0. DOCID:3294 SCORE: 0.00451369018863462
DOCNO: 1260732
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: epidemiology
AUTHOR: W Morton W
AUTHOR: G Starr G
AUTHOR: D Pohl D
AUTHOR: J Stoner J
AUTHOR: S Wagner S
AUTHOR: D Weswig D
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Skin cancer and water arsenic in Lane County, Oregon.
PUBDATE: 19760501
It was expected that the incidence of skin cancer would be related to the known high arsenic levels in water supplies of Lane County, Oregon. Incidence rates were based on all histopathologically confirmed cases among Lane County residents diagnosed during 1958-1971 and were compared to mean water arsenic levels measured during 1968-1974. Basal cell carcinoma had a mean annual incidence rate of 88 per 100,000, a 5:4::M:F sex ratio, and an increasing risk for both sexes in urban areas. Squamous cell carcinoma incidence was 50 per 100,000 and showed 2:1:M:F sex ratio but no urban predilection. Neither type of skin cancer was directly related to the arsenic levels as expected, although sporadic individuals with sufficient exposure could manifest the relationship. Fewer than expected drinking water sources were found to contain high arsenic content, so that the Lane County data do not necessarily contradict previous reports of positive correlation. The basal cell carcinoma pattern suggested that this disease might be potentiated by urban air pollutants.


1. DOCID:2701 SCORE: 0.00445100144863099
DOCNO: 806743
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: W Rapp W
AUTHOR: M Heim M
AUTHOR: J G von Mikulicz-Radecki JG
AUTHOR: R Ludwig R
PUBTYPE: Journal Article
JOURNALTITLE: Klinische Wochenschrift.
COUNTRY: GERMANY, WEST
TITLE: Alpha 1-acid glycoprotein in gastric cancer juice.
PUBDATE: 19750201
Gastric juice was neutralized (nGJ) in vivo by 80 ml of a phosphate buffer containing radiolabelled vitamin B12 as dilution indicator. Unprocessed nGJ was analyzed in the double gel diffusion technique for the presence of serum proteins using monospecific antisera. Alpha1-Acid glycoprotein (AGP) was found in a high incidence (36 out of 38 subjects) in nGJ of gastric cancer patients. AGP was also observed less frequently in nGJ of patients with Billroth II resections (6/15), metaplasia (11/52), gastric ulcer (3/24), chronic atrophic gastritis (2/26) and chronic gastritis (3/63). AGP was absent in the control group (0/21), in patients with surface gastritis (0/38) and in subjects with normal acid secretion (0/45). Immunochemical studies demonstrated no identity of AGP with human "gastrointestinal tumor associated antigens." In 7 out of 17 AGP positive samples immunochemical differences between gastric and serum AGP were observed.


2. DOCID:3036 SCORE: 0.00443784589978832
DOCNO: 845347
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Food Preferences
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: J A Carson JA
AUTHOR: A Gormican A
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Dietetic Association.
COUNTRY: UNITED STATES
TITLE: Taste acuity and food attitudes of selected patients with cancer.
PUBDATE: 19770401
Patients with cancer may display taste abnormalities. In this study, abnormalities observed before treatment involved decreased salt and sweet sensitivity. For some thresholds, greater abnormalities were observed among men and women, among patients with colon cancer than among those with breast cancer, and among those with a greater extent of disease. Observations of slight increases in thresholds for sour detection and bitter recognition during the early treatment period and normalization of high sweet recognition thresholds after two weeks of treatment suggest that additional changes in taste acuity may accompany short-term treatment with 5'fluorouracil. However, absence of a correlation of taste changes with changes in food preferences points to the role of other factors in determining patients' food preferences during such treatment. Consideration of the incidence of taste abnormalities in these groups of patients with cancer and observation of altered food attitudes among patients receiving 5-fluorouracil does provide a basis for general recommendations for serving foods which will appeal to these patients.


3. DOCID:3782 SCORE: 0.00415367282839524
DOCNO: 766958
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radiation-Sensitizing Agents
QUALIFIER: pharmacology
QUALIFIER: drug therapy
AUTHOR: T L Phillips TL
AUTHOR: K K Fu KK
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Quantification of combined radiation therapy and chemotherapy effects on critical normal tissues.
PUBDATE: 19760201
In order to determine the modification of radiation effects on critical normal tissues which occurs with combinations of radiation and cancer chemotherapy, a review of laboratory and clinical data has been carried out. Information on 10 different normal tissues is available. It is clear that the antibiotic cancer chemotherapeutic agents are the most likely to enhance radiation injury, with increased levels reported in all tissues except the central nervous system. The second most common type of injury with combination therapy appears to occur with drugs causing injury to the normal tissue on their own, such as adriamycin in the heart and methotrexate in the central nervous system. Quantification of the dose-effect factor is only available on a limited number of tissues, and, primarily, in experimental animals. From these limited data, it is clear that dose-effect factors between 1.1 and 1.8 are seen, indicating that radiation doses must be reduced by 10-80% for the same level of injury when combined with chemotherapy. The augmentation of radiation damage by cancer chemotherapeutic agents is a serious problem in a wide range of tissues, but a problem which can be dealt with by accurate knowledge as to the dose-effect factor and appropriate modification of the radiation treatment.


4. DOCID:3900 SCORE: 0.0037830256728123
DOCNO: 602971
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Smoking
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: cytology
AUTHOR: M R Melamed MR
AUTHOR: M B Zaman MB
AUTHOR: B J Flehinger BJ
AUTHOR: N Martini N
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of surgical pathology.
COUNTRY: UNITED STATES
TITLE: Radiologically occult in situ and incipient invasive epidermoid lung cancer: detection by sputum cytology in a survey of asymptomatic cigarette smokers.
PUBDATE: 19770301
Approximately 8000 cigarette-smoking men over the age of 45 have entered into a lung cancer detection program in New York City. Cytologic examinations of sputum were carried out on 4000 subjects and lung cancer was found by this technique in nine men with normal chest x-rays. Seven had in situ or incipient invasive epidermoid carcinoma confined to the bronchus. These seven cases were studied by detailed histologic examinations of the bronchial tree in the resected specimens through sixth generation subsegmental bronchi. It was concluded that: 1) invasive epidermoid carcinoma arises from carcinoma in situ of bronchial surface epithelium or an extension of that neoplastic epithelium in bronchial glands; 2) the site of origin is a segmental bronchus in most instances; and 3) each carcinoma should be considered as unifocal in origin even though there is a continuing risk of another primary lung cancer. It seems unlikely that squamous metaplasia or basal hyperplasia is an essential step in carcinogenesis; rather, we believe that carcinoma may arise in bronchial epithelium without regard to the presence or absence of basal hyperplasia or squamous metaplasia, which should be considered nonspecific reactions to injury that may or may not accompany carcinogenesis.


5. DOCID:3790 SCORE: 0.00352373071466495
DOCNO: 184044
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Viral
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Corallini A
AUTHOR: G Barbanti-Brodano G
AUTHOR: M Portolani M
AUTHOR: P G Balboni PG
AUTHOR: M P Grossi MP
AUTHOR: L Possati L
AUTHOR: C Honorati C
AUTHOR: M La Placa M
AUTHOR: A Mazzoni A
AUTHOR: A Caputo A
AUTHOR: U Veronesi U
AUTHOR: S Orefice S
AUTHOR: G Cardinali G
PUBTYPE: Journal Article
JOURNALTITLE: Infection and immunity.
COUNTRY: UNITED STATES
TITLE: Antibodies to BK virus structural and tumor antigens in human sera from normal persons and from patients with various diseases, including neoplasia.
PUBDATE: 19760601
Sera from 1,279 patients with various diseases were examined for the presence of antibodies to BK virus (BKV) capsid antigens. The percentage of positive sera was comparable in all the diseases except rheumatoid arthritis and chronic nephropathies, where a slightly higher prevalence was found. Sera from 952 patients with tumors were examined for the presence of antibodies to BKV tumor and capsid antigens in comparison with a matched control group of 501 blood donors. Sera from 11 tumor patients (1.15%) and from 4 normal controls (0.80%) had antibodies to BKV tumor antigen. No higher prevalence of antibodies to BKV capsid antigens was found in any cancer type except in carcinomas of the urinary bladder, where the percentage of positive sera and of sera with high titers was higher than in other groups. BKV infection is discussed in relation to its possible connection with human non-neoplastic diseases as well as with human tumors and to its activation under conditions of immunosuppressive therapy.


6. DOCID:3895 SCORE: 0.00309519395137199
DOCNO: 1082357
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: I Mittra I
AUTHOR: J Perrin J
AUTHOR: S Kumaoka S
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Thyroid and other autoantibodies in British and Japanese women: an epidemiological study of breast cancer.
PUBDATE: 19760101
To define the role of asymptomatic autoimmune thyroiditis in the cause of breast cancer, the presence of circulating thyroid autoantibodies was studied in two populations, one with a high risk of breast cancer (British women) and one with a low risk (Japanese women). Ostensibly healthy women and patients with breast cancer from both countries were studied. There was no difference in the incidence of thyroid autoantibodies between women with breast cancer and healthy women in either race. The incidence of thyroid autoantibodies in healthy British women, however, was two to three times that in healthy Japanese women. The incidence of reticulin antibodies, was considerably higher in both groups of Japanese women. No remarkable differences in the incidence of antinuclear, smooth-muscle, antimitochondrial, gastric parietal cell, or liver-kidney microsomal antibodies were found between women with breast cancer and healthy women or between the two races. Only the incidence of antinuclear antibodies was marginally higher in Japanese patients with advanced cancer. These results indicate that asymptomatic autoimmune thyroid disease is more prevalent among British than among Japanese women, but they fail to provide direct evidence that autoimmune thyroid disease is associated with breast cancer. Prospective studies of women with autoimmune thyroiditis and studies of young women from low-risk and high-risk populations are needed.


7. DOCID:3807 SCORE: 0.00306198975336404
DOCNO: 1182697
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
AUTHOR: G A LePage GA
AUTHOR: S R Naik SR
AUTHOR: S B Katakkar SB
AUTHOR: A Khaliq A
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: 9-beta-D-arabinofuranosyladenine 5'-phosphate metabolism and excretion in humans.
PUBDATE: 19751101
9-beta-D-Arabinofuranosyladenine (ara-A) was converted chemically to the 9-beta-D-arabinofuranosyladenine 5'-phosphate (ara-A-5'-P) and administered i.v. to four cancer patients in seven experiments. Urinary excretion and plasma levels of radioactivity were monitored for 24 hr in each case. Radioactivity present as unchanged ara-A-5'-P, ara-A, and the deamination product of ara-A, 9-beta-D-arabinofuranosylhypoxanthine, was determined. Excretion was, as in earlier studies with ara-A, given i.v., largely as 6-beta-D-arabinofuranosylhypoxanthine. However, in contrast to the 88 to 97% excretion of ara-A and products in 24 hr when ara-A was given by i.v. push, excretion was 41.47 to 79.1% in 24 hr when ara-A-5'-P was given. With the exception of one experiment at a low dose, where plasma ara-A levels were significant for 6 hr, the plasma levels of ara-A were sustained at significant levels for 24 hr after a single dose of ara-A-5'-P. The doses of ara-A-5'-P given were well tolerated by the four patients. Indications are that this derivative provides important advantages (solubility and sustained blood levels) over ara-A.


8. DOCID:2902 SCORE: 0.00305761559824569
DOCNO: 50444
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radionuclide Imaging
QUALIFIER: adverse effects
QUALIFIER: drug effects
QUALIFIER: chemically induced
AUTHOR: C Sawas-Dimopoulou C
AUTHOR: V Samara V
AUTHOR: N Anezyris N
PUBTYPE: Journal Article
JOURNALTITLE: Journal de radiologie, d'électrologie, et de médecine nucléaire.
COUNTRY: FRANCE
TITLE: [Comparative effectiveness of pulmonary scintigraphy and radiography in detecting toxic side-effects of Bleomycin treatment (author's transl)]
PUBDATE: 19750201
Pulmonary toxic effects subsequent to intravenous injections of bleomycin in cancer therapy have well been demonstrated. In order to prevent the acute pathological pulmonary manifestations of the treatment, it is necessary that the patient be submitted to repeated controls of the lungs. As yet, the efficiency of the current diagnostic procedures for detecting the lesions dues to bleomycin injections is not clearly demonstrated. The authors present the results of a comparative study on the effectiveness of radiological and scintigraphic examination of the lung in detecting toxic side-effects of bleomycin. Both procedures were used repeatedly on rabbits, before, during and after the bleomycin treatment. The findings are discussed on the basis of the macroscopic and histological examination of the lungs. The results demonstrate that pulmonary scintigraphy with radioactive macroaggregates is more sensitive than radiography in detecting the early lesions of the lungs after bleomycin treatment.


9. DOCID:3149 SCORE: 0.00300628530650605
DOCNO: 69387
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Autoantibodies
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: H Diederichsen H
AUTHOR: K Riisom K
AUTHOR: I Andersen I
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica et microbiologica Scandinavica. Section A, Pathology.
COUNTRY: DENMARK
TITLE: Peripheral immunofluorescence of hepatocytes. Relation to smooth muscle antibodies and bile canaliculi.
PUBDATE: 19770501
By means of indirect immunofluorescence microscopy, a peripheral fluorescence reaction with hepatocytes was found, surrounding the entire cell, with sera from patients with cancer and acute hepatitis and from normal blood donors. It was proved that this reaction was not related to bile canaliculi, contrary to bile canaliculi antibody demonstrated previously from patients with chronic active liver disease. By using fluorescein-conjugated anti-human IgG, the reaction with the periphery of the hepatocytes was produced to a more or less pronounced degree with almost all sera studied. The reaction seems not to be directed against contractile proteins on the liver cell membrane as only a minor part of these sera had also IgG smooth-muscle antibody, and anti actomyosin antibody obtained by affinity chromatografy did not react with the hepatocyte. When applying fluorescein-conjugated anti-human IgM the reaction with the periphery of the hepatocytes was observed in one fourth of the patients with acute hepatitis and only sera which contained also IgM smooth-muscle antibody.


10. DOCID:2708 SCORE: 0.0029923655017799
DOCNO: 867221
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: A J Edis AJ
PUBTYPE: Journal Article
JOURNALTITLE: The Surgical clinics of North America.
COUNTRY: UNITED STATES
TITLE: Surgical treatment for thyroid cancer.
PUBDATE: 19770601
Thyroid cancer, although a rare disease, may cause significant disability and even death. Its proper surgical management is based on an understanding of the different biolgoic behavior of the four subtypes. Papillary and follicular cancers are best managed by total lobectomy on the side of the lesion and subtotal lobectomy on the contralateral side, unless there is gross disease bilaterally or distant metastasis (in which circumstances total thyroidectomy is performed). Cervical lymph node metastasis, when present, is handled satisfactorily by modified neck dissection. Because of its high incidence of multicentricity and its more serious prognosis, medullary thyroid carcinoma is managed by total thyroidectomy and--usually--radical neck dissection for involved nodes. For anaplastic carcinoma, there is no effective treatment at present. Postoperatively, all patients should be given suppressive doses of thyroid hormone to prevent myxedema and to prevent cancer from recurring. Radioiodine therapy may be of value in suppressing metastasis of some papillary and follicular cancers that exhibit a high degree of follicular differentiation.


11. DOCID:1284 SCORE: 0.00283027501542608
DOCNO: 837781
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: F Incze F
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY, WEST
TITLE: [The Rapeutic principles in malignant rectal polyps based on late results]
PUBDATE: 19770101
The late results of various treatment of 114 patients with malignant rectal polyps were found to be similar over a 5-25-year follow-up. On this basis, the following principles of therapy were established: 1. All rectal polyps should be removed completely. 2. Local removal of a malignant polyp, looking macroscopically benign and of favorable size and location, is justified, even though a cancer - not infiltrating the stalk - is situated in the head of the polyp. In any other case a radical operation is indicated. 3. Patients should be held under a life-long supervision. 4. The control should be performed as an organized care.


12. DOCID:2112 SCORE: 0.00278688391721692
DOCNO: 189707
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: O H Beahrs OH
AUTHOR: S M Wilson SM
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Carcinoma of the anus.
PUBDATE: 19761001
Carcinoma of the anus represents about 2% of cancers of the large bowel. From 1950 to 1970, 20 patients were treated for this condition. Included were 113 patients with squamous cell carcinoma (31 perianal), 64 with basalid squamous carcinoma, 8 with Paget's disease of the anus, 7 with melanoma, 6 with basal cell carcinoma, and 6 with adenocarcinoma. Combined abdomino-perineal resection was the treatment of choice except for perianal lesions; for these, local excision was used most frequently. Inguinal node dissection was used infrequently, and it is not possible to draw meaningful conclusions from the data. Overall survival rates for patients having anal squamous cell carcinoma are similar except when lymphatic invasion is present; then basaloid lesions have a significantly better prognosis. For rare anal carcinomas, histopathologic findings dictate the end results-- the better the findings and more satisfactory the results.


13. DOCID:3464 SCORE: 0.00275625655141085
DOCNO: 591295
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: R Arnon R
AUTHOR: N Novik N
AUTHOR: J Haimovich J
AUTHOR: S Chaitchik S
PUBTYPE: Journal Article
JOURNALTITLE: Israel journal of medical sciences.
COUNTRY: ISRAEL
TITLE: Viroimmunoassay utilizing a synthetic peptide: a test equivalent to the carcinoembryonic antigen radioimmunoassay.
PUBDATE: 19771001
A recently developed immunoassay which utilizes the synthetic fragment CEA(1-11), corresponding to the N-terminal segment of carcinoembryonic antigen (CEA), was used for the evaluation of human sera. The various sera were tested for their capacity to inhibit the inactivation of the modified bacteriophage preparation CEA(1-11)-T4 by antiserum prepared against the bovine serum albumin (BSA) conjugate CEA(1-11)-BSA. In this immunological system both the free synthetic peptide and a semipurified preparation of intact CEA serve as inhibitors. Sera from a large proportion (85%) of patients with adenocarcinomas of the digestive tract, including the pancrease, gave 50 to 88% inhibition. Sera from patients with other cancers, particularly of breast and ovary, also caused inhibition, although it was less marked in both incidence and level. Most normal sera gave less than 40% inhibition, which was considered as the cutoff point. This assay, like the CEA radioimmunoassay, is not suitable for mass screening nor can it be the primary criterion for diagnosis of cancer, but it might be of value as a follow-up procedure for postoperative diagnosis and prognosis.


14. DOCID:3623 SCORE: 0.00270374397381433
DOCNO: 603843
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude to Death
QUALIFIER: psychology
AUTHOR: M L Vachon ML
AUTHOR: K Freedman K
AUTHOR: A Formo A
AUTHOR: J Rogers J
AUTHOR: W A Lyall WA
AUTHOR: S J Freeman SJ
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: The final illness in cancer: the widow's perspective.
PUBDATE: 19771101
Widows of cancer patients were compared with other widows in general and with widows of men with chronic cardiovascular disease in particular, special attention being given to the vicissitudes of the final illness. Despite the recent emphasis on the need for open communication about the impending death between the dying patient and his family, interviews with 73 women whose husbands had died of cancer revealed that 40% of those who had been told their husband was dying refused to accept the warning. Only 29% of the couples openly discussed the possibility of the husband dying of his disease. More than half of those who did not talk with their husband about the impending death reported that this made no difference to their initial adjustment to bereavement. The stress for a woman of her husband's final illness leads to an especially difficult bereavement period; for example, significantly more widows of cancer patients than of patients with other illnesses perceived themselves to be in poor health during the initial bereavement period. Some of the problems specific to cancer patients and their families are described, along with recommendations for their alleviation.