0. DOCID:3959 SCORE: 0.00684652195261322
DOCNO: 325740
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Transplantation
QUALIFIER: etiology
AUTHOR: A G Sheil AG
PUBTYPE: Journal Article
JOURNALTITLE: Transplantation proceedings.
COUNTRY: UNITED STATES
TITLE: Cancer in renal allograft recipients in Australia and New Zealand.
PUBDATE: 19770301
Total incidence and outcome of cancer in all renal allograft recipients in one geographic area are known: 126 (7%) of 1884 patients developed cancer during an 11-year period. Proportions with cancer 1 and 5 years following successful transplantation were 11% and 24%, respectively. Numbers, proportion of malignancies, and average time of diagnosis post transplantation were as follows: reticulum cell sarcoma (RCS) 15 (11%), 18 months; adenocarcinoma 8 (6%), 21/2 years; cancer of cervix 6 (5%), 41/2 years; leukemia 2 (2%), 5 years. All were highly malignant except cancer of the cervix, 2 localized forms of RCS, and 4 cases of cerebral RCS that responded to radiotherapy. Skin malignancy (SM) occurred in 97 patients (77% of cancers). The frequency increased with time, and after 4 years 18% of survivors had this cancer. In patients with SM 17% had multiple lesions when first diagnosed; further cancers or recurrences of the same type developed in 23%; another form of SM developed in 15%; metastases occurred 9 times (9%), 4 fatally. Six (6%) patients with SM developed other forms of malignancy, as compared to 33 (2%) of 1786 patients without SM. Ooulook for patients with SM with regard to survival and graft function was greatly improved at 5 years, as compared to that for patients without SM. Thereafter the outlook for patients with SM worsened rapidly because of additional effects of malignancy.


1. DOCID:3853 SCORE: 0.00547414046922971
DOCNO: 1277111
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: F N Rutledge FN
AUTHOR: J T Wharton JT
AUTHOR: G H Fletcher GH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Clinical studies with adjunctive surgery and irradiation therapy in the treatment of carcinoma of the cervix.
PUBDATE: 19760701
The majority of patients with cancer of the cervix are treated adequately by irradiation alone, and surgery is not necessary. A role for operation developsin certain patients with Stage I-II cancer of the cervix, who are prone to develop central recurrence if treated by irradiation alone. In these patients the primary lesion is massive. The vasculature to the center of these bulky or barrel-shaped cancer is insufficient, and a population of the cancer cells, perhaps related to anoxia, is more resistant to irradiation. The postirradiation conservative hysterectomy was incorporated into the treatment plan for 212 selected patients and the number of local recurrences was reduced. Incomplete cure of the peripheral component of the disease is another mechanism of treatment failure. This may occur, even though the primary lesion is cured. Patients with cervical cancers greater than 5 cm diameter have a high incidence of node metastasis, regardless of clinical stage. In those patients with positive nodes, the standard portals for external irradiation were expanded to include nodes at higher levels. The site of metastases was established by pretreatment laparotomy and the irradiation portals were then extended to include the involved nodes. Survival rates were not improved, because recurrences were not prevented, and death from treatment complications were high.


2. DOCID:6544 SCORE: 0.00546372442249698
DOCNO: 7364893
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: P Maillet P
AUTHOR: J Baulieux J
AUTHOR: J Boulez J
AUTHOR: J Burion J
AUTHOR: J L Peix JL
AUTHOR: R Donné R
PUBTYPE: Journal Article
JOURNALTITLE: Journal de chirurgie.
COUNTRY: FRANCE
TITLE: [Carcinoma of transverse colon (author's transl)]
PUBDATE: 19800101
A personal series of 83 cases of carcinoma of transverse colon has been analysed, as the recent works of international literature. The low percentage of success of these cancers is justified by the anatomical conditions and the pathological findings. Particularly, this prognosis is made worse by the high percentage of multivisceral cancers, hepatic metastases and emergency cases. The operative technics are very different. Beside the typical resections (right or left hemicolectomy), there remains one more important place for segmental colectomy. At least the subtotal colectomy gets some more indications, especially in the high risk patients. Only 28% of the resected cases shows a 5 years survival rate. This percentage is nearly the same as most of the recents statistics.


3. DOCID:6570 SCORE: 0.00546371581139327
DOCNO: 7376821
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: V S Partanen VS
AUTHOR: H Soininen H
AUTHOR: M Saksa M
AUTHOR: P Riekkinen P
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta neurologica Scandinavica.
COUNTRY: DENMARK
TITLE: Electromyographic and nerve conduction findings in a patient with neuromyotonia, normocalcemic tetany and small-cell lung cancer.
PUBDATE: 19800401
A 57-year-old man with neuromyotonia and normocalcemic tetany as probable paraneoplastic symptoms of small-cell lung cancer was examined neurophysiologically. In EMG, spontaneous action potential generation was demonstrated in peripheral motor axons. There were also time-locked high-frequency discharges after some voluntarily activated motor unit potentials. After electrical stimulation of motor axons, the M-response as well as spinal F-response or H-reflex was often followed by a sequence of oscillating potentials which could last several hundred msec. There was no evident peripheral polyneuropathy. Tetany subsided when carbamazepine therapy was started. The only striking abnormality in extensive laboratory studies was an increase in the plasma noradrenaline value.


4. DOCID:2859 SCORE: 0.00515730530677073
DOCNO: 922746
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: W B Malarkey WB
AUTHOR: L L Schroeder LL
AUTHOR: V C Stevens VC
AUTHOR: A G James AG
AUTHOR: R R Lanese RR
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Twenty-four-hour preoperative endocrine profiles in women with benign and malignant breast disease.
PUBDATE: 19771201
Mean 24-hr growth hormone, luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone concentrations determined preoperatively in 16 women with benign breast masses and 17 patients with breast cancer were similar to those levels found in 25 age- and weight-matched control subjects. Mean 24-hr testosterone levels, however, were significantly elevated in women with breast cancer evaluated in the luteal phase of their cycles and were normal in postmenopausal breast cancer women. In addition, serum thyroid-stimulating hormone, thyroxine, cholesterol, and triglyceride levels were normal in these subjects. Plasma cortisols and urinary 17-hydroxysteroid excretion tended to be higher in both the benign and malignant breast disease group and probably reflected preoperative anxiety. Hence, we have found normal concentrations of a variety of endocrine and other biochemical agents that can stimulate breast tissue growth and/or have been previously reported to be disordered in women with breast cancer.


5. DOCID:5714 SCORE: 0.00476864525226665
DOCNO: 7467359
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: H Rainer H
AUTHOR: P Bettelheim P
AUTHOR: C Bieglmayer C
AUTHOR: B Chaput B
AUTHOR: R Jakesz R
AUTHOR: A Kees A
AUTHOR: R Kolb R
AUTHOR: R Mörz R
AUTHOR: K Moser K
AUTHOR: G Reiner G
AUTHOR: M Schemper M
AUTHOR: J Spona J
PUBTYPE: Journal Article
JOURNALTITLE: Wiener klinische Wochenschrift.
COUNTRY: AUSTRIA
TITLE: [Oestrogen receptors and prognosis in breast cancer]
PUBDATE: 19801101
The determination of oestrogen receptors seems to be of prognostic value in the radically-operated breast cancer patient. Patients with negative receptor values exhibit early recurrence in a significantly higher percentage of cases than those with positive values. The prognostic implications of oestrogen receptor determination seem to be even higher than an assessment of axillary lymph node involvement. In metastatic breast carcinoma a correlation exists between response to hormonal therapy and receptor assay. The clinical implications for therapeutic management are discussed.


6. DOCID:1975 SCORE: 0.00474393050926048
DOCNO: 1181077
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Skin Tests
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: immunology
AUTHOR: T J Cunningham TJ
AUTHOR: P B Weber PB
AUTHOR: H D Teitelbaum HD
AUTHOR: F A Blumenstock FA
AUTHOR: C Charniga C
PUBTYPE: Journal Article
JOURNALTITLE: Clinical and experimental immunology.
COUNTRY: ENGLAND
TITLE: Delayed cutaneous hypersensitivity reactions to concanavalin A-binding tumour membrane components.
PUBDATE: 19750701
The use of affinity chromatography has permitted the isolation of those tumour membrane fractions possessing affinity for the lectin concanavalin A. That these fractions are rich in tumour-associated antigens is supported by their ability to induce delayed cutaneous hypersensitivity reactions. The tumour extracts possessing concanavalin affinity resulted in skin test reactivity of considerably greater frequency and magnitude than normal tissue fractions, disrupted unfractionated tumour membrane extracts, or tumour membrane fractions not possessing concanavalin A affinity. Although the present data does not permit the correlation of skin reactivity with patient or disease parameters, the isolation of augmented concentrations of tumour-associated antigens may lead to improved diagnostic and prognostic tests and vaccines for patients with cancer.


7. DOCID:3865 SCORE: 0.00457935432771904
DOCNO: 303543
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W Mattsson W
AUTHOR: A Arwidi A
AUTHOR: F von Eyben F
AUTHOR: C E Lindholm CE
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Phase II study of combined vincristine, adriamycin, cyclophosphamide, and methotrexate with citrovorum factor factor rescue in metastatic breast cancer.
PUBDATE: 19771101
Fifty patients with metastatic breast cancer were treated with 8-day courses of vincristine (1 mg iv, Day 1), adriamycin (50 mg/m2 iv, Day 1), cyclophosphamide (100 mg/m2 orally, Days 1-8), methotrexate (200 mg iv by 3-hour infusion, Day 8), and citrovorum factor rescue (15 mg in 12, 18, and 24 hours after methotrexate, Day 8) at 3-4-week intervals. Forty-two patients had previously received treatment with hormones and 17 patients had received chemotherapy. Fifteen patients achieved a complete remission (CR) and 24 patients a partial remission (PR). There was a significant correlation between the response and the number of metastatic organs (0.01 less than P less than 0.02). The response rate was roughly uniform irrespective of the organ predominantly involved (0.2 less than P less than 0.3). The remission duration was significantly longer for the patients with CR compared with that for the patients with PR (0.001 less than P less than 0.01). The patients who achieved CRs and PRs survived significantly longer than the patients with no change and progressive disease (P less than 0.001). The toxic effects of the treatment were acceptable and no drug-related deaths occurred.


8. DOCID:3201 SCORE: 0.00436770021038621
DOCNO: 196583
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: J R Farwell JR
AUTHOR: G W Farwell GW
AUTHOR: G J Dohrmann GJ
PUBTYPE: Journal Article
JOURNALTITLE: Archives of neurology.
COUNTRY: UNITED STATES
TITLE: A method for characterizing subgroups and related survivals in cancer patients. Application to brain tumors.
PUBDATE: 19770901
It has long been known that if the probability of dying of a given cancer remains constant over time, the logarithmic plot of survival of a group of patients with that cancer will be a straight line. More frequently, however, the probability of dying varies with time and the logarithmic survival plot is a curve. We believe that in some cases a population of patients with one type of neoplasm may be composed of several subgroups, each of which has a simple predictable course with a rectilinear survival plot. This article describes a method for partitioning such survival plots and identifying and characterizing the subgroups and applies the method to a group of patients with brain tumors. The value of being able to identify these subgroups and their relative proportions, the observations that can be made with this analysis regarding the nature of the various subgroups of brain tumors, and the implications of changes in the half-lives as well as the proportions of the subgroups with time are discussed.


9. DOCID:7996 SCORE: 0.00431323796963975
DOCNO: 151999
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fertilizers
DESCRIPTOR: Nitrates
QUALIFIER: epidemiology
AUTHOR: R Zaldívar R
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology.
COUNTRY: GERMANY, WEST
TITLE: A note on the use of nitrate fertilizers in a high-risk geographical area for stomach cancer.
PUBDATE: 19780901
Chile being the only country in the world producing natural fertilizers (NaNO3 and KNO3), it uses very large quantities of them for agricultural purposes. Since in early 1970 Zaldívar first related the use of fertilizers to stomach cancer mortality, it is of key interest to know the amount of nitrogen fertilizers used, expressed in tons of N, by province, for the period from 1945 to 69. Of a total of 420,750 tons of N for the nation, 238,950 tons were used in the high-risk provinces for stomach cancer (Colchagua, Curicó, Talca, Maule, Linares, Nuble, Concepción, Bio-Bio, Arauco, Malleco, Cautín). On the other hand, in the low-risk provinces (Tarapacá, Antofagasta, Atacama, Magallanes) only 2,550 tons were used. In Chile, the use of fertilizers increased from 37,550 (1945-50) to 185,050 (1965-69) tons of N.


10. DOCID:3356 SCORE: 0.00405351468750198
DOCNO: 1256510
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: M J Favus MJ
AUTHOR: A B Schneider AB
AUTHOR: M E Stachura ME
AUTHOR: J E Arnold JE
AUTHOR: U Y Ryo UY
AUTHOR: S M Pinsky SM
AUTHOR: M Colman M
AUTHOR: M J Arnold MJ
AUTHOR: L A Frohman LA
PUBTYPE: Journal Article
JOURNALTITLE: The New England journal of medicine.
COUNTRY: UNITED STATES
TITLE: Thyroid cancer occurring as a late consequence of head-and-neck irradiation. Evaluation of 1056 patients.
PUBDATE: 19760501
From January 1 to September 30, 1974, we examined 1056 of 5266 subjects (20.1%) who had received therapeutic irradiation primarily for infections and inflammatory disease of the upper respiratory tract at our institution during the 1940's and 1950's. The tonsillar and nasopharyngeal region was the treatment site in 85% of those examined. Palpable nodular thyroid disease was found in 16.5%, and nonpalpable lesions were detected by 99m Tc pertechnetate thyroid imaging in an additional 10.7%, for a prevalence of nodular disease of 27.2%. Operation on 71% with nodular disease revealed thyroid cancer in 33% (60 of 182). Preliminary analysis for potential risk factors suggests a correlation between radiation exposure and the presence of thyroid nodules (P less than 0.001). These findings indicate that nodular thyroid disease, both benign and malignant, continues as a major health problem for at least 35 years in exposed subjects.


11. DOCID:6466 SCORE: 0.00405251604774332
DOCNO: 427391
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: P N Cowen PN
AUTHOR: E A Benson EA
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Cytological study of fluid from breast cysts.
PUBDATE: 19790301
A series of 215 patients with breast cysts have provided 348 specimens of cyst fluid for cytological diagnosis. Only one of these specimens was reported positive for malignant cells and this patient had a carcinoma. Nine specimens were reported as suspicious, but none of these patients had or subsequently developed carcinoma. In 338 specimens cytology was negative. A total of 178 patients (294 specimens) was available for follow-up. Of these 2 proved to have carcinomas on immediate follow-up, i.e. a lump presisted after aspiration, and a further 2 patients developed cancers in the same breast, one 4 and the other 7 years after aspiration. We therefore conclude that the routine submission of breast cyst fluid for cytology is wasteful of time and resources.


12. DOCID:3312 SCORE: 0.00398645314610207
DOCNO: 813826
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: D G Miller DG
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: What is early diagnosis doing?
PUBDATE: 19760101
Programs for the early detection of cancer in the past have been beset with problems of low yield, inability to recruit high risk populations, poor utilization of physicians, and inadequate end results evaluation. Nevertheless, for twelve forms of cancer representing 80% of all cancers and 70% of all cancer mortality there is a useful form of early detection or prevention. Furthermore, the ultimate benefit of early diagnosis to patients is supported by long-term relative survival rate studies, and for certain forms of cancer by reduction in mortality rates as well. Efforts are now underway to develop risk factor detection programs which will overcome some of the aforementioned problems. One such program is the risk factor analysis project, operating in the CANSCREEN clinics, which was designed to detect high risk indicators for cancer which are amenable to intervention by primary prevention or diagnosis and treatment. A triage system with linkages to comprehensive cancer centers has been established and a medical information system prepared for centralized statistical and epidemiological studies. The clinics are operated entirely by nurse examiners and health educators. Results of pilot studies are encouraging with regard to the feasibility of implementing such programs.


13. DOCID:3410 SCORE: 0.00396147627534816
DOCNO: 577128
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: H K Pauli HK
AUTHOR: S Trotnow S
PUBTYPE: Journal Article
JOURNALTITLE: Archiv für Gynäkologie.
COUNTRY: GERMANY, WEST
TITLE: [Can the search for early stages of cancer of the cervix uteri be improved? An empirical and theoretical study from sociology in medicine (author's transl)]
PUBDATE: 19770301
Using a standardised questionnaire, 7356 women, patients at the Erlanger Universitäts-Frauenklinik, were interviewed. Women with cervical cancer or carcinoma in situ of the cervix were compared with the remaining patients. Social factors are described which are more frequent with women with cervical cancer than with other women. The more such individual factors are added together, the greater the risk of developing a cervical cancer. Further, social factors are investigated which prevent women from going to prophylactic examinations. The more such factors are encountered, the greater the probability that a woman will not go to prophylactic examinations. Both results were to be expected from common-sense, but until now confirmation by empirical investigation was lacking. The greater the risk of getting cervical cancer, the greater the probability that screening will be avoided. This result show that cervical cancer is to be expected in the greater proportion of about 70% of women over the age of 30 who do not go for prophylactic examination, compared with the 30% who undergo prophylactic examination anually.


14. DOCID:7933 SCORE: 0.00386097839381515
DOCNO: 274499
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: methods
AUTHOR: M da Costa M
AUTHOR: S P Rothenberg SP
AUTHOR: C Fischer C
AUTHOR: Z Rosenberg Z
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laboratory and clinical medicine.
COUNTRY: UNITED STATES
TITLE: The identification and measurement of a folate-binding protein in human serum by radioimmunoassay.
PUBDATE: 19780601
Antiserum raised in rabbits against the FBP obtained from CML cells, and the purified binder labeled with 125I, have been used for an RIA which can measure an immunologically similar protein in human serum. The concentration of the binding protein in normal serums ranged from 1.2 to 9.3 ng/ml, with a mean +/- S.E.M. of 3.8 +/- 0.4 ng/ml. Elevated values of the binder protein were measured in the serums from patients with folate deficiency, vitamin B12 deficiency, liver disease, uremia, myeloproliferative disease, chronic lymphocytic leukemia, and various types of cancer and in the serum from pregnant women. The concentration of the binder protein and the capacity of the serum to specifically bind isotopically labeled PGA correlated poorly, indicating that the binding protein concentration and degree of saturation by endogenous serum folate vary independently in many instances.