0. DOCID:3959 SCORE: 0.00684652195261322
DOCNO: 325740
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Transplantation
QUALIFIER: etiology
AUTHOR: A G Sheil AG
PUBTYPE: Journal Article
JOURNALTITLE: Transplantation proceedings.
COUNTRY: UNITED STATES
TITLE: Cancer in renal allograft recipients in Australia and New Zealand.
PUBDATE: 19770301
Total incidence and outcome of cancer in all renal allograft recipients in one geographic area are known: 126 (7%) of 1884 patients developed cancer during an 11-year period. Proportions with cancer 1 and 5 years following successful transplantation were 11% and 24%, respectively. Numbers, proportion of malignancies, and average time of diagnosis post transplantation were as follows: reticulum cell sarcoma (RCS) 15 (11%), 18 months; adenocarcinoma 8 (6%), 21/2 years; cancer of cervix 6 (5%), 41/2 years; leukemia 2 (2%), 5 years. All were highly malignant except cancer of the cervix, 2 localized forms of RCS, and 4 cases of cerebral RCS that responded to radiotherapy. Skin malignancy (SM) occurred in 97 patients (77% of cancers). The frequency increased with time, and after 4 years 18% of survivors had this cancer. In patients with SM 17% had multiple lesions when first diagnosed; further cancers or recurrences of the same type developed in 23%; another form of SM developed in 15%; metastases occurred 9 times (9%), 4 fatally. Six (6%) patients with SM developed other forms of malignancy, as compared to 33 (2%) of 1786 patients without SM. Ooulook for patients with SM with regard to survival and graft function was greatly improved at 5 years, as compared to that for patients without SM. Thereafter the outlook for patients with SM worsened rapidly because of additional effects of malignancy.

1. DOCID:14996 SCORE: 0.0057800739712571
DOCNO: 2722056
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: drug therapy
AUTHOR: E Kujansuu E
AUTHOR: T Rahko T
AUTHOR: R Punnonen R
AUTHOR: P Karma P
AFFILIATION: Department of Obstetrics and Gynecology, Tampere University Hospital, Finland.
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Evaluation of the hearing loss associated with cis-platinum treatment by high-frequency audiometry.
PUBDATE: 19890601
The effect of cis-platinum treatment on the hearing of 23 ovarian cancer patients was evaluated using standard and high-frequency audiometry. Twenty-two percent of the patients developed a hearing loss of at least 15 db, 13% in the range 125-8000 Hz and 9% only in the high-frequency area above 8 kHz. However, due to the high-frequency hearing loss (presbyacusis) in older patients high-frequency audiometry was often unobtainable. Hearing screening using standard pure-tone audiometry is recommended for cis-platinum patients as a routine procedure.

2. DOCID:3853 SCORE: 0.00547414046922971
DOCNO: 1277111
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: F N Rutledge FN
AUTHOR: J T Wharton JT
AUTHOR: G H Fletcher GH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Clinical studies with adjunctive surgery and irradiation therapy in the treatment of carcinoma of the cervix.
PUBDATE: 19760701
The majority of patients with cancer of the cervix are treated adequately by irradiation alone, and surgery is not necessary. A role for operation developsin certain patients with Stage I-II cancer of the cervix, who are prone to develop central recurrence if treated by irradiation alone. In these patients the primary lesion is massive. The vasculature to the center of these bulky or barrel-shaped cancer is insufficient, and a population of the cancer cells, perhaps related to anoxia, is more resistant to irradiation. The postirradiation conservative hysterectomy was incorporated into the treatment plan for 212 selected patients and the number of local recurrences was reduced. Incomplete cure of the peripheral component of the disease is another mechanism of treatment failure. This may occur, even though the primary lesion is cured. Patients with cervical cancers greater than 5 cm diameter have a high incidence of node metastasis, regardless of clinical stage. In those patients with positive nodes, the standard portals for external irradiation were expanded to include nodes at higher levels. The site of metastases was established by pretreatment laparotomy and the irradiation portals were then extended to include the involved nodes. Survival rates were not improved, because recurrences were not prevented, and death from treatment complications were high.

3. DOCID:6544 SCORE: 0.00546372442249698
DOCNO: 7364893
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: P Maillet P
AUTHOR: J Baulieux J
AUTHOR: J Boulez J
AUTHOR: J Burion J
AUTHOR: J L Peix JL
AUTHOR: R Donné R
PUBTYPE: Journal Article
JOURNALTITLE: Journal de chirurgie.
COUNTRY: FRANCE
TITLE: [Carcinoma of transverse colon (author's transl)]
PUBDATE: 19800101
A personal series of 83 cases of carcinoma of transverse colon has been analysed, as the recent works of international literature. The low percentage of success of these cancers is justified by the anatomical conditions and the pathological findings. Particularly, this prognosis is made worse by the high percentage of multivisceral cancers, hepatic metastases and emergency cases. The operative technics are very different. Beside the typical resections (right or left hemicolectomy), there remains one more important place for segmental colectomy. At least the subtotal colectomy gets some more indications, especially in the high risk patients. Only 28% of the resected cases shows a 5 years survival rate. This percentage is nearly the same as most of the recents statistics.

4. DOCID:6570 SCORE: 0.00546371581139327
DOCNO: 7376821
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: V S Partanen VS
AUTHOR: H Soininen H
AUTHOR: M Saksa M
AUTHOR: P Riekkinen P
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta neurologica Scandinavica.
COUNTRY: DENMARK
TITLE: Electromyographic and nerve conduction findings in a patient with neuromyotonia, normocalcemic tetany and small-cell lung cancer.
PUBDATE: 19800401
A 57-year-old man with neuromyotonia and normocalcemic tetany as probable paraneoplastic symptoms of small-cell lung cancer was examined neurophysiologically. In EMG, spontaneous action potential generation was demonstrated in peripheral motor axons. There were also time-locked high-frequency discharges after some voluntarily activated motor unit potentials. After electrical stimulation of motor axons, the M-response as well as spinal F-response or H-reflex was often followed by a sequence of oscillating potentials which could last several hundred msec. There was no evident peripheral polyneuropathy. Tetany subsided when carbamazepine therapy was started. The only striking abnormality in extensive laboratory studies was an increase in the plasma noradrenaline value.

5. DOCID:2859 SCORE: 0.00515730530677073
DOCNO: 922746
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: W B Malarkey WB
AUTHOR: L L Schroeder LL
AUTHOR: V C Stevens VC
AUTHOR: A G James AG
AUTHOR: R R Lanese RR
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Twenty-four-hour preoperative endocrine profiles in women with benign and malignant breast disease.
PUBDATE: 19771201
Mean 24-hr growth hormone, luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone concentrations determined preoperatively in 16 women with benign breast masses and 17 patients with breast cancer were similar to those levels found in 25 age- and weight-matched control subjects. Mean 24-hr testosterone levels, however, were significantly elevated in women with breast cancer evaluated in the luteal phase of their cycles and were normal in postmenopausal breast cancer women. In addition, serum thyroid-stimulating hormone, thyroxine, cholesterol, and triglyceride levels were normal in these subjects. Plasma cortisols and urinary 17-hydroxysteroid excretion tended to be higher in both the benign and malignant breast disease group and probably reflected preoperative anxiety. Hence, we have found normal concentrations of a variety of endocrine and other biochemical agents that can stimulate breast tissue growth and/or have been previously reported to be disordered in women with breast cancer.

6. DOCID:11234 SCORE: 0.00507248294456289
DOCNO: 6830599
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: H Yamamoto H
AUTHOR: M Tanaka M
AUTHOR: T Okochi T
AUTHOR: S Kishimoto S
PUBTYPE: Journal Article
JOURNALTITLE: Biochemical and biophysical research communications.
COUNTRY: UNITED STATES
TITLE: Interaction of human intestinal and hepatoma alkaline phosphatases with immobilized Cibacron Blue F3GA.
PUBDATE: 19830201
Possible interactions of human liver and intestinal alkaline phosphatases with Cibacron Blue F3GA were examined. The results indicated that the intestinal enzyme bound to the dye column whereas the liver enzyme did not. The affinity of intestinal alkaline phosphatase with the dye-ligand appeared to be biospecific, since a low concentration of purine nucleoside phosphates or potassium phosphate specifically reversed the binding. Taking advantage of the variant alkaline phosphatase from human hepatocellular cancer tissue to behave on the dye adsorbent in a similar fashion with the intestinal enzyme, it was purified by Cibacron Blue F3GA affinity chromatography, producing a 189-fold purification with a yield of 93%.

7. DOCID:11253 SCORE: 0.0050724809392806
DOCNO: 6610802
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: A Aboud A
AUTHOR: A U Buzdar AU
AUTHOR: H Y Yap HY
AUTHOR: G N Hortobagyi GN
AUTHOR: G R Blumenschein GR
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Combination chemotherapy for metastatic breast cancer with fluorouracil, adriamycin, cyclophosphamide, and methotrexate.
PUBDATE: 19840701
Twenty-nine patients with metastatic breast cancer were treated with fluorouracil, adriamycin, cyclophosphamide (FAC), and methotrexate (MTX), with or without leukovorin rescue. Of 24 evaluable patients, one achieved a complete remission and 17 had partial responses. The overall objective response rate was 75%. The median survival from initiation of chemotherapy for the responding patients was 18 months. Four patients (17%) with stable disease had a median survival of 25 months. The addition of MTX to FAC chemotherapy did not improve the therapeutic efficacy of this combination; it did, however, increase the overall toxicity, especially the infectious complications when compared to FAC alone.

8. DOCID:11831 SCORE: 0.00505942379731872
DOCNO: 6391119
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: urine
QUALIFIER: urine
QUALIFIER: diagnosis
AUTHOR: K Ueda K
AUTHOR: J Kato J
AUTHOR: T Seki T
PUBTYPE: Journal Article
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Urinary excretion of N-acetyl-beta-D-glucosaminidase in patients with urological disease: with special reference to hydronephrosis]
PUBDATE: 19840701
Activity of urinary N-acetyl-beta-D-glucosaminidase (NAG) has been studied in patients with urological diseases. In most patients with benign prostatic hyperplasia, prostate cancer and bladder cancer, activity of urinary NAG was elevated (92.9%), especially in cases of indwelling catheterization or poor visualization of IVU. Urinary NAGs were also elevated for all patients with renal stones, ureter stones, uretero-cutaneous stomy or a single kidney. In hydronephrosis or hydronephrosis with hydroureter patients, urinary NAG level was low pre-operatively, but increased post-operatively. Urinary beta 2-microglobulin (BMG) showed a similar tendency in patients with hydronephrosis or hydronephrosis with hydroureter. Electronmicroscopic observations of the kidney in such patients revealed many primary and secondary lysosomes.

9. DOCID:10354 SCORE: 0.00505054361941482
DOCNO: 6330947
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: A Janni A
AUTHOR: P Santini P
AUTHOR: A Mussi A
AUTHOR: G F Menconi GF
AUTHOR: M Miniati M
AUTHOR: C A Angeletti CA
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Results of en bloc resections for lung cancer.
PUBDATE: 19840601
The results of en bloc resection carried out in 33 patients with lung cancer involving the chest wall are described. Microscopic examination of the lung specimen revealed large cell anaplastic carcinoma in 14 cases, squamous carcinoma in 10, adenocarcinoma in 5, microcytoma and fibrosarcoma in 2 cases respectively. The 5 year survival, calculated according to the actuarial method, was 32%, only slightly lower than the 5 year overall survival observed in our survey. The long-term prognosis was essentially related to the presence of lymph node metastases, which were found to occur at a late stage of the clinical evolution.

10. DOCID:10383 SCORE: 0.0050505432043091
DOCNO: 6172573
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: administration & dosage
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: M E Leavens ME
AUTHOR: C S Hill CS
AUTHOR: D A Cech DA
AUTHOR: J B Weyland JB
AUTHOR: J S Weston JS
PUBTYPE: Journal Article
JOURNALTITLE: Journal of neurosurgery.
COUNTRY: UNITED STATES
TITLE: Intrathecal and intraventricular morphine for pain in cancer patients: initial study.
PUBDATE: 19820201
Intractable pain in six cancer patients was treated with lumbar intrathecal morphine (two patients) and intraventricular morphine (four patients). Daily percutaneous injections of morphine through Ommaya reservoirs were made. Initially, 1 mg of lumbar intrathecal morphine resulted in pain relief for 10 to 14 hours, and 2.5 to 4.0 mg of intraventricular morphine gave relief for 12 to 24 hours. This treatment was continued for 3 to 7 months in three of the adults. Morphine requirements gradually increased. Side effects were minimal, and there were no complications.

11. DOCID:10388 SCORE: 0.00505054301462286
DOCNO: 4048970
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: R J Mayer RJ
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Adjuvant therapy in rectal cancer: a protocol proposal.
PUBDATE: 19850901
The use of adjuvant radiation therapy and chemotherapy diminishes the likelihood of local-regional and distant recurrences and appears to prolong survival in patients who have undergone a complete surgical resection of a Dukes-Kirklin stage B2 or C rectal cancer. Patients with this malignant condition rarely develop peritoneal recurrences and therefore do not seem to be an appropriate group in which to evaluate the efficacy of intraperitoneal chemotherapy in gastrointestinal cancer. Such individuals, however, might serve as ideal subjects to examine objectively the merits of prolonged, ambulatory infusional chemotherapy through a prospective clinical trial comparing postoperative radiation therapy combined with 5-FU given in either protracted continuous infusional or intermittent bolus schedules.

12. DOCID:5714 SCORE: 0.00476864525226665
DOCNO: 7467359
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: H Rainer H
AUTHOR: P Bettelheim P
AUTHOR: C Bieglmayer C
AUTHOR: B Chaput B
AUTHOR: R Jakesz R
AUTHOR: A Kees A
AUTHOR: R Kolb R
AUTHOR: R Mörz R
AUTHOR: K Moser K
AUTHOR: G Reiner G
AUTHOR: M Schemper M
AUTHOR: J Spona J
PUBTYPE: Journal Article
JOURNALTITLE: Wiener klinische Wochenschrift.
COUNTRY: AUSTRIA
TITLE: [Oestrogen receptors and prognosis in breast cancer]
PUBDATE: 19801101
The determination of oestrogen receptors seems to be of prognostic value in the radically-operated breast cancer patient. Patients with negative receptor values exhibit early recurrence in a significantly higher percentage of cases than those with positive values. The prognostic implications of oestrogen receptor determination seem to be even higher than an assessment of axillary lymph node involvement. In metastatic breast carcinoma a correlation exists between response to hormonal therapy and receptor assay. The clinical implications for therapeutic management are discussed.

13. DOCID:1975 SCORE: 0.00474393050926048
DOCNO: 1181077
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Skin Tests
QUALIFIER: drug effects
QUALIFIER: pharmacology
QUALIFIER: immunology
AUTHOR: T J Cunningham TJ
AUTHOR: P B Weber PB
AUTHOR: H D Teitelbaum HD
AUTHOR: F A Blumenstock FA
AUTHOR: C Charniga C
PUBTYPE: Journal Article
JOURNALTITLE: Clinical and experimental immunology.
COUNTRY: ENGLAND
TITLE: Delayed cutaneous hypersensitivity reactions to concanavalin A-binding tumour membrane components.
PUBDATE: 19750701
The use of affinity chromatography has permitted the isolation of those tumour membrane fractions possessing affinity for the lectin concanavalin A. That these fractions are rich in tumour-associated antigens is supported by their ability to induce delayed cutaneous hypersensitivity reactions. The tumour extracts possessing concanavalin affinity resulted in skin test reactivity of considerably greater frequency and magnitude than normal tissue fractions, disrupted unfractionated tumour membrane extracts, or tumour membrane fractions not possessing concanavalin A affinity. Although the present data does not permit the correlation of skin reactivity with patient or disease parameters, the isolation of augmented concentrations of tumour-associated antigens may lead to improved diagnostic and prognostic tests and vaccines for patients with cancer.

14. DOCID:3865 SCORE: 0.00457935432771904
DOCNO: 303543
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W Mattsson W
AUTHOR: A Arwidi A
AUTHOR: F von Eyben F
AUTHOR: C E Lindholm CE
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Phase II study of combined vincristine, adriamycin, cyclophosphamide, and methotrexate with citrovorum factor factor rescue in metastatic breast cancer.
PUBDATE: 19771101
Fifty patients with metastatic breast cancer were treated with 8-day courses of vincristine (1 mg iv, Day 1), adriamycin (50 mg/m2 iv, Day 1), cyclophosphamide (100 mg/m2 orally, Days 1-8), methotrexate (200 mg iv by 3-hour infusion, Day 8), and citrovorum factor rescue (15 mg in 12, 18, and 24 hours after methotrexate, Day 8) at 3-4-week intervals. Forty-two patients had previously received treatment with hormones and 17 patients had received chemotherapy. Fifteen patients achieved a complete remission (CR) and 24 patients a partial remission (PR). There was a significant correlation between the response and the number of metastatic organs (0.01 less than P less than 0.02). The response rate was roughly uniform irrespective of the organ predominantly involved (0.2 less than P less than 0.3). The remission duration was significantly longer for the patients with CR compared with that for the patients with PR (0.001 less than P less than 0.01). The patients who achieved CRs and PRs survived significantly longer than the patients with no change and progressive disease (P less than 0.001). The toxic effects of the treatment were acceptable and no drug-related deaths occurred.