0. DOCID:14996 SCORE: 0.0057800739712571
DOCNO: 2722056
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: drug therapy
AUTHOR: E Kujansuu E
AUTHOR: T Rahko T
AUTHOR: R Punnonen R
AUTHOR: P Karma P
AFFILIATION: Department of Obstetrics and Gynecology, Tampere University Hospital, Finland.
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Evaluation of the hearing loss associated with cis-platinum treatment by high-frequency audiometry.
PUBDATE: 19890601
The effect of cis-platinum treatment on the hearing of 23 ovarian cancer patients was evaluated using standard and high-frequency audiometry. Twenty-two percent of the patients developed a hearing loss of at least 15 db, 13% in the range 125-8000 Hz and 9% only in the high-frequency area above 8 kHz. However, due to the high-frequency hearing loss (presbyacusis) in older patients high-frequency audiometry was often unobtainable. Hearing screening using standard pure-tone audiometry is recommended for cis-platinum patients as a routine procedure.

1. DOCID:11234 SCORE: 0.00507248294456289
DOCNO: 6830599
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: H Yamamoto H
AUTHOR: M Tanaka M
AUTHOR: T Okochi T
AUTHOR: S Kishimoto S
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Interaction of human intestinal and hepatoma alkaline phosphatases with immobilized Cibacron Blue F3GA.
PUBDATE: 19830201
Possible interactions of human liver and intestinal alkaline phosphatases with Cibacron Blue F3GA were examined. The results indicated that the intestinal enzyme bound to the dye column whereas the liver enzyme did not. The affinity of intestinal alkaline phosphatase with the dye-ligand appeared to be biospecific, since a low concentration of purine nucleoside phosphates or potassium phosphate specifically reversed the binding. Taking advantage of the variant alkaline phosphatase from human hepatocellular cancer tissue to behave on the dye adsorbent in a similar fashion with the intestinal enzyme, it was purified by Cibacron Blue F3GA affinity chromatography, producing a 189-fold purification with a yield of 93%.

2. DOCID:11253 SCORE: 0.0050724809392806
DOCNO: 6610802
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: A Aboud A
AUTHOR: A U Buzdar AU
AUTHOR: H Y Yap HY
AUTHOR: G N Hortobagyi GN
AUTHOR: G R Blumenschein GR
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Combination chemotherapy for metastatic breast cancer with fluorouracil, adriamycin, cyclophosphamide, and methotrexate.
PUBDATE: 19840701
Twenty-nine patients with metastatic breast cancer were treated with fluorouracil, adriamycin, cyclophosphamide (FAC), and methotrexate (MTX), with or without leukovorin rescue. Of 24 evaluable patients, one achieved a complete remission and 17 had partial responses. The overall objective response rate was 75%. The median survival from initiation of chemotherapy for the responding patients was 18 months. Four patients (17%) with stable disease had a median survival of 25 months. The addition of MTX to FAC chemotherapy did not improve the therapeutic efficacy of this combination; it did, however, increase the overall toxicity, especially the infectious complications when compared to FAC alone.

3. DOCID:11831 SCORE: 0.00505942379731872
DOCNO: 6391119
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: urine
QUALIFIER: urine
QUALIFIER: diagnosis
AUTHOR: K Ueda K
AUTHOR: J Kato J
AUTHOR: T Seki T
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Urinary excretion of N-acetyl-beta-D-glucosaminidase in patients with urological disease: with special reference to hydronephrosis]
PUBDATE: 19840701
Activity of urinary N-acetyl-beta-D-glucosaminidase (NAG) has been studied in patients with urological diseases. In most patients with benign prostatic hyperplasia, prostate cancer and bladder cancer, activity of urinary NAG was elevated (92.9%), especially in cases of indwelling catheterization or poor visualization of IVU. Urinary NAGs were also elevated for all patients with renal stones, ureter stones, uretero-cutaneous stomy or a single kidney. In hydronephrosis or hydronephrosis with hydroureter patients, urinary NAG level was low pre-operatively, but increased post-operatively. Urinary beta 2-microglobulin (BMG) showed a similar tendency in patients with hydronephrosis or hydronephrosis with hydroureter. Electronmicroscopic observations of the kidney in such patients revealed many primary and secondary lysosomes.

4. DOCID:10354 SCORE: 0.00505054361941482
DOCNO: 6330947
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: A Janni A
AUTHOR: P Santini P
AUTHOR: A Mussi A
AUTHOR: G F Menconi GF
AUTHOR: M Miniati M
AUTHOR: C A Angeletti CA
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Results of en bloc resections for lung cancer.
PUBDATE: 19840601
The results of en bloc resection carried out in 33 patients with lung cancer involving the chest wall are described. Microscopic examination of the lung specimen revealed large cell anaplastic carcinoma in 14 cases, squamous carcinoma in 10, adenocarcinoma in 5, microcytoma and fibrosarcoma in 2 cases respectively. The 5 year survival, calculated according to the actuarial method, was 32%, only slightly lower than the 5 year overall survival observed in our survey. The long-term prognosis was essentially related to the presence of lymph node metastases, which were found to occur at a late stage of the clinical evolution.

5. DOCID:10383 SCORE: 0.0050505432043091
DOCNO: 6172573
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: administration & dosage
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: M E Leavens ME
AUTHOR: C S Hill CS
AUTHOR: D A Cech DA
AUTHOR: J B Weyland JB
AUTHOR: J S Weston JS
PUBTYPE: Journal Article
JOURNALTITLE: Journal of neurosurgery.
COUNTRY: UNITED STATES
TITLE: Intrathecal and intraventricular morphine for pain in cancer patients: initial study.
PUBDATE: 19820201
Intractable pain in six cancer patients was treated with lumbar intrathecal morphine (two patients) and intraventricular morphine (four patients). Daily percutaneous injections of morphine through Ommaya reservoirs were made. Initially, 1 mg of lumbar intrathecal morphine resulted in pain relief for 10 to 14 hours, and 2.5 to 4.0 mg of intraventricular morphine gave relief for 12 to 24 hours. This treatment was continued for 3 to 7 months in three of the adults. Morphine requirements gradually increased. Side effects were minimal, and there were no complications.

6. DOCID:10388 SCORE: 0.00505054301462286
DOCNO: 4048970
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: R J Mayer RJ
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Adjuvant therapy in rectal cancer: a protocol proposal.
PUBDATE: 19850901
The use of adjuvant radiation therapy and chemotherapy diminishes the likelihood of local-regional and distant recurrences and appears to prolong survival in patients who have undergone a complete surgical resection of a Dukes-Kirklin stage B2 or C rectal cancer. Patients with this malignant condition rarely develop peritoneal recurrences and therefore do not seem to be an appropriate group in which to evaluate the efficacy of intraperitoneal chemotherapy in gastrointestinal cancer. Such individuals, however, might serve as ideal subjects to examine objectively the merits of prolonged, ambulatory infusional chemotherapy through a prospective clinical trial comparing postoperative radiation therapy combined with 5-FU given in either protracted continuous infusional or intermittent bolus schedules.

7. DOCID:10156 SCORE: 0.00454081878237178
DOCNO: 6620568
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: K Hanawa K
AUTHOR: S Takeda S
AUTHOR: Y Kasai Y
AUTHOR: Y Suzuki Y
AUTHOR: T Takahashi T
AUTHOR: T Mori T
AUTHOR: M Shinhara M
AUTHOR: M Miyauchi M
AUTHOR: K Kubota K
AUTHOR: Y Gotoh Y
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Surgical case of simultaneous triple cancers of the esophagus, stomach and colon]
PUBDATE: 19830801
We report a patient with synchronous triple cancers arising in the digestive tract. It was a combination of esophageal, gastric and colonic cancers; total excision was performed in one operation. Histological study confirmed that each cancer had developed independently. The esophageal cancer was of ulcerated type; histologically it was poorly differentiated squamous cell carcinoma. The gastric and colonic cancers were both of Borrmann II type and well differentiated adenocarcinoma.

8. DOCID:10179 SCORE: 0.00454081816789602
DOCNO: 6442624
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: A Ardizzoni A
AUTHOR: P Pronzato P
AUTHOR: P F Conte PF
AUTHOR: R Rosso R
PUBTYPE: Journal Article
JOURNALTITLE: Chemioterapia : international journal of the Mediterranean Society of Chemotherapy.
COUNTRY: ITALY
TITLE: Mitomycin C and 5-fluorouracil as second choice treatment in advanced breast cancer patients.
PUBDATE: 19840401
Twenty-six patients with advanced breast cancer, (12 previously treated with adriamycin-containing regimens, 14 not exposed to adriamycin because of poor cardiac performance), were treated with combination chemotherapy including mitomycin C plus 5-fluorouracil. Objective response was seen in 7/66 patients (26.9%) with a statistically higher response rate in patients with fewer than 2 metastatic sites. Because of mild toxicity this regimen can be safely used as second-line chemotherapy for heavily pretreated patients and as first-line treatment in patients with poor cardiac performance.

9. DOCID:15834 SCORE: 0.00450785479667393
DOCNO: 3811093
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: W W Bonney WW
AUTHOR: R A Robinson RA
AUTHOR: P A Lachenbruch PA
AUTHOR: D A Culp DA
PUBTYPE: Journal Article
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: Yield of cancer tissue from prostatic needle biopsy.
PUBDATE: 19870201
This study concerns the quality of human prostatic cancer needle biopsy specimens for routine diagnosis and for bioassay. We examined routine hematoxylin and eosin-stained microscopic sections from 20 prostatic cancer patients, 159 needle cores in all, 71 positive for tumor. Linear core measurements were made with a calibrated ocular micrometer, each segment counted positive if it contained any tumor. Among all subjects there were 35.5 cm of tumor-bearing core length, 26 per cent of the total core length but 60 per cent of the length if completely negative cores were excluded. From these data we calculate a 91 per cent probability of detecting any cancer present if at least 4 cores are taken.

10. DOCID:10682 SCORE: 0.0042326010608138
DOCNO: 6748246
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: K Sekiba K
AUTHOR: H Okuda H
AUTHOR: H Fukui H
AUTHOR: Y Ishii Y
AUTHOR: K Urabe K
AUTHOR: T Hasegawa T
AUTHOR: S Endo S
AUTHOR: Y Hasegawa Y
AUTHOR: Y Nakagiri Y
AUTHOR: K Sakaguchi K
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Functional saving in the treatment of cervical cancer]
PUBDATE: 19840501
The radicality of Okabayashi's radical hysterectomy for treatment of cervical cancer has been well-known. However, its radicality also brought up the disturbance of fertility, endocrine and sexual function as well as the dysfunction of micturition and defecation. As early cervical cancer cases have increased yearly, and social rehabilitation became more necessary nowadays, functional saving is important and must be considered as the responsibility of the oncologists. This report denotes the preservation of ovarian function, sexual rehabilitation as well as the fertility in the treatment of cervical cancer.

11. DOCID:15246 SCORE: 0.00408948025897898
DOCNO: 2560508
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: M Melato M
AUTHOR: P Peruzzo P
AUTHOR: L Laurino L
AUTHOR: M Valente M
AUTHOR: A Tussoni A
PUBTYPE: Journal Article
JOURNALTITLE: Klinicheskaia meditsina.
COUNTRY: USSR
TITLE: [Cancer of the liver (analysis of autopsy data)]
PUBDATE: 19891101
The findings at 26.879 autopsies, that is 70% of all the deaths registered in the Province of Trieste, obtained at the Institute of Pathologic Anatomy and Histology of Trieste from 1976 to 1985 were studied. Liver cancer showed in the Province the World Standardized Incidence Rate (WR) of 1.87 (females) and 12.78 (males), one of the highest ever observed in nonendemic areas. In view of close association between cancer of the liver and cirrhosis (88%), the authors studied the most important etiological factors of cirrhosis in the region, i.e. hepatitis B and alcohol abuse. Some effective measures are suggested to decrease the incidence of cirrhosis and eventually cancer of the liver.

12. DOCID:10049 SCORE: 0.0039575119803314
DOCNO: 6372767
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: M S Robertson MS
AUTHOR: J M Robinson JM
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Immediate pharyngoesophageal reconstruction. Use of a quilted skin-grafted pectoralis major muscle flap.
PUBDATE: 19840601
Pharyngoesophageal reconstruction continues to be a problem in the management of cancer involving the hypopharynx. In our experience, the use of deltopectoral and pectoralis major myocutaneous flaps for total reconstruction has been disappointing. We report four cases of immediate near-total reconstruction using a quilted , skin-grafted pectoralis major muscle flap. All cases had received full dosage preoperative irradiation. A thin-walled pharynx was created that has allowed early development of a good esophageal voice. There has been no stricture formation. All patients have experienced no difficulty in establishing a good oral intake.

13. DOCID:15695 SCORE: 0.0038536368654723
DOCNO: 2926989
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: T Kishimoto T
AUTHOR: K Okada K
AUTHOR: Y Nagake Y
AUTHOR: K Doi K
AUTHOR: Y Takusagawa Y
AUTHOR: T Ono T
AUTHOR: F Shimamoto F
AFFILIATION: Dept. of Clinical Investigation, Kure Kyosai Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [A case of asbestosis complicated with double cancer of the stomach and colon]
PUBDATE: 19890201
A case of a double cancer, a stomach and a colon cancer, in a 84-year-old man is reported. The patient had an occupational history of asbestos exposure while working at two shipyards. His chest X-ray revealed typical, pleural plaque with calcification. Further, a significant number of asbestos bodies in his autopsied lung tissue was detected. In spite of failure to detect asbestos bodies in the stomach and the colon, our findings suggest that these two cancers may have been induced by asbestos exposure.

14. DOCID:8933 SCORE: 0.00382473061990053
DOCNO: 6751281
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: cytology
AUTHOR: W Savino W
AUTHOR: G L Santa-Rosa GL
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Archivum histologicum Japonicum. Nippon soshikigaku kiroku.
COUNTRY: JAPAN
TITLE: Histophysiology of thymic epithelial reticular cells.
PUBDATE: 19820501
Thymic epithelial reticular cells together with lymphocytes constitute the thymic parenchyma. Morphologically they are characterized by the stellate aspect forming a cytoreticulum, a large and vesicular nucleus, a tonofilament-rich cytoplasm, and abundance of desmosomes. Besides the role of providing a structural support for lymphocytes, epithelial reticular cells are responsible for the secretion of thymic hormones which promote lymphocyte proliferation and maturation. Clinical evidence is now appearing suggesting such thymic hormones' use as therapeutic agents against immunodeficiency diseases and cancer.