0. DOCID:27226 SCORE: 0.00592260209031461
DOCNO: 9857368
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: therapy
AUTHOR: M J During MJ
AUTHOR: L M Ashenden LM
AFFILIATION: University of Auckland, New Zealand.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Molecular medicine today.
COUNTRY: ENGLAND
TITLE: Towards gene therapy for the central nervous system.
PUBDATE: 19981101
Gene therapy has generated enormous scientific, medical and public interest over the last decade. Clinical trials involving approximately 2000 patients worldwide have targeted simple genetic diseases such as cystic fibrosis, muscular dystrophy, adenosine deaminase deficiency, Gaucher's disease and familial hypercholesterolemia, as well as complex acquired diseases such as cancer and AIDS. The central nervous system is a new and particularly exciting target for gene therapy because its unique properties prevent the successful treatment of many neurological disorders by conventional means. This review discusses the potential applications of in vivo gene therapy to neurological disorders that have the greatest potential for genetic treatments.


1. DOCID:27177 SCORE: 0.00592260017694938
DOCNO: 10418054
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bronchoalveolar Lavage
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: A Cuguillière A
AUTHOR: H Bérard H
AUTHOR: G N'Guyen G
AUTHOR: J Miltgen J
AUTHOR: G Martet G
AUTHOR: J Eskandari J
AUTHOR: D Bonnet D
AFFILIATION: Service de Pneumologie, Hôpital d'Instruction des Armées Laveran, Marseille Armées.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Revue de pneumologie clinique.
COUNTRY: FRANCE
TITLE: [Cyclophosphamide-induced interstitial pneumopathy. Course data of bronchoalveolar lavage apropos of a case and review of the literature]
PUBDATE: 19990401
A patient treated with cyclophosphamide for breast cancer developed functional and clinicoradiological signs of sub-acute diffuse interstitial pneumopathy. Bronchoalveolar lavage revealed lymphocyte alveolitis. Differential diagnoses were excluded and the course was favorable after cyclophosphamide withdrawal. The bronchoalveolar lavage results obtained initially and at follow-up and two previous lavages reported in the literature demonstrate the importance of this examination in the diagnosis of drug-induced pneumopathy.


2. DOCID:31675 SCORE: 0.00498863423188473
DOCNO: 14712781
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Software Design
QUALIFIER: therapeutic use
QUALIFIER: standards
QUALIFIER: drug therapy
QUALIFIER: complications
AUTHOR: Akira Shimada A
AUTHOR: Toshimichi Nakaho T
AUTHOR: Ken Yazaki K
AUTHOR: Takeshi Ohara T
AUTHOR: Nobutaka Kikuchi N
AUTHOR: Hidekazu Watanabe H
AUTHOR: Hiroyuki Yamanaka H
AUTHOR: Masahiko Takahashi M
AUTHOR: Makoto Yamamuro M
AFFILIATION: Tohoku University Hospital Palliative Care Center.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: Japan
TITLE: [The attempt to standardize treatment protocols for cancer-related hypercalcemia: developing a data-based flowchart]
PUBDATE: 20031201
We developed a flowchart for the treatment of cancer-related hypercalcemia based on the review of previous reports. The treatment protocols were standardized in each group of four different ranges of serum calcium concentration (< 12, 12-14, 14-16, < 16 mg/dl). In each Ca range, specific treatment was adjusted according to the clinical evaluation of symptoms and progression of illness of the patients.


3. DOCID:29708 SCORE: 0.00493339969768645
DOCNO: 15522339
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: Chun Fang Zhou CF
AUTHOR: Jian Hua Zhu JH
AFFILIATION: Department of Chemistry, Nanjing University, Nanjing 210093, China.
PUBTYPE: Journal Article
JOURNALTITLE: Chemosphere.
COUNTRY: England
TITLE: Adsorption of nitrosamines in acidic solution by zeolites.
PUBDATE: 20050101
Adsorption of N-nitrosopyrrolidine (NPYR) by zeolite NaZSM-5, Hbeta and NaZSM-11 in acidic solution with pH of 1 was investigated. The NPYR uptake process obeyed the first-rate Lagegren kinetic equation describing adsorption, and the equilibrium data were fitted to the Langmuir or Freundlich adsorption equation. Zeolite ZSM-5, Hbeta and NaZSM-11 possessed a higher adsorption capacity than amorphous silica or ordered mesoporous siliceous SBA-15, implying their potential application for adsorption of nitrosamines in gastric juice to anti-cancer.


4. DOCID:29948 SCORE: 0.00475469315588801
DOCNO: 16205900
OWNER: NLM
STATUS: In-Process
AUTHOR: H Bonkhoff H
AFFILIATION: Praxis für Pathologie, Berlin. bonkhoff@prostapath.de
PUBTYPE: Journal Article
JOURNALTITLE: Der Pathologe.
COUNTRY: Germany
TITLE: [Prognostic factors in prostate cancer]
PUBDATE: 20051101
Since several therapeutic options are currently available for clinically organ-confined prostate cancer, morphological parameters have rapidly emerged as prognostic factors to stratify patients into different therapeutic modalities. In addition to the PSA value, pathologic stage, as defined by the TNM system, Gleason grade and the surgical margin status, other markers have prognostic implications. This includes the percent pattern 4/5 cancer, tumor volume, intraductal spread, large volume perineural invasion and molecular markers. This review discusses the methods of sampling and reporting in prostate pathology with an emphasis on well established and new prognostic factors.


5. DOCID:29607 SCORE: 0.00475468403159562
DOCNO: 16446258
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Thomas P Bradley TP
AUTHOR: Anne L Golden AL
AFFILIATION: Division of Oncology, North Shore University Hospital, New York University School of Medicine, 300 Community Drive, Manhasset, NY 11030, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Clinics in occupational and environmental medicine.
COUNTRY: United States
TITLE: Tobacco and carcinogens in the workplace.
PUBDATE: 20050201
Workplace exposures to carcinogens long have been associated with cancers, and corrective measures to limit exposures have resulted in reductions in such cancers and improved worker health. Some exposures are currently of historical interest, and many current or past exposures are associated with conflicting evidence as to causality. We present a brief overview of the effects of exposure to asbestos, tobacco, and other known carcinogens.


6. DOCID:27089 SCORE: 0.00445795613011041
DOCNO: 9787506
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: J Jarolím J
AUTHOR: V Vachalovský V
AUTHOR: J Novák J
AUTHOR: T Hanus T
AUTHOR: M Babjuk M
AUTHOR: L Safarík L
AUTHOR: J Dvorácek J
AUTHOR: B Matras B
AUTHOR: V Simon V
AUTHOR: E Votocek E
AUTHOR: K Novák K
AFFILIATION: Urologická klinika 1. LF UK a VFN Praha.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Casopís lékar̆ů c̆eských.
COUNTRY: CZECH REPUBLIC
TITLE: [Treatment of localized carcinoma of the prostate]
PUBDATE: 19980801
Review of the treatment of localized prostate cancer. The major attention is devoted to the surgical treatment. The radical retropubic prostatectomy is used most frequently. Problems of the indication, anatomical foundations and the technique of the surgery are discussed. The radical perineal prostatectomy is used less frequently. The radiation therapy is an alternative to the surgical treatment. The radiation therapy is recommended by urologists in patients, for whom is this treatment considered as more advantageous.


7. DOCID:27299 SCORE: 0.00414866627476458
DOCNO: 10088127
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: transplantation
QUALIFIER: methods
QUALIFIER: therapy
AUTHOR: C A Colaco CA
AFFILIATION: Quadrant Healthcare, Maris Lane, Cambridge, UK. camilo.colaco@quadrant.co.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Molecular medicine today.
COUNTRY: ENGLAND
TITLE: Why are dendritic cells central to cancer immunotherapy?
PUBDATE: 19990101
Dendritic cell (DC)-based immunotherapy is rapidly emerging as a viable alternative to radiation or chemotherapy in the treatment of cancer. The resurgence of interest in cancer immunotherapy reflects the promising results that have been obtained in both animal models and early clinical trials with the DC-based approach. Here I suggest that this optimism is justified because the efficient capture and presentation of antigens by DCs is central to the induction of an immune response. I argue that the mechanism by which DCs capture antigen suggests that the immune system might actually be 'blind' to tumours, thereby challenging the theory of immune surveillance.


8. DOCID:27724 SCORE: 0.00414866183758099
DOCNO: 10533411
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Medulla Oblongata
DESCRIPTOR: Neoplasm Metastasis
QUALIFIER: etiology
AUTHOR: E Brenne E
AUTHOR: S Kaasa S
AUTHOR: U Falkmer U
AUTHOR: K O Skaanes KO
AUTHOR: O S Husby OS
AUTHOR: G Myhr G
AUTHOR: G Nilsen G
AUTHOR: E R Bovim ER
AUTHOR: R Telhaug R
AFFILIATION: Kreftavdeling, Regionssykehuset i Trondheim.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Medullary compression in metastatic cancer]
PUBDATE: 19990901
Cancer patients with spinal cord compression may develop irreversible neurological deficit. The clinical picture implies back pain and subsequent neurological deficit. There is always a danger of rapid deterioration of the patient's condition. If spinal cord compression is suspected, the case is an emergency. MRI should be preferred in the diagnostic work-up, and corticosteroids be administered promptly. Radiation therapy or surgical treatment should be started as soon as possible. Patient outcome is related to the degree of neurological deficit at the start of treatment.


9. DOCID:30147 SCORE: 0.00410577401683747
DOCNO: 16062011
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Soy Foods
DESCRIPTOR: Soybeans
QUALIFIER: prevention & control
QUALIFIER: prevention & control
AUTHOR: Kazuhiro Uenishi K
AFFILIATION: Kagawa Nutrition University, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinical calcium.
COUNTRY: Japan
TITLE: [Recommended soy and soy products intake to prevent bone fracture and osteoporosis]
PUBDATE: 20050801
Soy contains isoflavones, which are phytoestrogens, and its intake may help to prevent some diseases including menopausal disorder, osteoporosis, and breast cancer. Natto, a fermented soy product, is rich in vitamin K, which also contributes to bone health. In this report, we overviewed peer-reviewed papers showing relationship between soy product intake and risks of bone fracture and osteoporosis. It is suggested that that intake of soy products is not strongly enough to conclude but possible to be efficient in prevention of bone fracture and osteoporosis.


10. DOCID:26958 SCORE: 0.00384249590331349
DOCNO: 10374686
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: A Giuliani A
AUTHOR: A Caporale A
AUTHOR: M Di Bari M
AUTHOR: M Demoro M
AUTHOR: P Mingazzini P
AFFILIATION: Istituto I Clinica Chirurgica, Università La Sapienza, Rome, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of experimental & clinical cancer research : CR.
COUNTRY: ITALY
TITLE: Isolated splenic metastasis from endometrial carcinoma.
PUBDATE: 19990301
Splenic involvement by carcinomatous metastases occurs late in the course of widely disseminated disease. Solitary metastasis to the spleen from a primary of any source is an uncommon event. We report a case of a 58-year-old woman in which an asymptomatic solitary metastatic endometrial adenocarcinoma of the spleen was detected 28 months after resection of the primary malignancy and treated by splenectomy. There are thirteen other reported cases of solitary splenic metastasis from gynecological cancers; in four of these reports the source was endometrial.


11. DOCID:26243 SCORE: 0.00379507013344033
DOCNO: 10611683
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: etiology
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: F McCormick F
AFFILIATION: UCSF Cancer Center, Cancer Research Institute, 2340 Sutter St, San Francisco, CA 94115, USA. mccormick@cc.ucsf.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in cell biology.
COUNTRY: ENGLAND
TITLE: Signalling networks that cause cancer.
PUBDATE: 19991201
Cancer is caused by the stepwise accumulation of mutations that affect growth control, differentiation and survival. The view that mutations affect discrete signalling pathways, each contributing to a specific aspect of the full malignant phenotype, has proved to be too simplistic. We now know that oncogenes and tumour suppressors depend on one another for their selective advantage, and that they affect multiple pathways that intersect and overlap. The interactive nature of each genetic change has important implications for cancer therapy and for the stepwise model of carcinogenesis.


12. DOCID:24792 SCORE: 0.00375085867768904
DOCNO: 10853141
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: M P Mehta MP
AFFILIATION: Department of Human Oncology, University of Wisconsin-Madison Medical School, 53792, USA. mehta@mail.humonc.wisc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: The contemporary role of radiation therapy in the management of lung cancer.
PUBDATE: 20000701
This article reviews the current role of radiotherapy in the management of non-small-cell lung cancer. This modality is used extensively in lung cancer patients. In a variety of different contexts, the specific indications, results, controversies, and emerging areas are highlighted, with an emphasis on the author's personal techniques and a review of the pertinent literature.


13. DOCID:31871 SCORE: 0.00372876178701704
DOCNO: 16277924
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: secondary
AUTHOR: Per Pfeiffer P
AUTHOR: Benny Vittrup Jensen BV
AFFILIATION: Odense Universitetshospital, Onkologisk Afdeling R.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Drug therapy of patients with metastatic colorectal cancer]
PUBDATE: 20051101
In less than a decade, metastatic cancer in the colon or rectum has changed from being primarily a surgically palliated disease to one in which there have been increasing successes with combination chemotherapy and molecular targeted therapy. Without treatment, only half of the patients are alive after six months, and there are almost no survivors after two years. With modern therapy, about half of the patients are now alive after two years and the survival time continues to increase. Instead of being a more or less acute life-threatening disease, metastatic colorectal cancer may exist as a chronic condition for years.


14. DOCID:27739 SCORE: 0.0037262149003144
DOCNO: 9615865
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Topoisomerases, Type I
QUALIFIER: antagonists & inhibitors
AUTHOR: Y Pommier Y
AFFILIATION: Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, MD 20892-4255, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biochimie.
COUNTRY: FRANCE
TITLE: Diversity of DNA topoisomerases I and inhibitors.
PUBDATE: 19980301
The present review first describes the different type I topoisomerases found in eukaryotic cells: nuclear topoisomerase I (top1), topoisomerase 3 (top3), mitochondrial topoisomerase I and viral topoisomerases I. The second part of the review provides extensive information on the topoisomerase I inhibitors identified to date. These drugs can be grouped in two categories: top1 poisons and top1 suppressors. Both inhibit enzyme catalytic activity but top1 poisons trap the top1 catalytic intermediates ('cleavage complexes') while top1 suppressors prevent or reverse top1 cleavage complexes. The molecular interactions of camptothecin with the top1 cleavage complexes are discussed as well as the mechanisms of selective killing of cancer cells.