0. DOCID:3859 SCORE: 0.00634097993423009
DOCNO: 890684
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
QUALIFIER: toxicity
QUALIFIER: toxicity
QUALIFIER: chemically induced
AUTHOR: T J Slaga TJ
AUTHOR: A Viaje A
AUTHOR: W M Bracken WM
AUTHOR: D L Berry DL
AUTHOR: S M Fischer SM
AUTHOR: D R Miller DR
AUTHOR: S M Leclerc SM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: NETHERLANDS
TITLE: Skin-tumor-initiating ability of benzo(a)pyrene-7,8-diol-9,10-epoxide (anti) when applied topically in tetrahydrofuran.
PUBDATE: 19770701
The skin-tumor-initiating abilities of various metabolites of benzo(a)pyrene (BP) were determined in mice by using a two-stage system of tumorigenesis. We previously reported that BP-7,8-dihydrodiol (+/- trans) was approximately as potent as BP, suggesting that it may be a proximate carcinogen, but the alleged ultimate carcinogen of BP [BP-7,8-dihydrodiol-9,10-epoxide (anti)] was a weak tumor initiator (Cancer Lett.2: 115, 1976). Because of its high reactivity, the tumor-initiating ability of the BP-7,8-dihydrodiol-9,10-epoxide (anti) was determined by using acetone, benzene, and tetrahydrofuran (THF) as the solvent vehicles. The 'diol-epoxide' of BP was found to be an effective tumor initiator when applied topically in THF. The effectiveness of the various vehicles for the 'diol-epoxide' was as follows: THF greater than benzene greater than acetone; however, acetone was the best solvent for BP tumor initiation. The BP-9,10-dihydrodiol and BP-3-hydroxy were found to be weak tumor initiators. BP-3-hydroxy was also tested for tumor-promoting ability and was found to be inactive in this capacity.

1. DOCID:3395 SCORE: 0.00409199444768006
DOCNO: 1087457
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: U Trabert U
AUTHOR: M Rosenthal M
AUTHOR: W Müller W
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Therapy of inflammatory-rheumatic diseases with levamisol, an immunity modulating substance]
PUBDATE: 19760901
Since cellular and humoral immune mechanisms were shown to be involved in the pathogenesis of rheumatic diseases, efforts have been made to influence these systems therapeutically. Aside from suppression of the immune response, studies have been conducted to evaluate to what extent immunostimulation might be of value in the treatment of rheumatic diseases. Levamisole, chemically a simple synthetic agent recently shown to have immunorestorative capacities in anergic cancer patients, has been administered in several rheumatic diseases. The drug was administered either continuously or intermittently in a daily dose of 150 mg over several months. In about half of the rheumatoid arthritis patients a significant improvement was noted. Beneficial effects and sometimes even dramatic improvement lere observed in some patients with systemic lupus erythematosus, ankylosing spondylitis and Reiter's syndrome. Levamisole did not alter the course of psoriatic arthritis. Significant adverse reactions were leukopenia and allergic skin reactions. Other side effects were mild and did not require interruption of drug intake. The use of levamisole in rheumatic diseases is still experimental, but with accumulating experience it may provide a true improvement in control of rheumatic diseases.

2. DOCID:2713 SCORE: 0.00389947294195058
DOCNO: 837371
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
AUTHOR: R M DePhilip RM
AUTHOR: W E Lynch WE
AUTHOR: I Lieberman I
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Nuclear DNA polymerases of human carcinomas.
PUBDATE: 19770301
Comparisons have been made of the DNA polymerases of normal human lung and cecum, primary carcinomas of human lung, breast, and cecum, and resting and regeneration rat liver. The picture for the normal human tissues is similar to the one for unstimulated rat liver, that for the human carcinomas resembles regenerating rat liver. The human tissues contain two polymerases with sedimentation coefficients of about 3 and 7 S, the enzymes are restricted to the nucleus, and the specific activities of the 7 S polymerase, but not of the 3 S enzyme, are elevated in the cancers. Just as with the regenerating rat liver polymerases, the 3 S activity of a bronchogenic carcinoma is unaffected by cytosine arabinoside 5'-triphosphate and only little reduced by novobiocin, whereas DNA synthesis by the 7 S enzyme is abolished by both compounds. A variety of other inhibitory agents have similar effects on the 7 S polymerases of the human carcinomas and regenerating rat liver.

3. DOCID:1623 SCORE: 0.00380706585807461
DOCNO: 804014
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: Y Gorsky Y
AUTHOR: D Sulitzeanu D
PUBTYPE: Journal Article
JOURNALTITLE: Journal of immunological methods.
COUNTRY: NETHERLANDS
TITLE: A radioactive antibody binding-inhibition assay, for the detection of cell-membrane related antigens in body fluids.
PUBDATE: 19750101
Antisera raised in rabbits against glutaraldehyde-fixed human breast cancer cells contain antibodies to human cell membrane components, as determined by immunofluorescence. Adsorption of such antisera onto polymerized human serum, followed by acid elution, yields purified antibodies reacting with human cell surface antigens, indicating that membrane related antigens are present in the serum. The purified antibodies were radioiodinated and shown to bind to an immunoadsorbent prepared by entrapping in a polyacrylamide gel pleural exudate of breast cancer patients. The specificity of the binding was confirmed by inhibition experiments. Data are presented demonstrating that at least some of the antibodies reacting in this radioimmunoassay are directed against antigens related to cell surface components.

4. DOCID:3805 SCORE: 0.00379563260091627
DOCNO: 56226
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigens, Neoplasm
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A C Hollinshead AC
AUTHOR: P B Chretien PB
AUTHOR: O B Lee OB
AUTHOR: J L Tarpley JL
AUTHOR: S E Kerney SE
AUTHOR: N A Silverman NA
AUTHOR: J C Alexander JC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: In vivo and in vitro measurements of the relationship of human squamous carcinomas to herpes simplex virus tumor-associated antigens.
PUBDATE: 19760201
An additional 244 unfiltered sera have now been studied in a series of controlled, coded tests to determine the relationship of squamous carcinomas of the head and neck and cervix to the presence of complement-fixing antibodies to herpesvirus-tumor-associated antigens (HSV-TAA) in both tumor-bearing and cured patients. Ninety % of sera from patients with squamous carcinomas had antibodies to HSV-TAA, in contrast to 11% of sera from patients with nonsquamous cancers and 4% of sera from noraml individuals. The temporal relationship of Stage 1 laryngeal carcinomas suggests that HSV-TAA appearance precedes the immune defects. An in vitro correlate of the previously demonstrated specific delayed hypersensitivity reactions in controlled skin tests of squamous carcinoma patients with HSV-TAA is reported. In leukocyte migration inhibition tests, the migration indices after incubation with HSV-TAA of peripheral blood leukocytes from patients with squamous carcinoma (x = 0.847) were in definite contrast to migration indices seen for normal leukocytes (x = 1.037) and patients with nonsquamous solid cancers (x = 1.03). Thus, these polypeptides elicit both humoral antibody response and cell-mediated reactivity.

5. DOCID:1937 SCORE: 0.00372106999938965
DOCNO: 866900
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: methods
AUTHOR: M Vider M
AUTHOR: F H DeLand FH
AUTHOR: Y Maruyama Y
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Revista interamericana de radiología.
COUNTRY: UNITED STATES
TITLE: Metastases in colo-rectal carcinoma by isotope bone scanning.
PUBDATE: 19770401
Eight of ten cases of colo-rectal cancer having positive radionuclide bone scans were observed in a Radiation Oncology Clinic in one year. Eight were referred to the institution after treatment elsewhere. In a series of fifty cases with their definitive therapy and evaluation at this institution, 33% of those with bone scans were positive. Review of recent literature shows that 50% of colo-rectal carcinoma have positive bone scans, usually following a multiple and widespread distribution including ribs, pelvis, vertebrae, skull or extremities. These studies indicate that bone scanning may greatly increase precision in staging of colo-rectal carcinoma and aid in the recognition of the truly localized primary lesion. The mechanism of spread of bone metastases in colo-rectal carcinoma was presumably through Batson's plexus.

6. DOCID:2044 SCORE: 0.00365518064492728
DOCNO: 1062970
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
QUALIFIER: mortality
AUTHOR: C G Kardinal CG
AUTHOR: J R Bateman JR
AUTHOR: J Weiner J
PUBTYPE: Journal Article
JOURNALTITLE: Archives of internal medicine.
COUNTRY: UNITED STATES
TITLE: Chronic granulocytic leukemia. Review of 536 cases.
PUBDATE: 19760301
The Western Cancer Study Group (WCSG) retrospectively reviewed chronic granulocytic leukemia (CGL) diagnosed during 1960 to 1974 from 22 institutions. In 100 cases, patients had positive findings for the Philadelphia chromosome (Ph'+). In 426 cases karyotyping was not done (Ph'?). Ten patients had no Ph' chromosome (Ph'-). The ten Ph'- patients ranged in age from 8 to 85 years and in survival from 1 to more than 125 months. Their small number and heterogeneity precluded statistical analysis, but this notable heterogeneity of the Ph'- group may well be typical. Busulfan prolonged survival in the Ph'+ and Ph'? patients. Females and younger patients tolerated their disease better than males and older patients. Survival studies without reference to the Ph' status, treatment, age at diagnosis, and sex are probably not valid.

7. DOCID:3733 SCORE: 0.00359557720118324
DOCNO: 1192400
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nutrition
QUALIFIER: epidemiology
AUTHOR: J E Dunn JE
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Cancer epidemiology in populations of the United States--with emphasis on Hawaii and California--and Japan.
PUBDATE: 19751101
The population of California and the San Francisco Bay Area has a number of ethnic components that differ in the frequency with which certain cancers occur. Mortality rates of California Janpanese and incidence data from the cancer reporting system of the Bay Area are analyzed for the cancer sites considered related to nutrition. The American Japanese of California are particularly amenable to epidemiological study because of the cancer data available from Japan for comparison with that of the California Japanese. The cancer rates occurring among the successive generations of the Japanese in California are compared to the rates in Japan and the white rates for the Bay Area. Gastric cancer rates undergo a stepwise reduction from the high rates in Japan to the intermediate rates of immigrant Japanese and the lower rates for the American born. Colon cancer rates are increased about equally in both generations of Japanese and are approaching the white rates. Cancers of the breast, uterine corpus, and ovary in women and the prostate for men are rapidly approaching the rates for the white population. Etiologies are continually being identified or indicated for a number of these cancers by epidemiological studies, and more specific identification of carcinogenic mechanisms should be possible by other disciplines.

8. DOCID:3965 SCORE: 0.00319227263475955
DOCNO: 1083868
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibody Formation
DESCRIPTOR: Immunosuppression
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
QUALIFIER: biosynthesis
QUALIFIER: immunology
AUTHOR: K Takatsu K
AUTHOR: K Ishizaka K
PUBTYPE: Journal Article
JOURNALTITLE: Journal of immunology (Baltimore, Md. : 1950)
COUNTRY: UNITED STATES
TITLE: Reaginic antibody formation in the mouse. VII. Induction of suppressor T cells for IgE and IgG antibody responses.
PUBDATE: 19760501
Intravenous injections of urea-denatured ovalbumin (UD-OA) into OA-primed high responder mice suppressed the antibody response not only to the priming antigen but also to subsequent immunization with dinitrophenyl derivatives of OA (DNP-OA). The transfer of normal spleen cells or OA-primed spleen cells into UD-OA-treated animals did not restore the capacity of responding to DNP-OA to form anti-DNP IgE and IgG antibodies. The transfer of splenic T cell fraction from the UD-OA-treated animals into normal syngeneic mice diminished both IgE and IgG antibody responses of the recipients to DNP-OA. The B cell-rich fraction from the same donors failed to affect the anti-hapten antibody response and enhanced anti-cancer (OA) IgG antibody response of the recipients. It was also found that the transfer of T cell-rich fraction of OA-primed spleen cells failed to suppress antibody response of the recipients to DNP-OA. The results indicated that spleen cells of UD-OA-treated mice contained suppressor T cells which are distinct from helper cells. Suppressive activity of T cells in the UD-OA treated animals was specific for OA. The transfer of the T cell-rich fraction failed to suppress anti-DNP antibody response of the recipients to DNP-KLH.

9. DOCID:1485 SCORE: 0.00307543133501028
DOCNO: 184553
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: J I Levy JI
AUTHOR: E W Geddes EW
AUTHOR: M C Kew MC
PUBTYPE: Journal Article
JOURNALTITLE: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
COUNTRY: SOUTH AFRICA
TITLE: The chest radiograph in primary liver cancer: an analysis of 449 cases.
PUBDATE: 19760801
The value of plain chest radiography in the diagnosis of primary hepatocellular cancer (PHC) was assessed in 449 patients. An elevated right hemidiaphragm and pulmonary metastases were present in 11% and strongly suggest a diagnosis of PHC. In all, the right hemidiaphragm was raised in 30% of patients. Pulmonary metastases were present on admission in 19% of patients and appeared later in a further 6%. Secondary deposits were found in the lungs at necropsy in 52% of patients, compared with only 24% in whom there was radiological evidence of metastases during life. In 36% of patients chest radiographs were normal on admission.

10. DOCID:2427 SCORE: 0.00305053984953928
DOCNO: 922118
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: RNA, Ribosomal
DESCRIPTOR: RNA, Transfer
QUALIFIER: metabolism
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: J E Besson JE
AUTHOR: J Briere J
AUTHOR: J Radisson J
AUTHOR: A M Chambosse AM
AUTHOR: N Dutrieux N
AUTHOR: M Berger M
PUBTYPE: Journal Article
JOURNALTITLE: Biomedicine / [publiée pour l'A.A.I.C.I.G.].
COUNTRY: FRANCE
TITLE: Ribosomal and transfer RNA contents of the normal and pathologic human thyroid gland.
PUBDATE: 19770701
One hundred and seventy seven pieces of normal or pathologic thyroid tissue from 17 patients were assayed for rRNA, tRNA and DNA content. The tRNA/DNA and rRNA/DNA ratios in pathologic tissue were statistically compared with the same ratios in normal tissue. In toxic adenoma (5 cases) and anoplastic cancer (2 cases), both ratios were increased. In cold nodules (9 cases), there was in increase of the tRNA/DNA ratio only in 1 case, of the rRNA/DNA ratio only in 4 cases, and of both ratios in 3 cases. In one case of a cold nodule in a Basedow's disease gland, there was no modification of these ratios. In Basedow's disease (3 cases), there was an increase of rRNA/DNA ratio only in one case.

11. DOCID:2914 SCORE: 0.00303680191881682
DOCNO: 875870
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: H Langhammer H
AUTHOR: R Sintermann R
AUTHOR: K Kempken K
AUTHOR: G Hör G
AUTHOR: H W Pabst HW
AUTHOR: M Fendl M
PUBTYPE: Journal Article
JOURNALTITLE: Medizinische Klinik.
COUNTRY: GERMANY, WEST
TITLE: [Diagnosis of skeletal metastases in prostatic cancer using gamma camera (author's transl)]
PUBDATE: 19770501
On 170 patients with histologically proven carcinoma of the prostate scintigraphic studies of the skeleton using gamma camera and follow-up examinations were performed and compared with x-ray as well as serum alkaline and acid phosphatase. Osseous metastases in 47% had no radiological evidence and were only scintigraphically detectable. Positive scans were registered in 48% of the patients with prostatic cancer, 20% of them were positive due to metastases and 28% were false positive caused by osteoarthrotic and arthritic changes, sporadically by post-traumatic lesions and in 3 cases by Paget's disease. At the time of the initial diagnosis of prostatic cancer 21% of 159 patients studied scintigraphically had radiological or scan evidence of osseous metastases. Analyses corresponding stages of tumor revealed an unequivocal dependance of the frequency of metastases upon the extent of the primary tumor. The successful treatment is characterized by the decreased uptake of radioactivity primarily accumulated in skeletal metastases.

12. DOCID:2137 SCORE: 0.00294470166023013
DOCNO: 889680
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: O M Jensen OM
AUTHOR: C S Muir CS
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Cancer in Yogyakarta, Indonesia: relative frequencies.
PUBDATE: 19770701
Some 1220 male and 2102 female cases of malignant neoplasms diagnosed histologically at the Department of Pathology of the Gadjah Mada University in Yogyakarta during the period 1970-73 were analysed. The most frequent tumour sites were among men: nasopharyngeal cancer, 21-8% and skin cancer, 17-6%. Among women the genital cancers were the most frequent with: cervix uteri, 25-7% chorionepithelioma, 3-7%, other uterus, 4-4% and ovary, 7-4%. Breast cancer comprised 17-0%, skin 9-6% and nasopharyngeal cancer 7-9%. Low frequencies were observed in both sexes for cancers of the gastro-intestinal tract and of the respiratory organs; previous reports of the rarity of gastric cancer were confirmed. The observed distribution is discussed in the light of possible biases, and compared with other material on the frequency of cancer from South East Asia.

13. DOCID:1783 SCORE: 0.00292048273154546
DOCNO: 877534
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: W Weber W
AUTHOR: G A Nagel GA
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Adjuvant chemotherapy of the colonic and rectal carcinoma: concepts and uptodate results]
PUBDATE: 19770601
The aim of adjuvant chemotherapy is the destruction of micrometastases after surgical removal of a malignant tumor. This treatment modality is gaining in importance in the light of experimental data and lcinical success in pediatric tumors. Results of ongoing studies in colo-rectal cancer show a marginal effect of prophylactic treatment with 5-fluorouracil. The treatment benefits in trials with historical controls are much greater than in studies with simultaneous controls. Use of historical controls is therefore of doubtful value. Ongoing trials use the combination of 5-fluorouracil and methyl-CCNU, which has been shown to double the remission rate in advanced gastrointestinal cancer. Adjuvant chemotherapy of colo-rectal cancer is still experimental and justified only in the framework of clinical trials.

14. DOCID:3071 SCORE: 0.00284440010701773
DOCNO: 1176207
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Transplantation
QUALIFIER: pathology
AUTHOR: C Merenda C
AUTHOR: B Sordat B
AUTHOR: J P Mach JP
AUTHOR: S Carrel S
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Human endometrial carcinomas serially transplanted in nude mice and established in continuous cell lines.
PUBDATE: 19751001
Three out of five human endometrial carcinomas were successfully grafted into nude mice (BALB/c/nu/nu). Two of these tumors could be maintained by serial transplantation. The morphological characteristics displayed by the grafted tumors were comparable to those of the original carcinomas. Permanent cell lines were established from these two tumors. Reinjection of cells grown in vitro into nude mice produced nodules of identical histology as compared to original solid transplants. The influence of medroxyprogesterone acetate on tumor growth in vivo and cell proliferation in vitro was studied. This hormonal treatment did not produce any significant effect on tumor cells, either in vitro or in vivo, for the two endometrial carcinomas. After medroxyprogesterone administration, a slight but non-significant growth inhibition of the tumor cells in vitro was observed and the tumor transplants in vivo did not appear to be influenced. The experiments illustrate the possible use of this model for testing potential anti-cancer agents.