0. DOCID:6872 SCORE: 0.00677674912745794
DOCNO: 6785940
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: U Dunzendorfer U
AUTHOR: D Drahovsky D
AUTHOR: H Schmidt-Gayk H
AUTHOR: H P Zahradnik HP
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Urologie und Nephrologie.
COUNTRY: GERMANY, EAST
TITLE: [Clinical significance of peptide hormones LH, FSH, TSH, prolactin, HCG, parathormone, calcitonin and prostaglandin F2 alpha in kidney neoplasms]
PUBDATE: 19810101
Peptide hormones LH, FSH, TSH, e-peptide, prolactin, HCG, PTH, calcitonin and prostaglandin F2 alpha were evaluated in 25 patients with renal adenocancer. Prolactin elevation found in 45% was unrelated to the stage of the disease, while aberrant TSH and FSH were more sensitive in indicating distant metastasis. Prostaglandin F2 alpha, measured as a stable degradation product 13,14-DHK-PGF2 alpha, was frequently elevated and normalized following tumor nephrectomy within 12 month. Serum PTH was decreased in patients with tumor dissemination suggesting resorptive hypercalcemina, whereas none of the patient had circulating HCG levels. Therefore even patients without any paraneoplastic syndromes have a frequent change of peptide hormones directly or indirectly caused by renal cancer.

1. DOCID:7754 SCORE: 0.00469758134683523
DOCNO: 7234414
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
AUTHOR: E Farber E
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica japonica.
COUNTRY: JAPAN
TITLE: The sequential analysis of cancer induction with chemicals.
PUBDATE: 19810101
A critical review of some of our current views on how chemicals induced cancer is presented. Emphasis is placed on pathologic processes, rather than on agents and on the many steps that lie between initial exposure to a carcinogen and the appearance of malignant neoplasia. The nature of some of the early steps in carcinogenesis is outlined including the early appearance during initiation of cells resistant to some of the inhibitory effect of carcinogens. This property is considered to be important in the development of cancer in at least one model of carcinogenesis. The essential characteristic of promotion, differential stimulation of proliferation of initiated cells, is discussed along with at least three possible mechanisms for such differential effects of promoting environments. The multistep hypothesis for cancer development is supported by observations of identifiable biochemical and biological properties of different cell populations at some steps. The implications of this for cancer diagnosis, prevention and control are briefly discussed.

2. DOCID:3294 SCORE: 0.00451369018863462
DOCNO: 1260732
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: epidemiology
AUTHOR: W Morton W
AUTHOR: G Starr G
AUTHOR: D Pohl D
AUTHOR: J Stoner J
AUTHOR: S Wagner S
AUTHOR: D Weswig D
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Skin cancer and water arsenic in Lane County, Oregon.
PUBDATE: 19760501
It was expected that the incidence of skin cancer would be related to the known high arsenic levels in water supplies of Lane County, Oregon. Incidence rates were based on all histopathologically confirmed cases among Lane County residents diagnosed during 1958-1971 and were compared to mean water arsenic levels measured during 1968-1974. Basal cell carcinoma had a mean annual incidence rate of 88 per 100,000, a 5:4::M:F sex ratio, and an increasing risk for both sexes in urban areas. Squamous cell carcinoma incidence was 50 per 100,000 and showed 2:1:M:F sex ratio but no urban predilection. Neither type of skin cancer was directly related to the arsenic levels as expected, although sporadic individuals with sufficient exposure could manifest the relationship. Fewer than expected drinking water sources were found to contain high arsenic content, so that the Lane County data do not necessarily contradict previous reports of positive correlation. The basal cell carcinoma pattern suggested that this disease might be potentiated by urban air pollutants.

3. DOCID:2701 SCORE: 0.00445100144863099
DOCNO: 806743
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: W Rapp W
AUTHOR: M Heim M
AUTHOR: J G von Mikulicz-Radecki JG
AUTHOR: R Ludwig R
PUBTYPE: Journal Article
JOURNALTITLE: Klinische Wochenschrift.
COUNTRY: GERMANY, WEST
TITLE: Alpha 1-acid glycoprotein in gastric cancer juice.
PUBDATE: 19750201
Gastric juice was neutralized (nGJ) in vivo by 80 ml of a phosphate buffer containing radiolabelled vitamin B12 as dilution indicator. Unprocessed nGJ was analyzed in the double gel diffusion technique for the presence of serum proteins using monospecific antisera. Alpha1-Acid glycoprotein (AGP) was found in a high incidence (36 out of 38 subjects) in nGJ of gastric cancer patients. AGP was also observed less frequently in nGJ of patients with Billroth II resections (6/15), metaplasia (11/52), gastric ulcer (3/24), chronic atrophic gastritis (2/26) and chronic gastritis (3/63). AGP was absent in the control group (0/21), in patients with surface gastritis (0/38) and in subjects with normal acid secretion (0/45). Immunochemical studies demonstrated no identity of AGP with human "gastrointestinal tumor associated antigens." In 7 out of 17 AGP positive samples immunochemical differences between gastric and serum AGP were observed.

4. DOCID:3036 SCORE: 0.00443784589978832
DOCNO: 845347
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Food Preferences
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: J A Carson JA
AUTHOR: A Gormican A
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Dietetic Association.
COUNTRY: UNITED STATES
TITLE: Taste acuity and food attitudes of selected patients with cancer.
PUBDATE: 19770401
Patients with cancer may display taste abnormalities. In this study, abnormalities observed before treatment involved decreased salt and sweet sensitivity. For some thresholds, greater abnormalities were observed among men and women, among patients with colon cancer than among those with breast cancer, and among those with a greater extent of disease. Observations of slight increases in thresholds for sour detection and bitter recognition during the early treatment period and normalization of high sweet recognition thresholds after two weeks of treatment suggest that additional changes in taste acuity may accompany short-term treatment with 5'fluorouracil. However, absence of a correlation of taste changes with changes in food preferences points to the role of other factors in determining patients' food preferences during such treatment. Consideration of the incidence of taste abnormalities in these groups of patients with cancer and observation of altered food attitudes among patients receiving 5-fluorouracil does provide a basis for general recommendations for serving foods which will appeal to these patients.

5. DOCID:3782 SCORE: 0.00415367282839524
DOCNO: 766958
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radiation-Sensitizing Agents
QUALIFIER: pharmacology
QUALIFIER: drug therapy
AUTHOR: T L Phillips TL
AUTHOR: K K Fu KK
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Quantification of combined radiation therapy and chemotherapy effects on critical normal tissues.
PUBDATE: 19760201
In order to determine the modification of radiation effects on critical normal tissues which occurs with combinations of radiation and cancer chemotherapy, a review of laboratory and clinical data has been carried out. Information on 10 different normal tissues is available. It is clear that the antibiotic cancer chemotherapeutic agents are the most likely to enhance radiation injury, with increased levels reported in all tissues except the central nervous system. The second most common type of injury with combination therapy appears to occur with drugs causing injury to the normal tissue on their own, such as adriamycin in the heart and methotrexate in the central nervous system. Quantification of the dose-effect factor is only available on a limited number of tissues, and, primarily, in experimental animals. From these limited data, it is clear that dose-effect factors between 1.1 and 1.8 are seen, indicating that radiation doses must be reduced by 10-80% for the same level of injury when combined with chemotherapy. The augmentation of radiation damage by cancer chemotherapeutic agents is a serious problem in a wide range of tissues, but a problem which can be dealt with by accurate knowledge as to the dose-effect factor and appropriate modification of the radiation treatment.

6. DOCID:7441 SCORE: 0.004064152512024
DOCNO: 7314368
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J L Siekavizza JL
AUTHOR: M E Bernardino ME
AUTHOR: N A Samaan NA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Suprarenal mass and its differential diagnosis.
PUBDATE: 19811201
Nine cases of suprarenal masses without endocrine abnormalities are presented: 2 adrenal pseudocysts, 2 adrenal myelolipomas, 2 neuroblastomas, 1 lymphoma metastatic to the adrenal glands, 1 teratoma, and 1 adrenal cortical carcinoma metastatic to the contralateral gland. The clinical and radiologic findings are discussed. Noninvasive and invasive procedures and their usefulness in diagnosing masses in the suprarenal area are reported. The importance of metastases to the adrenal glands in the differential diagnosis of suprarenal masses was investigated by reviewing the autopsies done from January through June, 1979, at The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas. Adrenal metastases were found in 26 per cent of the cases studied. Breast and lung carcinomas and lymphomas were the most commonly found neoplasia. The relative incidence of microscopic and macroscopic metastases in all patients with tumor is discussed.

7. DOCID:6794 SCORE: 0.00393132886453684
DOCNO: 12336894
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Contraceptives, Oral
DESCRIPTOR: Endometrium
DESCRIPTOR: Estrogens
DESCRIPTOR: Menopause
DESCRIPTOR: Progesterone
DESCRIPTOR: Prospective Studies
AUTHOR: M Paterson M
AUTHOR: T Wade-evans T
AUTHOR: D W Sturdee DW
AUTHOR: M H Thom MH
AUTHOR: J W Studd JW
PUBTYPE: Journal Article
JOURNALTITLE: Contraception, fertilité, sexualité.
COUNTRY: FRANCE
TITLE: [Endometrial disease after treatment with oestrogens and progestogens in the climateric (author's transl)]
PUBDATE: 19810401
This study was undertaken to examine the frequency of histologic endometrial anomalies with different types of estrogen therapy, whether or not associated to progesterone treatment. 1002 endometrial biopsies were done on 745 women who had received: 1) cyclic treatment with low-dose estrogen; 2) cyclic treatment with high-dose estrogen; 3) sequential estrogen-progestogen treatment; and 4) subcutaneous implant of estradiol. Frequency of abnormalities was 7.0% in the first group, 14.8% in the second group, 1.2% in the third group, and 14.8% in the fourth group. Without drawing definitive conclusions from these results, it seems possible to affirm that the use of progestogen diminishes the risk of endometrial cancer during menopause.

8. DOCID:3900 SCORE: 0.0037830256728123
DOCNO: 602971
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Smoking
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: cytology
AUTHOR: M R Melamed MR
AUTHOR: M B Zaman MB
AUTHOR: B J Flehinger BJ
AUTHOR: N Martini N
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of surgical pathology.
COUNTRY: UNITED STATES
TITLE: Radiologically occult in situ and incipient invasive epidermoid lung cancer: detection by sputum cytology in a survey of asymptomatic cigarette smokers.
PUBDATE: 19770301
Approximately 8000 cigarette-smoking men over the age of 45 have entered into a lung cancer detection program in New York City. Cytologic examinations of sputum were carried out on 4000 subjects and lung cancer was found by this technique in nine men with normal chest x-rays. Seven had in situ or incipient invasive epidermoid carcinoma confined to the bronchus. These seven cases were studied by detailed histologic examinations of the bronchial tree in the resected specimens through sixth generation subsegmental bronchi. It was concluded that: 1) invasive epidermoid carcinoma arises from carcinoma in situ of bronchial surface epithelium or an extension of that neoplastic epithelium in bronchial glands; 2) the site of origin is a segmental bronchus in most instances; and 3) each carcinoma should be considered as unifocal in origin even though there is a continuing risk of another primary lung cancer. It seems unlikely that squamous metaplasia or basal hyperplasia is an essential step in carcinogenesis; rather, we believe that carcinoma may arise in bronchial epithelium without regard to the presence or absence of basal hyperplasia or squamous metaplasia, which should be considered nonspecific reactions to injury that may or may not accompany carcinogenesis.

9. DOCID:6095 SCORE: 0.00363372751855618
DOCNO: 7422174
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: W Hernandez-Linares W
AUTHOR: A Puthawala A
AUTHOR: J F Nolan JF
AUTHOR: P H Jernstrom PH
AUTHOR: C P Morrow CP
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Carcinoma in situ of the vagina: past and present management.
PUBDATE: 19800901
The experience of the Southern California Cancer Center with carcinoma in situ of the vagina has been analyzed. Thirty-five patients were treated over 22 years. Patients with carcinoma in situ of the vagina are usually asymptomatic and most often have no visible or palpable lesions; diagnosis therefore depends upon directed biopsy in patients with abnormal routine vaginal cytology. Local radium application was the most frequent modality of treatment in this study group of patients, and excellent results were obtained. The need for cytologic evaluation after hysterectomy is emphasized. Colposcopy is a valuable aid in the diagnosis and follow-up of these patients.

10. DOCID:3790 SCORE: 0.00352373071466495
DOCNO: 184044
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Viral
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Corallini A
AUTHOR: G Barbanti-Brodano G
AUTHOR: M Portolani M
AUTHOR: P G Balboni PG
AUTHOR: M P Grossi MP
AUTHOR: L Possati L
AUTHOR: C Honorati C
AUTHOR: M La Placa M
AUTHOR: A Mazzoni A
AUTHOR: A Caputo A
AUTHOR: U Veronesi U
AUTHOR: S Orefice S
AUTHOR: G Cardinali G
PUBTYPE: Journal Article
JOURNALTITLE: Infection and immunity.
COUNTRY: UNITED STATES
TITLE: Antibodies to BK virus structural and tumor antigens in human sera from normal persons and from patients with various diseases, including neoplasia.
PUBDATE: 19760601
Sera from 1,279 patients with various diseases were examined for the presence of antibodies to BK virus (BKV) capsid antigens. The percentage of positive sera was comparable in all the diseases except rheumatoid arthritis and chronic nephropathies, where a slightly higher prevalence was found. Sera from 952 patients with tumors were examined for the presence of antibodies to BKV tumor and capsid antigens in comparison with a matched control group of 501 blood donors. Sera from 11 tumor patients (1.15%) and from 4 normal controls (0.80%) had antibodies to BKV tumor antigen. No higher prevalence of antibodies to BKV capsid antigens was found in any cancer type except in carcinomas of the urinary bladder, where the percentage of positive sera and of sera with high titers was higher than in other groups. BKV infection is discussed in relation to its possible connection with human non-neoplastic diseases as well as with human tumors and to its activation under conditions of immunosuppressive therapy.

11. DOCID:5254 SCORE: 0.00333624254210826
DOCNO: 7268622
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: J S Economou JS
PUBTYPE: Journal Article
JOURNALTITLE: Surgery, gynecology & obstetrics.
COUNTRY: UNITED STATES
TITLE: The role of antibody in tumor immunity.
PUBDATE: 19810901
Antibody may sensitize tumor cells for destruction by nonimmune host effector elements that include complement, macrophages, lymphocytes, neutrophils, eosinophils or platelets. Small numbers of tumor cells may be very efficiently suppressed in vivo. Antibody immunotherapy can also be used successfully in combination with other modalities, such as chemotherapy, in the treatment of larger tumor burdens. Perhaps the greatest potential application of antibody in cancer therapy is its use as a tumor-specific delivery vehicle for cytotoxic substances. The opportunity to produce large quantities of monoclonal antibody, afforded by current hybridoma technology, will revolutionize the application of antibody to cancer medicine.

12. DOCID:7339 SCORE: 0.00310000056714086
DOCNO: 665664
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: A B Miller AB
AUTHOR: A Kelly A
AUTHOR: N W Choi NW
AUTHOR: V Matthews V
AUTHOR: R W Morgan RW
AUTHOR: L Munan L
AUTHOR: J D Burch JD
AUTHOR: J Feather J
AUTHOR: G R Howe GR
AUTHOR: M Jain M
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: A study of diet and breast cancer.
PUBDATE: 19780601
A case-control study has been conducted in four areas in Canada in which 40 cases of breast cancer matched by age and marital status with neighborhood controls were administered a medical and dietary history questionnaire, a 24-hour recall of dietary information and a four-day diet record. The Study has produced evidence of an association between an increased intake of nutrients, especially total fat, in both pre-menopausal and post-menopausal women with breast cancer. Reasons why a weak association might have been anticipated are discussed, and it is concluded that in reality the association is stronger. Furthermore, its consistency with other evidence, both experimental and international, suggests that it is causal.

13. DOCID:3895 SCORE: 0.00309519395137199
DOCNO: 1082357
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: I Mittra I
AUTHOR: J Perrin J
AUTHOR: S Kumaoka S
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Thyroid and other autoantibodies in British and Japanese women: an epidemiological study of breast cancer.
PUBDATE: 19760101
To define the role of asymptomatic autoimmune thyroiditis in the cause of breast cancer, the presence of circulating thyroid autoantibodies was studied in two populations, one with a high risk of breast cancer (British women) and one with a low risk (Japanese women). Ostensibly healthy women and patients with breast cancer from both countries were studied. There was no difference in the incidence of thyroid autoantibodies between women with breast cancer and healthy women in either race. The incidence of thyroid autoantibodies in healthy British women, however, was two to three times that in healthy Japanese women. The incidence of reticulin antibodies, was considerably higher in both groups of Japanese women. No remarkable differences in the incidence of antinuclear, smooth-muscle, antimitochondrial, gastric parietal cell, or liver-kidney microsomal antibodies were found between women with breast cancer and healthy women or between the two races. Only the incidence of antinuclear antibodies was marginally higher in Japanese patients with advanced cancer. These results indicate that asymptomatic autoimmune thyroid disease is more prevalent among British than among Japanese women, but they fail to provide direct evidence that autoimmune thyroid disease is associated with breast cancer. Prospective studies of women with autoimmune thyroiditis and studies of young women from low-risk and high-risk populations are needed.

14. DOCID:3807 SCORE: 0.00306198975336404
DOCNO: 1182697
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
AUTHOR: G A LePage GA
AUTHOR: S R Naik SR
AUTHOR: S B Katakkar SB
AUTHOR: A Khaliq A
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: 9-beta-D-arabinofuranosyladenine 5'-phosphate metabolism and excretion in humans.
PUBDATE: 19751101
9-beta-D-Arabinofuranosyladenine (ara-A) was converted chemically to the 9-beta-D-arabinofuranosyladenine 5'-phosphate (ara-A-5'-P) and administered i.v. to four cancer patients in seven experiments. Urinary excretion and plasma levels of radioactivity were monitored for 24 hr in each case. Radioactivity present as unchanged ara-A-5'-P, ara-A, and the deamination product of ara-A, 9-beta-D-arabinofuranosylhypoxanthine, was determined. Excretion was, as in earlier studies with ara-A, given i.v., largely as 6-beta-D-arabinofuranosylhypoxanthine. However, in contrast to the 88 to 97% excretion of ara-A and products in 24 hr when ara-A was given by i.v. push, excretion was 41.47 to 79.1% in 24 hr when ara-A-5'-P was given. With the exception of one experiment at a low dose, where plasma ara-A levels were significant for 6 hr, the plasma levels of ara-A were sustained at significant levels for 24 hr after a single dose of ara-A-5'-P. The doses of ara-A-5'-P given were well tolerated by the four patients. Indications are that this derivative provides important advantages (solubility and sustained blood levels) over ara-A.