0. DOCID:19287 SCORE: 0.00591290212692053
DOCNO: 8248009
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: prevention & control
QUALIFIER: toxicity
QUALIFIER: therapeutic use
AUTHOR: Y Nagai Y
AUTHOR: T Horie T
AUTHOR: S Awazu S
AFFILIATION: Department of Biopharmaceutics, Tokyo College of Pharmacy, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Pharmacology & toxicology.
COUNTRY: DENMARK
TITLE: Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.
PUBDATE: 19930801
The effects of vitamin A on methotrexate treatment of mice inoculated with L1210 leukaemia cells or sarcoma 180 cells were studied. The small intestine of tumour transplanted mice was severely damaged after methotrexate treatment. Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage. The protective effect of vitamin A was histologically and biochemically demonstrated. Further, coadministration of vitamin A did not inhibit in vivo antitumour activity of methotrexate. Thus, biochemical modulation used to prevent methotrexate-induced malabsorption by vitamin A coadministration will be of great use in methotrexate cancer chemotherapy.

1. DOCID:31626 SCORE: 0.0055415422880045
DOCNO: 16258468
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Marcel Levi M
AFFILIATION: Academic Medical Center, 1105 AZ Amsterdam, the Netherlands. m.m.levi@amc.uva.nl.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical advances in hematology & oncology : H&O
COUNTRY: United States
TITLE: Cancer and thrombosis.
PUBDATE: 20031101
Cancer is frequently complicated by thrombosis, which may even be the first sign of an unrecognized cancer. There are several risk factors for cancer-associated thrombosis, such as type of malignancy, the presence of metastatic disease, and the use of chemotherapy. In most patients with cancer, a procoagulant state can be identified, ranging from subclinical laboratory abnormalities to full-blown disseminated intravascular coagulation. A specific entity is the occurrence of thrombotic microangiopathy that is specifi cally related to (high-dose) chemotherapy and radiotherapy. The pathogenetic pathways that play a role in the cancer-associated coagulopathy have been identified in recent years.

2. DOCID:17077 SCORE: 0.00462011929310087
DOCNO: 2261906
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinoma, Papillary
DESCRIPTOR: Thyroid Neoplasms
AUTHOR: I D Hay ID
AFFILIATION: Mayo Medical School, Rochester, Minnesota.
PUBTYPE: Journal Article
JOURNALTITLE: Endocrinology and metabolism clinics of North America.
COUNTRY: UNITED STATES
TITLE: Papillary thyroid carcinoma.
PUBDATE: 19900901
Multiple prognostic factors for outcome in papillary thyroid carcinoma are identified. For a cohort of 1500 consecutive patients followed an average of 16 years, survival rates for tumor recurrence and cause-specific mortality are described. Risk groups derived from novel prognostic scoring or staging systems and the role of DNA ploidy testing are discussed specifically. Lastly, controversies are reviewed regarding the extent of primary surgical resection and the efficacy of postoperative radioiodine remnant ablation in papillary thyroid cancer.

3. DOCID:29469 SCORE: 0.00426532552295475
DOCNO: 16274525
OWNER: NLM
STATUS: In-Process
AUTHOR: Philippe E Spiess PE
AUTHOR: Wassim Kassouf W
AUTHOR: Khoday Tukaram K
AUTHOR: Indrojit Roy I
AFFILIATION: Department of Urology, Saint Mary's Hospital, McGill University, Montreal, Quebec, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: The Canadian journal of urology.
COUNTRY: Canada
TITLE: Metastatic umbilical mass from transitional cell carcinoma of the bladder.
PUBDATE: 20051001
We present the case of an 83-year-old female presenting with an umbilical mass measuring 2 cm x 3 cm. This patient had an extensive prior history of transitional cell carcinoma of the bladder. A fine needle aspiration of this umbilical mass confirmed this to be metastatic transitional cell carcinoma and the diagnostic workup demonstrated the presence of invasive bladder cancer with metastatic liver lesions.

4. DOCID:23163 SCORE: 0.00419121240564207
DOCNO: 8719368
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: V Vatne V
AUTHOR: H Maartmann-Moe H
AUTHOR: J Hoestmark J
AFFILIATION: Dept. of Surgery, Gade Institute, Haukeland University Hospital, Bergen, Norway.
PUBTYPE: Journal Article
JOURNALTITLE: Scandinavian journal of urology and nephrology.
COUNTRY: SWEDEN
TITLE: The prognostic value of p53 in superficially infiltrating transitional cell carcinoma.
PUBDATE: 19951201
Approximately 1/3 of T1 bladder cancers treated by endoscopic resection alone will progress. Prognostic factors are needed to help selecting appropriate treatment for these tumors. The purpose of the present investigation was to study the relation between p53 nuclear overexpression and disease progression. Tumors from 59 patients were studied by means of immunohistochemical nuclear staining. Forty tumors showed p53 nuclear overexpression while 19 tumors scored negative for mutations. We could not demonstrate any correlation between mutations of the p53 protein and tumor grading. p53 nuclear overexpression was not related to disease progression.

5. DOCID:22296 SCORE: 0.00373058756960387
DOCNO: 8720345
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
QUALIFIER: radiography
AUTHOR: C Campisi C
AUTHOR: A Soluri A
AUTHOR: S Terenzi S
AUTHOR: A Zappalà A
AUTHOR: S Zinevrakis S
AFFILIATION: Istituto di Technologie Biomediche, Università degli Studi di Roma.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: La Clinica terapeutica.
COUNTRY: ITALY
TITLE: [Morphometric analysis of mammographic images in clinical oncology]
PUBDATE: 19951101
The three standard projections relative to mammographies of 40 patients with breast cancer pre-operatively classified as T1-T2 were analyzed by computerized morphometric elaborations. This method si able to better define view of images, permetting pre-operative connection of staging, with an increment of 30% if confronted with histologic TNM (pTNM). The utilization of method is discussed to evaluate the best way for the local definition of tumor extension, permitting to use a correctly conservative surgery (quadrantectomy, tumorectomy) in a greater number of patients.

6. DOCID:18500 SCORE: 0.00368849875463287
DOCNO: 1537014
AUTHOR: D J Shaw DJ
AUTHOR: R F Czaja RF
AFFILIATION: School of Library and Information Science, Indiana University, Bloomington 47405.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin of the Medical Library Association.
COUNTRY: UNITED STATES
TITLE: User interactions with the PDQ cancer information system.
PUBDATE: 19920101
Searches by end users and intermediaries on the online PDQ (Physician Data Query) cancer information system were observed. With the National Library of Medicine (NLM) menu-based interface, end users (physicians) averaged fewer steps per question, while with the BRS command-drive interface, intermediaries appeared to be more efficient. Cancer Information Service (CIS) searchers, who have more PDQ experience than end users or intermediaries, made greater use of command stacking to anticipate menu selections. Retrieval was more complete in the NLM system, where both the menus and predefined print formats assisted the searchers.

7. DOCID:27957 SCORE: 0.00336827515183928
DOCNO: 9512826
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M Lishner M
AUTHOR: G Koren G
AFFILIATION: Hospital for Sick Children, Toronto.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Canadian family physician Médecin de famille canadien.
COUNTRY: CANADA
TITLE: Breast cancer during pregnancy. Approach to rational management.
PUBDATE: 19980201
QUESTION: A 35-year-old woman attending my clinic in the 20th week of pregnancy had a lump in her breast. Open biopsy revealed ductal carcinoma. Radical mastectomy with axillary lymph node biopsy showed three out of 10 nodes positive. What are the short- and long-term implications of chemotherapy during pregnancy? ANSWER: Patients with breast cancer during pregnancy should be treated using the same criteria as their nonpregnant counterparts, with the modifications required by pregnancy. The benefits of the diagnostic workup and use of chemotherapy, radiotherapy, and surgery have to be weighed carefully against their risk to the unborn baby.

8. DOCID:31698 SCORE: 0.00335998064132005
DOCNO: 12428399
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: pathology
AUTHOR: Takashige Kuraki T
AUTHOR: Hideo Kobayashi H
AUTHOR: Keigo Takagi K
AUTHOR: Shinsuke Aida S
AFFILIATION: Third Department of Internal Medicine, National Defence Medical College, Tokorozawa-shi, Saitama-ken 359, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society.
COUNTRY: Japan
TITLE: [A case of lung cancer with cyst formation]
PUBDATE: 20020801
A 70-year-old man was admitted with a nodule adjacent to a cystic lesion in the right lower lung field. Diagnosis of lung cancer was made by transbronchial biopsy. A series of chest radiographs revealed that a cystic lesion had presented 8 years before, and that a nodule appeared on the hilar side of the cyst 5 years later. The cyst may have been formed by the check-valve mechanism due to the lung cancer.

9. DOCID:16944 SCORE: 0.00323425790566696
DOCNO: 1757281
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: H J Bashein HJ
AUTHOR: P Ginsberg P
AUTHOR: J R Zond JR
AUTHOR: L H Finkelstein LH
AFFILIATION: Department of Surgery, Osteopathic Medical Center of Philadelphia, Pa.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of the American Osteopathic Association.
COUNTRY: UNITED STATES
TITLE: Testicular metastasis from adenocarcinoma of the prostate.
PUBDATE: 19910901
Reported are two cases of prostate cancer metastatic to the testicle. Both patients underwent bilateral orchiectomies for treatment of symptomatic metastatic prostate cancer. Testicular metastasis was found incidentally in one patient and was suspected in the other. This site of spread is rare. The clinical significance and prognosis are discussed and the pertinent literature reviewed.

10. DOCID:27331 SCORE: 0.0032182166621738
DOCNO: 11769474
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: diagnosis
QUALIFIER: genetics
AUTHOR: T Ito T
AUTHOR: Y Okubo Y
AUTHOR: M Tachibana M
AFFILIATION: Department of Urology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023.
PUBTYPE: Journal Article
JOURNALTITLE: Rinsho byori. The Japanese journal of clinical pathology.
COUNTRY: Japan
TITLE: [Detection of PSA mRNA in prostate cancer patients' blood]
PUBDATE: 20011001
A sensitive technique using reverse transcriptase-polymerase chain reaction (RT-PCR) for PSA mRNA has been used to detect circulating tumor cells in the peripheral blood of prostate cancer patients. We evaluated the clinical utility of this method for staging and monitoring for prostate cancer. The number of patients who were RT-PCR positive was increased in higher clinical stages. This technique may provide useful information for treating patients with prostate cancer, especially candidates for radical prostatectomy. Confirming the value of this modality as a prognostic factor will require further study.

11. DOCID:31594 SCORE: 0.00299284792989632
DOCNO: 12495846
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Disease
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: Matthew J Wishart MJ
AUTHOR: Jack E Dixon JE
AFFILIATION: Dept of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-0606, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in cell biology.
COUNTRY: England
TITLE: PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease.
PUBDATE: 20021201
The phosphatase and tensin homolog deleted on chromosome ten (PTEN) and myotubularin (MTM1) represent subfamilies of protein tyrosine phosphatases whose principal physiological substrates are D3-phosphorylated inositol phospholipids. As lipid phosphatases, PTEN- and MTM1-related (MTMR) proteins dephosphorylate the products of phosphoinositide 3-kinases and antagonize downstream effectors that utilize 3-phosphoinositides as ligands for protein targeting domains or allosteric activation. Here, we describe the cellular mechanisms of PTEN and MTMR function and their role in the etiology of cancer and other human diseases.

12. DOCID:31039 SCORE: 0.00299281611655773
DOCNO: 16200194
OWNER: NLM
STATUS: In-Process
AUTHOR: Ravi Amaravadi R
AUTHOR: Craig B Thompson CB
AFFILIATION: Abramson Family Cancer Research Institute, Department of Cancer Biology and Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of clinical investigation.
COUNTRY: United States
TITLE: The survival kinases Akt and Pim as potential pharmacological targets.
PUBDATE: 20051001
The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.

13. DOCID:22563 SCORE: 0.00294294864913499
DOCNO: 7482586
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: etiology
AUTHOR: M Bounias M
AUTHOR: A Bonaly A
AFFILIATION: Biomathematics and Toxicology Unit, University of Avignon, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Toxicology letters.
COUNTRY: NETHERLANDS
TITLE: Beware of a new carcinogenic risk: promotion of promoters.
PUBDATE: 19951001
Restricting the evaluation of carcinogenic risk to genotoxicity or mutagenicity tests, as recently recommended by some researchers, is a hazardous operation, since the carcinogenic process involves a complex sequence of events in which no simple, necessary and sufficient condition is known for either the occurrence or non-occurrence of a cancer. None of the available tests exhibit a generalizable meaning, while none of the carcinogenic process phases should be neglected in prediction studies. In particular, ignoring promoter action and progression or proliferation, as well as targets specificity and other points, should lead to an underestimation of the actual risk.

14. DOCID:30048 SCORE: 0.0029397126910342
DOCNO: 16229380
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: blood supply
QUALIFIER: etiology
QUALIFIER: pathology
AUTHOR: Teruo Inamoto T
AUTHOR: Haruhito Azuma H
AUTHOR: Yusaku Iwamoto Y
AUTHOR: Takeshi Sakamoto T
AUTHOR: Yoji Katsuoka Y
AFFILIATION: The Department of Urology, Osaka Medical College.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: Japan
TITLE: A rare case of penile metastasis of testicular cancer presented with priapism.
PUBDATE: 20050901
Priapism is thought as a condition of penile erection that persists beyond or is unrelated to sexual stimulation. Commonly two different entities of priapism are known, one is low-flow priapism and the other is high-flow priapism. It is important to distinguish these two conditions for the subsequent different treatments. We report a rare case of an indistinguishable priapism caused by penile metastasis of testicular cancer.