0. DOCID:23696 SCORE: 0.00321904192051119
DOCNO: 7905152
AUTHOR: I Mittra I
AFFILIATION: Department of Surgery, Tata Memorial Hospital, Bombay, India.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Breast screening: the case for physical examination without mammography.
PUBDATE: 19940201
Many studies have shown that screening for breast cancer can reduce mortality from the disease. Mammography has come to be regarded as the screening method of choice, but evidence suggests that physical examination (PE) is at least as effective in reducing mortality. Mammography detects many non-infiltrating and small, non-palpable tumours, but we do not know whether these would ever cause symptoms or threaten the woman's life. It is doubtful whether the time gained by early mammographic detection confers any survival benefit over PE detection. PE has substantial advantages over mammography in terms of human and economic costs. The question we should be asking is not how to refine mammographic screening but whether we need it at all.


1. DOCID:23603 SCORE: 0.0032189919770037
DOCNO: 9313857
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Plants, Medicinal
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
AUTHOR: J A Beutler JA
AUTHOR: Y Kashman Y
AUTHOR: L K Pannell LK
AUTHOR: J H Cardellina JH
AUTHOR: M R Alexander MR
AUTHOR: M S Balaschak MS
AUTHOR: T R Prather TR
AUTHOR: R H Shoemaker RH
AUTHOR: M R Boyd MR
AFFILIATION: Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick, MD 21702-1201, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: ENGLAND
TITLE: Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum.
PUBDATE: 19970801
A series of new ester saponins, elliptosides A-J, has been isolated from the tropical plant Archidendron ellipticum (Leguminosae). These saponins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structures of elliptosides A, E, and F were elucidated by spectroscopic and chemical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line.


2. DOCID:22854 SCORE: 0.00292019161188648
DOCNO: 7784155
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: radiography
QUALIFIER: methods
AUTHOR: F Mimura F
AUTHOR: M Kusumoto M
AUTHOR: R Ono R
AUTHOR: T Nakamura T
AUTHOR: M Endo M
AUTHOR: M Zhang M
AUTHOR: K Kimura K
AUTHOR: E Itouji E
AUTHOR: M Kono M
AFFILIATION: Department of Radiology, Kobe University, School of Medicine.
PUBTYPE: Journal Article
JOURNALTITLE: Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica.
COUNTRY: JAPAN
TITLE: [Assessment by three-dimensional CT of pleural indentation or invasion by peripheral lung cancer]
PUBDATE: 19950401
We evaluated the effectiveness of three-dimensional (3D) CT for pleural indentation or invasion by peripheral lung cancer adjacent to pleura. Pleural indentation was shown in three of nine cases on conventional CT, and six cases were demonstrated three-dimensionally. 3D-CT was superior to conventional CT in demonstrating pleural indentation. Pleural invasion could not be assessed on 3D-CT because the pleura adjacent to the tumor was not visualized.


3. DOCID:22793 SCORE: 0.00292018226101085
DOCNO: 8979468
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: D N Rao DN
AUTHOR: P B Desai PB
AUTHOR: B Ganesh B
AFFILIATION: Divn. of Epidemiology & Biostatistics, Tata Memorial Hospital, Parel, Mumbai, India.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Indian journal of cancer.
COUNTRY: INDIA
TITLE: Epidemiological observations on cancer of the oesophagus--a review of Indian studies.
PUBDATE: 19960601
This is an epidemiological review on cancer of the oesophagus. In this attempt, all aspects of epidemiological factors based on national and international studies on oesophageal cancer have been brought out. The problem of this cancer in Indian context has been documented. The association of tobacco and alcohol habits with oesophageal cancer has been confirmed from the studies conducted in India. There is an urgent need to educate the common people about the harmful effect of these two habits and governments and voluntary organisation should take effective steps for its prevention.


4. DOCID:23485 SCORE: 0.00289708267023257
DOCNO: 8960894
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: R S Bresalier RS
AFFILIATION: Department of Medicine, University of Michigan School of Medicine, Ann Arbor, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastroenterology clinics of North America.
COUNTRY: UNITED STATES
TITLE: The biology of colorectal cancer metastasis.
PUBDATE: 19961201
Metastasis is a complex process involving a series of tumor-host interactions that follow tumor initiation and progression. Metastatic cancer cells must be capable of completing all stages of this process to establish secondary foci at distant sites. Most studies infer the functional significance of various observations based on models designed to emphasize the contributions of single molecules or ligand-receptor pairs. While providing useful insights into potential mechanisms of tumorigenesis and metastasis, additional studies are needed to elucidate the complex dynamic interactions involved in these processes. Nonetheless, a better understanding of how tumor cells metastasize is leading to new therapies to prevent and treat micrometastatic disease.


5. DOCID:23423 SCORE: 0.00289706739519319
DOCNO: 8695766
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genomic Imprinting
QUALIFIER: genetics
AUTHOR: J Squire J
AUTHOR: R Weksberg R
AFFILIATION: Department of Pathology, University of Toronto, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: Genomic imprinting in tumours.
PUBDATE: 19960201
In recent years it has become apparent that genomic imprinting may have a role in the development of certain types of cancer. Preferential loss or retention of one parental genotype in chromosomal regions known to be subject to imprinting have been found in specific cancers. This finding raises the possibility that an epigenetic mechanism such as imprinting may alter gene expression and lead to inactivation of tumour suppressor genes or activation or dominant oncogenes. Rearrangements within imprinted chromosomal domains have the potential to influence the stage- and tissue-specific expression of both tumour suppressor and growth promoting genes that cluster to such regions, thus influencing the initiation and progression of cancer.


6. DOCID:23590 SCORE: 0.00287731406459085
DOCNO: 7661576
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: pathology
QUALIFIER: therapy
QUALIFIER: pathology
AUTHOR: N Nishino N
AUTHOR: K Aoki K
AUTHOR: H Konno H
AUTHOR: Y Maruo Y
AUTHOR: T Tanaka T
AUTHOR: I Matsuda I
AUTHOR: T Kanai T
AUTHOR: S Baba S
AFFILIATION: 2nd Dept. of Surgery, Hamamatsu University School of Medicine.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Postoperative abdominal lymph node recurrence of intrathoracic esophageal cancer with a long-term complete response to radiation and split CF therapy (CDDP and 5-FU)--a case report]
PUBDATE: 19950801
We experienced complete remission in a patient with postoperative abdominal lymph node recurrence of intrathoracic esophageal cancer after treatment with radiation (60Co: 30 Gy) and split CF therapy (CDDP: 20 mg/day + 5-FU: 1 g/day for 5 days). Since then, this patient has remained in complete remission for 43 months with intermittent split CF therapy one or two times a year.


7. DOCID:23567 SCORE: 0.00287731000076564
DOCNO: 7803214
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: D Tripathy D
AFFILIATION: Mount Zion Cancer Center, University of California at San Francisco.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: How long should adjuvant tamoxifen be continued?
PUBDATE: 19941001
Tamoxifen can reduce the risk of relapse and death from breast cancer when used as adjuvant therapy for early stage breast cancer. While most trials have tested 1 or 2 years of therapy, it is now common to continue tamoxifen for 5 or more years. However, the optimal duration remains controversial. The complex physiologic and clinical effects of tamoxifen cannot be fully predicted by our rudimentary understanding of its basic mechanisms of action. An analysis of randomized clinical trials comparing different tamoxifen durations is therefore necessary. Individual patients' risks of breast cancer recurrence, other beneficial effects, and potential toxicities also must be entered into the decision-making process.


8. DOCID:21717 SCORE: 0.00287350745441965
DOCNO: 8751797
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: T Komiya T
AUTHOR: M Takada M
AFFILIATION: Second Dept. of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Chemotherapy of small cell lung cancer]
PUBDATE: 19960801
Chemotherapy of small cell lung cancer is reviewed. Combination chemotherapy with cisplatin/etoposide (PE) or CAV (cyclophosphamide, adriamycin and vincristine) alternating with PE was established as standard regimens. Dose intensive chemotherapy, such as weekly regimens or using G-CSF, is being investigated. In patients with limited disease (LD), combined modality treatment is proven to produce favorable results, but the best sequence or fractionation of thoracic radiotherapy is unknown. More progress in the treatment of small cell lung cancer is expected.


9. DOCID:21694 SCORE: 0.00287350578842399
DOCNO: 7490492
AUTHOR: S Jisander S
AUTHOR: P Aspenberg P
AUTHOR: L Salemark L
AUTHOR: J Wennerberg J
AFFILIATION: Department of Oral and Maxillofacial Surgery; University Hospital, Lund; Sweden.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of oral and maxillofacial surgery.
COUNTRY: DENMARK
TITLE: Mandibular reconstruction by secondary reimplantation of resected segments: a preliminary report.
PUBDATE: 19950801
This paper presents a new method of reconstructing the mandible after ablative surgery for cancer. This method uses autogenous grafts consisting of the respected part of the mandible, which is hollowed out, defatted in chloroform/methanol, sterilized with ethylene oxide, irradiated with beta-radiation (dose 25 kGy), and stored for 7-10 months. At reimplantation, they were filled with compressed, autogenous, particulate cancellous bone. All grafts took, and four of six host-graft junctions healed.


10. DOCID:22900 SCORE: 0.00277824520691651
DOCNO: 8657928
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
DESCRIPTOR: Surgical Instruments
QUALIFIER: radiotherapy
AUTHOR: M A Hunter MA
AUTHOR: T A McFall TA
AUTHOR: K A Hehr KA
AFFILIATION: Department of Radiation Oncology, Virginia Mason Medical Center, Seattle, WA 98111, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Breast-conserving surgery for primary breast cancer: necessity for surgical clips to define the tumor bed for radiation planning.
PUBDATE: 19960701
Radiographs obtained at definitive and boost irradiation in 50 patients with stage I-II breast cancer were retrospectively examined. Tangent target fields planned on the basis of surgical clips placed at excision biopsy were evaluated with simulation radiographs. Four (8%) of 50 tangent target fields would have been inadequate without clips, and 23 (46%) of the boost targets would have been missed (12 [24%], totally; 11 (22%), marginally). Radiopaque surgical clips placed at excision biopsy help plan boost-irradiation target fields.


11. DOCID:23843 SCORE: 0.0026551149992979
DOCNO: 8621101
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Medical Futility
QUALIFIER: organization & administration
QUALIFIER: organization & administration
AUTHOR: R N Butler RN
AUTHOR: R Burt R
AUTHOR: K M Foley KM
AUTHOR: J Morris J
AUTHOR: R S Morrison RS
AFFILIATION: Department of Geriatrics, Mount Sinai Medical Center, New York, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Geriatrics.
COUNTRY: UNITED STATES
TITLE: Palliative medicine: providing care when cure is not possible. A roundtable discussion: Part I.
PUBDATE: 19960501
Palliative medicine describes the care of patients with advanced disease. When cure is no longer possible, the goal becomes control of pain, other symptoms, and psychological distress. In the United States, palliation has been pioneered by the hospice movement for patients with disseminated cancer and AIDS. Palliative care is also appropriate for patients with many of the chronic diseases of aging. For medical, humanitarian, financial, and legal reasons, physicians are being called on to provide palliative care when they make the diagnosis of all illness that is unresponsive to curative treatment.


12. DOCID:23585 SCORE: 0.00250384357390537
DOCNO: 9772978
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: G Michel G
AUTHOR: P Morice P
AUTHOR: D Castaigne D
AUTHOR: P Lanoux P
AFFILIATION: Département de Chirurgie, Institut Gustave Roussy, Villejuif.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal de chirurgie.
COUNTRY: FRANCE
TITLE: [Surgical strategy for peritoneal carcinosis of ovarian origin]
PUBDATE: 19971101
Cancer of the ovary is usually discovered in an advanced stage after development of peritoneal carcinosis. Surgery is a fundamental element for diagnosis and treatment. Therapeutic strategy for cancer of the ovary discovered in an advanced stage includes first-line surgery and systematic postoperative chemotherapy. The essential prognostic factor is the quality of the initial surgical resection and the size of the residual tumoral tissue. Hysterectomy with adnexectomy, omentectomy, lumbo-ovarian and pelvic node dissection and extensive excision of visible carcinosis nodules, with if need digestive resection, are required for optimal tumor reduction. This aggressive surgery should be performed by well trained surgical teams.


13. DOCID:23500 SCORE: 0.00250378549776302
DOCNO: 9373297
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
DESCRIPTOR: Tomography, Emission-Computed
QUALIFIER: radionuclide imaging
QUALIFIER: methods
QUALIFIER: radionuclide imaging
AUTHOR: J D Luketich JD
AUTHOR: P Schauer P
AUTHOR: K Urso K
AUTHOR: D W Townsend DW
AUTHOR: C P Belani CP
AUTHOR: C Cidis Meltzer C
AUTHOR: P F Ferson PF
AUTHOR: R J Keenan RJ
AFFILIATION: University of Pittsburgh Medical Center, 300 Kaufmann Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Surgical endoscopy.
COUNTRY: GERMANY
TITLE: Minimally invasive surgical biopsy confirms PET findings in esophageal cancer.
PUBDATE: 19971201
This report describes our initial experience using positron emission tomography (PET) scanning in esophageal cancer patients. In two patients PET identified distant metastatic disease missed by conventional staging. Laparoscopic biopsy provided histological confirmation of metastases. In the third patient, locoregional lymph nodes were identified by PET and confirmed by surgical staging. In this preliminary report, PET appears to be a promising new noninvasive modality for staging patients with esophageal cancer.


14. DOCID:21534 SCORE: 0.00249302743508425
DOCNO: 9438871
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: CDC2-CDC28 Kinases
DESCRIPTOR: Drug Design
QUALIFIER: antagonists & inhibitors
QUALIFIER: chemistry
QUALIFIER: antagonists & inhibitors
QUALIFIER: chemistry
QUALIFIER: chemical synthesis
QUALIFIER: antagonists & inhibitors
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: L M Toledo LM
AUTHOR: N B Lydon NB
AFFILIATION: Kinetix Pharmaceuticals, Inc., Medford, MA 02155, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Structure (London, England)
COUNTRY: ENGLAND
TITLE: Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors.
PUBDATE: 19971201
Protein kinases are involved in a wide variety of signal transduction processes; their deregulation has been implicated in a number of human diseases, including cancer and disorders of the immune system. The recently determined structures of two protein kinases, cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of inhibitor-kinase interactions and inhibitor selectivity.