0. DOCID:3859 SCORE: 0.00634097993423009
DOCNO: 890684
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
QUALIFIER: toxicity
QUALIFIER: toxicity
QUALIFIER: chemically induced
AUTHOR: T J Slaga TJ
AUTHOR: A Viaje A
AUTHOR: W M Bracken WM
AUTHOR: D L Berry DL
AUTHOR: S M Fischer SM
AUTHOR: D R Miller DR
AUTHOR: S M Leclerc SM
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: NETHERLANDS
TITLE: Skin-tumor-initiating ability of benzo(a)pyrene-7,8-diol-9,10-epoxide (anti) when applied topically in tetrahydrofuran.
PUBDATE: 19770701
The skin-tumor-initiating abilities of various metabolites of benzo(a)pyrene (BP) were determined in mice by using a two-stage system of tumorigenesis. We previously reported that BP-7,8-dihydrodiol (+/- trans) was approximately as potent as BP, suggesting that it may be a proximate carcinogen, but the alleged ultimate carcinogen of BP [BP-7,8-dihydrodiol-9,10-epoxide (anti)] was a weak tumor initiator (Cancer Lett.2: 115, 1976). Because of its high reactivity, the tumor-initiating ability of the BP-7,8-dihydrodiol-9,10-epoxide (anti) was determined by using acetone, benzene, and tetrahydrofuran (THF) as the solvent vehicles. The 'diol-epoxide' of BP was found to be an effective tumor initiator when applied topically in THF. The effectiveness of the various vehicles for the 'diol-epoxide' was as follows: THF greater than benzene greater than acetone; however, acetone was the best solvent for BP tumor initiation. The BP-9,10-dihydrodiol and BP-3-hydroxy were found to be weak tumor initiators. BP-3-hydroxy was also tested for tumor-promoting ability and was found to be inactive in this capacity.

1. DOCID:19287 SCORE: 0.00591290212692053
DOCNO: 8248009
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: prevention & control
QUALIFIER: toxicity
QUALIFIER: therapeutic use
AUTHOR: Y Nagai Y
AUTHOR: T Horie T
AUTHOR: S Awazu S
AFFILIATION: Department of Biopharmaceutics, Tokyo College of Pharmacy, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Pharmacology & toxicology.
COUNTRY: DENMARK
TITLE: Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.
PUBDATE: 19930801
The effects of vitamin A on methotrexate treatment of mice inoculated with L1210 leukaemia cells or sarcoma 180 cells were studied. The small intestine of tumour transplanted mice was severely damaged after methotrexate treatment. Coadministration of vitamin A with methotrexate protected the small intestine from methotrexate-induced damage. The protective effect of vitamin A was histologically and biochemically demonstrated. Further, coadministration of vitamin A did not inhibit in vivo antitumour activity of methotrexate. Thus, biochemical modulation used to prevent methotrexate-induced malabsorption by vitamin A coadministration will be of great use in methotrexate cancer chemotherapy.

2. DOCID:31626 SCORE: 0.0055415422880045
DOCNO: 16258468
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Marcel Levi M
AFFILIATION: Academic Medical Center, 1105 AZ Amsterdam, the Netherlands. m.m.levi@amc.uva.nl.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical advances in hematology & oncology : H&O
COUNTRY: United States
TITLE: Cancer and thrombosis.
PUBDATE: 20031101
Cancer is frequently complicated by thrombosis, which may even be the first sign of an unrecognized cancer. There are several risk factors for cancer-associated thrombosis, such as type of malignancy, the presence of metastatic disease, and the use of chemotherapy. In most patients with cancer, a procoagulant state can be identified, ranging from subclinical laboratory abnormalities to full-blown disseminated intravascular coagulation. A specific entity is the occurrence of thrombotic microangiopathy that is specifi cally related to (high-dose) chemotherapy and radiotherapy. The pathogenetic pathways that play a role in the cancer-associated coagulopathy have been identified in recent years.

3. DOCID:6980 SCORE: 0.00514024124975449
DOCNO: 7314116
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: S Asaki S
AUTHOR: T Nishimura T
AUTHOR: M Sato M
AUTHOR: S Shibuki S
AUTHOR: S Iwai S
AUTHOR: S Ito S
AUTHOR: T Ikeda T
AUTHOR: S Yambe S
AUTHOR: Y Goto Y
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Endoscopic gastric polypectomy using high frequency current: its significance for total biopsy of gastric polyp.
PUBDATE: 19811101
Endoscopic polypectomy using high frequency current was performed for 281 out of 345 gastric polyps (230 cases), while the remaining 64 small polyps were cauterized. Histopathologic examinations carried out in 274 out of the 281 polypectomized polyps confirmed gastritis polyposa in 41 lesions, hyperplastic polyps in 216 including 3 cases of neoplasm, atypical epithelium in 4, submucosal tumor in 2, and polypoid cancer in 1. This procedure of endoscopic polypectomy has proved to enable histologic examination of a polyp as a whole, and to allow a highly risk-free endoscopic treatment of polyps. In the currently observed 216 hyperplastic polyps, 3(1.4%) were found to have neoplastic changes.

4. DOCID:6920 SCORE: 0.00487158079661877
DOCNO: 6456802
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
DESCRIPTOR: Surgical Procedures, Operative
AUTHOR: M M Cohen MM
PUBTYPE: Journal Article
JOURNALTITLE: Canadian journal of surgery. Journal canadien de chirurgie.
COUNTRY: CANADA
TITLE: Peritoneoscopy in general surgery.
PUBDATE: 19810901
Peritoneoscopy is a simple and effective means of diagnosing or excluding intra-abdominal disease. It is currently underutilized and merits increased recognition particularly by general surgeons. The first 77 peritoneoscopic examinations performed by a general surgeon in a large hospital associated with a cancer agency are reviewed. An exact diagnosis was made in 78% of 58 patients in whom the primary diagnosis was in doubt and in 93% of that group management was influenced. Surgical exploration of the abdomen was avoided in 29 patients. The major indications for using the method were: to search for metastases, to evaluate the acute abdomen and to stage lymphoma. Local anesthesia and nitrous oxide insufflation were used almost exclusively. Biopsy was performed in 36 patients and there was one death directly attributable to liver biopsy. In two patients peritoneoscopy was unsuccessful.

5. DOCID:7426 SCORE: 0.004853172470502
DOCNO: 435650
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pharmacology
AUTHOR: W Schreml W
AUTHOR: H P Lohrmann HP
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Blut.
COUNTRY: GERMANY, WEST
TITLE: No effects of levamisole on cytotoxic drug-induced changes of human granulopoiesis.
PUBDATE: 19790401
The effect of Levamisole on the human granulopoiesis was studied in patients randomized to receive, in addition to adjuvant chemotherapy for primary breast cancer, either no other treatment or additional unspecific immune therapy with Levamisole. The reaction of granulopoiesis to the cytostatic drugs, as characterized by changes of peripheral blood polymorphonuclear neutrophils (PMN), functional bone marrow granulocyte reserve, serial bone marrow cytology, and granulopoietic stem cells (CFU-C) in marrow and blood, was not affected by administration of Levamisole. The data support the concept that Levamisole has no direct effect on human bone marrow granulopoiesis, but that an allergic mechanism is involved in the pathogenesis of Levamisole-induced agranulocytosis. The expectation that Levamisole exerts a beneficial effect by stimulation of the granulopoiesis, as previously suggested for BCG and Corynebacterium parvum, could not be substantiated in our studies.

6. DOCID:17077 SCORE: 0.00462011929310087
DOCNO: 2261906
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinoma, Papillary
DESCRIPTOR: Thyroid Neoplasms
AUTHOR: I D Hay ID
AFFILIATION: Mayo Medical School, Rochester, Minnesota.
PUBTYPE: Journal Article
JOURNALTITLE: Endocrinology and metabolism clinics of North America.
COUNTRY: UNITED STATES
TITLE: Papillary thyroid carcinoma.
PUBDATE: 19900901
Multiple prognostic factors for outcome in papillary thyroid carcinoma are identified. For a cohort of 1500 consecutive patients followed an average of 16 years, survival rates for tumor recurrence and cause-specific mortality are described. Risk groups derived from novel prognostic scoring or staging systems and the role of DNA ploidy testing are discussed specifically. Lastly, controversies are reviewed regarding the extent of primary surgical resection and the efficacy of postoperative radioiodine remnant ablation in papillary thyroid cancer.

7. DOCID:5965 SCORE: 0.0044521241510551
DOCNO: 7425943
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: D E Schuller DE
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Limitations of the pectoralis major myocutaneous flap in head and neck cancer reconstruction.
PUBDATE: 19801101
The pectoralis major myocutaneous flap represents a major contribution to head and neck cancer reconstruction. Its advantages are improved viability, capabilities for one-stage reconstruction, and effective carotid artery protection. Limitations of the flap center around the thickness of the skin-subcutaneous fat-muscle complex that is used to reconstruct and also the bulkiness of the muscle pedicle, which has the potential to obscure recurrent neck disease until it is well advanced. Although it appears that this flap will rightfully become a commonly used technique, there may still be specific times when either regional skin flaps or free flaps are preferable to the pectoralis major myocutaneous flap.

8. DOCID:6000 SCORE: 0.00426898193862893
DOCNO: 6455106
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: E Tilchen E
AUTHOR: Y Z Patt YZ
AUTHOR: C M McBride CM
AUTHOR: S Wallace S
AUTHOR: V Chuang V
AUTHOR: C M Mavligit CM
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Sequence of regional chemotherapy and surgery. Management of colorectal adenocarcinoma confined to the liver.
PUBDATE: 19810701
Four patients with clinically nonresectable unilobar hepatic metastases from colorectal cancer were treated with a sequentially combined approach of intrahepatic arterial chemotherapy followed by surgery. Partial regression (greater than or equal to 50%) induced by chemotherapy and associated with a decline in plasma carcinoembryonic antigen level was followed successfully by a complete hepatic tumor resection in three out of four patients. All three patients continue to be free of disease from 13+ to 21+ months. This combined approach may improve the salvage rate of patients with regionally confined hepatic metastases.

9. DOCID:29469 SCORE: 0.00426532552295475
DOCNO: 16274525
OWNER: NLM
STATUS: In-Process
AUTHOR: Philippe E Spiess PE
AUTHOR: Wassim Kassouf W
AUTHOR: Khoday Tukaram K
AUTHOR: Indrojit Roy I
AFFILIATION: Department of Urology, Saint Mary's Hospital, McGill University, Montreal, Quebec, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: The Canadian journal of urology.
COUNTRY: Canada
TITLE: Metastatic umbilical mass from transitional cell carcinoma of the bladder.
PUBDATE: 20051001
We present the case of an 83-year-old female presenting with an umbilical mass measuring 2 cm x 3 cm. This patient had an extensive prior history of transitional cell carcinoma of the bladder. A fine needle aspiration of this umbilical mass confirmed this to be metastatic transitional cell carcinoma and the diagnostic workup demonstrated the presence of invasive bladder cancer with metastatic liver lesions.

10. DOCID:23163 SCORE: 0.00419121240564207
DOCNO: 8719368
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: V Vatne V
AUTHOR: H Maartmann-Moe H
AUTHOR: J Hoestmark J
AFFILIATION: Dept. of Surgery, Gade Institute, Haukeland University Hospital, Bergen, Norway.
PUBTYPE: Journal Article
JOURNALTITLE: Scandinavian journal of urology and nephrology.
COUNTRY: SWEDEN
TITLE: The prognostic value of p53 in superficially infiltrating transitional cell carcinoma.
PUBDATE: 19951201
Approximately 1/3 of T1 bladder cancers treated by endoscopic resection alone will progress. Prognostic factors are needed to help selecting appropriate treatment for these tumors. The purpose of the present investigation was to study the relation between p53 nuclear overexpression and disease progression. Tumors from 59 patients were studied by means of immunohistochemical nuclear staining. Forty tumors showed p53 nuclear overexpression while 19 tumors scored negative for mutations. We could not demonstrate any correlation between mutations of the p53 protein and tumor grading. p53 nuclear overexpression was not related to disease progression.

11. DOCID:7010 SCORE: 0.00410514466651338
DOCNO: 376097
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antibodies, Neoplasm
DESCRIPTOR: Rheumatoid Factor
QUALIFIER: immunology
AUTHOR: A E Giuliano AE
AUTHOR: R Irie R
AUTHOR: D L Morton DL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Rheumatoid factor in melanoma patients: alterations of humoral tumor immunity in vitro.
PUBDATE: 19790501
Rheumatoid factors (RF) were associated with alterations of antibody reactions to melanoma cells in vitro by two serologic assays. Removal of RF from melanoma patients' sera by absorption with Cohn's Fraction II coated latex particles enhanced seroreactivity in the Immune Adherence (IA) assay and diminished IgM detection by the Indirect Membrane Immunofluorescence (IMI) assay. The addition of serum with high titers of RF to these assay systems led to diminution of IA reactivity and enhancement of IgM detection by IMI. Since these factors are found in cancer patients' sera and can alter humoral immune reactions directed against antigens on the membranes of tumor cells, their presence should be recognized when performing assays with tumor target cells. RF may be of significance in the host-tumor relationship in vivo.

12. DOCID:3395 SCORE: 0.00409199444768006
DOCNO: 1087457
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: U Trabert U
AUTHOR: M Rosenthal M
AUTHOR: W Müller W
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Therapy of inflammatory-rheumatic diseases with levamisol, an immunity modulating substance]
PUBDATE: 19760901
Since cellular and humoral immune mechanisms were shown to be involved in the pathogenesis of rheumatic diseases, efforts have been made to influence these systems therapeutically. Aside from suppression of the immune response, studies have been conducted to evaluate to what extent immunostimulation might be of value in the treatment of rheumatic diseases. Levamisole, chemically a simple synthetic agent recently shown to have immunorestorative capacities in anergic cancer patients, has been administered in several rheumatic diseases. The drug was administered either continuously or intermittently in a daily dose of 150 mg over several months. In about half of the rheumatoid arthritis patients a significant improvement was noted. Beneficial effects and sometimes even dramatic improvement lere observed in some patients with systemic lupus erythematosus, ankylosing spondylitis and Reiter's syndrome. Levamisole did not alter the course of psoriatic arthritis. Significant adverse reactions were leukopenia and allergic skin reactions. Other side effects were mild and did not require interruption of drug intake. The use of levamisole in rheumatic diseases is still experimental, but with accumulating experience it may provide a true improvement in control of rheumatic diseases.

13. DOCID:9760 SCORE: 0.00408383522036682
DOCNO: 4016536
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Length of Stay
QUALIFIER: surgery
QUALIFIER: etiology
AUTHOR: G Tejler G
AUTHOR: K Aspegren K
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Complications and hospital stay after surgery for breast cancer: a prospective study of 385 patients.
PUBDATE: 19850701
General complications, wound complications and hospital stay after surgery for operable mammary carcinoma were studied prospectively in 385 patients treated by either modified radical mastectomy (324 operations) or segmental resection with axillary dissection (71 operations). The overall infection rate was 3.6 per cent. Postoperative seromas were noted in 34.8 per cent of the wounds. Other complications were few. The average hospital stay was 7.2 days. Seventeen per cent of the total number of days in hospital for these patients were due to factors other than the mammary cancer.

14. DOCID:2713 SCORE: 0.00389947294195058
DOCNO: 837371
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
AUTHOR: R M DePhilip RM
AUTHOR: W E Lynch WE
AUTHOR: I Lieberman I
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Nuclear DNA polymerases of human carcinomas.
PUBDATE: 19770301
Comparisons have been made of the DNA polymerases of normal human lung and cecum, primary carcinomas of human lung, breast, and cecum, and resting and regeneration rat liver. The picture for the normal human tissues is similar to the one for unstimulated rat liver, that for the human carcinomas resembles regenerating rat liver. The human tissues contain two polymerases with sedimentation coefficients of about 3 and 7 S, the enzymes are restricted to the nucleus, and the specific activities of the 7 S polymerase, but not of the 3 S enzyme, are elevated in the cancers. Just as with the regenerating rat liver polymerases, the 3 S activity of a bronchogenic carcinoma is unaffected by cytosine arabinoside 5'-triphosphate and only little reduced by novobiocin, whereas DNA synthesis by the 7 S enzyme is abolished by both compounds. A variety of other inhibitory agents have similar effects on the 7 S polymerases of the human carcinomas and regenerating rat liver.