0. DOCID:3859 SCORE: 0.00634097993423009
DOCNO: 890684
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
QUALIFIER: toxicity
QUALIFIER: toxicity
QUALIFIER: chemically induced
AUTHOR: T J Slaga TJ
AUTHOR: A Viaje A
AUTHOR: W M Bracken WM
AUTHOR: D L Berry DL
AUTHOR: S M Fischer SM
AUTHOR: D R Miller DR
AUTHOR: S M Leclerc SM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: NETHERLANDS
TITLE: Skin-tumor-initiating ability of benzo(a)pyrene-7,8-diol-9,10-epoxide (anti) when applied topically in tetrahydrofuran.
PUBDATE: 19770701
The skin-tumor-initiating abilities of various metabolites of benzo(a)pyrene (BP) were determined in mice by using a two-stage system of tumorigenesis. We previously reported that BP-7,8-dihydrodiol (+/- trans) was approximately as potent as BP, suggesting that it may be a proximate carcinogen, but the alleged ultimate carcinogen of BP [BP-7,8-dihydrodiol-9,10-epoxide (anti)] was a weak tumor initiator (Cancer Lett.2: 115, 1976). Because of its high reactivity, the tumor-initiating ability of the BP-7,8-dihydrodiol-9,10-epoxide (anti) was determined by using acetone, benzene, and tetrahydrofuran (THF) as the solvent vehicles. The 'diol-epoxide' of BP was found to be an effective tumor initiator when applied topically in THF. The effectiveness of the various vehicles for the 'diol-epoxide' was as follows: THF greater than benzene greater than acetone; however, acetone was the best solvent for BP tumor initiation. The BP-9,10-dihydrodiol and BP-3-hydroxy were found to be weak tumor initiators. BP-3-hydroxy was also tested for tumor-promoting ability and was found to be inactive in this capacity.


1. DOCID:6980 SCORE: 0.00514024124975449
DOCNO: 7314116
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: S Asaki S
AUTHOR: T Nishimura T
AUTHOR: M Sato M
AUTHOR: S Shibuki S
AUTHOR: S Iwai S
AUTHOR: S Ito S
AUTHOR: T Ikeda T
AUTHOR: S Yambe S
AUTHOR: Y Goto Y
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Endoscopic gastric polypectomy using high frequency current: its significance for total biopsy of gastric polyp.
PUBDATE: 19811101
Endoscopic polypectomy using high frequency current was performed for 281 out of 345 gastric polyps (230 cases), while the remaining 64 small polyps were cauterized. Histopathologic examinations carried out in 274 out of the 281 polypectomized polyps confirmed gastritis polyposa in 41 lesions, hyperplastic polyps in 216 including 3 cases of neoplasm, atypical epithelium in 4, submucosal tumor in 2, and polypoid cancer in 1. This procedure of endoscopic polypectomy has proved to enable histologic examination of a polyp as a whole, and to allow a highly risk-free endoscopic treatment of polyps. In the currently observed 216 hyperplastic polyps, 3(1.4%) were found to have neoplastic changes.


2. DOCID:6920 SCORE: 0.00487158079661877
DOCNO: 6456802
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
DESCRIPTOR: Surgical Procedures, Operative
AUTHOR: M M Cohen MM
PUBTYPE: Journal Article
JOURNALTITLE: Canadian journal of surgery. Journal canadien de chirurgie.
COUNTRY: CANADA
TITLE: Peritoneoscopy in general surgery.
PUBDATE: 19810901
Peritoneoscopy is a simple and effective means of diagnosing or excluding intra-abdominal disease. It is currently underutilized and merits increased recognition particularly by general surgeons. The first 77 peritoneoscopic examinations performed by a general surgeon in a large hospital associated with a cancer agency are reviewed. An exact diagnosis was made in 78% of 58 patients in whom the primary diagnosis was in doubt and in 93% of that group management was influenced. Surgical exploration of the abdomen was avoided in 29 patients. The major indications for using the method were: to search for metastases, to evaluate the acute abdomen and to stage lymphoma. Local anesthesia and nitrous oxide insufflation were used almost exclusively. Biopsy was performed in 36 patients and there was one death directly attributable to liver biopsy. In two patients peritoneoscopy was unsuccessful.


3. DOCID:7426 SCORE: 0.004853172470502
DOCNO: 435650
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pharmacology
AUTHOR: W Schreml W
AUTHOR: H P Lohrmann HP
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Blut.
COUNTRY: GERMANY, WEST
TITLE: No effects of levamisole on cytotoxic drug-induced changes of human granulopoiesis.
PUBDATE: 19790401
The effect of Levamisole on the human granulopoiesis was studied in patients randomized to receive, in addition to adjuvant chemotherapy for primary breast cancer, either no other treatment or additional unspecific immune therapy with Levamisole. The reaction of granulopoiesis to the cytostatic drugs, as characterized by changes of peripheral blood polymorphonuclear neutrophils (PMN), functional bone marrow granulocyte reserve, serial bone marrow cytology, and granulopoietic stem cells (CFU-C) in marrow and blood, was not affected by administration of Levamisole. The data support the concept that Levamisole has no direct effect on human bone marrow granulopoiesis, but that an allergic mechanism is involved in the pathogenesis of Levamisole-induced agranulocytosis. The expectation that Levamisole exerts a beneficial effect by stimulation of the granulopoiesis, as previously suggested for BCG and Corynebacterium parvum, could not be substantiated in our studies.


4. DOCID:5965 SCORE: 0.0044521241510551
DOCNO: 7425943
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: D E Schuller DE
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Limitations of the pectoralis major myocutaneous flap in head and neck cancer reconstruction.
PUBDATE: 19801101
The pectoralis major myocutaneous flap represents a major contribution to head and neck cancer reconstruction. Its advantages are improved viability, capabilities for one-stage reconstruction, and effective carotid artery protection. Limitations of the flap center around the thickness of the skin-subcutaneous fat-muscle complex that is used to reconstruct and also the bulkiness of the muscle pedicle, which has the potential to obscure recurrent neck disease until it is well advanced. Although it appears that this flap will rightfully become a commonly used technique, there may still be specific times when either regional skin flaps or free flaps are preferable to the pectoralis major myocutaneous flap.


5. DOCID:6000 SCORE: 0.00426898193862893
DOCNO: 6455106
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: E Tilchen E
AUTHOR: Y Z Patt YZ
AUTHOR: C M McBride CM
AUTHOR: S Wallace S
AUTHOR: V Chuang V
AUTHOR: C M Mavligit CM
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Sequence of regional chemotherapy and surgery. Management of colorectal adenocarcinoma confined to the liver.
PUBDATE: 19810701
Four patients with clinically nonresectable unilobar hepatic metastases from colorectal cancer were treated with a sequentially combined approach of intrahepatic arterial chemotherapy followed by surgery. Partial regression (greater than or equal to 50%) induced by chemotherapy and associated with a decline in plasma carcinoembryonic antigen level was followed successfully by a complete hepatic tumor resection in three out of four patients. All three patients continue to be free of disease from 13+ to 21+ months. This combined approach may improve the salvage rate of patients with regionally confined hepatic metastases.


6. DOCID:7010 SCORE: 0.00410514466651338
DOCNO: 376097
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Neoplasm
DESCRIPTOR: Rheumatoid Factor
QUALIFIER: immunology
AUTHOR: A E Giuliano AE
AUTHOR: R Irie R
AUTHOR: D L Morton DL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Rheumatoid factor in melanoma patients: alterations of humoral tumor immunity in vitro.
PUBDATE: 19790501
Rheumatoid factors (RF) were associated with alterations of antibody reactions to melanoma cells in vitro by two serologic assays. Removal of RF from melanoma patients' sera by absorption with Cohn's Fraction II coated latex particles enhanced seroreactivity in the Immune Adherence (IA) assay and diminished IgM detection by the Indirect Membrane Immunofluorescence (IMI) assay. The addition of serum with high titers of RF to these assay systems led to diminution of IA reactivity and enhancement of IgM detection by IMI. Since these factors are found in cancer patients' sera and can alter humoral immune reactions directed against antigens on the membranes of tumor cells, their presence should be recognized when performing assays with tumor target cells. RF may be of significance in the host-tumor relationship in vivo.


7. DOCID:3395 SCORE: 0.00409199444768006
DOCNO: 1087457
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: U Trabert U
AUTHOR: M Rosenthal M
AUTHOR: W Müller W
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Therapy of inflammatory-rheumatic diseases with levamisol, an immunity modulating substance]
PUBDATE: 19760901
Since cellular and humoral immune mechanisms were shown to be involved in the pathogenesis of rheumatic diseases, efforts have been made to influence these systems therapeutically. Aside from suppression of the immune response, studies have been conducted to evaluate to what extent immunostimulation might be of value in the treatment of rheumatic diseases. Levamisole, chemically a simple synthetic agent recently shown to have immunorestorative capacities in anergic cancer patients, has been administered in several rheumatic diseases. The drug was administered either continuously or intermittently in a daily dose of 150 mg over several months. In about half of the rheumatoid arthritis patients a significant improvement was noted. Beneficial effects and sometimes even dramatic improvement lere observed in some patients with systemic lupus erythematosus, ankylosing spondylitis and Reiter's syndrome. Levamisole did not alter the course of psoriatic arthritis. Significant adverse reactions were leukopenia and allergic skin reactions. Other side effects were mild and did not require interruption of drug intake. The use of levamisole in rheumatic diseases is still experimental, but with accumulating experience it may provide a true improvement in control of rheumatic diseases.


8. DOCID:9760 SCORE: 0.00408383522036682
DOCNO: 4016536
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Length of Stay
QUALIFIER: surgery
QUALIFIER: etiology
AUTHOR: G Tejler G
AUTHOR: K Aspegren K
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Complications and hospital stay after surgery for breast cancer: a prospective study of 385 patients.
PUBDATE: 19850701
General complications, wound complications and hospital stay after surgery for operable mammary carcinoma were studied prospectively in 385 patients treated by either modified radical mastectomy (324 operations) or segmental resection with axillary dissection (71 operations). The overall infection rate was 3.6 per cent. Postoperative seromas were noted in 34.8 per cent of the wounds. Other complications were few. The average hospital stay was 7.2 days. Seventeen per cent of the total number of days in hospital for these patients were due to factors other than the mammary cancer.


9. DOCID:2713 SCORE: 0.00389947294195058
DOCNO: 837371
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
AUTHOR: R M DePhilip RM
AUTHOR: W E Lynch WE
AUTHOR: I Lieberman I
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Nuclear DNA polymerases of human carcinomas.
PUBDATE: 19770301
Comparisons have been made of the DNA polymerases of normal human lung and cecum, primary carcinomas of human lung, breast, and cecum, and resting and regeneration rat liver. The picture for the normal human tissues is similar to the one for unstimulated rat liver, that for the human carcinomas resembles regenerating rat liver. The human tissues contain two polymerases with sedimentation coefficients of about 3 and 7 S, the enzymes are restricted to the nucleus, and the specific activities of the 7 S polymerase, but not of the 3 S enzyme, are elevated in the cancers. Just as with the regenerating rat liver polymerases, the 3 S activity of a bronchogenic carcinoma is unaffected by cytosine arabinoside 5'-triphosphate and only little reduced by novobiocin, whereas DNA synthesis by the 7 S enzyme is abolished by both compounds. A variety of other inhibitory agents have similar effects on the 7 S polymerases of the human carcinomas and regenerating rat liver.


10. DOCID:14784 SCORE: 0.00386636671850409
DOCNO: 3674744
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: G Roseau G
AUTHOR: J Leport J
AUTHOR: M Cerf M
AFFILIATION: Service d'Hépato-Gastro-Entérologie, Hôpital Louis-Mourier, Colombes.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annales de gastroentérologie et d'hépatologie.
COUNTRY: FRANCE
TITLE: [Malignant degeneration of Ménétrier disease]
PUBDATE: 19871001
Gastric cancer was found in a patient in whom Menetrier's disease had been diagnosed 18 months before. In Menetrier's disease, incidence of cancer is as high as 14% of cases. But in only 5 cases of literature including the present one, has the time sequence been clearly documented. Metachronous tumours may be found 1 to 5 years after giant hypertrophic gastritis has been diagnozed. Such data make medical management, including anti-secretory drugs and periodic endoscopic survey, hazardous. We suggest that in documented Menetrier's disease elective total gastrectomy should still be considered as a treatment of choice.


11. DOCID:15437 SCORE: 0.0038545810302224
DOCNO: 3631869
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sigmoidoscopy
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: K D Vellacott KD
AUTHOR: A M Roe AM
AUTHOR: N J Mortensen NJ
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Royal College of Surgeons of England.
COUNTRY: ENGLAND
TITLE: An evaluation of a direct access flexible fibreoptic sigmoidoscopy service.
PUBDATE: 19870701
During a 3 year period 146 general practitioners referred 630 patients to a direct access flexible sigmoidoscopy clinic. The yield was 53.3% with significant colonic or rectal pathology in 30%. Twenty six cancers, 4 Dukes' A, and 38 patients with symptomatic adenomatous polyps were detected. Five further cancers were detected by subsequent barium enemas. The service reduced delay in diagnosing colorectal pathology but did not reduce the number of barium enemas requested by general practitioners. It is suggested that where facilities are already available, such a service to investigate rectal bleeding in patients over 40 years is of benefit both to patients and general practitioners.


12. DOCID:1623 SCORE: 0.00380706585807461
DOCNO: 804014
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: Y Gorsky Y
AUTHOR: D Sulitzeanu D
PUBTYPE: Journal Article
JOURNALTITLE: Journal of immunological methods.
COUNTRY: NETHERLANDS
TITLE: A radioactive antibody binding-inhibition assay, for the detection of cell-membrane related antigens in body fluids.
PUBDATE: 19750101
Antisera raised in rabbits against glutaraldehyde-fixed human breast cancer cells contain antibodies to human cell membrane components, as determined by immunofluorescence. Adsorption of such antisera onto polymerized human serum, followed by acid elution, yields purified antibodies reacting with human cell surface antigens, indicating that membrane related antigens are present in the serum. The purified antibodies were radioiodinated and shown to bind to an immunoadsorbent prepared by entrapping in a polyacrylamide gel pleural exudate of breast cancer patients. The specificity of the binding was confirmed by inhibition experiments. Data are presented demonstrating that at least some of the antibodies reacting in this radioimmunoassay are directed against antigens related to cell surface components.


13. DOCID:3805 SCORE: 0.00379563260091627
DOCNO: 56226
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigens, Neoplasm
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A C Hollinshead AC
AUTHOR: P B Chretien PB
AUTHOR: O B Lee OB
AUTHOR: J L Tarpley JL
AUTHOR: S E Kerney SE
AUTHOR: N A Silverman NA
AUTHOR: J C Alexander JC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: In vivo and in vitro measurements of the relationship of human squamous carcinomas to herpes simplex virus tumor-associated antigens.
PUBDATE: 19760201
An additional 244 unfiltered sera have now been studied in a series of controlled, coded tests to determine the relationship of squamous carcinomas of the head and neck and cervix to the presence of complement-fixing antibodies to herpesvirus-tumor-associated antigens (HSV-TAA) in both tumor-bearing and cured patients. Ninety % of sera from patients with squamous carcinomas had antibodies to HSV-TAA, in contrast to 11% of sera from patients with nonsquamous cancers and 4% of sera from noraml individuals. The temporal relationship of Stage 1 laryngeal carcinomas suggests that HSV-TAA appearance precedes the immune defects. An in vitro correlate of the previously demonstrated specific delayed hypersensitivity reactions in controlled skin tests of squamous carcinoma patients with HSV-TAA is reported. In leukocyte migration inhibition tests, the migration indices after incubation with HSV-TAA of peripheral blood leukocytes from patients with squamous carcinoma (x = 0.847) were in definite contrast to migration indices seen for normal leukocytes (x = 1.037) and patients with nonsquamous solid cancers (x = 1.03). Thus, these polypeptides elicit both humoral antibody response and cell-mediated reactivity.


14. DOCID:11520 SCORE: 0.00373322660321165
DOCNO: 4057568
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: Y Yoshizumi Y
AUTHOR: S Sima S
AUTHOR: Y Sugiura Y
AUTHOR: H Yonekawa H
AUTHOR: T Ogata T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [A case of superficial esophageal cancer with metastasis to the gastric wall]
PUBDATE: 19850801
A 65-year-old man with superficial esophageal cancer associated with gastric wall metastasis is presented. He had suffered from epigastralgia and dysphagia for two months. X-Ray and endoscopic examination revealed esophageal erosion at the right wall of the lower esophagus and a large gastric submucosal tumor at the lesser curvature of the upper and middle stomach. Resection of the lower esophagus and total gastrectomy were performed. Histologically, the erosion of the lower esophagus was moderately differentiated squamous cell carcinoma invading as deep as the submucosal tissue and the tumor of the stomach was metastasis of the esophageal cancer. Intramural metastasis of esophageal cancer was discussed.