0. DOCID:25906 SCORE: 0.00320976388752809
DOCNO: 10193595
AUTHOR: B A Johnson BA
AFFILIATION: Hamot Family Practice Residency Program, Erie, Pennsylvania, USA.
PUBTYPE: Corrected and Republished Article
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American family physician.
COUNTRY: UNITED STATES
TITLE: Flexible sigmoidoscopy: screening for colorectal cancer.
PUBDATE: 19990301
Flexible sigmoidoscopy is an important screening procedure because of its ability to detect early changes in the distal colon. The 60-cm flexible sigmoidoscope provides excellent visualization with minimal discomfort to patients. Successful sigmoidoscopy requires adequate patient preparation, proper equipment and an experienced examiner who can recognize both normal and abnormal findings. Complications arising from sigmoidoscopy are rare, but patients may experience some cramping, gas or watery stools. Screening and primary preventive measures, including regular exercise and increased dietary fiber intake, can lower the morbidity and mortality associated with colorectal cancer.


1. DOCID:27999 SCORE: 0.00320850940057698
DOCNO: 12057053
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: S K Gibbons SK
AUTHOR: H M Keys HM
AFFILIATION: Department of Radiation Oncology, MC-95, Albany Medical Center, 43 New Scotland Avenue, Albany, NY 12208, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current treatment options in oncology.
COUNTRY: United States
TITLE: Advanced cervical cancer.
PUBDATE: 20000601
Several large, prospectively randomized clinical trials run by multi-institutional cooperative groups have established that the best treatment for advanced cancer of the cervix is primary radiotherapy with concurrent, cisplatin-based chemotherapy. In fact, patients with earlier stage cervix cancer with poor prognostic indicators (large, bulky tumors, positive pelvic lymph nodes, or unexpected parametrial disease at the time of surgery) also show a survival benefit with this approach. Adequate radiation dosing (both external beam and intracavitary) is essential. The additional benefit of periaortic lymph node irradiation is debated, but generally accepted, for patients with locally advanced disease or pelvic lymph node involvement.


2. DOCID:27969 SCORE: 0.00317697610894408
DOCNO: 11147228
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: R A Larson RA
AFFILIATION: Section of Hematology/Oncology, Department of Medicine and Cancer Research Center, University of Chicago, Chicago, Ilinois, USA. rlarson@medicine.bsd.uchicago.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: United States
TITLE: Recent clinical trials in acute lymphocytic leukemia by the Cancer and Leukemia Group B.
PUBDATE: 20001201
The Cancer and Leukemia Group B (CALGB) has performed a series of studies evaluating different aspects of remission induction and postremission treatment in adults with acute lymphocytic leukemia (ALL). In recent years, these clinical trials have been supplemented by systematic morphologic, immunophenotyping, cytogenetic, and molecular genetic studies leading to the identification of different risk groups of patients who may warrant individualized treatments. These protocols have enrolled all adult patients older than 15 years with ALL, without an upper age restriction, and did not exclude Philadelphia (Ph) chromosome-positive patients.


3. DOCID:27924 SCORE: 0.00317695871216401
DOCNO: 10783521
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug therapy
QUALIFIER: pharmacology
AUTHOR: R Schlemmer R
AUTHOR: T Spruss T
AUTHOR: G Bernhardt G
AUTHOR: H Schönenberger H
AFFILIATION: Lehrstuhl für Pharmazeutische Chemie II, Universität Regensburg, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Archiv der Pharmazie.
COUNTRY: GERMANY
TITLE: Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part 1: The MXT-M-3.2 breast cancer stimulates the growth of an identical second graft; [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplat inum (II) inhibits this process.
PUBDATE: 20000301
The MXT-M-3.2 breast cancer implanted into female B6D2F1 mice accelerates the growth of an identical second tumor. This process is inhibited by [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl) ethylenediamine]dichloroplatinum(II). The possible modes of action of this compound as a biological response modifier are discussed.


4. DOCID:27730 SCORE: 0.00310202309589073
DOCNO: 9808633
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Anticarcinogenic Agents
QUALIFIER: prevention & control
QUALIFIER: therapeutic use
AUTHOR: C Ip C
AFFILIATION: Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of nutrition.
COUNTRY: UNITED STATES
TITLE: Lessons from basic research in selenium and cancer prevention.
PUBDATE: 19981101
The article reviews the progress in basic research of selenium and cancer prevention during the past decade. Special emphasis is placed on the following four major areas of discussion: 1) chemical forms of selenium and anticarcinogenic activity; 2) selenium-enriched food; 3) in vitro effects of selenite vs. monomethylated selenium; and 4) aromatic selenium compounds. It is clear that basic research has contributed new knowledge to our understanding of selenium biochemistry, anticancer efficacy and regulation of cell growth. Some of this information could be ready for incorporation into the design of a second-generation selenium trial in humans.


5. DOCID:25715 SCORE: 0.00301783058322784
DOCNO: 9587869
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: Y Inoue Y
AUTHOR: R Yozu R
AUTHOR: T Ueda T
AUTHOR: S Kawada S
AFFILIATION: Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of heart valve disease.
COUNTRY: ENGLAND
TITLE: A case report of Candida parapsilosis endocarditis.
PUBDATE: 19980301
A 57-year-old male was treated for fungal endocarditis caused by Candida parapsilosis which precipitated severe cardiac valve vegetation and insufficiency. His condition resulted from a three-month installation of a central venous catheter for hyperalimentation and chemotherapy following total gastrectomy for gastric cancer. Aortic valve replacement combined with fluconazole administration resulted in satisfactory recovery with no adverse events during an 18-month follow up period.


6. DOCID:25642 SCORE: 0.00301781339689424
DOCNO: 11833331
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: M F Driuk MF
AUTHOR: S P Galych SP
AUTHOR: M M Driuk MM
AUTHOR: O O Lytvynenko OO
PUBTYPE: Journal Article
JOURNALTITLE: Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukraïny, Naukove tovarystvo khirurhiv Ukraïny.
COUNTRY: Ukraine
TITLE: [Technical aspects of one stage reconstruction of mammary glands using autologous tissue after mastectomy for the mammary gland cancer]
PUBDATE: 20011001
In 36 patients the first experience of performance of one-stage mammarial glands reconstruction is presented, using tissues of their own after conduction of mastectomy for the mammarial gland cancer. In 27 women patients the transposition or free microvascular transplantation of lower musculocutaneous flap basing on m. Rectus abdominis (transverse rectus abdominis musculocutaneous TRAM-flap) was performed, in 9--transposition of m. Latissimus dorsi flap.


7. DOCID:26895 SCORE: 0.00298952168272255
DOCNO: 10511710
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Division
DESCRIPTOR: Chromosome Segregation
QUALIFIER: genetics
QUALIFIER: metabolism
AUTHOR: J R Bischoff JR
AUTHOR: G D Plowman GD
AFFILIATION: SUGEN, 230 East Grand Avenue, South San Francisco, CA 94080-4811, USA. jim-bischoff@sugen.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in cell biology.
COUNTRY: ENGLAND
TITLE: The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.
PUBDATE: 19991101
Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis. Proper chromosome segregation and cytokinesis ensure that each daughter cell receives the full complement of genetic material. Defects in these processes can lead to aneuploidy and the propagation of genetic abnormalities. This review discusses the Aurora/Ipl1p kinases in terms of their protein structure and proposed function in mitotic cells and also the potential role of aurora2 in human cancer.


8. DOCID:26842 SCORE: 0.00298949777566418
DOCNO: 11074611
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: diagnosis
AUTHOR: F E Alexander FE
AFFILIATION: Department of Public Health Sciences, University of Edinburgh, Edinburgh, EH8 9AG, United Kingdom. freda.alexander@ed.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Microscopy research and technique.
COUNTRY: UNITED STATES
TITLE: Prostate cancer screening.
PUBDATE: 20001201
Prostate cancer is an important and growing public health problem. PSA testing is able to lead to the identification of large numbers of cases of prostate cancer while still asymptomatic. This provides the potential for important reductions in prostate cancer mortality through the introduction of screening programs. The most reliable evidence that this potential can be realised can only come from randomised controlled trials (RCTs). Alternative sources of evidence are compared with that from RCTs; the costs of a wrong decision would be high and it is argued that the case for RCTs is clear.


9. DOCID:27108 SCORE: 0.0028373744827699
DOCNO: 11783101
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: C Wang C
AUTHOR: T Ding T
AUTHOR: L Chang L
AFFILIATION: Shanxi Tumor Hospital, Taiyuan 030013, China.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: China
TITLE: [A randomized clinical study of preoperative chemotherapy for esophageal carcinoma]
PUBDATE: 20010501
OBJECTIVE: To evaluate the effect of preoperative chemotherapy on the prognosis of stage II or III patients with esophageal carcinoma. METHODS: From February 1991 to June 1994, 50 patients with stage II, III esophageal carcinoma were treated with preoperative combination (CDDP) chemotherapy and compared with 50 patients received operation alone. RESULTS: The 5-year survival rate of the operation group and preoperative chemotherapy group was 32% and 46%, respectively. The difference was statistically significant. CONCLUSION: Preoperative chemotherapy improves survival of surgically treated esophageal cancer patients.


10. DOCID:27037 SCORE: 0.00283733272614689
DOCNO: 11322034
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: L Martín Carbonero L
AUTHOR: C González Galán C
AUTHOR: E Pintor Holguín E
AUTHOR: J Hinojosa Mena-Bernal J
AUTHOR: A Fernández-Cruz Pérez A
AUTHOR: E Sierra González E
AFFILIATION: Servicios de Medicina Interna III, Hospital Clínico San Carlos, Madrid.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Anales de medicina interna (Madrid, Spain : 1984)
COUNTRY: Spain
TITLE: [Micronodular pulmonary infiltration as first manifestation of metastatic hepatocellular carcinoma]
PUBDATE: 20001101
Infectious diseases, as tuberculosis, and metastatic cancers are the main causes of multiple pulmonary micronodules on chest radiographs. Many cancers can produce this anomaly, but the most common are thyroid, melanoma and gastrointestinal (colon and pancreas). Hepatocellular carcinoma can produce lung metastasis, but seldom makes bilateral pulmonary micronodules. Here we present the case of a woman with a hepatocarcinoma that appeared as a bilateral micronodular disease on the chest radiograph.


11. DOCID:27515 SCORE: 0.00273798661922171
DOCNO: 9485115
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: J K Berge JK
AUTHOR: S B Kapadia SB
AUTHOR: E N Myers EN
AFFILIATION: Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pa, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Archives of otolaryngology--head & neck surgery.
COUNTRY: UNITED STATES
TITLE: Osteosarcoma of the larynx.
PUBDATE: 19980201
Malignant mesenchymal tumors of the larynx constitute 0.3% to 1% of all laryngeal cancers, and of these osteosarcoma is the rarest. Our review of the literature identified only 12 cases of osteosarcoma of the larynx, all of which occurred in men. Rarely, osteosarcoma of the larynx may follow radiation therapy for squamous cell carcinoma, or the larynx may be the site of metastatic osteosarcoma. We report a case of primary laryngeal osteosarcoma arising in the cricoid cartilage and the first case of osteosarcoma of the larynx occurring in a woman.


12. DOCID:27517 SCORE: 0.00271378514830587
DOCNO: 10370944
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: J L Pariente JL
AUTHOR: C Theodore C
AUTHOR: J L Davin JL
AUTHOR: P Rischmann P
AUTHOR: D Chopin D
AFFILIATION: Service d'Urologie, Groupe Hospitalier Pellegrin, Bordeaux, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie.
COUNTRY: FRANCE
TITLE: [Place of chemotherapy in the treatment of invasive bladder tumors]
PUBDATE: 19990401
Urothelial bladder tumours are chemosensitive. Chemotherapy is indicated in the case of metastatic bladder cancer. The M-VAC protocol remains the reference treatment. The efficacy of this protocol is estimated to be about 18% in terms of complete responses and 20% of these responding patients achieve long-term survival. New combinations, comprising drugs such as ifosfamide, gallium nitrate, paclitaxel or gemcitabine, appear to be promising. Neoadjuvant and adjuvant chemotherapy cannot be considered to be standard treatment at the present time.


13. DOCID:27484 SCORE: 0.00271377851426937
DOCNO: 10198441
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
AUTHOR: K Hoffmann K
AUTHOR: G Brosch G
AUTHOR: P Loidl P
AUTHOR: M Jung M
AFFILIATION: Department of Pharmaceutical Chemistry, Westfälische Wilhelms-Universität Münster, Hittorfstrasse 58-62,48149 Münster, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Nucleic acids research.
COUNTRY: ENGLAND
TITLE: A non-isotopic assay for histone deacetylase activity.
PUBDATE: 19990501
Inhibitors of histone deacetylase (HD) bear great potential as new drugs due to their ability to modulate transcription and to induce apoptosis or differentiation in cancer cells. To study the activity of HD and the effect of potential inhibitors in vitro so far only radio-active assays have existed. For the search of new inhibitors and for the use in HD identification and purification we established a simple, non-radioactive assay that allows screening of large numbers of compounds. The assay is based on an aminocoumarin derivative of an Omega-acetylated lysine as enzyme substrate.


14. DOCID:27980 SCORE: 0.00260402824636417
DOCNO: 11140871
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: methods
AUTHOR: C E Cox CE
AUTHOR: C J Salud CJ
AUTHOR: M A Harrinton MA
AFFILIATION: H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, Tampa 33612, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Surgical clinics of North America.
COUNTRY: United States
TITLE: The role of selective sentinel lymph node dissection in breast cancer.
PUBDATE: 20001201
Axillary nodal status continues to be the most statistically significant predictor of survival for patients with breast cancer. Although still providing regional control of axillary disease, axillary dissection is more important as a staging and prognostic tool. Trials are currently underway to investigate the possibility of replacing the current standard treatment of breast cancer, axillary lymph node dissection, with the less invasive lymphatic mapping and sentinel lymph node biopsy. This issue and the technical aspects of sentinel lymph node mapping for breast cancer are discussed in detail in this article.