0. DOCID:6980 SCORE: 0.00514024124975449
DOCNO: 7314116
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: S Asaki S
AUTHOR: T Nishimura T
AUTHOR: M Sato M
AUTHOR: S Shibuki S
AUTHOR: S Iwai S
AUTHOR: S Ito S
AUTHOR: T Ikeda T
AUTHOR: S Yambe S
AUTHOR: Y Goto Y
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Endoscopic gastric polypectomy using high frequency current: its significance for total biopsy of gastric polyp.
PUBDATE: 19811101
Endoscopic polypectomy using high frequency current was performed for 281 out of 345 gastric polyps (230 cases), while the remaining 64 small polyps were cauterized. Histopathologic examinations carried out in 274 out of the 281 polypectomized polyps confirmed gastritis polyposa in 41 lesions, hyperplastic polyps in 216 including 3 cases of neoplasm, atypical epithelium in 4, submucosal tumor in 2, and polypoid cancer in 1. This procedure of endoscopic polypectomy has proved to enable histologic examination of a polyp as a whole, and to allow a highly risk-free endoscopic treatment of polyps. In the currently observed 216 hyperplastic polyps, 3(1.4%) were found to have neoplastic changes.


1. DOCID:6920 SCORE: 0.00487158079661877
DOCNO: 6456802
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
DESCRIPTOR: Surgical Procedures, Operative
AUTHOR: M M Cohen MM
PUBTYPE: Journal Article
JOURNALTITLE: Canadian journal of surgery. Journal canadien de chirurgie.
COUNTRY: CANADA
TITLE: Peritoneoscopy in general surgery.
PUBDATE: 19810901
Peritoneoscopy is a simple and effective means of diagnosing or excluding intra-abdominal disease. It is currently underutilized and merits increased recognition particularly by general surgeons. The first 77 peritoneoscopic examinations performed by a general surgeon in a large hospital associated with a cancer agency are reviewed. An exact diagnosis was made in 78% of 58 patients in whom the primary diagnosis was in doubt and in 93% of that group management was influenced. Surgical exploration of the abdomen was avoided in 29 patients. The major indications for using the method were: to search for metastases, to evaluate the acute abdomen and to stage lymphoma. Local anesthesia and nitrous oxide insufflation were used almost exclusively. Biopsy was performed in 36 patients and there was one death directly attributable to liver biopsy. In two patients peritoneoscopy was unsuccessful.


2. DOCID:7426 SCORE: 0.004853172470502
DOCNO: 435650
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pharmacology
AUTHOR: W Schreml W
AUTHOR: H P Lohrmann HP
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Blut.
COUNTRY: GERMANY, WEST
TITLE: No effects of levamisole on cytotoxic drug-induced changes of human granulopoiesis.
PUBDATE: 19790401
The effect of Levamisole on the human granulopoiesis was studied in patients randomized to receive, in addition to adjuvant chemotherapy for primary breast cancer, either no other treatment or additional unspecific immune therapy with Levamisole. The reaction of granulopoiesis to the cytostatic drugs, as characterized by changes of peripheral blood polymorphonuclear neutrophils (PMN), functional bone marrow granulocyte reserve, serial bone marrow cytology, and granulopoietic stem cells (CFU-C) in marrow and blood, was not affected by administration of Levamisole. The data support the concept that Levamisole has no direct effect on human bone marrow granulopoiesis, but that an allergic mechanism is involved in the pathogenesis of Levamisole-induced agranulocytosis. The expectation that Levamisole exerts a beneficial effect by stimulation of the granulopoiesis, as previously suggested for BCG and Corynebacterium parvum, could not be substantiated in our studies.


3. DOCID:5965 SCORE: 0.0044521241510551
DOCNO: 7425943
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: D E Schuller DE
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Limitations of the pectoralis major myocutaneous flap in head and neck cancer reconstruction.
PUBDATE: 19801101
The pectoralis major myocutaneous flap represents a major contribution to head and neck cancer reconstruction. Its advantages are improved viability, capabilities for one-stage reconstruction, and effective carotid artery protection. Limitations of the flap center around the thickness of the skin-subcutaneous fat-muscle complex that is used to reconstruct and also the bulkiness of the muscle pedicle, which has the potential to obscure recurrent neck disease until it is well advanced. Although it appears that this flap will rightfully become a commonly used technique, there may still be specific times when either regional skin flaps or free flaps are preferable to the pectoralis major myocutaneous flap.


4. DOCID:6000 SCORE: 0.00426898193862893
DOCNO: 6455106
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: E Tilchen E
AUTHOR: Y Z Patt YZ
AUTHOR: C M McBride CM
AUTHOR: S Wallace S
AUTHOR: V Chuang V
AUTHOR: C M Mavligit CM
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Sequence of regional chemotherapy and surgery. Management of colorectal adenocarcinoma confined to the liver.
PUBDATE: 19810701
Four patients with clinically nonresectable unilobar hepatic metastases from colorectal cancer were treated with a sequentially combined approach of intrahepatic arterial chemotherapy followed by surgery. Partial regression (greater than or equal to 50%) induced by chemotherapy and associated with a decline in plasma carcinoembryonic antigen level was followed successfully by a complete hepatic tumor resection in three out of four patients. All three patients continue to be free of disease from 13+ to 21+ months. This combined approach may improve the salvage rate of patients with regionally confined hepatic metastases.


5. DOCID:7010 SCORE: 0.00410514466651338
DOCNO: 376097
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Neoplasm
DESCRIPTOR: Rheumatoid Factor
QUALIFIER: immunology
AUTHOR: A E Giuliano AE
AUTHOR: R Irie R
AUTHOR: D L Morton DL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Rheumatoid factor in melanoma patients: alterations of humoral tumor immunity in vitro.
PUBDATE: 19790501
Rheumatoid factors (RF) were associated with alterations of antibody reactions to melanoma cells in vitro by two serologic assays. Removal of RF from melanoma patients' sera by absorption with Cohn's Fraction II coated latex particles enhanced seroreactivity in the Immune Adherence (IA) assay and diminished IgM detection by the Indirect Membrane Immunofluorescence (IMI) assay. The addition of serum with high titers of RF to these assay systems led to diminution of IA reactivity and enhancement of IgM detection by IMI. Since these factors are found in cancer patients' sera and can alter humoral immune reactions directed against antigens on the membranes of tumor cells, their presence should be recognized when performing assays with tumor target cells. RF may be of significance in the host-tumor relationship in vivo.


6. DOCID:7149 SCORE: 0.00356001112023024
DOCNO: 7214362
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: drug effects
QUALIFIER: therapeutic use
AUTHOR: C van den Bogert C
AUTHOR: B H Dontje BH
AUTHOR: J J Wybenga JJ
AUTHOR: A M Kroon AM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Arrest of in vivo proliferation of Zajdela tumor cells by inhibition of mitochondrial protein synthesis.
PUBDATE: 19810501
The proliferation of Zajdela tumor cells, grown in vivo in Wistar rats, is arrested by low amounts of oxytetracycline. Oxytetracycline is administered by means of continuous infusion in such a way that the oxytetracycline concentration in serum and ascitic fluid is maintained at a level at which only mitochondrial protein synthesis is blocked. Under these conditions, Zajdela mitochondrial tumor cells cease dividing after a few cell generations, an event which is preceded by reduction of cytochrome c oxidase activity of the tumor cells. Toxicity to host tissues is limited to the immune system which is apparently suppressed by the drug. Even so, oxytetracycline might have therapeutic potential in human cancer therapy, especially because it does not influence the hemopoietic system.


7. DOCID:6585 SCORE: 0.00350656037308218
DOCNO: 7220407
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude to Health
DESCRIPTOR: Mass Screening
QUALIFIER: epidemiology
AUTHOR: T V Taylor TV
AUTHOR: S Rimmer S
AUTHOR: A P Forrest AP
PUBTYPE: Journal Article
JOURNALTITLE: Postgraduate medical journal.
COUNTRY: ENGLAND
TITLE: The patient's subjective attitude towards screening for breast cancer. Should screening be extended to other forms of cancer?
PUBDATE: 19801001
A sample of 500 consecutive women without symptoms of breast disease attending a breast screening clinic were investigated regarding their attitude to breast screening and to the extension of the screening programme to other forms of cancer. Attendance at the screening clinic was found to be reassuring by 94.2%, and 96.4% felt that the screening programme should be extended to include other forms of malignancy. There was a history of either respiratory or alimentary tract symptoms, and of smoking, or a family history of cancer in 41% of these women. The study shows that Edinburgh women are enthusiastic for breast screening and for its extension to include other forms of cancer.


8. DOCID:7546 SCORE: 0.00327378262736592
DOCNO: 420174
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: R P Sherwin RP
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical pathology.
COUNTRY: UNITED STATES
TITLE: Juxtanuclear lymphocytes in histocultures of mammary cancer.
PUBDATE: 19790101
Juxtanuclear lymphocytes in histocultures of mammary cancer. Am J Clin Pathol 71: 64-71, 1979. This is the first report of a special orientation of autochthonous lymphocytes at a juxtanuclear zone of human mammary cancer cells in primary histocultures. The phenomenon, juxtanuclear orientation of lymphocytes, was observed in 99 histocultures from 16 of 45 (35%) successfully explanted cancers. A total of 686 instances of juxtanuclear orientation of lymphocytes was counted, versus 354 instances of random lymphocytic activities; juxtanuclear/random ratios ranged from 0.2 to 5.2. Ratio determinations may be potentially useful for assistance in evaluating prognosis; the preliminary findings are inconclusive but suggest that a ratio of one or more may indicate a more favorable clinical course. The immediate importance of juxtanuclear orientation of lymphocytes is that it offers a new measurement of pathologic lymphocytic activity that should have applications in basic and clinical studies of host responses in general.


9. DOCID:7657 SCORE: 0.00321186573340809
DOCNO: 7233567
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: administration & dosage
QUALIFIER: analysis
AUTHOR: G Pizzocaro G
AUTHOR: M Valente M
AUTHOR: I Cataldo I
AUTHOR: P Vezzoni P
AUTHOR: G Di Fronzo G
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Estrogen receptors and MPA treatment in metastatic renal carcinoma. A preliminary report.
PUBDATE: 19801201
Ten previously untreated patients with metastatic renal carcinoma underwent transperitoneal radical nephrectomy followed by high dosage MPA treatment. Estrogen receptors were determined in the specimen of all cases by the dextran-coated charcoal method: both the neoplastic tissue and the healthy parenchyma were tested. The disease progressed in 8 cases, and 2 patients are alive without any evidence of progressive disease 12 and 27 months after the operation. Very low receptor levels were detected in these 2 cases and one of them could be defined as borderline with our threshold criterion. However, receptors were undetectable in the neoplastic tissue from 4 of 8 patients who progressed. These questionable results justified the start of a prospective multicentric trial to study in a large number of cases both hormone receptors and clinical response to hormone therapy in human renal cancer.


10. DOCID:7587 SCORE: 0.00320526588761198
DOCNO: 480383
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: National Institutes of Health (U.S.)
DESCRIPTOR: Neoplasms
DESCRIPTOR: Peer Review
DESCRIPTOR: Research Support
AUTHOR: J T Kalberer JT
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Treatment of young investigators in the National Cancer Program.
PUBDATE: 19791001
To ascertain whether young investigators (those 35 years of age and under) receive equitable treatment in the National Cancer Institute's (NCI) peer review process, we analyzed recommendation and award rates for new traditional grant applicants for 3 fiscal years (nine cycles of review). The more than 4,500 applications studied showed markedly higher recommendation and award rates for younger investigators than for senior scientists; a peak award rate differential of 15% was reached. The study also revealed that young scientists submitted just one-fourth of all the traditional grant applications sent to NCI and received less than one-third of the funds awarded. These results were consistent throughout the National Institutes of Health. As a follow-up, survey results are reported that assess researchers' attitudes and perceptions of the young scientist's role in the current biomedical review system.


11. DOCID:5762 SCORE: 0.00297884643309414
DOCNO: 7361768
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Periodicity
QUALIFIER: methods
AUTHOR: F Halberg F
AUTHOR: H F Kabat HF
AUTHOR: P Klein P
PUBTYPE: Journal Article
JOURNALTITLE: American journal of hospital pharmacy.
COUNTRY: UNITED STATES
TITLE: Chronopharmacology: a therapeutic frontier.
PUBDATE: 19800101
Chronopharmacology, the study of time-dependent physiological response to drugs, and its relationship to current drug therapy are discussed. The objective of chronotherapy is to apply chronobiologic principles to the treatment of human disease. The appropriate patients for chronotherapy are those who are receiving high-risk drugs, who have a high-risk disease (e.g., cancer) or who are receiving a high-cost drug. Although little is known of the chronobiologic characteristics of many drugs or diseases, researchers should take into account the possible relationship of chronobiology to drug effects when designing therapeutic trials. Drug therapy can be optimized by tailoring dosing schedules and distribution systems to chronobiologic patterns.


12. DOCID:6904 SCORE: 0.00293918497100495
DOCNO: 102146
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Technology, Radiologic
QUALIFIER: radiography
AUTHOR: B J Flehinger BJ
AUTHOR: M R Melamed MR
AUTHOR: R T Heelan RT
AUTHOR: C M McGinnis CM
AUTHOR: M B Zaman MB
AUTHOR: N Martini N
PUBTYPE: Journal Article
JOURNALTITLE: AJR. American journal of roentgenology.
COUNTRY: UNITED STATES
TITLE: Accuracy of chest film screening by technologists in the New York early lung cancer detection program.
PUBDATE: 19781001
A study of the feasibility of using specially trained radiologic technologists to screen chest radiographs was undertaken as part of an early lung cancer detection program. In their initial examination, 8,000 men had posteroanterior and lateral chest films which were prepared and evaluated by two specially trained technologists prior to interpretation by a radiologist. The technologists' accuracy in screening was subsequently assessed by comparison with the radiologist's interpretation and with clinical follow-up information. There were differences in the level of suspicion of the two technologists, but both were effective in selecting a subset of the screened population that contained the men with radiologically identifiable lung cancer.


13. DOCID:7979 SCORE: 0.00278136067562289
DOCNO: 205189
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mastectomy
QUALIFIER: therapy
QUALIFIER: administration & dosage
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: D Morris D
AUTHOR: J Aisner J
AUTHOR: E G Elias EG
AUTHOR: P H Wiernik PH
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Mastectomy as an adjunct to combination chemotherapy.
PUBDATE: 19780301
Three patients with metastatic breast carcinoma who had untreated locally advanced primary tumors were treated initially with combination chemotherapy followed by hygienic mastectomy. There was marked regression of the primary tumor in each case after chemotherapy, allowing for a technically simpler mastectomy without skin grafts. There were no serious postoperative complications, or delay in the resumption of systemic chemotherapy in any of them. The postoperative chemotherapy produced complete disappearance of the distant metastases and the patients remain clinically free of disease without local recurrence for 21, 10, and 7 months, respectively. One of these patients had inflammatory carcinoma and did well with this combined approach. These findings suggest a rationale for such an approach in patients with inflammatory carcinoma and may be applicable to patients with stage III breast cancer in whom the primary tumors are locally advanced and technically difficult to resect.


14. DOCID:6867 SCORE: 0.00277708776786894
DOCNO: 6945589
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pathology
QUALIFIER: pharmacology
AUTHOR: R Lim R
AUTHOR: S Nakagawa S
AUTHOR: B G Arnason BG
AUTHOR: D E Turriff DE
PUBTYPE: Journal Article
JOURNALTITLE: Proceedings of the National Academy of Sciences of the United States of America.
COUNTRY: UNITED STATES
TITLE: Glia maturation factor promotes contact inhibition in cancer cells.
PUBDATE: 19810701
The effect of bovine glia maturation factor on the growth pattern of cancer cells was investigated in the rat glioma cell line 354A. When the cells were grown in the serum-free defined medium N2 in the absence of the factor, the cells proliferated with a doubling time of 24 hr without showing contact inhibition. After reaching confluency, the cell layer formed numerous foci from which heaps of cell colonies arose. The addition of glia maturation factor to the culture stimulated cell division in the logarithmic phase but prevented overgrowth once the cells arrived at confluency. The ability of glia maturation factor to restore contact inhibition suggests a regulatory role in normal and neoplastic cells.