0. DOCID:27601 SCORE: 0.00234078379696054
DOCNO: 15687572
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: R L Wahl RL
AFFILIATION: University of Michigan Medical Center, Ann Arbor, MI 48109-0028, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Breast disease.
COUNTRY: Netherlands
TITLE: Positron Emission Tomography (PET): an update on applications in breast cancer.
PUBDATE: 19980801
Positron Emission Tomography (PET) is an imaging method which detects alterations in tumor physiology and displays them in an anatomically precise manner. Historically, the method has been a research tool, but it is being increasingly applied to clinical imaging problems. PET, using the glucose analog 18-F-fluoro-2-deoxy-D-glucose (FDG), has been applied most widely and shows promise in detecting primary cancers, characterizing breast masses, staging for axillary metastases, evaluating for systemic metastases, and following response to therapy. This review summarizes the current status of this technique, which is in rapid evolution as new tracers and new imaging cameras become available.


1. DOCID:25758 SCORE: 0.00182842893210269
DOCNO: 10388857
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Stents
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: instrumentation
AUTHOR: W Mayoral W
AUTHOR: D E Fleischer DE
AFFILIATION: Department of Medicine, Division of Gastroenterology, Georgetown University Medical Center, Washington, District of Columbia, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastrointestinal endoscopy clinics of North America.
COUNTRY: UNITED STATES
TITLE: The esophacoil stent for malignant esophageal obstruction.
PUBDATE: 19990701
Esophageal cancer is the seventh most common cause of cancer-related deaths in men in the United States. For a disease in which 60% of patients are incurable at presentation, palliative therapy is the main treatment option. Palliative measures include surgery, radiation therapy, chemotherapy, photodynamic therapy, endoscopic dilation, endoscopic ablation, and the use of endoscopic prostheses. This article reviews the characteristics, technique, efficacy, and complications of the Esophacoil stent for malignant esophageal strictures.


2. DOCID:27578 SCORE: 0.0014058954249173
DOCNO: 10688731
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: T Kono T
AUTHOR: M Ishii M
AUTHOR: N Negoro N
AUTHOR: S Taniguchi S
AFFILIATION: Department of Dermatology, First Department of Internal Medicine, Osaka City University Medical School, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Academy of Dermatology.
COUNTRY: UNITED STATES
TITLE: Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.
PUBDATE: 20000301
UFT, a combination of uracil and tegafur, is a second-generation anticancer agent. UFT has been used in Japan, other Asian countries, South America, and Russia. Recently, UFT has been extensively studied for colorectal, pancreatic, and various types of cancer in North America and Europe, especially with leukovorin. We report a case of a scleroderma-like reaction induced by long-term administration of UFT. This is the first report of UFT-induced scleroderma-like reaction.


3. DOCID:27165 SCORE: 0.00139316512382265
DOCNO: 10865513
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Implantation
DESCRIPTOR: Magnetic Resonance Imaging
DESCRIPTOR: Mammography
QUALIFIER: transplantation
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: M Unterweger M
AUTHOR: C Meuli-Simmen C
AUTHOR: R Caduff R
AUTHOR: R A Kubik-Huch RA
AFFILIATION: Institut für Diagnostische Radiologie, Universitätsspitals Zürich. martin.unterweger@dmr.usz.ch
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis.
COUNTRY: SWITZERLAND
TITLE: [Breast imaging after augmentation with homologous adipose tissue implant]
PUBDATE: 20000501
The implantation of cadaveric fat for breast augmentation, which has been performed up to the Seventies, is nowadays considered obsolete. Since complications frequently arise many years later, we are, however, occasionally confronted with the problematic consequences of the technique. The present case report describes the clinical, mammographic and for the first time to our knowledge MR-mammographic findings of a mammoplasty with cadaveric fat in a 57-year-old patient with a history of breast cancer.


4. DOCID:27681 SCORE: 0.00138069801393381
DOCNO: 11081539
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug effects
QUALIFIER: drug therapy
AUTHOR: K S Slobod KS
AUTHOR: G H Taylor GH
AUTHOR: J T Sandlund JT
AUTHOR: P Furth P
AUTHOR: K J Helton KJ
AUTHOR: J W Sixbey JW
PUBTYPE: Case Reports
PUBTYPE: Letter
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Epstein-Barr virus-targeted therapy for AIDS-related primary lymphoma of the central nervous system.
PUBDATE: 20001001
Epstein-Barr virus (EBV) targeted therapeutic strategies for viral associated malignant diseases have received only perfunctory consideration, first, because latent herpesviruses have been intractable to antiviral chemotherapy and, second, because the role EBV has in maintenance of the malignant cell phenotype has been uncertain. Two patients with EBV related primary central nervous system lymphoma (PCNSL) in the setting of advanced AIDS, were treated with low dose hydroxyurea based on in vitro anti-EBV activity. The responses obtained here suggest the promise of antiviral approaches in select cancers.


5. DOCID:27711 SCORE: 0.00134526708640731
DOCNO: 10489053
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: pathology
QUALIFIER: immunology
AUTHOR: F Ferracci F
AUTHOR: G Fassetta G
AUTHOR: M H Butler MH
AUTHOR: S Floyd S
AUTHOR: M Solimena M
AUTHOR: P De Camilli P
AFFILIATION: Department of Neurology, Ospedale di Belluno, Italy.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Neurology.
COUNTRY: UNITED STATES
TITLE: A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer.
PUBDATE: 19990901
A 72-year-old woman developed a lower motor neuron syndrome (MNS) 4 months before the appearance of breast cancer. Monoparesis progressed to quadriparesis despite high-dose IV immunoglobulins, plasma exchange, and azathioprine, and high-dose IV methylprednisolone. The patient improved only after the removal of the tumor. MRI demonstrated hyperintensities in the cervical spinal cord. The patient had antibodies that reacted with axonal initial segments and nodes of Ranvier. The findings suggest that in this patient lower MNS may be a paraneoplastic condition associated with breast cancer.


6. DOCID:27526 SCORE: 0.00120643432158955
DOCNO: 11930528
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse Practitioners
DESCRIPTOR: Primary Health Care
QUALIFIER: nursing
AUTHOR: M E Markle ME
AFFILIATION: Center for Family Health, Northeast Elementary School, Jackson, Michigan, USA. marklema@pilot.msu.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the American Academy of Nurse Practitioners.
COUNTRY: United States
TITLE: Polycystic ovary syndrome: implications for the advanced practice nurse in primary care.
PUBDATE: 20010401
PURPOSE: To discuss the diagnosis and management of polycystic ovary syndrome (PCOS) by the advanced practice nurse in primary care. DATA SOURCES: Selected research and clinical articles. CONCLUSIONS: The disorder is an endocrinopathy characterized by chronic anovulation, resulting in multiple ovarian cysts. Recent research suggests a genetic etiology and a close association with obesity. Patients often present with hyperandrogenism, irregular menses, and infertility. Management is directed at the alleviation of individual symptoms. IMPLICATIONS FOR PRACTICE: If left untreated, cardiovascular disease, abnormal insulin metabolism, and ovarian and endometrial cancers may develop.


7. DOCID:26587 SCORE: 0.00110031698799076
DOCNO: 10966851
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: L A Aaltonen LA
AFFILIATION: Department of Medical Genetics, University of Helsinki, P.O. Box 21, FIN-00014, Finland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: Hereditary intestinal cancer.
PUBDATE: 20000801
Mechanisms involved in hereditary intestinal cancer are likely to play a role in sporadic tumorigenesis as well. Studies focusing on the molecular biology underlying these syndromes has contributed considerably to our knowledge on molecular bases of malignant transformation. It can be concluded, that there are two aspects to the importance of studies on intestinal cancer predisposition. First, the families suffering from cancer proneness need help which can, to some extent, be provided through molecular genetic studies. Second, the resources appointed to such research have produced scientific advances with outstanding importance to our understanding of common malignant diseases.


8. DOCID:25532 SCORE: 0.00108507850529906
DOCNO: 10866406
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: S D Kuduk SD
AUTHOR: T C Harris TC
AUTHOR: F F Zheng FF
AUTHOR: L Sepp-Lorenzino L
AUTHOR: Q Ouerfelli Q
AUTHOR: N Rosen N
AUTHOR: S J Danishefsky SJ
AFFILIATION: Departement of Medicine, Sloan-Kettering Institute for Cancer Research, New York, NY 10021, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry letters.
COUNTRY: ENGLAND
TITLE: Synthesis and evaluation of geldanamycin-testosterone hybrids.
PUBDATE: 20000601
Geldanamycin (GDM) binds to the Hsp90 chaperone protein resulting in the degradation of several important signaling proteins. A series of GDM-testosterone linked hybrids has been synthesized and evaluated for activity against prostate cancer cell lines. The hybrid with the greatest activity exhibits potent and selective cytotoxicity against prostate cancer cells containing the androgen receptor.


9. DOCID:26207 SCORE: 0.00107027841601336
DOCNO: 11263852
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Estrogen Replacement Therapy
DESCRIPTOR: Menopause
DESCRIPTOR: Menopause, Premature
QUALIFIER: drug therapy
AUTHOR: H C Moore HC
AFFILIATION: Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA. mooreh1@ccf.org
PUBTYPE: Journal Article
JOURNALTITLE: Cleveland Clinic journal of medicine.
COUNTRY: United States
TITLE: Managing menopause after breast cancer: balancing risks and benefits.
PUBDATE: 20010301
Many women now survive breast cancer, but find themselves at increased risk of menopausal complications. How to manage menopause after breast cancer is a complex issue, given that estrogen has a role in the development of breast cancer and valid concerns exist about estrogen replacement therapy in patients who have had breast cancer. This article explores the relationship between estrogens and breast cancer and discusses management options for a variety of menopausal complications in breast cancer survivors.


10. DOCID:27734 SCORE: 0.000939981641152905
DOCNO: 9696939
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cereals
DESCRIPTOR: Dietary Fiber
QUALIFIER: epidemiology
AUTHOR: C La Vecchia C
AUTHOR: L Chatenoud L
AFFILIATION: Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
COUNTRY: ENGLAND
TITLE: Fibres, whole-grain foods and breast and other cancers.
PUBDATE: 19980501
The possible relationship between fibre intake and breast cancer risk has been considered in several studies, but the issue is still unsettled. Epidemiological data are compatible with moderate protection from fibre-rich foods against the risk of breast cancer, but also with an absence of association. The apparently inconsistent results may be due to chance or bias, to different approaches to data analysis and interpretation, but may also reflect heterogeneity in the dietary sources of fibres (cereals or vegetables and fruit) in various populations, and different correlates of fibre intake.


11. DOCID:27952 SCORE: 0.000935431588142589
DOCNO: 9690990
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: A de la Chapelle A
AUTHOR: P Peltomäki P
AFFILIATION: Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA. delachapelle-1@medctr.osu.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: ENGLAND
TITLE: The genetics of hereditary common cancers.
PUBDATE: 19980601
Subsets of patients with common cancers belong to families in which the predisposition is inherited in a regular Mendelian fashion. Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chromosome 1 (HPC1) has been proposed on the basis of linkage analysis. Major challenges are to determine the population incidence of these mutations, their penetrance, phenotypic expression, and the effects of modifier genes and epigenetic factors. Finally, the role of encoded proteins in carcinogenesis is a matter of major interest.


12. DOCID:27033 SCORE: 0.000866126026644951
DOCNO: 11219976
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: nursing
QUALIFIER: methods
AUTHOR: E Hollywood E
AUTHOR: D Semple D
AFFILIATION: Gastrointestinal Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: United States
TITLE: Nursing strategies for patients on oral chemotherapy.
PUBDATE: 20010101
Oncology nurses play a pivotal role in educating the cancer patient who is about to commence oral chemotherapy. Increasing numbers of patients are receiving oral chemotherapy at home, and with this move to oral self-administration, there has been a critical shift in responsibility of management from the provider to patient. Oral regimens pose new challenges in patient selection and education. Recognition of factors that affect patient compliance will be particularly important with oral chemotherapy. Strategy tools for the patient and provider will need to be developed to ensure optimal compliance and safety.


13. DOCID:26046 SCORE: 0.000837937738671628
DOCNO: 11204368
AUTHOR: P Jain P
AUTHOR: A C Arroliga AC
AFFILIATION: Department of Medicine, Louis A. Johnson VA Medical Center, Clarksburg, West Virginia 26301, USA. rrpj@msn.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cleveland Clinic journal of medicine.
COUNTRY: United States
TITLE: Spiral CT for lung cancer screening: is it ready for prime time?
PUBDATE: 20010101
Low-dose spiral computed tomography (CT) shows promise as a screening test for lung cancer, as it detects many more malignant pulmonary nodules than does standard plain radiography of the chest. Yet until more data are available we need to temper our enthusiasm. No studies have yet determined if using low-dose spiral CT as a screening test will lead to lower mortality rates. This paper reviews the issue of lung cancer screening and low-dose spiral CT.


14. DOCID:26155 SCORE: 0.00083690435586445
DOCNO: 10349817
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: M Uszyński M
AFFILIATION: Katedry i Zakładu Propedeutyki Medycyny Akademii Medycznej w Bydgoszczy.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ginekologia polska.
COUNTRY: POLAND
TITLE: [Fibrinolytic substances formation by cancer. Pathogenetic sequelae]
PUBDATE: 19990201
A survey of literature has been presented relating to fibrinolytic substances secreted by malignant tumors, and the role of those substances in the progression of cancer. Particular attention has been given to the effects of plasmin proteolysis which is generated in the extracellular matrix by urokinase plasminogen activator (uPA) complexed with its receptor (uPAR). The paper also discusses the usefulness of the markings of the substances under discussion for diagnostic-prognostic purposes, and a perspective of using the new research in therapy, for example, by using antibodies anti-uPA and anti-uPAR.