0. DOCID:27226 SCORE: 0.00592260209031461
DOCNO: 9857368
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: therapy
AUTHOR: M J During MJ
AUTHOR: L M Ashenden LM
AFFILIATION: University of Auckland, New Zealand.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Molecular medicine today.
COUNTRY: ENGLAND
TITLE: Towards gene therapy for the central nervous system.
PUBDATE: 19981101
Gene therapy has generated enormous scientific, medical and public interest over the last decade. Clinical trials involving approximately 2000 patients worldwide have targeted simple genetic diseases such as cystic fibrosis, muscular dystrophy, adenosine deaminase deficiency, Gaucher's disease and familial hypercholesterolemia, as well as complex acquired diseases such as cancer and AIDS. The central nervous system is a new and particularly exciting target for gene therapy because its unique properties prevent the successful treatment of many neurological disorders by conventional means. This review discusses the potential applications of in vivo gene therapy to neurological disorders that have the greatest potential for genetic treatments.

1. DOCID:27177 SCORE: 0.00592260017694938
DOCNO: 10418054
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bronchoalveolar Lavage
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: A Cuguillière A
AUTHOR: H Bérard H
AUTHOR: G N'Guyen G
AUTHOR: J Miltgen J
AUTHOR: G Martet G
AUTHOR: J Eskandari J
AUTHOR: D Bonnet D
AFFILIATION: Service de Pneumologie, Hôpital d'Instruction des Armées Laveran, Marseille Armées.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Revue de pneumologie clinique.
COUNTRY: FRANCE
TITLE: [Cyclophosphamide-induced interstitial pneumopathy. Course data of bronchoalveolar lavage apropos of a case and review of the literature]
PUBDATE: 19990401
A patient treated with cyclophosphamide for breast cancer developed functional and clinicoradiological signs of sub-acute diffuse interstitial pneumopathy. Bronchoalveolar lavage revealed lymphocyte alveolitis. Differential diagnoses were excluded and the course was favorable after cyclophosphamide withdrawal. The bronchoalveolar lavage results obtained initially and at follow-up and two previous lavages reported in the literature demonstrate the importance of this examination in the diagnosis of drug-induced pneumopathy.

2. DOCID:27089 SCORE: 0.00445795613011041
DOCNO: 9787506
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: J Jarolím J
AUTHOR: V Vachalovský V
AUTHOR: J Novák J
AUTHOR: T Hanus T
AUTHOR: M Babjuk M
AUTHOR: L Safarík L
AUTHOR: J Dvorácek J
AUTHOR: B Matras B
AUTHOR: V Simon V
AUTHOR: E Votocek E
AUTHOR: K Novák K
AFFILIATION: Urologická klinika 1. LF UK a VFN Praha.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Casopís lékar̆ů c̆eských.
COUNTRY: CZECH REPUBLIC
TITLE: [Treatment of localized carcinoma of the prostate]
PUBDATE: 19980801
Review of the treatment of localized prostate cancer. The major attention is devoted to the surgical treatment. The radical retropubic prostatectomy is used most frequently. Problems of the indication, anatomical foundations and the technique of the surgery are discussed. The radical perineal prostatectomy is used less frequently. The radiation therapy is an alternative to the surgical treatment. The radiation therapy is recommended by urologists in patients, for whom is this treatment considered as more advantageous.

3. DOCID:27299 SCORE: 0.00414866627476458
DOCNO: 10088127
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: transplantation
QUALIFIER: methods
QUALIFIER: therapy
AUTHOR: C A Colaco CA
AFFILIATION: Quadrant Healthcare, Maris Lane, Cambridge, UK. camilo.colaco@quadrant.co.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Molecular medicine today.
COUNTRY: ENGLAND
TITLE: Why are dendritic cells central to cancer immunotherapy?
PUBDATE: 19990101
Dendritic cell (DC)-based immunotherapy is rapidly emerging as a viable alternative to radiation or chemotherapy in the treatment of cancer. The resurgence of interest in cancer immunotherapy reflects the promising results that have been obtained in both animal models and early clinical trials with the DC-based approach. Here I suggest that this optimism is justified because the efficient capture and presentation of antigens by DCs is central to the induction of an immune response. I argue that the mechanism by which DCs capture antigen suggests that the immune system might actually be 'blind' to tumours, thereby challenging the theory of immune surveillance.

4. DOCID:27724 SCORE: 0.00414866183758099
DOCNO: 10533411
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Medulla Oblongata
DESCRIPTOR: Neoplasm Metastasis
QUALIFIER: etiology
AUTHOR: E Brenne E
AUTHOR: S Kaasa S
AUTHOR: U Falkmer U
AUTHOR: K O Skaanes KO
AUTHOR: O S Husby OS
AUTHOR: G Myhr G
AUTHOR: G Nilsen G
AUTHOR: E R Bovim ER
AUTHOR: R Telhaug R
AFFILIATION: Kreftavdeling, Regionssykehuset i Trondheim.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Medullary compression in metastatic cancer]
PUBDATE: 19990901
Cancer patients with spinal cord compression may develop irreversible neurological deficit. The clinical picture implies back pain and subsequent neurological deficit. There is always a danger of rapid deterioration of the patient's condition. If spinal cord compression is suspected, the case is an emergency. MRI should be preferred in the diagnostic work-up, and corticosteroids be administered promptly. Radiation therapy or surgical treatment should be started as soon as possible. Patient outcome is related to the degree of neurological deficit at the start of treatment.

5. DOCID:26958 SCORE: 0.00384249590331349
DOCNO: 10374686
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: A Giuliani A
AUTHOR: A Caporale A
AUTHOR: M Di Bari M
AUTHOR: M Demoro M
AUTHOR: P Mingazzini P
AFFILIATION: Istituto I Clinica Chirurgica, Università La Sapienza, Rome, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of experimental & clinical cancer research : CR.
COUNTRY: ITALY
TITLE: Isolated splenic metastasis from endometrial carcinoma.
PUBDATE: 19990301
Splenic involvement by carcinomatous metastases occurs late in the course of widely disseminated disease. Solitary metastasis to the spleen from a primary of any source is an uncommon event. We report a case of a 58-year-old woman in which an asymptomatic solitary metastatic endometrial adenocarcinoma of the spleen was detected 28 months after resection of the primary malignancy and treated by splenectomy. There are thirteen other reported cases of solitary splenic metastasis from gynecological cancers; in four of these reports the source was endometrial.

6. DOCID:26243 SCORE: 0.00379507013344033
DOCNO: 10611683
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: etiology
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: F McCormick F
AFFILIATION: UCSF Cancer Center, Cancer Research Institute, 2340 Sutter St, San Francisco, CA 94115, USA. mccormick@cc.ucsf.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in cell biology.
COUNTRY: ENGLAND
TITLE: Signalling networks that cause cancer.
PUBDATE: 19991201
Cancer is caused by the stepwise accumulation of mutations that affect growth control, differentiation and survival. The view that mutations affect discrete signalling pathways, each contributing to a specific aspect of the full malignant phenotype, has proved to be too simplistic. We now know that oncogenes and tumour suppressors depend on one another for their selective advantage, and that they affect multiple pathways that intersect and overlap. The interactive nature of each genetic change has important implications for cancer therapy and for the stepwise model of carcinogenesis.

7. DOCID:24792 SCORE: 0.00375085867768904
DOCNO: 10853141
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: M P Mehta MP
AFFILIATION: Department of Human Oncology, University of Wisconsin-Madison Medical School, 53792, USA. mehta@mail.humonc.wisc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: The contemporary role of radiation therapy in the management of lung cancer.
PUBDATE: 20000701
This article reviews the current role of radiotherapy in the management of non-small-cell lung cancer. This modality is used extensively in lung cancer patients. In a variety of different contexts, the specific indications, results, controversies, and emerging areas are highlighted, with an emphasis on the author's personal techniques and a review of the pertinent literature.

8. DOCID:27739 SCORE: 0.0037262149003144
DOCNO: 9615865
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Topoisomerases, Type I
QUALIFIER: antagonists & inhibitors
AUTHOR: Y Pommier Y
AFFILIATION: Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, MD 20892-4255, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biochimie.
COUNTRY: FRANCE
TITLE: Diversity of DNA topoisomerases I and inhibitors.
PUBDATE: 19980301
The present review first describes the different type I topoisomerases found in eukaryotic cells: nuclear topoisomerase I (top1), topoisomerase 3 (top3), mitochondrial topoisomerase I and viral topoisomerases I. The second part of the review provides extensive information on the topoisomerase I inhibitors identified to date. These drugs can be grouped in two categories: top1 poisons and top1 suppressors. Both inhibit enzyme catalytic activity but top1 poisons trap the top1 catalytic intermediates ('cleavage complexes') while top1 suppressors prevent or reverse top1 cleavage complexes. The molecular interactions of camptothecin with the top1 cleavage complexes are discussed as well as the mechanisms of selective killing of cancer cells.

9. DOCID:27594 SCORE: 0.00350574245236538
DOCNO: 10885906
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
AUTHOR: C J Moody CJ
AUTHOR: J R Roffey JR
AUTHOR: E Swann E
AUTHOR: S Lockyer S
AUTHOR: S Houlbrook S
AUTHOR: I J Strafford IJ
AFFILIATION: School of Chemistry, University of Exeter, Devon, UK. c.j.moody@exeter.ac.uk
PUBTYPE: Journal Article
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: Synthesis and cytotoxic activity of thiazolyl indolequinones.
PUBDATE: 19990701
A number of thiazolyl indolequinones have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was determined in the human breast cancer SKBr3 cell line. Selected compounds were also studied in human lung carcinoma A549 and PV9 cell lines. In addition, some compounds were evaluated for their possible bioreductive action by determining their cytotoxicity towards V79 Chinese hamster lung fibroblasts in air and under anaerobic (hypoxic) conditions.

10. DOCID:26146 SCORE: 0.00303882923565096
DOCNO: 10679384
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: metabolism
QUALIFIER: physiology
QUALIFIER: enzymology
AUTHOR: J K Karow JK
AUTHOR: L Wu L
AUTHOR: I D Hickson ID
AFFILIATION: Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: ENGLAND
TITLE: RecQ family helicases: roles in cancer and aging.
PUBDATE: 20000201
The RecQ family of DNA helicases includes at least three members in humans that are defective in genetic disorders associated with cancer predisposition and/or premature aging. Recent studies have shed light on the roles of RecQ helicases in suppressing 'promiscuous' genetic recombination and in ensuring accurate chromosome segregation. In particular, the biochemical properties of several family members have been characterised and functional interactions with other nuclear proteins have been defined.

11. DOCID:24622 SCORE: 0.00286575127913256
DOCNO: 9628955
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: R L Wahl RL
AFFILIATION: Division of Nuclear Medicine, Department of Internal Medicine and Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0028, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Primary care.
COUNTRY: UNITED STATES
TITLE: Progress in nuclear medicine imaging of cancers.
PUBDATE: 19980601
Nuclear imaging is assuming an increasing role in the management of patients with cancer. A variety of new radiopharmaceuticals, several antibody or peptide based, as well as innovative uses of existing radiopharmaceuticals, mean that most nuclear medicine departments equipped with standard imaging devices can image the single photon imaging agents without difficulty.

12. DOCID:25091 SCORE: 0.00274806484343766
DOCNO: 9881821
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Erythrocytes
DESCRIPTOR: Models, Genetic
DESCRIPTOR: Mutation
QUALIFIER: epidemiology
QUALIFIER: genetics
AUTHOR: B I Gerashchenko BI
AFFILIATION: Institute of Experimental Radiology, Center for Radiation Medicine, Kiev, Ukraine.
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Erythrocyte as a potential model for study of lifelong somatic mutations.
PUBDATE: 19980801
The detection and measurement of somatic cell mutation in vivo is an important subject of research for the assessment of human cancer risk induced by various environmental genotoxic factors. The possible mechanisms which influence the persistence of mutant cells of the hematoimmune system in the peripheral blood are presented. The erythroid system is a system which accumulates mutational lesions and so stably generates red blood cells with various phenotypic changes.

13. DOCID:26809 SCORE: 0.00268818248112056
DOCNO: 11249761
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, p53
QUALIFIER: methods
QUALIFIER: genetics
QUALIFIER: therapy
AUTHOR: D L Barnard DL
AFFILIATION: Institute for Antiviral Research, Utah State University, 5600 Main Hill, Logan, UT 84322, USA. honery@cc.usu.edu
PUBTYPE: Clinical Trial
PUBTYPE: Clinical Trial, Phase I
PUBTYPE: Clinical Trial, Phase II
PUBTYPE: Clinical Trial, Phase III
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in molecular therapeutics.
COUNTRY: England
TITLE: Technology evaluation: Sch-58500, Canji.
PUBDATE: 20001001
Sch-58500 is a gene therapy utilizing the p53 gene and is under development by Canji and Schering-Plough for the potential treatment of various types of cancer. It is in phase II/III clinical trials in the US for stage III ovarian cancer [328228,328893], phase II clinical trials for hepatocellular and colorectal cancer metastatic to the liver [273331,324279], and phase I clinical trials for several other types of cancer [282801,284932,328228].

14. DOCID:26783 SCORE: 0.0026881812995093
DOCNO: 9858294
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
QUALIFIER: secondary
QUALIFIER: radionuclide imaging
AUTHOR: D Wheat D
AUTHOR: P McCarthy P
AFFILIATION: University College Hospital, Galway, Ireland.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical nuclear medicine.
COUNTRY: UNITED STATES
TITLE: Metastatic pulmonary, gastric, and renal calcification demonstrated on bone scintigraphy in a patient with malignant melanoma and renal failure.
PUBDATE: 19981201
PURPOSE: This case report describes the clinical, scintigraphic, and pathologic findings in a patient with an unexpected finding of a cutaneous malignant melanoma. METHOD: Multiple imaging studies were done, as was a pathologic examination of a suspicious pigmented lesion on the patient's back. RESULT: A Tc-99m MDP bone scan showed diffuse uptake in the skeleton, lungs, kidneys, and stomach. CONCLUSION: Metastatic calcification, as shown by isotope scintigraphy, is an unusual manifestation of metastatic cancer from a primary cutaneous melanoma.