with squamous esophageal cancer seen in Edinburgh from 1931 to 1969 was studied. Since 1949 more radical surgical treatment has been offered and since 1956 more radical radiotherapy. From 1949 to 1969 there has been a swing over from mainly surgical to mainly radiation treatment associated with a rise in the overall one and five-year survival rates to 32% and 9% respectively. The main reason for failure is the prevalence of disseminated disease. The significant mortality of surgical treatment limits its usefulness. Too often, radiotherapy fails because of recurrence of tumor within the irradiated volume. In the upper 2/3 of the esophagus irradiation is preferable to surgery because of better sirvoval. In the lower 1/3 the two methods achieve similar long term survival but following irradiation the short term survival is better and the patient retains a normal stomach. Improvement could be achieved by prevention, earlier diagnosis, improved tumor delineation and a wide range of measures to improve the local effectiveness of irradiation.


2. DOCID:11184 SCORE: 0.00412642516244434
DOCNO: 7079145
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: therapy
QUALIFIER: administration & dosage
AUTHOR: G Richer G
AUTHOR: F K Jansen FK
AUTHOR: P Gros P
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Immunotoxins (author's transl)]
PUBDATE: 19820401
Immunotoxins are hybrid molecules made up of an antibody and of the toxic subunit of a polypeptidic toxin. They act on the principle that the antibody binds the molecule to a cellular antigen which it specifically recognizes, so that the cytotoxic component only kills those cells that bear the antigen. Cell hybridizations obtained by fusion now produce monoclonal antibodies specific enough to bind the antigens present on certain malignant cells. In vitro experiments have demonstrated the high specific activity of immunotoxins against malignant cells, and this seems to be confirmed by in vivo experiments in mice. Such experimental results suggest that immunotoxins may eventually be used in the treatment of cancer as well as for other pharmacological purposes.


3. DOCID:2781 SCORE: 0.00385026935349113
DOCNO: 1174852
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: M Caplin M
AUTHOR: F Festenstein F
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Relation between lung cancer, chronic bronchitis, and airways obstruction.
PUBDATE: 19750901
Since cigarette smoking is an important cause of lung cancer and chronic bronchitis both conditions should occur together more often in cigarette smokers than would result from chance. If they do commonly occur together then severe airways obstruction, which is often associated with chronic bronchitis, should also be often associated with lung cancer. To discover whether this were so three groups of patients were studied at the London Chest Hospital. Two hundred men and 43 women who presented with lung cancer provided information on the prevalence of defined chronic bronchitis and airways obstruction in those suffering from lung cancer. The third group consisted of 233 men presenting with defined chronic bronchitis who were kept under observation to discover how many would die from lung cancer. The results suggested that simple bronchitis and lung cancer often occur together but that obstructive bronchitis and lung cancer do not often occur together. The lack of association between lung cancer and severe airways obstruction requires an explanation.


4. DOCID:10315 SCORE: 0.00347350528737929
DOCNO: 6857286
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: R A Saavedra RA
AUTHOR: G R Anderson GR
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: A cancer-associated lactate dehydrogenase is expressed in normal retina.
PUBDATE: 19830701
An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase k, is found in high concentrations in cultured cells transformed by the Kirsten murine sarcoma virus and in many human cancer tissues. In experiments described here high levels of a lactate dehydrogenase k activity were detected in extracts of normal rodent retina. This activity had the same key properties as the human tumor isozyme, namely, a highly cathodic electrophoretic mobility and inhibition of enzymatic activity by oxygen and 5',5'-dipurinenucleoside tetraphosphates. Expression of this activity in the retina may be related to the high aerobic glycolysis characteristic of the retina, a metabolic feature shared with many tumors.


5. DOCID:7197 SCORE: 0.00338970262926924
DOCNO: 7304598
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Maternal Age
QUALIFIER: etiology
AUTHOR: C Bain C
AUTHOR: W Willett W
AUTHOR: B Rosner B
AUTHOR: F E Speizer FE
AUTHOR: C Belanger C
AUTHOR: C H Hennekens CH
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Early age at first birth and decreased risk of breast cancer.
PUBDATE: 19811101
The relationship between age at birth of a first child and breast cancer was evaluated for 1159 affected women and 11,590 women without cancer in data collected in 1976 among married female registered nurses residing in 11 states in the United States. A positive trend of increasing risk of breast cancer with later ages at first birth was found (chi 2(1) for trend in proportions = 30.9, p less than 0.01). Adjustment for potential confounding variables by multiple logistic regression did not affect this trend. The presence of this relationship using non-hospitalized controls of similar social status to cases supports the reality of this association, which has recently been challenged as an artifact due to inappropriate choice of hospitalized controls.


6. DOCID:2724 SCORE: 0.00333378674769768
DOCNO: 1186792
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: K J Ryan KJ
PUBTYPE: Journal Article
JOURNALTITLE: The New England journal of medicine.
COUNTRY: UNITED STATES
TITLE: Editorial: Cancer risk and estrogen use in the menopause.
PUBDATE: 19751201
A cancer-inducing role for endogenous estrogens has been confounded by increased evidence of human female breast and endometrial cancer after the menopause when estrogen production is decreasing. The endocrine change occurring after the menopause is a shift from estradiol-17-Beta of ovarian origin to estrone synthesized in the periphery. Reports have indicated that a risk of endometrial cancer is considerably higher in menopausal women and up to 5 times higher in women taking estrogen. Thromboembolism, coronary disease and stroke are estrogen-related risks which appear age and dose-dependent. When the putative cancer risk is added to these risks, estrogens become agents which should be used with care. Risks such as prior thromboembolic events, migraine headaches, a family history of cancer or excessive smoking should be considered as contraindications to estrogen use. All these factors contribute to the need for more research and knowledge in the area of the altered hormonal state of the untreated menopause.


7. DOCID:13322 SCORE: 0.00320684827297891
DOCNO: 2659583
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diagnostic Imaging
DESCRIPTOR: Technetium Compounds
QUALIFIER: diagnosis
AUTHOR: W Gordenne W
AUTHOR: E Bauduin E
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal belge de radiologie.
COUNTRY: BELGIUM
TITLE: Diagnostic accuracy of new imaging techniques in breast diseases.
PUBDATE: 19890201
During the last decade, the hypothetical carcinogenic effects of mammography have lead to new technical developments in X-ray diagnosis and to the use of other imaging techniques such as ultrasonography (US), transillumination, magnetic resonance imaging (MRI). Many preliminary studies were published but few clinical trials are really convincing. According to the definition of a diagnostic tool, none of these new modalities is supposed to supplant mammography in the diagnosis of breast cancer. Improvements are expected by digital mammography in the near future.


8. DOCID:13360 SCORE: 0.0032068471706367
DOCNO: 3951093
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: C Hogstedt C
AUTHOR: L Aringer L
AUTHOR: A Gustavsson A
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Epidemiologic support for ethylene oxide as a cancer-causing agent.
PUBDATE: 19860301
The mortality and incidence of cancer in three groups of workers with occupational exposure to ethylene oxide have been assessed. Eight cases of leukemia have occurred among 733 ethylene oxide-exposed workers compared with an expected 0.8 cases. Six cases of stomach cancer have been reported compared with 0.65 cases expected. These epidemiologic results provide support for an increased risk of malignancy in individuals with extended and intermittent exposure to low concentrations of ethylene oxide.


9. DOCID:14944 SCORE: 0.00320052926678202
DOCNO: 3606015
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: blood
AUTHOR: A J Taylor AJ
AUTHOR: H I Pandov HI
AUTHOR: N Lawson N
PUBTYPE: Journal Article
JOURNALTITLE: Annals of clinical biochemistry.
COUNTRY: ENGLAND
TITLE: Determination of erythrocyte fatty acids by capillary gas liquid chromatography.
PUBDATE: 19870501
A capillary gas liquid chromatography method was established for the routine determination of fatty acid profiles from washed erythrocyte membranes. Only the five major fatty acids found in erythrocytes (palmitic, stearic, oleic, linoleic and arachidonic acids) had acceptable precision (CVs less than 10.0%) for use in establishing quantitative differences between groups of individuals. Reference values were established for the relative amounts of these five fatty acids in adults. Significant alterations in the relative concentrations of oleic and arachidonic acids were found after storage at +4 degrees C for 24 h, which has important implications in the study of changes in erythrocyte fatty acids in cancer and diabetes.


10. DOCID:6523 SCORE: 0.00312280185110921
DOCNO: 6172161
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: D Franco D
AUTHOR: J Morin J
AUTHOR: A M Szekely AM
AUTHOR: H Bismuth H
PUBTYPE: Journal Article
JOURNALTITLE: Biomedicine / [publiée pour l'A.A.I.C.I.G.].
COUNTRY: FRANCE
TITLE: Enhancement of Aflatoxin B1 induced liver carcinogenesis by portal diversion in the rat.
PUBDATE: 19811001
Conflicting results have been reported on the influence of portacaval anastomosis on liver carcinogenesis. The purpose of this investigation was to study the effect of portal diversion on liver carcinogenesis induced in the rat by a potent chemical liver carcinogen, Aflatoxin B1 (AFB1). Liver tumors appeared earlier and were significantly bigger in rats with shunts than in sham-operated controls. Portal diversion also induced in rats fed AFB1 a splenic atrophy with nearly complete disappearance of Malpighian corpuscles suggesting a profound immunodepression. This might be responsible for the enhancement of liver cancer by portacaval anastomosis in the rats fed AFB1. Thus, the influence of portal diversion on liver cancers appears to be multifactorial.


11. DOCID:5078 SCORE: 0.0031228005605278
DOCNO: 11643610
OWNER: KIE
STATUS: MEDLINE
DESCRIPTOR: Death
DESCRIPTOR: Mass Media
DESCRIPTOR: Terminal Care
DESCRIPTOR: Terminally Ill
AUTHOR: Bernard Towers B
PUBTYPE: Journal Article
JOURNALTITLE: Journal of medical ethics.
COUNTRY: United States
TITLE: A television triumph about death and dying.
PUBDATE: 19800601
Towers reviews Joan Robinson: One Woman's Story, an American documentary film about a terminal cancer patient that was first broadcast by the Public Broadcasting Service on 21 January 1980. The film was made at the instigation of Robinson, a writer and editor, and covers the last twenty-two months of her life from the diagnosis of incurable ovarian cancer to her graveside funeral service. Towers praises the film-makers for their empathetic and sensitive handling of a difficult subject, and recommends that the film be made available for teaching purposes.


12. DOCID:31319 SCORE: 0.00311012224593751
DOCNO: 12087457
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Air Pollution, Indoor
DESCRIPTOR: Environmental Exposure
DESCRIPTOR: Gamma Rays
DESCRIPTOR: Housing
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: British journal of cancer.
COUNTRY: Scotland
TITLE: The United Kingdom Childhood Cancer Study of exposure to domestic sources of ionising radiation: 2: gamma radiation.
PUBDATE: 20020601
This article reports measurements of household levels of gamma and cosmic rays at the addresses of children with cancer at the time of diagnosis and six months before, and of similar data at the addresses of control children. There is no indication of increased risk with increasing dose rates either in matched or unmatched analyses, with or without adjustment for deprivation. Sub-division by diagnostic group did not reveal any association with any specific types of malignancy. Studies of the relationship between household gamma rays and radon concentration show no evidence of any interactions.


13. DOCID:1142 SCORE: 0.00305118482505069
DOCNO: 1216392
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gallbladder Neoplasms
AUTHOR: A E Dmitriev AE
AUTHOR: A S Tatevosian AS
AUTHOR: V A Oranskiĭ VA
AUTHOR: N G Sal'kova NG
PUBTYPE: Journal Article
JOURNALTITLE: Vestnik khirurgii imeni I. I. Grekova.
COUNTRY: USSR
TITLE: [Clinical course and diagnosis of cancer of the gallbladder]
PUBDATE: 19751201
Basing on clinical observations over 51 patients with cancer of the gallbladder the authors support the opinion of many medical researchers that, in most cases, the disease develop with cholelithiasis in the background. To establish the diagnosis of cancer of the bladder prior to surgery is possible only taking into account the complex of manifestations in patients with a persistant anamnesis of cholelithiasis. The mortality rate is high. One of the effective prophylactic measures against development of the bladder cancer is felt to be an early operative treatment for cholelithiasis and its complications.


14. DOCID:1160 SCORE: 0.00305118237055336
DOCNO: 817700
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood supply
QUALIFIER: blood supply
QUALIFIER: blood supply
QUALIFIER: pathology
QUALIFIER: complications
AUTHOR: E Olszewski E
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Vascularization of ossified cartilage and the spread of cancer in the larynx.
PUBDATE: 19760401
Twenty specimens for laryngectomy in extensive cancer of the larynx were examined after injecting the blood vessels with silicone rubber. The behavior of the vessels during the process of destruction of the laryngeal cartilages by the neoplasm were evaluated, as was the part played by the vascular system in spreading cancer in the larynx and its passage beyond the anatomical borders of this organ. Cartilages are damaged by cancer mainly in ossified and vascularized sites. The nonossified and avascular cartilages, on the contrary, are maintained in an almost unchanged condition amid the extensive tumorous masses surrounding them.