0. DOCID:11230 SCORE: 0.00447502627130499
DOCNO: 6189578
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: cerebrospinal fluid
QUALIFIER: diagnosis
QUALIFIER: cerebrospinal fluid
AUTHOR: T R Koch TR
AUTHOR: K M Lichtenfeld KM
AUTHOR: P H Wiernik PH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Detection of central nervous system metastasis with cerebrospinal fluid beta-2-microglobulin.
PUBDATE: 19830701
Beta-2-microglobulin determinations in cerebrospinal fluid (CSF) of patients with leukemia, lymphoma, and oat cell carcinoma were performed to evaluate the utility of this test in early detection of metastasis to the central nervous system (CNS). In the presence of CNS disease, significantly higher levels (P less than 0.001) were found than in normals or patients without CNS disease. Serial measurements were performed on two patients, and in all cases beta-2-microglobulin became elevated coincident with CNS relapse, and returned to normal as remission was achieved. Serial testing of CSF beta-2-microglobulin, in patients with cancers known to invade the CNS, should facilitate prompt treatment of CNS metastasis.


1. DOCID:11652 SCORE: 0.00437614174066267
DOCNO: 3865009
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Occupations
DESCRIPTOR: Veterans
QUALIFIER: mortality
AUTHOR: A Blair A
AUTHOR: J Walrath J
AUTHOR: E Rogot E
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Mortality patterns among U.S. veterans by occupation. I. Cancer.
PUBDATE: 19851201
The mortality experience of a nation-wide cohort of 293,958 veterans was analyzed by occupation and industry to generate hypotheses in occupational cancer. Results are presented on 107,563 deaths occurring between 1954 and 1970. Information on usual employment (occupation and industry) and smoking habits was available from questionnaires completed in 1954 and 1957. Complete enumeration of these results by occupation and industry is available as special National Cancer Institute monographs from the author (A. B.). This report presents the mortality experience for selected occupations. Excesses of lung cancer among shipyard workers, truck drivers, and plumbers are consistent with previous reports. Elevated risks for stomach cancer among carpenters and machinists may reflect exposure to dusts, abrasives, and cutting oils.


2. DOCID:10385 SCORE: 0.00322508106215266
DOCNO: 4040405
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Disease Models, Animal
DESCRIPTOR: Mice, Nude
DESCRIPTOR: Rats, Mutant Strains
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: E S Revazova ES
AUTHOR: Iu N Solov'ev IuN
AUTHOR: T V Iudicheva TV
PUBTYPE: Journal Article
JOURNALTITLE: Biulleten' eksperimental'noń≠ biologii i meditsiny.
COUNTRY: USSR
TITLE: [Strains of human gastrointestinal and uterine tumors transplantable into athymic mice and rats]
PUBDATE: 19850701
The authors describe strains of human cancer of the stomach, colon, cervix and corpus uteri as well as uterine chorionepitheliomas transplanted into nude mice and rats. The histological appearance of these strains is in full accordance with that of primary tumors. Electrophoresis of lactate dehydrogenase isozymes indicates that the strains mainly consist of human cells. The strains are transplanted in nude animals at various time intervals. The strains of human gastric cancer are transplanted from animal to animal in a month and those of corpus uteri in a week.


3. DOCID:10378 SCORE: 0.00322507683461693
DOCNO: 6985190
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
AUTHOR: T Tatezawa T
AUTHOR: Y Hiramatsu Y
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Effectiveness of CT in the determination of the extent of infiltration of head and neck cancer]
PUBDATE: 19820201
For cancer therapy, especially radiation therapy, it is very important to determinate the invaded region. Since computed tomography (CT) is introduced into medical radiography, it has become well known that it has a highly diagnostic value not only for the intracranial lesions, but also for extracranial pathological processes. In this paper, 4 cases (pinealoma, rhabdomyosarcoma of the ear, nasopharynx tumor and Histiocytosis X of the orbit) are presented. In each case, pre-therapeutic and posttherapeutic CT images are shown. CT is also very useful during and after therapy in patients with malignancy of the head and neck.


4. DOCID:10308 SCORE: 0.00282186282606943
DOCNO: 6348344
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Multiple Primary
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: M Kimura M
AUTHOR: K Higuchi K
AUTHOR: E Shiina E
AUTHOR: K Hojo K
AUTHOR: Y Hosoda Y
AUTHOR: S Miura S
AUTHOR: T Kitayama T
AUTHOR: M Hojo M
AUTHOR: A Yagita A
AUTHOR: S Kawamura S
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [2 cases of bullous pemphigoid and Bowen's disease associated with esophageal cancer]
PUBDATE: 19830501
There are many published reports on the combination of malignant tumors of the digestive tract and various skin diseases. To date, 8 cases with combined bullous pemphigoid and malignant tumor, or Bowen's disease and malignant tumor, have been reported in Japan. In only 2 cases was the esophageal cancer combined with skin disease. The pathophysiological relationship between skin diseases and malignant tumors of the digestive tract remains unknown.


5. DOCID:9552 SCORE: 0.00227125466884381
DOCNO: 3919351
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: surgery
QUALIFIER: etiology
AUTHOR: R T Zern RT
AUTHOR: D L Clarke-Pearson DL
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Pneumatosis intestinalis associated with enteral feeding by catheter jejunostomy.
PUBDATE: 19850301
Pneumatosis intestinalis is an unusual, but potentially serious, postoperative complication. The differential diagnosis includes life-threatening conditions, such as intestinal necrosis, that may require immediate surgical intervention. The authors describe a case of pneumatosis intestinalis occurring postoperatively in a seriously ill patient with advanced ovarian cancer. The cause of pneumatosis intestinalis was attributed to enteral feeding by catheter jejunostomy, and a successful outcome is reported after conservative management. As the use of enteral feeding through catheter jejunostomies will likely increase, this cause of pneumatosis intestinalis must be recognized.


6. DOCID:10294 SCORE: 0.00207788050889479
DOCNO: 6368331
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bone Marrow Transplantation
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: R Vriesendorp R
AUTHOR: J G Aalders JG
AUTHOR: D T Sleijfer DT
AUTHOR: P E Postmus PE
AUTHOR: P H Willemse PH
AUTHOR: J Bouma J
AUTHOR: N H Mulder NH
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Effective high-dose chemotherapy with autologous bone marrow infusion in resistant ovarian cancer.
PUBDATE: 19840301
Two patients with persistent minimal ovarian cancer after conventional polychemotherapy were treated with high doses of cyclophosphamide and VP 16-213 followed by autologous bone marrow infusion. Ten months afterward no clinical signs of tumor were apparent. In one patient the complete response was surgically documented. Toxicity included cardiac and pulmonary arrest during marrow infusion in one patient, but was otherwise manageable. This method of late intensification of chemotherapy in patients with persisting ovarian cancer merits further investigation.


7. DOCID:11166 SCORE: 0.002035977961511
DOCNO: 6353396
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: adverse effects
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: R Stuart-Harris R
AUTHOR: R Buckman R
AUTHOR: I Starke I
AUTHOR: E Wiltshaw E
PUBTYPE: Clinical Trial
PUBTYPE: Controlled Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Postgraduate medical journal.
COUNTRY: ENGLAND
TITLE: Chlorpromazine, placebo and droperidol in the treatment of nausea and vomiting associated with cisplatin therapy.
PUBDATE: 19830801
The use of cisplatin may be associated with severe nausea and vomiting. Two separate, randomized, double-blind trials, comparing the anti-emetic effect of chlorpromazine with placebo and chlorpromazine with droperidol, were conducted in patients receiving cisplatin for ovarian cancer. Chlorpromazine was statistically superior to placebo in the control of nausea and vomiting in those patients treated with chlorpromazine had significantly less nausea than with droperidol, but there were no other significant differences between chlorpromazine and droperidol. Toxicities of chlorpromazine and droperidol were similar. Chlorpromazine shows useful activity against cisplatin nausea and vomiting.


8. DOCID:9402 SCORE: 0.00197059810917016
DOCNO: 6437356
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: R R Love RR
AUTHOR: J F Morrissey JF
PUBTYPE: Journal Article
JOURNALTITLE: Archives of internal medicine.
COUNTRY: UNITED STATES
TITLE: Colonoscopy in asymptomatic individuals with a family history of colorectal cancer.
PUBDATE: 19841101
A prevalence screening program with colonoscopy was undertaken in four kindreds manifesting the cancer family syndrome. Forty-five percent of counseled patients underwent colonoscopy, providing 42 asymptomatic individuals. Seven patients (17%) were found to have adenomatous or villous polyps; two of these were malignant and one showed epithelial atypia. Three of the seven patients with polyps had multiple lesions. Only two patients had rectosigmoid polyps. From these limited data, colonoscopy is recommended as a useful screening procedure in individuals at high risk for colorectal cancer.


9. DOCID:9425 SCORE: 0.00197059795562803
DOCNO: 7076098
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cannabis
QUALIFIER: therapeutic use
AUTHOR: M E Heim ME
PUBTYPE: Journal Article
JOURNALTITLE: Fortschritte der Medizin.
COUNTRY: GERMANY, EAST
TITLE: [Cannabis and cannabinoids. Possibilities of their therapeutic use]
PUBDATE: 19820301
Newer aspects of therapeutic potentials of cannabis and cannabinoids are reviewed. The major active constituent of cannabis sativa, delta-9-tetrahydrocannabinol and synthetic cannabinoids are evaluated in several clinical trials on their antiemetic efficacy in cancer chemotherapy induced vomiting. 80% of patients refractory to standard antiemetic treatment could be improved with the synthetic cannabinoid levonantradol. Other therapeutic effects, which are presently investigated in clinical trials are analgesia, antispasticity, anticonvulsion and the reduction of intraocular pressure in glaucoma. The future goal of cannabinoid research is the separation between specific pharmacologic activities and undesirable psychotropic effects.


10. DOCID:9773 SCORE: 0.00183534379509798
DOCNO: 6331720
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: diagnosis
AUTHOR: M Moskowitz M
PUBTYPE: Journal Article
JOURNALTITLE: AJR. American journal of roentgenology.
COUNTRY: UNITED STATES
TITLE: Mammography to screen asymptomatic women for breast cancer.
PUBDATE: 19840901
Despite the lack of absolute confirmation from a properly controlled clinical trial, there is now sufficient evidence to permit the working assumption that screening mammography beginning at age 40 will play a substantial role in controlling breast cancer. An analysis of available data indicates that the benefits of mammographic screening far exceed potential risk, and that earlier detection of cancer will actually add years to life rather than simply permit an earlier diagnosis. American radiologists are now challenged to provide screening mammography in an easily accessible and inexpensive form, so that it is effectively available to all women over age 40.


11. DOCID:10767 SCORE: 0.00180128347222428
DOCNO: 6840436
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: H Hisazumi H
AUTHOR: K Nakajima K
AUTHOR: T Uchibayashi T
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: Chemosensitivity of established human bladder carcinoma cell lines in vitro.
PUBDATE: 19830201
The cytotoxic effects of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-nitrosourea hydrochloride, thio-TEPA, 4'-dimethyl-epipodophyllotoxin-beta-D-ethylidine glucoside, bleomycin, cis-platinum, mitomycin C, adriamycin and carbazilquinone on asynchronous cells of established human bladder carcinoma lines (KK-47, KW-103 and RT4) were investigated by the in vitro colony formation technique. The dose-survival curves were classified into 2 types: biphasic type (bleomycin) and exponential decrease type (the others). These types and the 50 and 90% growth inhibition doses of the drugs may offer a guide to chemotherapeutic design as well as to the selection of possibly effective agents for bladder cancer therapy.


12. DOCID:10189 SCORE: 0.00178884558806023
DOCNO: 4012968
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: J E Fowler JE
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Radical prostatectomy for stage A2 and B prostatic carcinoma. Operative experience.
PUBDATE: 19850701
We compared the operative experiences and the postoperative and late complications of radical prostatectomy in 17 patients with Stage A2 and 64 patients with Stage B prostatic cancer. The operative time, estimated blood loss, incidence of intraoperative complications, frequency of surgical specimen fragmentation, and duration of hospitalization were similar for the two groups when stratified by surgical approach. Postoperative complications were more frequent in the Stage B group. Six per cent of the patients in each group were severely incontinent after surgery. In this experience recent partial prostatectomy did not appear to increase the risks of radical prostatectomy or decrease the likelihood of complete excision of the prostate.


13. DOCID:9454 SCORE: 0.00178012617346318
DOCNO: 6534486
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: G Smith G
AUTHOR: C Theodorou C
AUTHOR: G Field G
AUTHOR: T B Hargreave TB
AUTHOR: G D Chisholm GD
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: Intravesical methotrexate in the treatment of superficial bladder cancer.
PUBDATE: 19841201
Thirty patients with superficial bladder cancer (Tis, Ta, Tl) difficult to control by endoscopic means were given a total of 49 courses of methotrexate at fortnightly intervals. Four concentrations were investigated. In 14 courses this was the sole treatment and in the remainder the methotrexate was given as prophylaxis. Toxicity was not a problem but in both groups, although there was some evidence of anti-tumour activity, there were high recurrence rates and intravesical methotrexate cannot be recommended.


14. DOCID:8723 SCORE: 0.00167985497401557
DOCNO: 4005877
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: administration & dosage
AUTHOR: G P Sarna GP
AUTHOR: R A Figlin RA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Phase II trial of alpha-lymphoblastoid interferon given weekly as treatment of advanced breast cancer.
PUBDATE: 19850501
Eighteen patients with advanced breast cancer refractory to first-line chemotherapy and hormonal therapy (or estrogen receptor-negative) were treated with human alpha-lymphoblastoid interferon (Wellferon) in a dose of 30 X 10(6) U/m2 im weekly. None of 15 patients receiving three or more doses achieved a partial or complete response. Toxicity was substantial and included fatigue, malaise, fever, hematologic suppression, nausea/vomiting, and diarrhea.