0. DOCID:31626 SCORE: 0.0055415422880045
DOCNO: 16258468
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Marcel Levi M
AFFILIATION: Academic Medical Center, 1105 AZ Amsterdam, the Netherlands. m.m.levi@amc.uva.nl.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical advances in hematology & oncology : H&O
COUNTRY: United States
TITLE: Cancer and thrombosis.
PUBDATE: 20031101
Cancer is frequently complicated by thrombosis, which may even be the first sign of an unrecognized cancer. There are several risk factors for cancer-associated thrombosis, such as type of malignancy, the presence of metastatic disease, and the use of chemotherapy. In most patients with cancer, a procoagulant state can be identified, ranging from subclinical laboratory abnormalities to full-blown disseminated intravascular coagulation. A specific entity is the occurrence of thrombotic microangiopathy that is specifi cally related to (high-dose) chemotherapy and radiotherapy. The pathogenetic pathways that play a role in the cancer-associated coagulopathy have been identified in recent years.


1. DOCID:29469 SCORE: 0.00426532552295475
DOCNO: 16274525
OWNER: NLM
STATUS: In-Process
AUTHOR: Philippe E Spiess PE
AUTHOR: Wassim Kassouf W
AUTHOR: Khoday Tukaram K
AUTHOR: Indrojit Roy I
AFFILIATION: Department of Urology, Saint Mary's Hospital, McGill University, Montreal, Quebec, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: The Canadian journal of urology.
COUNTRY: Canada
TITLE: Metastatic umbilical mass from transitional cell carcinoma of the bladder.
PUBDATE: 20051001
We present the case of an 83-year-old female presenting with an umbilical mass measuring 2 cm x 3 cm. This patient had an extensive prior history of transitional cell carcinoma of the bladder. A fine needle aspiration of this umbilical mass confirmed this to be metastatic transitional cell carcinoma and the diagnostic workup demonstrated the presence of invasive bladder cancer with metastatic liver lesions.


2. DOCID:27957 SCORE: 0.00336827515183928
DOCNO: 9512826
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M Lishner M
AUTHOR: G Koren G
AFFILIATION: Hospital for Sick Children, Toronto.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Canadian family physician Médecin de famille canadien.
COUNTRY: CANADA
TITLE: Breast cancer during pregnancy. Approach to rational management.
PUBDATE: 19980201
QUESTION: A 35-year-old woman attending my clinic in the 20th week of pregnancy had a lump in her breast. Open biopsy revealed ductal carcinoma. Radical mastectomy with axillary lymph node biopsy showed three out of 10 nodes positive. What are the short- and long-term implications of chemotherapy during pregnancy? ANSWER: Patients with breast cancer during pregnancy should be treated using the same criteria as their nonpregnant counterparts, with the modifications required by pregnancy. The benefits of the diagnostic workup and use of chemotherapy, radiotherapy, and surgery have to be weighed carefully against their risk to the unborn baby.


3. DOCID:31698 SCORE: 0.00335998064132005
DOCNO: 12428399
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: pathology
AUTHOR: Takashige Kuraki T
AUTHOR: Hideo Kobayashi H
AUTHOR: Keigo Takagi K
AUTHOR: Shinsuke Aida S
AFFILIATION: Third Department of Internal Medicine, National Defence Medical College, Tokorozawa-shi, Saitama-ken 359, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society.
COUNTRY: Japan
TITLE: [A case of lung cancer with cyst formation]
PUBDATE: 20020801
A 70-year-old man was admitted with a nodule adjacent to a cystic lesion in the right lower lung field. Diagnosis of lung cancer was made by transbronchial biopsy. A series of chest radiographs revealed that a cystic lesion had presented 8 years before, and that a nodule appeared on the hilar side of the cyst 5 years later. The cyst may have been formed by the check-valve mechanism due to the lung cancer.


4. DOCID:27331 SCORE: 0.0032182166621738
DOCNO: 11769474
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: diagnosis
QUALIFIER: genetics
AUTHOR: T Ito T
AUTHOR: Y Okubo Y
AUTHOR: M Tachibana M
AFFILIATION: Department of Urology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023.
PUBTYPE: Journal Article
JOURNALTITLE: Rinsho byori. The Japanese journal of clinical pathology.
COUNTRY: Japan
TITLE: [Detection of PSA mRNA in prostate cancer patients' blood]
PUBDATE: 20011001
A sensitive technique using reverse transcriptase-polymerase chain reaction (RT-PCR) for PSA mRNA has been used to detect circulating tumor cells in the peripheral blood of prostate cancer patients. We evaluated the clinical utility of this method for staging and monitoring for prostate cancer. The number of patients who were RT-PCR positive was increased in higher clinical stages. This technique may provide useful information for treating patients with prostate cancer, especially candidates for radical prostatectomy. Confirming the value of this modality as a prognostic factor will require further study.


5. DOCID:31594 SCORE: 0.00299284792989632
DOCNO: 12495846
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Disease
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: Matthew J Wishart MJ
AUTHOR: Jack E Dixon JE
AFFILIATION: Dept of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-0606, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in cell biology.
COUNTRY: England
TITLE: PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease.
PUBDATE: 20021201
The phosphatase and tensin homolog deleted on chromosome ten (PTEN) and myotubularin (MTM1) represent subfamilies of protein tyrosine phosphatases whose principal physiological substrates are D3-phosphorylated inositol phospholipids. As lipid phosphatases, PTEN- and MTM1-related (MTMR) proteins dephosphorylate the products of phosphoinositide 3-kinases and antagonize downstream effectors that utilize 3-phosphoinositides as ligands for protein targeting domains or allosteric activation. Here, we describe the cellular mechanisms of PTEN and MTMR function and their role in the etiology of cancer and other human diseases.


6. DOCID:31039 SCORE: 0.00299281611655773
DOCNO: 16200194
OWNER: NLM
STATUS: In-Process
AUTHOR: Ravi Amaravadi R
AUTHOR: Craig B Thompson CB
AFFILIATION: Abramson Family Cancer Research Institute, Department of Cancer Biology and Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of clinical investigation.
COUNTRY: United States
TITLE: The survival kinases Akt and Pim as potential pharmacological targets.
PUBDATE: 20051001
The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.


7. DOCID:30048 SCORE: 0.0029397126910342
DOCNO: 16229380
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: blood supply
QUALIFIER: etiology
QUALIFIER: pathology
AUTHOR: Teruo Inamoto T
AUTHOR: Haruhito Azuma H
AUTHOR: Yusaku Iwamoto Y
AUTHOR: Takeshi Sakamoto T
AUTHOR: Yoji Katsuoka Y
AFFILIATION: The Department of Urology, Osaka Medical College.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: Japan
TITLE: A rare case of penile metastasis of testicular cancer presented with priapism.
PUBDATE: 20050901
Priapism is thought as a condition of penile erection that persists beyond or is unrelated to sexual stimulation. Commonly two different entities of priapism are known, one is low-flow priapism and the other is high-flow priapism. It is important to distinguish these two conditions for the subsequent different treatments. We report a rare case of an indistinguishable priapism caused by penile metastasis of testicular cancer.


8. DOCID:27575 SCORE: 0.00289097706364174
DOCNO: 10786894
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
AUTHOR: C Sarto C
AUTHOR: P A Binz PA
AUTHOR: P Mocarelli P
AFFILIATION: University Department of Clinical Pathology, Desio Hospital, Desio-Milan, Italy. sarto@uds.unimib.it
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Electrophoresis.
COUNTRY: GERMANY
TITLE: Heat shock proteins in human cancer.
PUBDATE: 20000401
The heat shock proteins (hsp) are ubiquitous molecules induced in cells exposed to sublethal heat shock, present in all living cells, and highly conserved during evolution. Their function is to protect cells from environmental stress damage by binding to partially denatured proteins, dissociating protein aggregates, to regulate the correct folding, and to cooperate in transporting newly synthesized polypeptides to the target organelles. The molecular chaperones are involved in numerous diseases, including cancer, revealing changes of expression. In this review, we mainly describe the relationship of hsp expression with human cancer, and discuss what is known about their post-translational modifications according to malignancies.


9. DOCID:30598 SCORE: 0.00279369263554012
DOCNO: 16099785
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, ras
DESCRIPTOR: Mutation
QUALIFIER: genetics
AUTHOR: A B Hassan AB
AUTHOR: C Paraskeva C
AFFILIATION: Department of Cellular and Molecular Medicine (formerly Pathology and Microbiology), School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK. Bass.Hassan@Bristol.ac.uk
PUBTYPE: Journal Article
JOURNALTITLE: Gut.
COUNTRY: England
TITLE: Colorectal cancer prognosis: is it all mutation, mutation, mutation?
PUBDATE: 20050901
For the 500,000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts. K-ras, but not p53 or APC, mutations appear to be associated with poorer overall survival in colorectal cancer patients.


10. DOCID:29297 SCORE: 0.0027446726494684
DOCNO: 15164869
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Oncologic Nursing
AUTHOR: Joanne Itano J
PUBTYPE: Journal Article
JOURNALTITLE: Hawaii medical journal.
COUNTRY: United States
TITLE: Oncology nurses ... who are we?
PUBDATE: 20040401
Oncology nursing has matured into a well-established specialty in nursing. The scope of practice for the oncology nurse is broad and spans the continuum of cancer care. Oncology nurses have important roles in all aspects of cancer care. The ONS is the largest organization of oncology professionals in the United States with a membership of about 30,000 and has contributed to the development of oncology nursing through its many educational programs, support of research, opportunities for networking, establishment of certification examinations, and development of an active foundation.


11. DOCID:31380 SCORE: 0.00271183037191059
DOCNO: 15649090
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: instrumentation
QUALIFIER: methods
QUALIFIER: diagnostic use
AUTHOR: Elise C Fear EC
AFFILIATION: Electrical and Computer Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada. fear@ucalgary.ca
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Technology in cancer research & treatment.
COUNTRY: United States
TITLE: Microwave imaging of the breast.
PUBDATE: 20050201
Microwave imaging for medical applications has been of interest for many years. Recently, microwave imaging for breast cancer detection has gained attention due to advances in imaging algorithms, microwave hardware and computational power. The breast is relatively translucent to microwaves, accessible for imaging, and there appears to be a significant electromagnetic property contrast between tumors and healthy tissues. Therefore, breast imaging may be the first clinically viable application of microwave imaging. This paper reviews recent developments in passive, hybrid, and active approaches to microwave breast cancer detection.


12. DOCID:29265 SCORE: 0.00260231455687258
DOCNO: 12360192
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: Gary Thomas G
AFFILIATION: Vollum Institute, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. thomasg@ohsu.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Molecular cell biology.
COUNTRY: England
TITLE: Furin at the cutting edge: from protein traffic to embryogenesis and disease.
PUBDATE: 20021001
Furin catalyses a simple biochemical reaction--the proteolytic maturation of proprotein substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and important roles in homeostasis, as well as in diseases ranging from Alzheimer's disease and cancer to anthrax and Ebola fever. This review summarizes various features of furin--its structural and enzymatic properties, intracellular localization, trafficking, substrates, and roles in vivo.


13. DOCID:27382 SCORE: 0.00258652887192637
DOCNO: 12532841
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: W Wang W
AUTHOR: T J Tong TJ
AFFILIATION: Department of Biochemistry and Molecular Biology, Beijing Medical University, Beijing 100083.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Sheng li ke xue jin zhan [Progress in physiology].
COUNTRY: China
TITLE: [The key enzyme of cholesterol synthesis pathway: HMG-CoA reductase and disease]
PUBDATE: 19990101
In eukaryotes, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a key enzyme that catalyses the synthesis of a precusor of cholesterol as well as non-sterol isoprenoids, mevalonate. The regulation of the enzyme activity occurs at the transcription, post-transcription, translation and protein degradation levels. Cholesterol contributes to the generation and development of atherosclerosis while non-sterol isoprenoids play a role in regulation of cell proliferation, signal transduction and generation of cancers. At present, the enzyme is the target of several drugs effective against atherosclerosis.


14. DOCID:29176 SCORE: 0.00249361988653526
DOCNO: 16231245
OWNER: NLM
STATUS: In-Process
AUTHOR: T Stripf T
AUTHOR: B M Lippert BM
AFFILIATION: Universitätsklinik und Poliklinik für HNO-Heilkunde, Universität Mainz. stripf@hno.klinik.uni-mainz.de
PUBTYPE: Journal Article
JOURNALTITLE: Laryngo- rhino- otologie.
COUNTRY: Germany
TITLE: [Nutrition in patients with head and neck cancer]
PUBDATE: 20051001
Nutrition in Patients with Head and Neck Cancer. Malnutrition is common in patients with head and neck cancer. Due to natural course of disease or therapy, malnutrition may increase. This leads to a reduced prognosis, quality of life, and should be considered in early stages of the disease. First choice is an enteral feeding via a nasogastral feeding tube or a PEG. In special cases a parenteral nutrition may be necessary.