0. DOCID:23797 SCORE: 0.00365619783856612
DOCNO: 7774935
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 17
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: Y Miki Y
AUTHOR: J J Swensen JJ
AUTHOR: M R Hobbs MR
AUTHOR: B S DeHoff BS
AUTHOR: P R Rosteck PR
AUTHOR: M H Skolnick MH
AUTHOR: S L Neuhausen SL
AFFILIATION: Department of Medical Informatics, University of Utah Medical School, Salt Lake City 84108, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Genomics.
COUNTRY: UNITED STATES
TITLE: A physical map encompassing GP2B, EPB3, D17S183, D17S78, D17S1183, and D17S1184.
PUBDATE: 19950101
The q21 region of chromosome 17 contains the gene BRCA1, which is involved in familial early-onset breast and ovarian cancers. A physical map of a region that extends from a distal boundary of the BRCA1 region, D17S78, to GP2B has been constructed. The map consists of 30 STSs, including 2 new short tandem repeat polymorphic markers. The contig is composed of a mixture of 7 YACs, 5 P1 plasmids, and 14 cosmids and was ordered by STS-content mapping.


1. DOCID:23796 SCORE: 0.00365619284666829
DOCNO: 9436031
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: therapy
AUTHOR: A Gotoh A
AUTHOR: S Kamidono S
AUTHOR: L W Chung LW
AFFILIATION: Department of Urology, Kobe University School of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Clinical application for gene therapy in prostate cancer]
PUBDATE: 19971101
Hormone treatment, radiotherapy and anti-cancer chemotherapy are often used to treat prostate cancer. However, there is no effective method of treating hormone-independent prostate cancer. In this study, we attempted to establish a new treatment method for hormone-independent prostate cancer. We developed a new recombinant adenovirus vector containing a suicide gene and controlled by a tissue specific promoter, and examined the usefulness of gene therapy for hormone-independence and PSA expression in prostate cancer. We have also examined the usefulness of gene therapy involving an adenovirus and various tumor suppressor genes for human prostate cancer cells, which are under trial in the United States.


2. DOCID:23793 SCORE: 0.00365618811107172
DOCNO: 8956457
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: immunology
AUTHOR: D Mumberg D
AUTHOR: M Wick M
AUTHOR: H Schreiber H
AFFILIATION: Department of Pathology, University of Chicago, IL 60637, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in immunology.
COUNTRY: UNITED STATES
TITLE: Unique tumor antigens redefined as mutant tumor-specific antigens.
PUBDATE: 19961001
The extraordinary specificity of immune responses mediated by T cells against individual syngeneic tumors has led to the concept that many tumor antigens are 'unique'. The recent isolation of several T-cell-recognized unique antigens from various murine and human tumors has shown that the antigenic peptides are caused by somatic mutations and, thus, are truly tumor-specific. The following review summarizes current knowledge about these mutant tumor-specific antigens and their possible role in the development and progression of cancer. It also discusses some functional differences between mutant tumor-specific and shared tumor antigens, which generally represent unaltered peptides, also present on some normal cells.


3. DOCID:23761 SCORE: 0.003656183562524
DOCNO: 7776283
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Biopsy
QUALIFIER: pathology
AUTHOR: K A Gunning KA
AUTHOR: C D Griffith CD
AUTHOR: L McLean L
AUTHOR: M McElroy M
AUTHOR: B Kaye B
AUTHOR: D Scott D
AUTHOR: J Shrimanker J
AFFILIATION: Breast Screening Unit, Newcastle General Hospital, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Royal College of Surgeons of Edinburgh.
COUNTRY: ENGLAND
TITLE: Assessment of a specimen mount for biopsy of impalpable breast lesions.
PUBDATE: 19950401
Biopsy of the impalpable breast lesion is an increasing part of the surgical workload as a result of the National Breast Cancer Screening Programme. A specimen mount card has been described to orientate such specimens in three dimensions prior to radiological and pathological examination. Experience with 243 biopsies in this unit has shown it to be a useful aid in determining completeness of excision. It may also be used as a guide to further surgery when excision is incomplete and breast conservation is the treatment option of choice.


4. DOCID:22729 SCORE: 0.00313779967165117
DOCNO: 8569673
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: A S Hawatmeh AS
AUTHOR: F P Walters FP
AUTHOR: C A Wooster CA
AFFILIATION: South County Urological, Inc., St. Louis, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Missouri medicine.
COUNTRY: UNITED STATES
TITLE: Early clinical experience with percutaneous cryosurgical ablation of the prostate.
PUBDATE: 19951101
In 1993 we started offering transrectal ultrasound-guided percutaneous cryosurgical ablation of the prostate (PCAP) as a treatment alternative for localized prostate cancer. Through 1994, 85 patients underwent PCAP and 53 had 3-6 month postoperative biopsies. A learning curve effect was observed: 46% of early patients had positive postoperative biopsies, versus only 9% of later ones. With repeat PCAP on the early patients, currently 87% of the biopsied patients are disease free. While longer follow-up is necessary, it appears that PCAP merits further investigation as a treatment alternative for localized prostate cancer.


5. DOCID:23083 SCORE: 0.00271511691380652
DOCNO: 7742511
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Papillomavirus, Human
QUALIFIER: virology
AUTHOR: C M McLachlin CM
AFFILIATION: Department of Pathology, Victoria Hospital, London, Ontario, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in obstetrics & gynecology.
COUNTRY: UNITED STATES
TITLE: Pathology of human papillomavirus in the female genital tract.
PUBDATE: 19950201
Human papillomavirus (HPV) has emerged as a major factor in the genesis of intraepithelial and invasive neoplasms of the female genital tract. The strength of the relationship of HPV to genital neoplasia has been supported by studies involving epidemiologic, clinical, pathologic and molecular data. The many subtypes of HPV have been characterized into risk groups that reflect their propensity to be associated with cancer precursors and invasive disease. The strong correlation between HPV and squamous dysplasia suggests that classification of cervical intraepithelial lesions into similar risk categories should be possible. However, the clinical predictive value of HPV testing and typing remains controversial.


6. DOCID:23396 SCORE: 0.00221773177222421
DOCNO: 9248852
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: J W Mulder JW
AUTHOR: V J Wielenga VJ
AUTHOR: S T Pals ST
AUTHOR: G J Offerhaus GJ
AFFILIATION: Academic Medical Centre, University of Amsterdam, Department of Pathology, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Histochemical journal.
COUNTRY: ENGLAND
TITLE: p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis.
PUBDATE: 19970601
Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppressor gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encountered in the immunohistochemical detection of these proteins. Immunohistochemistry potentially forms a procedure applicable for routine diagnosis and prognostication. Therefore, p53 expression and the independent prognostic importance of CD44v6 expression is given particular emphasis, and other molecular events underlying colorectal carcinogenesis are only mentioned briefly.


7. DOCID:23414 SCORE: 0.00218806980973469
DOCNO: 8939849
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle
QUALIFIER: pathology
AUTHOR: C J Sherr CJ
AFFILIATION: Howard Hughes Medical Institute, Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA. sherr@stjude.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Cancer cell cycles.
PUBDATE: 19961201
Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16(INK4a) and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RB) and control exit from the G1 phase of the cell cycle, are so frequent in human cancers that inactivation of this pathway may well be necessary for tumor development. Like the tumor suppressor protein p53, components of this "RB pathway," although not essential for the cell cycle per se, may participate in checkpoint functions that regulate homeostatic tissue renewal throughout life.


8. DOCID:23877 SCORE: 0.00191442595180878
DOCNO: 7932330
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: history
AUTHOR: A M Shulutko AM
AFFILIATION: Surgical Department, Sechenov Moscow Medical Academy, Russia.
PUBTYPE: Historical Article
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the Royal College of Surgeons of Edinburgh.
COUNTRY: ENGLAND
TITLE: Some aspects of surgery in Russia.
PUBDATE: 19940601
A surgeon from the Moscow Medical Academy, Professor Alexander Shulutko, is the first recipient of the Johnson & Johnson Medical Travelling Fellowship and has completed a one-month study tour in the United Kingdom. Professor Shulutko, 42, a general surgeon specializing in abdominal surgery, is Head of the Department of Surgery at the Academy, one of Russia's most prestigious medical teaching institutions. During his tour he visited the Western General Hospital, Edinburgh, Royal Liverpool University Hospital, Edinburgh Royal Infirmary, Aberdeen Royal Infirmary, Ninewells Hospital, Dundee and Western Infirmary, Glasgow, and attended a consensus conference on colorectal cancer and the annual Clinical and Scientific meeting of the Royal College of Surgeons of Edinburgh.


9. DOCID:22697 SCORE: 0.00189244614856901
DOCNO: 9015349
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: metabolism
QUALIFIER: pathology
QUALIFIER: metabolism
QUALIFIER: pathology
AUTHOR: S Fucile S
AUTHOR: M Napolitano M
AUTHOR: E Mattei E
AFFILIATION: Laboratorio di Biofisica, Centro Ricerca Sperimentale Istituto Regina Elena, Rome, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Cholinergic stimulation of human microcytoma cell line H69.
PUBDATE: 19970101
Experiments were addressed to investigate the mechanisms by which cholinergic stimulation is coupled to the enhancement of proliferation of small cell lung cancer cells H69. Muscarinic stimulation triggers the release of cytosolic Ca2+ and of inositol(1,4,5)trisphosphate with comparable time courses. The presence of alpha-bungarotoxin or the absence of Ca2+ in external medium suppresses enhancement of clonal growth induced by brief applications of nicotine. Here we suggest that Ca2+ mobilization represents a trigger for the enhancement of small cell lung cancer cell proliferation upon cholinergic stimulation.


10. DOCID:23235 SCORE: 0.00181787062337821
DOCNO: 8839240
AUTHOR: Z Ye Z
AUTHOR: H Shimomura H
AUTHOR: S Kudo S
AUTHOR: T Arao T
AUTHOR: Y Sato Y
AUTHOR: T Ono T
AFFILIATION: Department of Dermatology, Kumamoto Rosai Hospital, Yatsushiro, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of dermatology.
COUNTRY: JAPAN
TITLE: A case of lymphocutaneous nocardiosis with a review of lymphocutaneous nocardiosis reported in Japan.
PUBDATE: 19960201
An 82-year-old Japanese male developed nodules and ulcers along the lymphatics after a fall in the garden of his house resulting in injuries to the dorsum of his left hand which lasted for 3 months. Nocardia brasiliensis was isolated from a nodule, supporting a diagnosis of the lymphocutaneous type of nocardiosis. He had previously developed generalized bone metastasis from prostatic cancer, and his resulting depressed immunity might have played a part in the nocardiosis genesis. Sixteen cases of the lymphocutaneous type of nocardiosis reported in Japan were reviewed.


11. DOCID:22765 SCORE: 0.0014272056302921
DOCNO: 8014531
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: therapy
QUALIFIER: complications
AUTHOR: C Ripamonti C
AFFILIATION: Pain Therapy and Palliative Care Division, National Cancer Institute, Milan, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pain and symptom management.
COUNTRY: UNITED STATES
TITLE: Management of bowel obstruction in advanced cancer patients.
PUBDATE: 19940401
Bowel obstruction is a common and distressing outcome in patients with abdominal or pelvic cancer. While surgery must remain the primary treatment for malignant obstruction, it is now recognized that there is a group of patients with advanced disease or poor general condition who are unfit for surgery and require alternative management to relieve distressing symptoms. A number of treatment options are now available for the patient with advanced cancer who develops intestinal obstruction. This review examines the indications for surgery, the use of nasogastric tube and percutaneous gastrostomy, and the place of drugs for symptom control.


12. DOCID:22695 SCORE: 0.00142719888446753
DOCNO: 9101541
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: prevention & control
AUTHOR: H Saito H
AFFILIATION: First Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Nippon Geka Gakkai zasshi.
COUNTRY: JAPAN
TITLE: [Colorectal cancer: Japanese screening program today]
PUBDATE: 19970301
Colorectal cancer screening using immunochemical fecal occult blood tests has been performed supported by legislation since 1992 in Japan. Approximately 3.6 million persons were screened and 5,400 cases of colorectal cancer were found in 1993. The effectiveness of the screening program has been evaluated by several observational studies. It has been strongly suggested that risk of dying of colorectal cancer would be reduced by 60% for those screened annually by the program. Japanese screening program today seems to be promising in terms of the mortality reduction, however, issues such as limitation of capacity for diagnostic work-ups should be resolved.


13. DOCID:20354 SCORE: 0.00133701923320417
DOCNO: 8087513
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: surgery
AUTHOR: R J Ginsberg RJ
AFFILIATION: Department of Surgery, Cornell University Medical College, New York, NY 10021.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Lung cancer (Amsterdam, Netherlands)
COUNTRY: IRELAND
TITLE: Surgical considerations after preoperative treatment.
PUBDATE: 19940301
With the increased use of induction chemo(radio)therapy followed by surgical resection for locally advanced lung cancer, the surgeon must be aware of the potential toxicities of the various chemotherapeutic and radiotherapeutic strategies. Also, because of tumor necrosis and local toxicities of the treatment, surgical therapy can be difficult and therefore perioperative care is critical.


14. DOCID:22587 SCORE: 0.00131409127329532
DOCNO: 7930899
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: chemically induced
AUTHOR: M Johansen M
AUTHOR: E Overgaard E
AUTHOR: A Toft A
AFFILIATION: Department of Otolaryngology, Vejle County Hospital, Denmark.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: ENGLAND
TITLE: Severe chronic inflammation of the mucous membranes in the eyes and upper respiratory tract due to work-related exposure to hexavalent chromium.
PUBDATE: 19940701
Chronic inflammation of the skin and mucous membranes following prolonged exposure to high doses of toxic hexavalent chromium is well known in the occupational medical literature. Perforation of the nasal septum is a cardinal clinical feature. Late development of cancer in the respiratory system is established. A recently diagnosed case with an unusually severe affect on the eyes is described. The industrial usage of chromium and its toxicological profile is reviewed.