0. DOCID:19287 SCORE: 0.00591290212692053
DOCNO: 8248009
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: prevention & control
QUALIFIER: toxicity
QUALIFIER: therapeutic use
AUTHOR: Y Nagai Y
AUTHOR: T Horie T
AUTHOR: S Awazu S
AFFILIATION: Department of Biopharmaceutics, Tokyo College of Pharmacy, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Pharmacology & toxicology.
COUNTRY: DENMARK
TITLE: Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.
PUBDATE: 19930801
The effects of vitamin A on methotrexate treatment of mice inoculated with L1210 leukaemia cells or sarcoma 180 cells were studied. The small intestine of tumour transplanted mice was severely damaged after methotrexate treatment. Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage. The protective effect of vitamin A was histologically and biochemically demonstrated. Further, coadministration of vitamin A did not inhibit in vivo antitumour activity of methotrexate. Thus, biochemical modulation used to prevent methotrexate-induced malabsorption by vitamin A coadministration will be of great use in methotrexate cancer chemotherapy.

1. DOCID:17077 SCORE: 0.00462011929310087
DOCNO: 2261906
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinoma, Papillary
DESCRIPTOR: Thyroid Neoplasms
AUTHOR: I D Hay ID
AFFILIATION: Mayo Medical School, Rochester, Minnesota.
PUBTYPE: Journal Article
JOURNALTITLE: Endocrinology and metabolism clinics of North America.
COUNTRY: UNITED STATES
TITLE: Papillary thyroid carcinoma.
PUBDATE: 19900901
Multiple prognostic factors for outcome in papillary thyroid carcinoma are identified. For a cohort of 1500 consecutive patients followed an average of 16 years, survival rates for tumor recurrence and cause-specific mortality are described. Risk groups derived from novel prognostic scoring or staging systems and the role of DNA ploidy testing are discussed specifically. Lastly, controversies are reviewed regarding the extent of primary surgical resection and the efficacy of postoperative radioiodine remnant ablation in papillary thyroid cancer.

2. DOCID:23163 SCORE: 0.00419121240564207
DOCNO: 8719368
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: V Vatne V
AUTHOR: H Maartmann-Moe H
AUTHOR: J Hoestmark J
AFFILIATION: Dept. of Surgery, Gade Institute, Haukeland University Hospital, Bergen, Norway.
PUBTYPE: Journal Article
JOURNALTITLE: Scandinavian journal of urology and nephrology.
COUNTRY: SWEDEN
TITLE: The prognostic value of p53 in superficially infiltrating transitional cell carcinoma.
PUBDATE: 19951201
Approximately 1/3 of T1 bladder cancers treated by endoscopic resection alone will progress. Prognostic factors are needed to help selecting appropriate treatment for these tumors. The purpose of the present investigation was to study the relation between p53 nuclear overexpression and disease progression. Tumors from 59 patients were studied by means of immunohistochemical nuclear staining. Forty tumors showed p53 nuclear overexpression while 19 tumors scored negative for mutations. We could not demonstrate any correlation between mutations of the p53 protein and tumor grading. p53 nuclear overexpression was not related to disease progression.

3. DOCID:22296 SCORE: 0.00373058756960387
DOCNO: 8720345
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: radiography
AUTHOR: C Campisi C
AUTHOR: A Soluri A
AUTHOR: S Terenzi S
AUTHOR: A Zappalà A
AUTHOR: S Zinevrakis S
AFFILIATION: Istituto di Technologie Biomediche, Università degli Studi di Roma.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: La Clinica terapeutica.
COUNTRY: ITALY
TITLE: [Morphometric analysis of mammographic images in clinical oncology]
PUBDATE: 19951101
The three standard projections relative to mammographies of 40 patients with breast cancer pre-operatively classified as T1-T2 were analyzed by computerized morphometric elaborations. This method si able to better define view of images, permetting pre-operative connection of staging, with an increment of 30% if confronted with histologic TNM (pTNM). The utilization of method is discussed to evaluate the best way for the local definition of tumor extension, permitting to use a correctly conservative surgery (quadrantectomy, tumorectomy) in a greater number of patients.

4. DOCID:18500 SCORE: 0.00368849875463287
DOCNO: 1537014
AUTHOR: D J Shaw DJ
AUTHOR: R F Czaja RF
AFFILIATION: School of Library and Information Science, Indiana University, Bloomington 47405.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin of the Medical Library Association.
COUNTRY: UNITED STATES
TITLE: User interactions with the PDQ cancer information system.
PUBDATE: 19920101
Searches by end users and intermediaries on the online PDQ (Physician Data Query) cancer information system were observed. With the National Library of Medicine (NLM) menu-based interface, end users (physicians) averaged fewer steps per question, while with the BRS command-drive interface, intermediaries appeared to be more efficient. Cancer Information Service (CIS) searchers, who have more PDQ experience than end users or intermediaries, made greater use of command stacking to anticipate menu selections. Retrieval was more complete in the NLM system, where both the menus and predefined print formats assisted the searchers.

5. DOCID:16944 SCORE: 0.00323425790566696
DOCNO: 1757281
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: H J Bashein HJ
AUTHOR: P Ginsberg P
AUTHOR: J R Zond JR
AUTHOR: L H Finkelstein LH
AFFILIATION: Department of Surgery, Osteopathic Medical Center of Philadelphia, Pa.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of the American Osteopathic Association.
COUNTRY: UNITED STATES
TITLE: Testicular metastasis from adenocarcinoma of the prostate.
PUBDATE: 19910901
Reported are two cases of prostate cancer metastatic to the testicle. Both patients underwent bilateral orchiectomies for treatment of symptomatic metastatic prostate cancer. Testicular metastasis was found incidentally in one patient and was suspected in the other. This site of spread is rare. The clinical significance and prognosis are discussed and the pertinent literature reviewed.

6. DOCID:22563 SCORE: 0.00294294864913499
DOCNO: 7482586
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: etiology
AUTHOR: M Bounias M
AUTHOR: A Bonaly A
AFFILIATION: Biomathematics and Toxicology Unit, University of Avignon, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Toxicology letters.
COUNTRY: NETHERLANDS
TITLE: Beware of a new carcinogenic risk: promotion of promoters.
PUBDATE: 19951001
Restricting the evaluation of carcinogenic risk to genotoxicity or mutagenicity tests, as recently recommended by some researchers, is a hazardous operation, since the carcinogenic process involves a complex sequence of events in which no simple, necessary and sufficient condition is known for either the occurrence or non-occurrence of a cancer. None of the available tests exhibit a generalizable meaning, while none of the carcinogenic process phases should be neglected in prediction studies. In particular, ignoring promoter action and progression or proliferation, as well as targets specificity and other points, should lead to an underestimation of the actual risk.

7. DOCID:23340 SCORE: 0.00280260081059
DOCNO: 8646605
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: K Ishikawa K
AUTHOR: H Nakano H
AUTHOR: T Fujioka T
AUTHOR: I Nagakubo I
AFFILIATION: Department of Urology, Tachikawa Mutualaid Hospital, Tokyo, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: JAPAN
TITLE: Testicular cancer in father and son.
PUBDATE: 19960101
The occurrence of testicular tumors in closely related family members is rare. We report a case of testicular cancers in a father and son. The father had pure seminoma, and his son developed a mixed nonseminomatous germ cell tumor. The peripheral blood lymphocytes in both patients were tested for 52 HLA specificities, and the patients were found to have six in common. The son was homozygous for HLA A24. The association between certain HLA antigens, other genetic factors, and testicular cancer requires further study to improve the care and counseling of patients and their families.

8. DOCID:17727 SCORE: 0.002622936989823
DOCNO: 1902750
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Education
QUALIFIER: prevention & control
QUALIFIER: adverse effects
AUTHOR: D Hill D
AUTHOR: R Borland R
AUTHOR: B Karazija B
AFFILIATION: Anti-Cancer Council of Victoria, Carlton South, Melbourne, Australia.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of addiction.
COUNTRY: ENGLAND
TITLE: Centre for behavioural research in cancer.
PUBDATE: 19910301
The Centre for Behavioural Research in Cancer (CBRC) is one of two research centres housed at the Anti-Cancer Council of Victoria, the other being an epidemiological research centre. The CBRC's main focus for research is in smoking behaviour. A feature of the Centre is its close organizational and professional links with Victoria's large publicly funded smoking prevention programme. This provides opportunities to conduct programme-related research, to influence the nature of tobacco reduction interventions and to evaluate outcomes.

9. DOCID:22725 SCORE: 0.00253186221404489
DOCNO: 8645013
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood supply
QUALIFIER: pathology
AUTHOR: M Toi M
AUTHOR: T Tominaga T
AFFILIATION: Dept. of Surgery, Tokyo Metropolitan Komagome Hospital, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Breast cancer angiogenesis]
PUBDATE: 19960501
Recent clinical investigations have confirmed that angiogenesis is a basic property of solid tumors as well as proliferation, invasion and metastasis. In addition to the fundamental analysis of tumor angiogenesis in clinical tumors, the focus has been on clinical applications of tumor angiogenesis. Representatives are applications for prognostic indicators of primary breast tumor and for antiangiogenesis therapy. The clinical value of angiogenesis-related factors as a tumor marker and diagnostic applications targeting newly-developed vasculatures have been investigated. In this review, recent new findings on the clinical applications of tumor angiogenesis in human tumors, particularly breast cancer, will be summarized and discussed.

10. DOCID:19404 SCORE: 0.0025170874392367
DOCNO: 1804611
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: innervation
AUTHOR: Y X Wu YX
AFFILIATION: First Affiliated Hospital, Henan Medical University, Zhengzhou.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua fu chan ke za zhi.
COUNTRY: CHINA
TITLE: [Preservation of pelvic nerve plexus during radical hysterectomy]
PUBDATE: 19911101
Preservation of the pelvic nerve plexus at the sites of uterosacral and cardinal ligaments was practiced during radical hysterectomy in 104 cases of cervical cancer (study group). Conventional radical hysterectomy without preservation of nerve plexus was performed in 100 cases (control group). The amount of residual urine was measured postoperatively to evaluate the recovery of function of urination. The average time of recovery of normal urination was 18.25 +/- 1.93 days for the study group and 24.05 +/- 1.68 days for the control group (P less than 0.01). There was no difference of 5- and 10-year survival rates between these two groups (P greater than 0.05).

11. DOCID:19520 SCORE: 0.00250039014300207
DOCNO: 2273076
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Type A Personality
QUALIFIER: methods
QUALIFIER: prevention & control
QUALIFIER: prevention & control
QUALIFIER: methods
AUTHOR: R Grossarth-Maticek R
AUTHOR: H J Eysenck HJ
AFFILIATION: Institute of Psychiatry, University of London.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of behavior therapy and experimental psychiatry.
COUNTRY: UNITED STATES
TITLE: Prophylactic effects of psychoanalysis on cancer-prone and coronary heart disease-prone probands, as compared with control groups and behaviour therapy groups.
PUBDATE: 19900601
It has been shown repeatedly that behaviour therapy fulfils a useful prophylactic function in the prevention of cancer and coronary heart disease. The present study investigates the effects of orthodox psychoanalytic treatment on the eventual probability of death from cancer and coronary heart disease in probands treated by psychoanalysis for over two years, probands who broke off psychoanalytic treatment after less than two years, and various control groups. Psychoanalysis is shown to have a significantly negative effect on survival after seven years follow-up.

12. DOCID:23545 SCORE: 0.00249142567531956
DOCNO: 8661826
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, Emission-Computed
QUALIFIER: radionuclide imaging
QUALIFIER: instrumentation
AUTHOR: W H Blahd WH
AUTHOR: C V Brown CV
AUTHOR: S A Khonsary SA
AUTHOR: J B Farahi JB
AUTHOR: N Quinones N
AUTHOR: J Y Ribe JY
AUTHOR: J J Coyle JJ
AUTHOR: E C Glass EC
AUTHOR: M A Mandelkern MA
AFFILIATION: Nuclear Medicine Service, West Los Angeles Veterans Affairs Medical Center, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA.
PUBTYPE: Journal Article
JOURNALTITLE: World journal of surgery.
COUNTRY: UNITED STATES
TITLE: PET scans of abdominal malignancy.
PUBDATE: 19960201
Positron emission tomography (PET) with fluorine-18-2-d-deoxyglucose (FDG) currently is being integrated into clinical oncology because it provides unique functional information that can be applied to the management of cancer. In particular, it is useful for assessing tumor activity and growth, evaluating efficacy of therapy, and detecting tumor recurrence. Studies have demonstrated the value of whole-body PET-FDG imaging when staging and managing abdominal malignancy.

13. DOCID:23440 SCORE: 0.00247807922086938
DOCNO: 8534957
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Damage
QUALIFIER: genetics
AUTHOR: B C Blount BC
AUTHOR: B N Ames BN
AFFILIATION: Biomedical Mass Spectrometry Unit, University of New South Wales, Kensington, Australia.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Baillière's clinical haematology.
COUNTRY: ENGLAND
TITLE: DNA damage in folate deficiency.
PUBDATE: 19950901
Folate deficiency significantly increases uracil content and chromosome breaks (as measured by micronucleated cells) in human leukocyte DNA. Folate supplementation reduces both the uracil content of DNA and the frequency of micronucleated cells, indicating that uracil misincorporation may play a causative role in folate deficiency-induced chromosome breaks. A calculation is presented to explain how the levels of uracil found in DNA could cause chromosome breaks. Based on this calculation, the frequency of uracil repair events that might result in double-strand DNA breaks increases by 1752-fold. These results are consistent with clinical and epidemiological evidence linking folate deficiency to DNA damage and cancer.

14. DOCID:18154 SCORE: 0.00247123707602469
DOCNO: 2120919
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: adverse effects
AUTHOR: I O Olubuyide IO
AUTHOR: E A Bamgboye EA
AFFILIATION: Department of Medicine, University College Hospital, Ibadan, Nigeria.
PUBTYPE: Journal Article
JOURNALTITLE: African journal of medicine and medical sciences.
COUNTRY: ENGLAND
TITLE: A case-controlled study of the current role of cigarette smoking and alcohol consumption in primary liver cell carcinoma in Nigerians.
PUBDATE: 19900901
This paper describes the findings of a case-controlled study of 100 patients with primary liver cell carcinoma, sex- and age-matched with another 100 patients seen at the orthopaedic clinic of the University College Hospital, Ibadan. Contrary to widespread belief, the relative risks of cigarette smoking and alcohol consumption were not found to be statistically significant. The implication of this on the possible aetiology of primary liver cancer is discussed.