0. DOCID:19770 SCORE: 0.00411804893472438
DOCNO: 8465713
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: H C Seim HC
AUTHOR: K B Holtmeier KB
AFFILIATION: University of Minnesota Medical School-Minneapolis.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American family physician.
COUNTRY: UNITED STATES
TITLE: Treatment of obesity in the elderly.
PUBDATE: 19930401
Obesity is a common form of malnutrition among the elderly. Excessive weight gain is associated with decreased physical activity and a progressive decline in caloric requirements for weight maintenance. Obesity increases the risk of myocardial infarction, stroke, hypertension, noninsulin-dependent diabetes, osteoarthritis of the lower extremities and several types of cancer. Specific guidelines are recommended for weight-loss programs used in the elderly. While calories from dietary fats and carbohydrates are restricted, a protein intake of approximately 70 g per day is desirable. Exercise is an important part of the weight-loss program and contributes to a general sense of well-being. Limitation of motion may necessitate innovative forms of exercise for elderly patients.


1. DOCID:19240 SCORE: 0.00349300740927031
DOCNO: 1952807
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: L Iselius L
AUTHOR: J Slack J
AUTHOR: M Littler M
AUTHOR: N E Morton NE
AFFILIATION: Department of Community Medicine, Southampton General Hospital, UK.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annals of human genetics.
COUNTRY: ENGLAND
TITLE: Genetic epidemiology of breast cancer in Britain.
PUBDATE: 19910501
A complex segregation analysis was conducted on two British series (one consecutive series of probands with breast cancer and one series ascertained through a normal consultand). Altogether there were 1248 nuclear families with breast cancer. A dominant gene with a frequency of 0.003 giving a lifetime penetrance of 0.83 is favoured. Ovarian, endometrial and cancers associated with the SBLA syndrome, as well as benign breast disease, were significantly more common in familial breast cancer than in families of single cases. Probands in families with more than one individual with breast cancer were non-significantly younger than isolated probands.


2. DOCID:18566 SCORE: 0.00342195226798255
DOCNO: 1544087
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: prevention & control
AUTHOR: I C Henderson IC
AFFILIATION: Department of Medicine, UCSF 94143.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Biologic variations of tumors.
PUBDATE: 19920401
Few tumors are so heterogeneous in their growth rates and patterns of metastasis as breast cancer. In general, the clinical phase of this disease is much longer than that of most other tumors. It is assumed that the preclinical phase is similarly long and this is one reason that the use of screening mammography has reduced breast cancer mortality. Mammography is not equally effective in all patient populations, but it has not yet been possible to precisely define those populations of women more or less likely to benefit from periodic mammography. Future studies should place greater emphasis on the correlation between frequency of mammography and biologic variations.


3. DOCID:19372 SCORE: 0.00335036168392636
DOCNO: 8490868
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adolescent Psychology
QUALIFIER: psychology
AUTHOR: R S Ettinger RS
AUTHOR: S P Heiney SP
AFFILIATION: Children's Center for Cancer and Blood Disorders, Richland Memorial Hospital, Columbia, SC 29203.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Cancer in adolescents and young adults. Psychosocial concerns, coping strategies, and interventions.
PUBDATE: 19930501
Adolescent cancer patients present a unique challenge to health care professionals because of the impact of the disease and its treatment on the successful acquisition of age-appropriate developmental milestones, as well as the psychosocial concerns raised by the illness itself. Understanding normal adolescent development provides a framework for identifying psychosocial concerns, predicting problems, and developing appropriate interventional strategies for adolescents with cancer. A comprehensive support program with specific goals of promoting adjustment to the illness and providing a basis for community reentry by strengthening recognized coping strategies based on identified psychosocial concerns is described as a model.


4. DOCID:18268 SCORE: 0.00318675779515172
DOCNO: 1653088
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: P Chou P
AFFILIATION: Institute of Public Health, National Yang-Ming Medical College, Taipei, R.O.C.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Zhonghua yi xue za zhi = Chinese medical journal; Free China ed.
COUNTRY: TAIWAN
TITLE: Review on cervical cancer screening.
PUBDATE: 19910701
This article reviews literature of cervical cancer screening including the following topics: (1) basic conditions concerning screening; (2) consensus on cervical cancer screening; (3) some limitations and problems of cancer screening; (4) intervals of cervical cancer screening; (5) evaluation of cervical cancer screening; (6) methods for cervical cancer screening; (7) target population for screening (participants of both screening and rescreening); (8) selective screening (teenagers, pregnant women, prostitutes, hospital patients, clinic patients, immunosuppressive patients, and referral); (9) reports on screening programs in various countries; and (10) cost and benefit of screening.


5. DOCID:19964 SCORE: 0.00309314102023091
DOCNO: 1369366
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ligands
DESCRIPTOR: Radioligand Assay
QUALIFIER: analysis
AUTHOR: I Shaw I
AFFILIATION: Xenova Ltd, Slough, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in biotechnology.
COUNTRY: ENGLAND
TITLE: Receptor-based assays in screening for biologically active substances.
PUBDATE: 19920201
Molecular biology has identified new receptors and ligands which are deregulated in diseases such as cancer and autoimmune conditions and which provide rational targets for therapeutic intervention. Advances in instrumentation and methodology make it possible to screen large numbers of samples in simple receptor-ligand binding assays in the search for drug candidates. Caution must be exercised in the interpretation of data derived from such assays. This is particularly pertinent to the recently characterized receptors, such as the cytokine receptors, as we do not fully understand the relationship between the receptor type and the linkage of receptors to the appropriate or inappropriate second messenger systems that are used in the experimental screening protocols and the disease state.


6. DOCID:17432 SCORE: 0.00308572358825818
DOCNO: 2048611
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: standards
AUTHOR: S G Pillsbury SG
AUTHOR: J S Link JS
AUTHOR: S Roux S
AFFILIATION: Memorial Breast Center, Memorial Cancer Institute, Long Beach Memorial Medical Center, CA.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Improved mammographic accuracy.
PUBDATE: 19910601
Use of ancillary imaging studies to evaluate suspicious screening mammograms can improve their positive predictive value for detecting malignant lesions. In 1989 8181 screening mammograms were performed at the breast evaluation center at Memorial Hospital Medical Center in Long Beach. A total of 670 patients were called back for magnification views or ultrasonographic evaluation, and 92 of these patients underwent surgical biopsy. There were 42 cancers diagnosed, yielding an accuracy rate of 46%.


7. DOCID:18529 SCORE: 0.00303480440125242
DOCNO: 2140522
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: A Leviton A
AFFILIATION: Harvard Medical School, Boston, MA.
PUBTYPE: Journal Article
PUBTYPE: Meta-Analysis
JOURNALTITLE: Cancer letters.
COUNTRY: NETHERLANDS
TITLE: Methylxanthine consumption and the risk of ovarian malignancy.
PUBDATE: 19900501
Between 1970 and 1988, reports were published about two ecological studies, six case-control studies and one cohort study that evaluated the relationship between methylxanthine consumption and the risk of ovarian cancer. Because of the limitations of ecological studies, no inferences are based on them. All of the case-control studies recruited hospital controls. Nevertheless, four of the six had risk ratios of 1.5 or less. The one cohort study, which showed no relationship between coffee drinking and ovarian cancer, has low power. From these studies, it appears that coffee and tea consumption do not increase the risk of ovarian cancer.


8. DOCID:18284 SCORE: 0.00303237614651393
DOCNO: 2214157
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: H Sasaki H
AUTHOR: K Ochiai K
AUTHOR: Y Terashima Y
AFFILIATION: Dept. of Obstet. & Gynecol., Jikei Med. Univ. School of Med.
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Significance of second look surgery in the therapy of ovarian cancer]
PUBDATE: 19900801
Second look surgery (SLO) has two kinds of significance in therapy of ovarian cancer. One is a diagnostic value in persistence or not of ovarian cancer. The other is a second cytoreductive surgery. SLO as a diagnostic value is very much valuable to determine prognosis and therapies. On the other hand, SLO as a second cytoreductive surgery prolonged survival periods, however did not affect long term survival rate. Hence, their significance of SLO is not established to acquired good prognosis in long term.


9. DOCID:17490 SCORE: 0.00291984275706477
DOCNO: 2096823
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
AUTHOR: E N Olsuf'eva EN
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bioorganicheskaia khimiia.
COUNTRY: USSR
TITLE: [Synthesis and antitumor activity of new analogs of anthracycline antibiotics modified by aglycon]
PUBDATE: 19901101
Anthracycline antibiotics widely used, along with their semisynthetic analogues, in human cancer chemotherapy, are O-glycosides having as aglycon 7,8,9,10-tetrahydronaphtacenequinone-5,10-with some hydroxy groups, a side chain at C-9 and sugar(s) residues, usually at C-7. The review includes the most important studies on the chemical modification of the aglycon moiety of daunorubicin, doxorubicin and carminomycin during last ten years. Activity of the compounds on experimental tumours is described and their structure-activity relationship is discussed.


10. DOCID:17676 SCORE: 0.00290610979215986
DOCNO: 2230608
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: radiation effects
AUTHOR: J H Riggs JH
AUTHOR: G D Schultz GD
AUTHOR: S A Hanes SA
AFFILIATION: Los Angeles College of Chiropractic, Whittier, CA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of manipulative and physiological therapeutics.
COUNTRY: UNITED STATES
TITLE: Radiation induced fracture of the scapula.
PUBDATE: 19901001
A case of radiation induced osteonecrosis resulting in a fracture of the scapula in a 76-yr-old female patient with a history of breast carcinoma is presented. Diagnostic imaging, laboratory recommendations and clinical findings are discussed along with an algorithm for the safe management of patients with a history of cancer and musculoskeletal complaints. This case demonstrates the necessity of a thorough investigation of musculoskeletal complaints in patients with previous bone-seeking carcinomas.


11. DOCID:19321 SCORE: 0.00287186264725287
DOCNO: 1813699
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: H Nakaba H
AUTHOR: M Miyata M
AUTHOR: M Hamaji M
AUTHOR: M Izukura M
AUTHOR: K Okumura K
AUTHOR: Y Kawashima Y
AFFILIATION: First Department of Surgery, Osaka University Medical School, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: Gastric varices formation due to pancreatic tumor: a case of successful resection of cystadenocarcinoma.
PUBDATE: 19910901
We report a 70-year-old woman with gastric varices due to splenic vein obstruction by a cystadenocarcinoma of the caudal pancreas. Most of the pancreatic cancer had already extensively progressed and was unresectable when an obstruction of the splenic vein was also discovered. Two contributing factors are thought to have enabled us to perform a curative resection in this case: (1) the gastric varices were detected by chance in a mass survey, (2) the cancer was not so advanced as to be unresectable.


12. DOCID:18714 SCORE: 0.00286304721137231
DOCNO: 1471110
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude to Health
DESCRIPTOR: Psychiatry
DESCRIPTOR: Public Opinion
DESCRIPTOR: Research Support
DESCRIPTOR: Television
QUALIFIER: psychology
AUTHOR: V Fønnebø V
AUTHOR: A J Søgaard AJ
AFFILIATION: Institutt for samfunnsmedisin, Universitetet i Tromsø.
PUBTYPE: Journal Article
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Knowledge about the attitude to mental disorders. An interview study prior to last autumn's TV-action]
PUBDATE: 19921001
In June 1992 a random sample of 1,191 Norwegians were interviewed about their knowledge concerning mental disorders and psychiatric research, and their attitudes in this connection. The study shows that people tend to underestimate the prevalence of mental illness, and they are less willing to talk freely about a mental disorder in the family than about cancer. People have a relatively good understanding of the aetiology of mental disorders. They are less willing, however, to support psychiatric research financially compared with cancer research.


13. DOCID:19221 SCORE: 0.00284373186663185
DOCNO: 1504181
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: metabolism
QUALIFIER: pharmacokinetics
AUTHOR: K H Sit KH
AUTHOR: B H Bay BH
AUTHOR: K P Wong KP
AFFILIATION: Department of Anatomy, Faculty of Medicine, National University of Singapore, Kent Ridge.
PUBTYPE: Journal Article
JOURNALTITLE: Biotechnic & histochemistry : official publication of the Biological Stain Commission.
COUNTRY: UNITED STATES
TITLE: Distinctive uptake of neutral red by mitotic cancer cells.
PUBDATE: 19920701
Neutral red stains both normal and cancer mitotic cells, but uptake by living mitotic cancer cells is distinctly higher than in normal cells. This new approach to cancer cell identification is demonstrated in 4 established tumorigenic cancer cell lines: human skin epidermoid carcinoma A431, mouse Cloudman malignant melanoma, human oral epidermoid carcinoma and rat hepatoma. Human Chang liver cells served as normal controls. With epidermal growth factor (EGF) prepulse, neutral red uptake is dramatically enhanced. The possibility of a causal relationship with M-phase specific phosphorylation is discussed.


14. DOCID:19281 SCORE: 0.00284372983373342
DOCNO: 2069397
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: S Okada S
AUTHOR: N Okazaki N
AFFILIATION: Dept. of Internal Medicine, National Cancer Center Hospital, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Chemotherapy in cancers of the gallbladder and bile ducts]
PUBDATE: 19910701
Chemotherapy for cancers of the biliary tract remains underdeveloped, mainly because of their low incidence. There have been no well-designed chemotherapeutic trials based on a sufficient number of cases in this field. The summarized results from the literature and our experience indicate no standard regimen for chemotherapy of the biliary tract cancers. To improve chemotherapy for these cancers, the development of new active anticancer agents is essential. And, for clinical trials of chemotherapy for this relatively rare cancer, a cooperative group study is considered to be necessary to obtain meaningful results within a reasonable period.