0. DOCID:6872 SCORE: 0.00677674912745794
DOCNO: 6785940
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: U Dunzendorfer U
AUTHOR: D Drahovsky D
AUTHOR: H Schmidt-Gayk H
AUTHOR: H P Zahradnik HP
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Urologie und Nephrologie.
COUNTRY: GERMANY, EAST
TITLE: [Clinical significance of peptide hormones LH, FSH, TSH, prolactin, HCG, parathormone, calcitonin and prostaglandin F2 alpha in kidney neoplasms]
PUBDATE: 19810101
Peptide hormones LH, FSH, TSH, e-peptide, prolactin, HCG, PTH, calcitonin and prostaglandin F2 alpha were evaluated in 25 patients with renal adenocancer. Prolactin elevation found in 45% was unrelated to the stage of the disease, while aberrant TSH and FSH were more sensitive in indicating distant metastasis. Prostaglandin F2 alpha, measured as a stable degradation product 13,14-DHK-PGF2 alpha, was frequently elevated and normalized following tumor nephrectomy within 12 month. Serum PTH was decreased in patients with tumor dissemination suggesting resorptive hypercalcemina, whereas none of the patient had circulating HCG levels. Therefore even patients without any paraneoplastic syndromes have a frequent change of peptide hormones directly or indirectly caused by renal cancer.


1. DOCID:7754 SCORE: 0.00469758134683523
DOCNO: 7234414
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
AUTHOR: E Farber E
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica japonica.
COUNTRY: JAPAN
TITLE: The sequential analysis of cancer induction with chemicals.
PUBDATE: 19810101
A critical review of some of our current views on how chemicals induced cancer is presented. Emphasis is placed on pathologic processes, rather than on agents and on the many steps that lie between initial exposure to a carcinogen and the appearance of malignant neoplasia. The nature of some of the early steps in carcinogenesis is outlined including the early appearance during initiation of cells resistant to some of the inhibitory effect of carcinogens. This property is considered to be important in the development of cancer in at least one model of carcinogenesis. The essential characteristic of promotion, differential stimulation of proliferation of initiated cells, is discussed along with at least three possible mechanisms for such differential effects of promoting environments. The multistep hypothesis for cancer development is supported by observations of identifiable biochemical and biological properties of different cell populations at some steps. The implications of this for cancer diagnosis, prevention and control are briefly discussed.


2. DOCID:7441 SCORE: 0.004064152512024
DOCNO: 7314368
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J L Siekavizza JL
AUTHOR: M E Bernardino ME
AUTHOR: N A Samaan NA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Suprarenal mass and its differential diagnosis.
PUBDATE: 19811201
Nine cases of suprarenal masses without endocrine abnormalities are presented: 2 adrenal pseudocysts, 2 adrenal myelolipomas, 2 neuroblastomas, 1 lymphoma metastatic to the adrenal glands, 1 teratoma, and 1 adrenal cortical carcinoma metastatic to the contralateral gland. The clinical and radiologic findings are discussed. Noninvasive and invasive procedures and their usefulness in diagnosing masses in the suprarenal area are reported. The importance of metastases to the adrenal glands in the differential diagnosis of suprarenal masses was investigated by reviewing the autopsies done from January through June, 1979, at The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas. Adrenal metastases were found in 26 per cent of the cases studied. Breast and lung carcinomas and lymphomas were the most commonly found neoplasia. The relative incidence of microscopic and macroscopic metastases in all patients with tumor is discussed.


3. DOCID:6794 SCORE: 0.00393132886453684
DOCNO: 12336894
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Contraceptives, Oral
DESCRIPTOR: Endometrium
DESCRIPTOR: Estrogens
DESCRIPTOR: Menopause
DESCRIPTOR: Progesterone
DESCRIPTOR: Prospective Studies
AUTHOR: M Paterson M
AUTHOR: T Wade-evans T
AUTHOR: D W Sturdee DW
AUTHOR: M H Thom MH
AUTHOR: J W Studd JW
PUBTYPE: Journal Article
JOURNALTITLE: Contraception, fertilité, sexualité.
COUNTRY: FRANCE
TITLE: [Endometrial disease after treatment with oestrogens and progestogens in the climateric (author's transl)]
PUBDATE: 19810401
This study was undertaken to examine the frequency of histologic endometrial anomalies with different types of estrogen therapy, whether or not associated to progesterone treatment. 1002 endometrial biopsies were done on 745 women who had received: 1) cyclic treatment with low-dose estrogen; 2) cyclic treatment with high-dose estrogen; 3) sequential estrogen-progestogen treatment; and 4) subcutaneous implant of estradiol. Frequency of abnormalities was 7.0% in the first group, 14.8% in the second group, 1.2% in the third group, and 14.8% in the fourth group. Without drawing definitive conclusions from these results, it seems possible to affirm that the use of progestogen diminishes the risk of endometrial cancer during menopause.


4. DOCID:6095 SCORE: 0.00363372751855618
DOCNO: 7422174
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: W Hernandez-Linares W
AUTHOR: A Puthawala A
AUTHOR: J F Nolan JF
AUTHOR: P H Jernstrom PH
AUTHOR: C P Morrow CP
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Carcinoma in situ of the vagina: past and present management.
PUBDATE: 19800901
The experience of the Southern California Cancer Center with carcinoma in situ of the vagina has been analyzed. Thirty-five patients were treated over 22 years. Patients with carcinoma in situ of the vagina are usually asymptomatic and most often have no visible or palpable lesions; diagnosis therefore depends upon directed biopsy in patients with abnormal routine vaginal cytology. Local radium application was the most frequent modality of treatment in this study group of patients, and excellent results were obtained. The need for cytologic evaluation after hysterectomy is emphasized. Colposcopy is a valuable aid in the diagnosis and follow-up of these patients.


5. DOCID:5254 SCORE: 0.00333624254210826
DOCNO: 7268622
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: J S Economou JS
PUBTYPE: Journal Article
JOURNALTITLE: Surgery, gynecology & obstetrics.
COUNTRY: UNITED STATES
TITLE: The role of antibody in tumor immunity.
PUBDATE: 19810901
Antibody may sensitize tumor cells for destruction by nonimmune host effector elements that include complement, macrophages, lymphocytes, neutrophils, eosinophils or platelets. Small numbers of tumor cells may be very efficiently suppressed in vivo. Antibody immunotherapy can also be used successfully in combination with other modalities, such as chemotherapy, in the treatment of larger tumor burdens. Perhaps the greatest potential application of antibody in cancer therapy is its use as a tumor-specific delivery vehicle for cytotoxic substances. The opportunity to produce large quantities of monoclonal antibody, afforded by current hybridoma technology, will revolutionize the application of antibody to cancer medicine.


6. DOCID:7339 SCORE: 0.00310000056714086
DOCNO: 665664
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: A B Miller AB
AUTHOR: A Kelly A
AUTHOR: N W Choi NW
AUTHOR: V Matthews V
AUTHOR: R W Morgan RW
AUTHOR: L Munan L
AUTHOR: J D Burch JD
AUTHOR: J Feather J
AUTHOR: G R Howe GR
AUTHOR: M Jain M
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: A study of diet and breast cancer.
PUBDATE: 19780601
A case-control study has been conducted in four areas in Canada in which 40 cases of breast cancer matched by age and marital status with neighborhood controls were administered a medical and dietary history questionnaire, a 24-hour recall of dietary information and a four-day diet record. The Study has produced evidence of an association between an increased intake of nutrients, especially total fat, in both pre-menopausal and post-menopausal women with breast cancer. Reasons why a weak association might have been anticipated are discussed, and it is concluded that in reality the association is stronger. Furthermore, its consistency with other evidence, both experimental and international, suggests that it is causal.


7. DOCID:7903 SCORE: 0.00286625790769076
DOCNO: 6986082
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: epidemiology
QUALIFIER: prevention & control
AUTHOR: H D Costello HD
AUTHOR: D E Snider DE
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: The incidence of cancer among participants in controlled, randomized isoniazid preventive therapy trial.
PUBDATE: 19800101
Cancer morbidity and mortality were examined among 11,894 Puerto Rican participants in a US Public Health Service preventive therapy trial begun in 1957. The mean duration of follow-up was 18 years (range 16-19 years). No statistically significant difference in overall cancer rates was observed between the participants in the trial assigned isoniazid and those assigned placebo. There were also no significant differences between the groups when rates for specific types of cancer and age-specific cancer rates were compared. No trend toward an increasing cancer rate in the isoniazid group was observed with the passage of time. The mortality rate due to cancer was similar in the two groups. These data coupled with other information reported in the literature provide substantial evidence that isoniazid, when given in the usual therapeutic doses, is not carcinogenic in humans.


8. DOCID:5545 SCORE: 0.00240019749954413
DOCNO: 6450126
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: M Haertel M
PUBTYPE: Journal Article
JOURNALTITLE: RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin.
COUNTRY: GERMANY, WEST
TITLE: [Computer tomography for gynaecological carcinomas (authors's transl)]
PUBDATE: 19800601
The morphology of gynaecological cancers was studied by computer tomography in 220 ovarian and uterine carcinomas. The value of the method with regard to staging and diagnosis is discussed. Non-invasive computer tomography for gynaecological cancers is indicated. 1. In order to obtain significant information regarding the extent of the tumour and its regional metastases. 2. In order to reduce the need for other invasive diagnostic measures. 3. For improving treatment by interdisciplinary procedures, particularly with respect to planning of radiation therapy. 4. For the early recognition of recurrences and for objective evaluation of the result of treatment.


9. DOCID:6283 SCORE: 0.00231058416287166
DOCNO: 7383864
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Neoplasms
QUALIFIER: secondary
QUALIFIER: secondary
AUTHOR: F Bacourt F
AUTHOR: B Franc B
AUTHOR: L Hannoun L
AUTHOR: G Chomette G
AUTHOR: H Garnier H
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Thyroid metastases from renal tumours: 3 cases (author's transl)]
PUBDATE: 19800501
Metastatic tumours from clear cell renal cancer were found in 3 out of 4 000 thyroidectomy specimens. These tumours appeared on scintigrams as low density nodules, one to three in number, and were accompanied in one case by signs of hyperthyroidism. They were treated by partial excision 4, 5 and 7 years after nephrectomy. One patient relapsed, was re-operated upon 2 years later and is still alive after one year. The other two patients showed no sign of relapse after 2 and 4 years respectively. When the renal history is unknown it is difficult histologically to differentiate these tumours from clear cell epitheliomas of the thyroid gland.


10. DOCID:7580 SCORE: 0.00224870262490595
DOCNO: 7370523
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: D N Clarke DN
AUTHOR: P F Jones PF
AUTHOR: C D Needham CD
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Outcome in colorectal carcinoma: seven-year study of a population.
PUBDATE: 19800201
All 433 patients with colorectal cancer who presented in the north-east of Scotland during 1968 and 1969 were followed up for seven years or until death intervened. The incidence of colorectal cancer in the region was the highest recorded in Great Britain. Half the patients were incurable at the time of diagnosis. Nevertheless, of the 195 survivors of radical resection 146 (75%) did not die of carcinoma during the next seven years. Men with "curable" rectal cancer showed a substantially lower corrected survival rate (42%) than women (70%), but this was due to intercurrent disease not recurrence. Comparable figures for colonic carcinoma showed no difference between men (75%) and women (77%). The overall picture of colorectal cancer has apparently not changed for 20 years. Nevertheless, earlier diagnosis and timely operation--possibly with adjuvant chemotherapy--may produce useful long-term results.


11. DOCID:7091 SCORE: 0.00223418055152979
DOCNO: 6163174
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: D H Hussey DH
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: A comparison of treatment methods for germinal cell tumors of the testis other than pure seminoma.
PUBDATE: 19810401
The results of three approaches to management of the regional lymphatics for Stage I and Stage II nonseminomatous testicular tumors were reviewed. For clinical Stage I disease, the results achieved with orchiectomy and radiation therapy alone are equal to those achieved with orchiectomy and lymphadenectomy. Although the results with preoperative radiotherapy and lymphadenectomy are slightly better, the lymphadenectomy almost always results in aspermia and infertility. The effectiveness of radiotherapy alone is determined by the volume of cancer. Local tumor control with irradiation is good if the tumor burden is relatively small. The local control rates, however, are diminished if the metastases are greater than 2 cm in diameter. The results with preoperative radiotherapy and lymphadenectomy for patients with clinical Stage II disease are superior to those achieved with either primary lymphadenectomy or radiotherapy alone.


12. DOCID:6163 SCORE: 0.00214631274833603
DOCNO: 732055
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Gotoh A
AUTHOR: Y Iwashima Y
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: Precancerous lesions of the colon and rectum.
PUBDATE: 19781201
Fourty-six cases of polyps and polypoid lesions of the colon and rectum were operated at the First Department of Surgery, Gifu University School of Medicine during the last 16 years. Polyps were classified into five groups according to their degree of atypicality and the relationship between polyps and cancer was investigated. The adenomatous polyps were prone to become malignant and it appears that the larger the polyp size, the greater the incidence of severe atypia and the greater the polyps' malignant potentiality. The malignant polyps developed more frequently in the distal colon and rectum than in other parts. Focal and invasive cancers limited to the submucosal layer were found exclusively in the sigmoid colon and rectum.


13. DOCID:7247 SCORE: 0.00202350468021793
DOCNO: 7457482
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: P F Jacques PF
AUTHOR: S C Hartz SC
AUTHOR: R W Tuthill RW
AUTHOR: C Hollingsworth C
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Elimination of "lead time" bias in assessing the effect of early breast cancer diagnosis.
PUBDATE: 19810101
The relationship between diagnosis of breast cancer in the localized stage of disease and improved prognosis for 234 female breast cancer patients aged 55 years and older was examined. Cause of death was used as an indicator of prognosis because, unlike measures of survival, it is unaffected by "lead time" bias. A three- to fourfold increase in the risk of death from breast cancer was observed among women diagnosed in the advanced stages of breast cancer relative to those diagnosed in the localized stage. The results indicate that diagnosis in the localized stage of breast cancer was associated with an improved prognosis, and that "lead time" bias cannot explain the observed association between stage at diagnosis and prognosis for female breast cancer patients aged 55 years and older.


14. DOCID:7780 SCORE: 0.00202057332188146
DOCNO: 718312
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Radiation-Induced
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: C P Roudebush CP
AUTHOR: G T Asteris GT
AUTHOR: L J DeGroot LJ
PUBTYPE: Journal Article
JOURNALTITLE: Archives of internal medicine.
COUNTRY: UNITED STATES
TITLE: Natural history of radiation-associated thyroid cancer.
PUBDATE: 19781101
The clinical courses of 91 patients with radiation-associated thyroid cancer were compared with courses in a control population. Radiation-associated carcinoma appears to be a disease of younger persons, and 90% of the tumors are papillary. No anaplastic or medullary tumors were observed. Ninety percent of the tumors were larger than those found in an autopsy series that surveyed for "biologically benign" thyroid tumors. There was a higher incidence of multicentric disease, locally invasive disease, and distant metastases in the population that had had x-ray exposure. Although the population with x-ray exposure had had more aggressive treatment, more recurrences were present in patients who had had radiation therapy. The death rate was similar in both groups. Parathyroid adenoma occurred more frequently in the population that had radiation exposure than in controls and appears to be a radiation-associated illness.