0. DOCID:11234 SCORE: 0.00507248294456289
DOCNO: 6830599
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: H Yamamoto H
AUTHOR: M Tanaka M
AUTHOR: T Okochi T
AUTHOR: S Kishimoto S
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Interaction of human intestinal and hepatoma alkaline phosphatases with immobilized Cibacron Blue F3GA.
PUBDATE: 19830201
Possible interactions of human liver and intestinal alkaline phosphatases with Cibacron Blue F3GA were examined. The results indicated that the intestinal enzyme bound to the dye column whereas the liver enzyme did not. The affinity of intestinal alkaline phosphatase with the dye-ligand appeared to be biospecific, since a low concentration of purine nucleoside phosphates or potassium phosphate specifically reversed the binding. Taking advantage of the variant alkaline phosphatase from human hepatocellular cancer tissue to behave on the dye adsorbent in a similar fashion with the intestinal enzyme, it was purified by Cibacron Blue F3GA affinity chromatography, producing a 189-fold purification with a yield of 93%.

1. DOCID:11253 SCORE: 0.0050724809392806
DOCNO: 6610802
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: A Aboud A
AUTHOR: A U Buzdar AU
AUTHOR: H Y Yap HY
AUTHOR: G N Hortobagyi GN
AUTHOR: G R Blumenschein GR
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Combination chemotherapy for metastatic breast cancer with fluorouracil, adriamycin, cyclophosphamide, and methotrexate.
PUBDATE: 19840701
Twenty-nine patients with metastatic breast cancer were treated with fluorouracil, adriamycin, cyclophosphamide (FAC), and methotrexate (MTX), with or without leukovorin rescue. Of 24 evaluable patients, one achieved a complete remission and 17 had partial responses. The overall objective response rate was 75%. The median survival from initiation of chemotherapy for the responding patients was 18 months. Four patients (17%) with stable disease had a median survival of 25 months. The addition of MTX to FAC chemotherapy did not improve the therapeutic efficacy of this combination; it did, however, increase the overall toxicity, especially the infectious complications when compared to FAC alone.

2. DOCID:11831 SCORE: 0.00505942379731872
DOCNO: 6391119
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: urine
QUALIFIER: urine
QUALIFIER: diagnosis
AUTHOR: K Ueda K
AUTHOR: J Kato J
AUTHOR: T Seki T
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Urinary excretion of N-acetyl-beta-D-glucosaminidase in patients with urological disease: with special reference to hydronephrosis]
PUBDATE: 19840701
Activity of urinary N-acetyl-beta-D-glucosaminidase (NAG) has been studied in patients with urological diseases. In most patients with benign prostatic hyperplasia, prostate cancer and bladder cancer, activity of urinary NAG was elevated (92.9%), especially in cases of indwelling catheterization or poor visualization of IVU. Urinary NAGs were also elevated for all patients with renal stones, ureter stones, uretero-cutaneous stomy or a single kidney. In hydronephrosis or hydronephrosis with hydroureter patients, urinary NAG level was low pre-operatively, but increased post-operatively. Urinary beta 2-microglobulin (BMG) showed a similar tendency in patients with hydronephrosis or hydronephrosis with hydroureter. Electronmicroscopic observations of the kidney in such patients revealed many primary and secondary lysosomes.

3. DOCID:10354 SCORE: 0.00505054361941482
DOCNO: 6330947
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: A Janni A
AUTHOR: P Santini P
AUTHOR: A Mussi A
AUTHOR: G F Menconi GF
AUTHOR: M Miniati M
AUTHOR: C A Angeletti CA
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Results of en bloc resections for lung cancer.
PUBDATE: 19840601
The results of en bloc resection carried out in 33 patients with lung cancer involving the chest wall are described. Microscopic examination of the lung specimen revealed large cell anaplastic carcinoma in 14 cases, squamous carcinoma in 10, adenocarcinoma in 5, microcytoma and fibrosarcoma in 2 cases respectively. The 5 year survival, calculated according to the actuarial method, was 32%, only slightly lower than the 5 year overall survival observed in our survey. The long-term prognosis was essentially related to the presence of lymph node metastases, which were found to occur at a late stage of the clinical evolution.

4. DOCID:10383 SCORE: 0.0050505432043091
DOCNO: 6172573
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: administration & dosage
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: M E Leavens ME
AUTHOR: C S Hill CS
AUTHOR: D A Cech DA
AUTHOR: J B Weyland JB
AUTHOR: J S Weston JS
PUBTYPE: Journal Article
JOURNALTITLE: Journal of neurosurgery.
COUNTRY: UNITED STATES
TITLE: Intrathecal and intraventricular morphine for pain in cancer patients: initial study.
PUBDATE: 19820201
Intractable pain in six cancer patients was treated with lumbar intrathecal morphine (two patients) and intraventricular morphine (four patients). Daily percutaneous injections of morphine through Ommaya reservoirs were made. Initially, 1 mg of lumbar intrathecal morphine resulted in pain relief for 10 to 14 hours, and 2.5 to 4.0 mg of intraventricular morphine gave relief for 12 to 24 hours. This treatment was continued for 3 to 7 months in three of the adults. Morphine requirements gradually increased. Side effects were minimal, and there were no complications.

5. DOCID:10388 SCORE: 0.00505054301462286
DOCNO: 4048970
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: R J Mayer RJ
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Adjuvant therapy in rectal cancer: a protocol proposal.
PUBDATE: 19850901
The use of adjuvant radiation therapy and chemotherapy diminishes the likelihood of local-regional and distant recurrences and appears to prolong survival in patients who have undergone a complete surgical resection of a Dukes-Kirklin stage B2 or C rectal cancer. Patients with this malignant condition rarely develop peritoneal recurrences and therefore do not seem to be an appropriate group in which to evaluate the efficacy of intraperitoneal chemotherapy in gastrointestinal cancer. Such individuals, however, might serve as ideal subjects to examine objectively the merits of prolonged, ambulatory infusional chemotherapy through a prospective clinical trial comparing postoperative radiation therapy combined with 5-FU given in either protracted continuous infusional or intermittent bolus schedules.

6. DOCID:10156 SCORE: 0.00454081878237178
DOCNO: 6620568
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: K Hanawa K
AUTHOR: S Takeda S
AUTHOR: Y Kasai Y
AUTHOR: Y Suzuki Y
AUTHOR: T Takahashi T
AUTHOR: T Mori T
AUTHOR: M Shinhara M
AUTHOR: M Miyauchi M
AUTHOR: K Kubota K
AUTHOR: Y Gotoh Y
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Surgical case of simultaneous triple cancers of the esophagus, stomach and colon]
PUBDATE: 19830801
We report a patient with synchronous triple cancers arising in the digestive tract. It was a combination of esophageal, gastric and colonic cancers; total excision was performed in one operation. Histological study confirmed that each cancer had developed independently. The esophageal cancer was of ulcerated type; histologically it was poorly differentiated squamous cell carcinoma. The gastric and colonic cancers were both of Borrmann II type and well differentiated adenocarcinoma.

7. DOCID:10179 SCORE: 0.00454081816789602
DOCNO: 6442624
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: A Ardizzoni A
AUTHOR: P Pronzato P
AUTHOR: P F Conte PF
AUTHOR: R Rosso R
PUBTYPE: Journal Article
JOURNALTITLE: Chemioterapia : international journal of the Mediterranean Society of Chemotherapy.
COUNTRY: ITALY
TITLE: Mitomycin C and 5-fluorouracil as second choice treatment in advanced breast cancer patients.
PUBDATE: 19840401
Twenty-six patients with advanced breast cancer, (12 previously treated with adriamycin-containing regimens, 14 not exposed to adriamycin because of poor cardiac performance), were treated with combination chemotherapy including mitomycin C plus 5-fluorouracil. Objective response was seen in 7/66 patients (26.9%) with a statistically higher response rate in patients with fewer than 2 metastatic sites. Because of mild toxicity this regimen can be safely used as second-line chemotherapy for heavily pretreated patients and as first-line treatment in patients with poor cardiac performance.

8. DOCID:10682 SCORE: 0.0042326010608138
DOCNO: 6748246
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: K Sekiba K
AUTHOR: H Okuda H
AUTHOR: H Fukui H
AUTHOR: Y Ishii Y
AUTHOR: K Urabe K
AUTHOR: T Hasegawa T
AUTHOR: S Endo S
AUTHOR: Y Hasegawa Y
AUTHOR: Y Nakagiri Y
AUTHOR: K Sakaguchi K
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Functional saving in the treatment of cervical cancer]
PUBDATE: 19840501
The radicality of Okabayashi's radical hysterectomy for treatment of cervical cancer has been well-known. However, its radicality also brought up the disturbance of fertility, endocrine and sexual function as well as the dysfunction of micturition and defecation. As early cervical cancer cases have increased yearly, and social rehabilitation became more necessary nowadays, functional saving is important and must be considered as the responsibility of the oncologists. This report denotes the preservation of ovarian function, sexual rehabilitation as well as the fertility in the treatment of cervical cancer.

9. DOCID:10049 SCORE: 0.0039575119803314
DOCNO: 6372767
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: M S Robertson MS
AUTHOR: J M Robinson JM
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Immediate pharyngoesophageal reconstruction. Use of a quilted skin-grafted pectoralis major muscle flap.
PUBDATE: 19840601
Pharyngoesophageal reconstruction continues to be a problem in the management of cancer involving the hypopharynx. In our experience, the use of deltopectoral and pectoralis major myocutaneous flaps for total reconstruction has been disappointing. We report four cases of immediate near-total reconstruction using a quilted , skin-grafted pectoralis major muscle flap. All cases had received full dosage preoperative irradiation. A thin-walled pharynx was created that has allowed early development of a good esophageal voice. There has been no stricture formation. All patients have experienced no difficulty in establishing a good oral intake.

10. DOCID:8933 SCORE: 0.00382473061990053
DOCNO: 6751281
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: cytology
AUTHOR: W Savino W
AUTHOR: G L Santa-Rosa GL
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Archivum histologicum Japonicum. Nippon soshikigaku kiroku.
COUNTRY: JAPAN
TITLE: Histophysiology of thymic epithelial reticular cells.
PUBDATE: 19820501
Thymic epithelial reticular cells together with lymphocytes constitute the thymic parenchyma. Morphologically they are characterized by the stellate aspect forming a cytoreticulum, a large and vesicular nucleus, a tonofilament-rich cytoplasm, and abundance of desmosomes. Besides the role of providing a structural support for lymphocytes, epithelial reticular cells are responsible for the secretion of thymic hormones which promote lymphocyte proliferation and maturation. Clinical evidence is now appearing suggesting such thymic hormones' use as therapeutic agents against immunodeficiency diseases and cancer.

11. DOCID:9954 SCORE: 0.00372098801353392
DOCNO: 6854779
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: methods
QUALIFIER: pathology
QUALIFIER: diagnosis
AUTHOR: D H Hosking DH
AUTHOR: M Paraskevas M
AUTHOR: O R Hellsten OR
AUTHOR: E W Ramsey EW
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: The cytological diagnosis of prostatic carcinoma by transrectal fine needle aspiration.
PUBDATE: 19830501
During a 2-year period a prospective study was conducted, comparing the accuracy of transrectal fine needle aspiration with that of transperineal needle biopsy in the diagnosis of prostatic carcinoma. With increasing experience the accuracy of aspiration was found to be at least equal to that of biopsy. Blood cultures 1 hour postoperatively in 1 group and 5 minutes postoperatively in another revealed a low incidence of bacteremia. Our findings suggest that prostatic aspiration should be used more widely as the initial diagnostic procedure for suspected prostatic cancer.

12. DOCID:10097 SCORE: 0.00357789740662602
DOCNO: 6210055
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: methods
AUTHOR: M Ohashi M
AUTHOR: M Nakane M
AUTHOR: Y Sugita Y
AUTHOR: S Taniguchi S
AUTHOR: J Nagata J
AUTHOR: K Asano K
AUTHOR: T Yaguchi T
AUTHOR: K Ito K
AUTHOR: H Yamada H
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Treatment of esophageal cancer by endoscopic administration of peplomycin ointment]
PUBDATE: 19841201
Pepleomycin ointment was developed to improve the antitumor activity afforded by endoscopic therapy for esophageal cancer. Through the esophagoscope we could observe this ointment specifically attacking the lesion. Furthermore we were able to recognize that peplomycin was acting directly on the lymph nodes as well as the tumor in a resected portion of the esophagus. It is hopefully anticipated that this method will be used as a combination therapy in pre-operative and inoperable esophageal cancer.

13. DOCID:10400 SCORE: 0.00356610606446958
DOCNO: 4004116
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: F C Rose FC
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Academy of Medicine, Singapore.
COUNTRY: SINGAPORE
TITLE: Problems in the management of stroke.
PUBDATE: 19850101
Cerebral vascular accidents are the third commonest cause of death in the western world, after heart disease and cancer. Although they occur at any age, the risk greatly increases as we get older and, as life expectancy is increasing in all countries, cerebral vascular accidents are becoming commoner. In addition to being a major cause of death, stroke is the single most common cause of chronic disability, the care of which requires considerable financial resources, both to the individual patient, who suffers loss of earning power, to his family, and to the state. This paper reviews the many different drugs that are used in stroke and points out their advantages and disadvantages.

14. DOCID:11348 SCORE: 0.0035536562223978
DOCNO: 2856896
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: C B Tuttle CB
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: Drug management of pain in cancer patients.
PUBDATE: 19850101
Chronic severe cancer pain is often not well controlled because both patient and physician have a poor understanding of the nature of the pain and of the actions of various potent analgesics. Physicians often fail to tailor analgesic dosages to the needs of the individual and unnecessarily limit the dosage because they have an ill founded fear that the patient will become addicted. The basis of rational management of cancer pain with drugs is an appropriate analgesic given regularly in doses adequate to suppress pain continuously. This review compares the potent analgesics and identifies and discusses those that have a role in treating chronic cancer pain. It emphasizes the value of morphine sulfate and gives information on starting and individualizing dosages and managing side effects.