0. DOCID:23797 SCORE: 0.00365619783856612
DOCNO: 7774935
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 17
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: Y Miki Y
AUTHOR: J J Swensen JJ
AUTHOR: M R Hobbs MR
AUTHOR: B S DeHoff BS
AUTHOR: P R Rosteck PR
AUTHOR: M H Skolnick MH
AUTHOR: S L Neuhausen SL
AFFILIATION: Department of Medical Informatics, University of Utah Medical School, Salt Lake City 84108, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Genomics.
COUNTRY: UNITED STATES
TITLE: A physical map encompassing GP2B, EPB3, D17S183, D17S78, D17S1183, and D17S1184.
PUBDATE: 19950101
The q21 region of chromosome 17 contains the gene BRCA1, which is involved in familial early-onset breast and ovarian cancers. A physical map of a region that extends from a distal boundary of the BRCA1 region, D17S78, to GP2B has been constructed. The map consists of 30 STSs, including 2 new short tandem repeat polymorphic markers. The contig is composed of a mixture of 7 YACs, 5 P1 plasmids, and 14 cosmids and was ordered by STS-content mapping.

1. DOCID:23796 SCORE: 0.00365619284666829
DOCNO: 9436031
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: therapy
AUTHOR: A Gotoh A
AUTHOR: S Kamidono S
AUTHOR: L W Chung LW
AFFILIATION: Department of Urology, Kobe University School of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Clinical application for gene therapy in prostate cancer]
PUBDATE: 19971101
Hormone treatment, radiotherapy and anti-cancer chemotherapy are often used to treat prostate cancer. However, there is no effective method of treating hormone-independent prostate cancer. In this study, we attempted to establish a new treatment method for hormone-independent prostate cancer. We developed a new recombinant adenovirus vector containing a suicide gene and controlled by a tissue specific promoter, and examined the usefulness of gene therapy for hormone-independence and PSA expression in prostate cancer. We have also examined the usefulness of gene therapy involving an adenovirus and various tumor suppressor genes for human prostate cancer cells, which are under trial in the United States.

2. DOCID:23793 SCORE: 0.00365618811107172
DOCNO: 8956457
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: immunology
AUTHOR: D Mumberg D
AUTHOR: M Wick M
AUTHOR: H Schreiber H
AFFILIATION: Department of Pathology, University of Chicago, IL 60637, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in immunology.
COUNTRY: UNITED STATES
TITLE: Unique tumor antigens redefined as mutant tumor-specific antigens.
PUBDATE: 19961001
The extraordinary specificity of immune responses mediated by T cells against individual syngeneic tumors has led to the concept that many tumor antigens are 'unique'. The recent isolation of several T-cell-recognized unique antigens from various murine and human tumors has shown that the antigenic peptides are caused by somatic mutations and, thus, are truly tumor-specific. The following review summarizes current knowledge about these mutant tumor-specific antigens and their possible role in the development and progression of cancer. It also discusses some functional differences between mutant tumor-specific and shared tumor antigens, which generally represent unaltered peptides, also present on some normal cells.

3. DOCID:23761 SCORE: 0.003656183562524
DOCNO: 7776283
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Biopsy
QUALIFIER: pathology
AUTHOR: K A Gunning KA
AUTHOR: C D Griffith CD
AUTHOR: L McLean L
AUTHOR: M McElroy M
AUTHOR: B Kaye B
AUTHOR: D Scott D
AUTHOR: J Shrimanker J
AFFILIATION: Breast Screening Unit, Newcastle General Hospital, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Royal College of Surgeons of Edinburgh.
COUNTRY: ENGLAND
TITLE: Assessment of a specimen mount for biopsy of impalpable breast lesions.
PUBDATE: 19950401
Biopsy of the impalpable breast lesion is an increasing part of the surgical workload as a result of the National Breast Cancer Screening Programme. A specimen mount card has been described to orientate such specimens in three dimensions prior to radiological and pathological examination. Experience with 243 biopsies in this unit has shown it to be a useful aid in determining completeness of excision. It may also be used as a guide to further surgery when excision is incomplete and breast conservation is the treatment option of choice.

4. DOCID:18916 SCORE: 0.00317330274113601
DOCNO: 2297418
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: drug therapy
QUALIFIER: chemically induced
QUALIFIER: drug therapy
QUALIFIER: chemically induced
AUTHOR: G J Petruzzelli GJ
AUTHOR: J T Johnson JT
AUTHOR: E J de Vries EJ
AFFILIATION: Department of Otolaryngology, University of Pittsburgh, School of Medicine, Eye and Ear Institute, PA 15213.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology--head & neck surgery.
COUNTRY: UNITED STATES
TITLE: Neutropenic enterocolitis. A new complication of head and neck cancer chemotherapy.
PUBDATE: 19900201
Neutropenic enterocolitis is a recognized complication of immunosuppression or chemotherapy for leukemia. It presents as severe abdominal pain and tenderness, fever, and diarrhea associated with granulocytopenia. Gastrointestinal symptoms associated with chemotherapy for head and neck neoplasms include nausea and emesis, but not acute abdominal distress. We present, to our knowledge, the first case of neutropenic enterocolitis in a patient receiving cisplatin and fluorouracil chemotherapy for metastatic head and neck cancer.

5. DOCID:18879 SCORE: 0.00317329871372921
DOCNO: 1732933
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: standards
QUALIFIER: methods
QUALIFIER: standards
AUTHOR: E A Sickles EA
AFFILIATION: Department of Radiology, UCSF School of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Radiologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Quality assurance. How to audit your own mammography practice.
PUBDATE: 19920101
The medical audit is an important component of a comprehensive mammography quality assurance program. It provides a direct assessment of one's ability to detect otherwise occult breast cancer, the ultimate indicator of mammography performance. Audits must be properly planned, executed, interpreted, and used. The audit that shows successful clinical results can be used to build and maintain a high state of morale among mammography personnel as well as to encourage new and repeat referrals to a mammography practice. The audit that uncovers a deficiency in clinical performance can be instrumental in helping to plan remedial measures that correct the problem.

6. DOCID:22729 SCORE: 0.00313779967165117
DOCNO: 8569673
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: A S Hawatmeh AS
AUTHOR: F P Walters FP
AUTHOR: C A Wooster CA
AFFILIATION: South County Urological, Inc., St. Louis, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Missouri medicine.
COUNTRY: UNITED STATES
TITLE: Early clinical experience with percutaneous cryosurgical ablation of the prostate.
PUBDATE: 19951101
In 1993 we started offering transrectal ultrasound-guided percutaneous cryosurgical ablation of the prostate (PCAP) as a treatment alternative for localized prostate cancer. Through 1994, 85 patients underwent PCAP and 53 had 3-6 month postoperative biopsies. A learning curve effect was observed: 46% of early patients had positive postoperative biopsies, versus only 9% of later ones. With repeat PCAP on the early patients, currently 87% of the biopsied patients are disease free. While longer follow-up is necessary, it appears that PCAP merits further investigation as a treatment alternative for localized prostate cancer.

7. DOCID:23083 SCORE: 0.00271511691380652
DOCNO: 7742511
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Papillomavirus, Human
QUALIFIER: virology
AUTHOR: C M McLachlin CM
AFFILIATION: Department of Pathology, Victoria Hospital, London, Ontario, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in obstetrics & gynecology.
COUNTRY: UNITED STATES
TITLE: Pathology of human papillomavirus in the female genital tract.
PUBDATE: 19950201
Human papillomavirus (HPV) has emerged as a major factor in the genesis of intraepithelial and invasive neoplasms of the female genital tract. The strength of the relationship of HPV to genital neoplasia has been supported by studies involving epidemiologic, clinical, pathologic and molecular data. The many subtypes of HPV have been characterized into risk groups that reflect their propensity to be associated with cancer precursors and invasive disease. The strong correlation between HPV and squamous dysplasia suggests that classification of cervical intraepithelial lesions into similar risk categories should be possible. However, the clinical predictive value of HPV testing and typing remains controversial.

8. DOCID:27601 SCORE: 0.00234078379696054
DOCNO: 15687572
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: R L Wahl RL
AFFILIATION: University of Michigan Medical Center, Ann Arbor, MI 48109-0028, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Breast disease.
COUNTRY: Netherlands
TITLE: Positron Emission Tomography (PET): an update on applications in breast cancer.
PUBDATE: 19980801
Positron Emission Tomography (PET) is an imaging method which detects alterations in tumor physiology and displays them in an anatomically precise manner. Historically, the method has been a research tool, but it is being increasingly applied to clinical imaging problems. PET, using the glucose analog 18-F-fluoro-2-deoxy-D-glucose (FDG), has been applied most widely and shows promise in detecting primary cancers, characterizing breast masses, staging for axillary metastases, evaluating for systemic metastases, and following response to therapy. This review summarizes the current status of this technique, which is in rapid evolution as new tracers and new imaging cameras become available.

9. DOCID:23396 SCORE: 0.00221773177222421
DOCNO: 9248852
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: J W Mulder JW
AUTHOR: V J Wielenga VJ
AUTHOR: S T Pals ST
AUTHOR: G J Offerhaus GJ
AFFILIATION: Academic Medical Centre, University of Amsterdam, Department of Pathology, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Histochemical journal.
COUNTRY: ENGLAND
TITLE: p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis.
PUBDATE: 19970601
Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppressor gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encountered in the immunohistochemical detection of these proteins. Immunohistochemistry potentially forms a procedure applicable for routine diagnosis and prognostication. Therefore, p53 expression and the independent prognostic importance of CD44v6 expression is given particular emphasis, and other molecular events underlying colorectal carcinogenesis are only mentioned briefly.

10. DOCID:23414 SCORE: 0.00218806980973469
DOCNO: 8939849
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle
QUALIFIER: pathology
AUTHOR: C J Sherr CJ
AFFILIATION: Howard Hughes Medical Institute, Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA. sherr@stjude.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Cancer cell cycles.
PUBDATE: 19961201
Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16(INK4a) and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RB) and control exit from the G1 phase of the cell cycle, are so frequent in human cancers that inactivation of this pathway may well be necessary for tumor development. Like the tumor suppressor protein p53, components of this "RB pathway," although not essential for the cell cycle per se, may participate in checkpoint functions that regulate homeostatic tissue renewal throughout life.

11. DOCID:19902 SCORE: 0.00216210429429159
DOCNO: 1912263
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Biometry
DESCRIPTOR: Survival Analysis
QUALIFIER: statistics & numerical data
AUTHOR: J Grüger J
AUTHOR: R Kay R
AUTHOR: M Schumacher M
AFFILIATION: Dornier-System GmbH, Friedrichshafen, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: The validity of inferences based on incomplete observations in disease state models.
PUBDATE: 19910601
In many survival time studies or studies on the progression of a disease, information is often incomplete in the sense that it is known only that a patient has been in certain disease states at several time points. In this paper, conditions concerning the interrelationship between the disease process and the examination scheme (i.e., the pattern of examination times) are derived under which a valid statistical inference is possible. These conditions are confronted with examination schemes that are of practical importance in clinical research. A cancer marker study is used as an example to estimate the magnitude of the potential bias when the conditions derived are violated.

12. DOCID:18012 SCORE: 0.00209162379735444
DOCNO: 2129232
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: toxicity
QUALIFIER: toxicity
QUALIFIER: toxicity
AUTHOR: D P Hsieh DP
AFFILIATION: Department of Environmental Toxicology, University of California, Davis 95616.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of toxicological sciences.
COUNTRY: JAPAN
TITLE: Biological reactive intermediates of bisfuranoid mycotoxins.
PUBDATE: 19901201
Based on the mode of action of AFB1 and the activities of its biologically active intermediates, one may conclude that: 1. The mode of toxic action of the bisfuranoid mycotoxin is through epoxidation of the vinyl ether double bond of their dihydrobisfuran functionality. 2. The DNA and plasma albumin adducts formed in vivo may be useful in the molecular dosimetry of these environmental carcinogens. 3. Monitoring of these adducts of AFB1 in biological samples so far indicates that aflatoxin is likely involved in the etiology of human liver cancer.

13. DOCID:23877 SCORE: 0.00191442595180878
DOCNO: 7932330
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: history
AUTHOR: A M Shulutko AM
AFFILIATION: Surgical Department, Sechenov Moscow Medical Academy, Russia.
PUBTYPE: Historical Article
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of the Royal College of Surgeons of Edinburgh.
COUNTRY: ENGLAND
TITLE: Some aspects of surgery in Russia.
PUBDATE: 19940601
A surgeon from the Moscow Medical Academy, Professor Alexander Shulutko, is the first recipient of the Johnson & Johnson Medical Travelling Fellowship and has completed a one-month study tour in the United Kingdom. Professor Shulutko, 42, a general surgeon specializing in abdominal surgery, is Head of the Department of Surgery at the Academy, one of Russia's most prestigious medical teaching institutions. During his tour he visited the Western General Hospital, Edinburgh, Royal Liverpool University Hospital, Edinburgh Royal Infirmary, Aberdeen Royal Infirmary, Ninewells Hospital, Dundee and Western Infirmary, Glasgow, and attended a consensus conference on colorectal cancer and the annual Clinical and Scientific meeting of the Royal College of Surgeons of Edinburgh.

14. DOCID:22697 SCORE: 0.00189244614856901
DOCNO: 9015349
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: metabolism
QUALIFIER: pathology
QUALIFIER: metabolism
QUALIFIER: pathology
AUTHOR: S Fucile S
AUTHOR: M Napolitano M
AUTHOR: E Mattei E
AFFILIATION: Laboratorio di Biofisica, Centro Ricerca Sperimentale Istituto Regina Elena, Rome, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Cholinergic stimulation of human microcytoma cell line H69.
PUBDATE: 19970101
Experiments were addressed to investigate the mechanisms by which cholinergic stimulation is coupled to the enhancement of proliferation of small cell lung cancer cells H69. Muscarinic stimulation triggers the release of cytosolic Ca2+ and of inositol(1,4,5)trisphosphate with comparable time courses. The presence of alpha-bungarotoxin or the absence of Ca2+ in external medium suppresses enhancement of clonal growth induced by brief applications of nicotine. Here we suggest that Ca2+ mobilization represents a trigger for the enhancement of small cell lung cancer cell proliferation upon cholinergic stimulation.