0. DOCID:19770 SCORE: 0.00411804893472438
DOCNO: 8465713
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: H C Seim HC
AUTHOR: K B Holtmeier KB
AFFILIATION: University of Minnesota Medical School-Minneapolis.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American family physician.
COUNTRY: UNITED STATES
TITLE: Treatment of obesity in the elderly.
PUBDATE: 19930401
Obesity is a common form of malnutrition among the elderly. Excessive weight gain is associated with decreased physical activity and a progressive decline in caloric requirements for weight maintenance. Obesity increases the risk of myocardial infarction, stroke, hypertension, noninsulin-dependent diabetes, osteoarthritis of the lower extremities and several types of cancer. Specific guidelines are recommended for weight-loss programs used in the elderly. While calories from dietary fats and carbohydrates are restricted, a protein intake of approximately 70 g per day is desirable. Exercise is an important part of the weight-loss program and contributes to a general sense of well-being. Limitation of motion may necessitate innovative forms of exercise for elderly patients.

1. DOCID:23125 SCORE: 0.00405106671070477
DOCNO: 9186218
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Knee Joint
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: H Aoshima H
AUTHOR: K Kushida K
AUTHOR: M Okada M
AUTHOR: Y Kageyama Y
AUTHOR: T Inoue T
AUTHOR: H Tomita H
AFFILIATION: Department of Orthopaedics, Hamamatsu University School of Medicine, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical orthopaedics and related research.
COUNTRY: UNITED STATES
TITLE: Neuropathic arthropathy caused by paraneoplastic sensory neuropathy. A case report.
PUBDATE: 19970601
Neuropathic arthropathy of both knees after paraneoplastic sensory neuropathy developed in a 64-year-old woman. The patient was found to have small cell lung cancer 2 months after the onset of a sensory neuropathy that was diagnosed as paraneoplastic sensory neuropathy, a nonmetastatic neurologic complication in patients with malignancy. The onset of paraneoplastic sensory neuropathy was followed by the gradual onset of neuropathic arthropathy. This is the first well documented report on neuropathic arthropathy in a patient with paraneoplastic sensory neuropathy.

2. DOCID:22177 SCORE: 0.00402976152982515
DOCNO: 9555127
AUTHOR: H Galjaard H
AFFILIATION: Academisch Ziekenhuis Rotterdam-Dijkzigt, afd. Klinische Genetica, Rotterdam.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nederlands tijdschrift voor geneeskunde.
COUNTRY: NETHERLANDS
TITLE: [Future developments in genetic research. I. Technological possibilities]
PUBDATE: 19971201
The attention in genetic research is shifting from the determination' of (rare) monogenic disorders to identification of genetic risk factors for important diseases at adult age. Mapping of all man's 80,000-100,000 genes will also provide more insight into the gene polymorphisms and mutations that are associated with various types of cancer, certain cardiovascular diseases, diabetes and neurodegenerative disorders, including Alzheimer dementia. Apart from new diagnostic possibilities, the DNA techniques create new prospects for the study of the pathogenesis of diseases and the devising of new strategies for treatment. Examples are familial hypercholesterolaemia, diabetes, breast cancer and colorectal carcinoma.

3. DOCID:21956 SCORE: 0.0039672339709477
DOCNO: 7661187
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: microbiology
QUALIFIER: complications
AUTHOR: M Merle-Melet M
AUTHOR: F Mory F
AUTHOR: B Stempfel B
AUTHOR: P Maurer P
AUTHOR: D Régent D
AUTHOR: S Parent S
AUTHOR: J M Tortuyaux JM
AUTHOR: L Bresler L
AUTHOR: P Boissel P
AFFILIATION: Department of Infectious Diseases-Intensive Care Unit, Brabois University Hospital, Vandoeuvre, France.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of gastroenterology.
COUNTRY: UNITED STATES
TITLE: Actinomyces naeslundii, acute cholecystitis, and carcinoma of the gallbladder.
PUBDATE: 19950901
This report describes the first case of biliary actinomycosis associated with an adenocarcinoma of the gallbladder. Actinomyces naeslundii was encountered as a pure isolate after a precise and careful identification. Although, in diagnosis, cancer and actinomycosis are often confused, the simultaneous occurrence of actinomycosis in cancer lesions can happen. This case illustrates the diagnostic challenge of actinomycosis.

4. DOCID:23968 SCORE: 0.00387802299272291
DOCNO: 7835803
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ovarian Neoplasms
AUTHOR: R F Ozols RF
AFFILIATION: Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Research directions in epithelial ovarian cancer.
PUBDATE: 19941201
Major improvements in survival from ovarian cancer will likely result from a combined effort in prevention, diagnosis, screening, and treatment. Oral contraceptives can decrease the risk of ovarian cancer in women with a family history of the disease. Screening currently is not routinely recommended and awaits further refinements in tumor markers and image techniques. Surgery and chemotherapy have been the cornerstones of treatment for most patients with ovarian cancer. Paclitaxel plus a platinum compound has now become a new standard chemotherapy regimen. However, numerous clinical questions need to be explored in prospectively randomized trials to determine how best to use this agent. Basic research in ovarian cancer will likely lead to the novel therapeutic targets and completely new approaches.

5. DOCID:21772 SCORE: 0.00368775498413673
DOCNO: 8004624
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
DESCRIPTOR: Malpractice
DESCRIPTOR: Risk Management
AUTHOR: R J Brenner RJ
AFFILIATION: Department of Breast Imaging, John Wayne Cancer Institute, Los Angeles, California.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Breast cancer evaluation. Medical-legal and risk management considerations for the clinician.
PUBDATE: 19940701
The legal consequences for physicians involved in the treatment of patients who are at risk for or have developed breast cancer are many. The law of negligence, which is concerned with departures from reasonable standards of conduct, govern most of the cases that come to legal attention. Several other torts or civil infractions, however, may be applicable to such practices. Lessons learned from both trial and appellate decisions rendered in this field offer some guidance to avoid untoward medical and legal consequences.

6. DOCID:19240 SCORE: 0.00349300740927031
DOCNO: 1952807
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: L Iselius L
AUTHOR: J Slack J
AUTHOR: M Littler M
AUTHOR: N E Morton NE
AFFILIATION: Department of Community Medicine, Southampton General Hospital, UK.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annals of human genetics.
COUNTRY: ENGLAND
TITLE: Genetic epidemiology of breast cancer in Britain.
PUBDATE: 19910501
A complex segregation analysis was conducted on two British series (one consecutive series of probands with breast cancer and one series ascertained through a normal consultand). Altogether there were 1248 nuclear families with breast cancer. A dominant gene with a frequency of 0.003 giving a lifetime penetrance of 0.83 is favoured. Ovarian, endometrial and cancers associated with the SBLA syndrome, as well as benign breast disease, were significantly more common in familial breast cancer than in families of single cases. Probands in families with more than one individual with breast cancer were non-significantly younger than isolated probands.

7. DOCID:18566 SCORE: 0.00342195226798255
DOCNO: 1544087
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: prevention & control
AUTHOR: I C Henderson IC
AFFILIATION: Department of Medicine, UCSF 94143.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Biologic variations of tumors.
PUBDATE: 19920401
Few tumors are so heterogeneous in their growth rates and patterns of metastasis as breast cancer. In general, the clinical phase of this disease is much longer than that of most other tumors. It is assumed that the preclinical phase is similarly long and this is one reason that the use of screening mammography has reduced breast cancer mortality. Mammography is not equally effective in all patient populations, but it has not yet been possible to precisely define those populations of women more or less likely to benefit from periodic mammography. Future studies should place greater emphasis on the correlation between frequency of mammography and biologic variations.

8. DOCID:19372 SCORE: 0.00335036168392636
DOCNO: 8490868
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adolescent Psychology
QUALIFIER: psychology
AUTHOR: R S Ettinger RS
AUTHOR: S P Heiney SP
AFFILIATION: Children's Center for Cancer and Blood Disorders, Richland Memorial Hospital, Columbia, SC 29203.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Cancer in adolescents and young adults. Psychosocial concerns, coping strategies, and interventions.
PUBDATE: 19930501
Adolescent cancer patients present a unique challenge to health care professionals because of the impact of the disease and its treatment on the successful acquisition of age-appropriate developmental milestones, as well as the psychosocial concerns raised by the illness itself. Understanding normal adolescent development provides a framework for identifying psychosocial concerns, predicting problems, and developing appropriate interventional strategies for adolescents with cancer. A comprehensive support program with specific goals of promoting adjustment to the illness and providing a basis for community reentry by strengthening recognized coping strategies based on identified psychosocial concerns is described as a model.

9. DOCID:22751 SCORE: 0.00325210212723798
DOCNO: 7851141
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: U Engel U
AUTHOR: A Kucharski A
AUTHOR: C Zornig C
AFFILIATION: I. Chirurgische Abteilung, Allgemeines Krankenhaus Hamburg-Harburg.
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY
TITLE: [Limited radical approach in differentiated thyroid gland cancers. A prospective study of 107 patients]
PUBDATE: 19941201
From 1979 until 1987 a prospective study about limited radical therapy of 107 patients with differentiated cancer of the thyroid was performed. Nearly all of the tumors were occult papillary or encapsulated papillary and follicular carcinomas. The thyroid was not completely resected. Postoperative therapy consisted in TSH-suppression. After a follow-up of 7.5 (5-12) years one patient had died because of the tumor disease. Four patients had to be reoperated for lymph node metastases and then stayed free of disease as all other patients.

10. DOCID:22769 SCORE: 0.00325209975401083
DOCNO: 7944497
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: K Hirama K
AUTHOR: Y Mikami Y
AUTHOR: T Nishi T
AUTHOR: H Suzuki H
AUTHOR: Y Sugiyama Y
AUTHOR: M Konn M
AFFILIATION: Dept. of Surgery, Hirosaki University School of Medicine.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of gastric cancer with Borrmann type 4 responding to 5-FU-MMC combined chemotherapy]
PUBDATE: 19941001
A 70-year-old man with advanced Borrmann type 4 was preoperatively treated with 5-FU-MMC combined chemotherapy. The primary tumor including a palpable mass in the abdomen was diminished, and eventually the patient underwent curative resection. This preoperative regimen for advanced Borrmann type 4 gastric cancer might be recommended from the standpoint of less adverse effects of chemotherapy. The patient died suddenly of cardiac infarction in 9 months without recurrent signs.

11. DOCID:18268 SCORE: 0.00318675779515172
DOCNO: 1653088
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: P Chou P
AFFILIATION: Institute of Public Health, National Yang-Ming Medical College, Taipei, R.O.C.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Zhonghua yi xue za zhi = Chinese medical journal; Free China ed.
COUNTRY: TAIWAN
TITLE: Review on cervical cancer screening.
PUBDATE: 19910701
This article reviews literature of cervical cancer screening including the following topics: (1) basic conditions concerning screening; (2) consensus on cervical cancer screening; (3) some limitations and problems of cancer screening; (4) intervals of cervical cancer screening; (5) evaluation of cervical cancer screening; (6) methods for cervical cancer screening; (7) target population for screening (participants of both screening and rescreening); (8) selective screening (teenagers, pregnant women, prostitutes, hospital patients, clinic patients, immunosuppressive patients, and referral); (9) reports on screening programs in various countries; and (10) cost and benefit of screening.

12. DOCID:23949 SCORE: 0.00318438177823973
DOCNO: 7480625
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Astronauts
DESCRIPTOR: Radiation Protection
DESCRIPTOR: Space Flight
AUTHOR: E A Blakely EA
AUTHOR: R J Fry RJ
AFFILIATION: Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Radiation and environmental biophysics.
COUNTRY: GERMANY
TITLE: Radiation protection in space.
PUBDATE: 19950801
The challenge for planning radiation protection in space is to estimate the risk of events of low probability after low levels of irradiation. This work has revealed many gaps in our knowledge that require further study. Despite investigations of several irradiated populations, the atomic-bomb survivors remain the primary basis for estimating the risk of ionizing radiation. Compared with previous estimates, two new independent evaluations of available information indicate a significantly greater risk of stochastic effects of radiation (cancer and genetic effects) by about a factor of three for radiation workers, including space travelers. This paper presents a brief historical perspective of the international effort to assure radiation protection in space.

13. DOCID:21051 SCORE: 0.00316877189059502
DOCNO: 7701001
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: chemistry
AUTHOR: D B Wickramaratne DB
AUTHOR: W Mar W
AUTHOR: H Chai H
AUTHOR: J J Castillo JJ
AUTHOR: N R Farnsworth NR
AUTHOR: D D Soejarto DD
AUTHOR: G A Cordell GA
AUTHOR: J M Pezzuto JM
AUTHOR: A D Kinghorn AD
PUBTYPE: Letter
JOURNALTITLE: Planta medica.
COUNTRY: GERMANY
TITLE: Cytotoxic constituents of Bursera permollis.
PUBDATE: 19950201
Four cytotoxic lignans were isolated from the stem bark of Bursera permollis (Burseraceae), namely, deoxypodophyllotoxin (1), beta-peltatin methyl ether (2), picro-beta-peltatin methyl ether (3), and dehydro-beta-peltatin methyl ether (4). Also isolated was the inactive lignan, nemerosin (5). Compounds 1 and 2 were potently cytotoxic when evaluated against a panel of human cancer cell lines.

14. DOCID:21941 SCORE: 0.00314768035519341
DOCNO: 8691628
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunoconjugates
DESCRIPTOR: Tumor Markers, Biological
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: T Yamaguchi T
AUTHOR: T Takahashi T
AUTHOR: K Kitamura K
AUTHOR: E Otsuji E
AFFILIATION: First Department of Surgery, Kyoto Prefectural University of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Application of tumor marker for immunotargeting therapy of cancer]
PUBDATE: 19960601
For many years, attempts have been made to utilize the monoclonal antibody against tumor markers for diagnostic purposes. On the other hand, studies with various form of immunoconjugate have demonstrated some therapeutic promise. In this paper, the ideal tumor marker for immunotargeting therapy will be discussed. Results of clinical trials of radioimmunoconjugates, immunotoxin and chemoimmunoconjugates will be reviewed and prospects of these new approaches for the treatment of cancer patients will be presented.