0. DOCID:7453 SCORE: 0.00367491007195241
DOCNO: 7438698
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: surgery
QUALIFIER: drug therapy
AUTHOR: R F Kaiko RF
PUBTYPE: Journal Article
JOURNALTITLE: Clinical pharmacology and therapeutics.
COUNTRY: UNITED STATES
TITLE: Age and morphine analgesia in cancer patients with postoperative pain.
PUBDATE: 19801201
Our objective was to identify age-related differences in analgesia after 8 and 16 mg morphine intramuscularly. Retrospective analyses of controlled relative analgesic potency assays in 947 postoperative cancer patients revealed differences among age groups (18 to 29, 30 to 49, 50 to 69, and 70 to 89 yr) in total pain relief and duration of relief with little differences in peak relief. Weight and initial pain intensity were in the same range among age and dose groups. Aging was associated with enhanced analgesia. The difference in total relief between the extremes of adult age was approximately twice that with twice the dose. While in 50% of the oldest group relief was no longer obtained at 5 hr, in 50% of the youngest group relief was no longer obtained at 3 hr. These observations suggest that age is a factor in morphine analgesia.


1. DOCID:7595 SCORE: 0.00352160714940418
DOCNO: 667820
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: biosynthesis
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: biosynthesis
AUTHOR: J Vaage J
AUTHOR: S Agarwal S
AUTHOR: J L Reinertsen JL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Effect of progressive neoplastic growth on the decarboxylation of DL-[1-14C]ornithine by lymphocytes from C3H/He tumor hosts.
PUBDATE: 19780801
The reactivity of normal and tumor host lymphocytes incubated with normal serum or with serum or malignant ascites fluid from tumor hosts was measured by the ability of the lymphocytes to synthesize ornithine decarboxylase after phytohemagglutinin stimulation. Each of three tumors tested (a solid fibrosarcoma, an ascites mammary carcinoma, and an ascites ovarian carcinoma) caused increasing unresponsiveness in the lymphocytes of mice with progressing syngeneic neoplastic growth. The sera and particularly the malignant ascites fluids from mice given implants of the ascites cancers became progressively inhibitory to the activation of lymphocytes from tumor hosts as well as from normal mice. The serum from mice carrying s.c. implants of the fibrosarcoma enhanced the activation of lymphocytes from tumor hosts and from normal mice during early tumor growth before it also became inhibitory.


2. DOCID:7928 SCORE: 0.0032951406069967
DOCNO: 83401
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: Y Matsumura Y
AUTHOR: Y Nomura Y
AUTHOR: S Eguchi S
AUTHOR: T Yanagita T
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of antibiotics.
COUNTRY: JAPAN
TITLE: [Histological appearances of cancer of the head and neck treated with pepleomycin (NK 631) (author's transl)]
PUBDATE: 19781101
Clinical findings and histopathological appearances in the patients with cancer of the head and neck treated with a new anti-tumor agent, pepleomycin, are reported. The total dosage of the new drug was within 100 mg on the average; however, the responses to chemotherapy were considerably favorable in general. Pepleomycin was markedly effective in two patients, moderately effective in seven, and ineffective in one. Microscopic evidences of regression of cancer cells were demonstrated in six surgical materials. Pepleomycin was shown to have an even more selective action on squamous cell carcinoma than bleomycin. The reactions of the surrounding tissue and skin to combination therapy, including pepleomycin, remained comparable to those to bleomycin. Side effects of the drug were slight fever and transient anorexia. No fibrosis of the lung was seen during eight months of observation.


3. DOCID:7199 SCORE: 0.00329207847570701
DOCNO: 7272692
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gastrectomy
QUALIFIER: surgery
AUTHOR: N J Lygidakis NJ
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Total gastrectomy for gastric carcinoma: a retrospective study of different procedures and assessment of a new technique of gastric reconstruction.
PUBDATE: 19810901
A retrospective study of the value of reconstructive surgery after total gastrectomy of gastric carcinoma in 118 patients who underwent different types of reconstructive procedures is presented. Dissatisfaction with established methods of reconstruction led to the development of a new technique. The new method was associated with less regurgitation, less dumping and functioned as a reservoir without undue delay in emptying time. It was associated with an improved quality of life in the postoperative period, with minimal dumping symptoms, maintenance of weight and the ability to return to work. The mortality and morbidity of the new method are acceptable and it thus offers not only an improved reconstructive procedure for total gastrectomy after resection for gastric cancer, but offers potential for reconstructive surgery after total gastrectomy carried out for other reasons.


4. DOCID:7237 SCORE: 0.00321575985484088
DOCNO: 7023668
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: E Gurpide E
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Hormone receptors in endometrial cancer.
PUBDATE: 19810701
Similarities between endometrial and mammary tissue as targets for ovarian hormones indicate that measurements of estradiol and progesterone receptor (RE and RP) levels may be as useful in endometrial cancer as they are in breast cancer for the prediction of responses to treatment with steroids and antiestrogens. Receptor levels cannot be inferred from the degree of differentiation of the endometrial tumors, although RP values are lower in poorly differentiated adenocarcinoma. Current studies aim to relate RP levels to objective remissions of metastases after progestin therapy, and attempts are being made to increase RP with tamoxifen before treatment with progestins or assaying for RP. In vitro studies aim to elucidate fundamental problems related to the action of steroids on the tumors, e.g., mechanism by which receptors mediate the effects of pharmacologic doses of drugs, factors that regulate receptor levels, and homogeneity in the distribution of receptors in tumor cell populations.


5. DOCID:7229 SCORE: 0.00297227974097132
DOCNO: 661348
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: J D Harviel JD
AUTHOR: J J McNamara JJ
AUTHOR: C J Straehley CJ
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of thoracic and cardiovascular surgery.
COUNTRY: UNITED STATES
TITLE: Surgical treatment of lung cancer in patients over the age of 70 years.
PUBDATE: 19780601
Eighty patients of 70 years of age with lung cancer have been treated since 1964. Forty-eight received no therapy or chemotherapy and/or irradiation. Mean survival was 3.5 to 10 months, and only three (6%) survived for 2 years. Twenty-two of 32 patients selected for thoracotomy underwent resection for cure (70%). The operative mortality rate was 18% for resection, and 64% of the patients survived for at least 2 years. The incidence of exploratory thoracotomy decreased in the last 5 years of the study with the introduction of more rigorous preoperative evaluation. The poor survival rate without resection and the favorable survival rate following recovery from resection support the continued use of surgical resection for lung cancer in elderly patients, despite an increased operative risk.


6. DOCID:6610 SCORE: 0.00296808937869239
DOCNO: 758876
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Recurrence, Local
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: N W Pearlman NW
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Treatment outcome in recurrent head and neck cancer.
PUBDATE: 19790101
One hundred cases of recurrent oral, pharyngeal, or laryngeal squamous cancer were reviewed to determine the contribution of retreatment of such lesions to overall survival. Thirty percent (8/27) of locally recurrent T1-2 primary lesions and 4% (1/28) of recurrent T3-4 lesions were cured by retreatment. Forty-five percent (5/11) of patients with conversion of N0 necks were salvaged, while no cures of neck recurrence after an earlier elective (four) or therapeutic (22) neck dissection were seen. Three of eight patients with isolated lung recurrence were salvaged. Patients benefiting most from retreatment were those with local recurrence of small primary lesions, conversion of a previously N0 neck, or isolated lung disease. Those with other types of recurrence were helped much less.


7. DOCID:7881 SCORE: 0.00294320739610352
DOCNO: 6944677
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: drug therapy
AUTHOR: D J Krutchkoff DJ
AUTHOR: E Eisenberg E
AUTHOR: A A Neckritz AA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Oral surgery, oral medicine, and oral pathology.
COUNTRY: UNITED STATES
TITLE: Epidermoid carcinoma of the gingiva: a possible relationship to PUVA therapy.
PUBDATE: 19810701
A case of squamous cell carcinoma arising in the gingiva of a 30-year-old nonsmoking woman receiving PUVA therapy for vitiligo is reported. There were no typical predisposing factors for oral cancer in the history, other than the latter therapy. Although there are several previous reports of cutaneous carcinoma developing in patients under PUVA therapy, most of such involve development of tumors on skin surfaces exposed to direct ultraviolet radiation either through sunlight or via therapeutic mode.s In this case, there was no direct ultraviolet exposure at the site of carcinoma. We suggest the possibility that, in this case, PUVA may exerted a carcinogenic influence via systemic distribution of ultraviolet-activated psoralens or its metabolites to the gingiva. The possibility of microbial interaction with substances within gingival inflammatory exudate to produce carcinogenic substances is postulated.


8. DOCID:7860 SCORE: 0.00289460820864701
DOCNO: 420868
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood
DESCRIPTOR: Magnetic Resonance Spectroscopy
QUALIFIER: analysis
AUTHOR: L A McLachlan LA
AUTHOR: W Hamilton W
PUBTYPE: Journal Article
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: NETHERLANDS
TITLE: The effect of cancer on the spin-lattice relaxation time of mouse blood and tissue.
PUBDATE: 19790201
Spin-lattice relaxation time measurements were made on the muscle, heart, kidneys, spleen, liver, brain and blood of both normal mice and those injected with Sarcoma-180. As well as a marked increase in the relaxation time of the tumour itself, mice injected with Sarcoma-180 showed a rise in the kidney relaxation time, along with blood relaxation times which were often either above or below the range found in normal mice. Correlation coefficients for the relaxation times of the various organs were calculated and found to be very sensitive to the physiological state of the animal. For healthy mice, the correlations were reasonably high, but even mild stress decreased the correlations, whilst the presence of cancer almost completely destroyed the correlations. These findings are all consistent with the hypothesis that cancer affects the water regulatory system of the animal as a whole.


9. DOCID:7286 SCORE: 0.00286806060910418
DOCNO: 662126
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Intestinal Neoplasms
DESCRIPTOR: Leiomyoma
QUALIFIER: complications
AUTHOR: P Caione P
AUTHOR: M Rivosecchi M
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Minerva chirurgica.
COUNTRY: ITALY
TITLE: [Tumors of Meckel's diverticulum]
PUBDATE: 19780401
The presentation of a rare case of leiomyoma of Meckel's diverticulum in a boy of 5 yr forms the starting point for a discussion of such cancers. In adult age, the complication is not so rare as the sporadic publications would suggest, incidence of tumoral forms being around 1 : 50 M.D. with a high malignancy frequency. In paediatric age, on the other hand, the tumoral degeneration of a M.D. is an exceptional occurrence: a review of more than 1,200 reported cases and personal experience (48 cases of M.D. in 15 yrs) confirm the rarity of the observation. The need to seek M.D. on each occasion and remove it to prevent the risk of tumoral degeneration in adult age is stressed. M.D. surgical removal tecniques are commented on and emphasis laid on the desirability of ample intestinal resection in cases of cancer of the diverticulum.


10. DOCID:7443 SCORE: 0.00285619423993541
DOCNO: 7293295
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: E Schmid E
AUTHOR: K Rettenmayr K
AUTHOR: E Blaich E
AUTHOR: H Gehl H
AUTHOR: H Schwarzkopf H
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Gastroenterologie.
COUNTRY: GERMANY, WEST
TITLE: [The role of gastroscopy for preoperative reliability of diagnosis and operability in gastric cancer. Retrospective analysis at a county hospital (author's transl)]
PUBDATE: 19810901
The evaluation of 535 patients with gastric cancer observed in two 5-years periods with low (3%) and high (84%) preoperative endoscopic frequence demonstrated: 1. Change of the diagnostic procedure, mainly on the basis of out-patients examination, 2. a diminished role of preoperative X-ray examination for decisions about the further proceeding. 3. no more unnecessary probatory laparotomies without a lesion requiring surgery, 4. improved preoperative exclusion from surgery of patients supposed to be not operable, resulting in a reduction of explorative laparotomies and a relative increase of gastrectomies, and finally 5. a significant increase in early gastric cancer with a concomitant decrease of stage 2 and 3. The percentage of the largest group of gastric cancer in stage 4 remained constant, however.


11. DOCID:7536 SCORE: 0.00278078428570533
DOCNO: 475971
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: chemically induced
QUALIFIER: administration & dosage
AUTHOR: H Barbason H
AUTHOR: V Smoliar V
AUTHOR: A Fridman-Manduzio A
AUTHOR: E H Betz EH
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Effects of discontinuation of chronic feeding of diethylnitrosamine on the development of hepatomas in adult rats.
PUBDATE: 19790801
Diethylnitrosamine (DENA) at 10 mg/kg was fed to adult rats either continuously or for periods ranging from 1 to 10 weeks. Survival correlated inversely with the duration of carcinogen feeding. Less than 4 weeks of DENA feeding produced only preneoplastic foci that persisted indefinitely; 4 weeks were found to be necessary for the transformation of preneoplastic lesions into liver cancers; after 6 weeks, the incidence of hepatomas was 100%. The process of liver cancerization appeared to be identical whether DENA was fed for 8 weeks or continuously up to the time of death. These results are discussed in the light of the evolution of the homoeostatic control of liver-cell division during DENA feeding, in order to distinguish the different successive roles played by the carcinogen.


12. DOCID:7233 SCORE: 0.00273226924101605
DOCNO: 7296516
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: Y Kato Y
AUTHOR: T Kitagawa T
AUTHOR: K Nakamura K
AUTHOR: H Sugano H
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Changes in the histologic types of gastric carcinoma in Japan.
PUBDATE: 19811101
The changes in histologic types of gastric carcinoma in Japan in recent years was studied utilizing the 4147 cases surgically resected at the Cancer Institute Hospital, Tokyo, from 1955 to 1974. All carcinomas were classified as either well-differentiated or poorly differentiated, and the ratio of the former to the latter (WPR) was calculated for the first decade (1955-1964) and the second decade (1965-1974). A decline in the WPR was observed, although the difference was not statistically significant. However, when the material was subdivided according to the site of the tumor in the stomach, a decrease in the WPR was markedly visible in the area designated as Fl-area, i.e., a part of the fundic area susceptible to intestinalization. When limited to this area, the difference was statistically significant (P less than 0.05).


13. DOCID:7243 SCORE: 0.00272712870867751
DOCNO: 6788060
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: immunology
AUTHOR: R H Stevens RH
AUTHOR: D A Cole DA
AUTHOR: H F Cheng HF
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.
PUBDATE: 19810601
An apparently unique circulating common oncofoetal protein has been identified in rat small-bowel, colonic and pancreatic adenocarcinomas. The tumours were induced by ionizing radiation (small bowel), an alkyl hydrocarbon, 1,2-dimethylhydrazine (colon) and a polyaromatic hydrocarbon, 7,12-dimethylbenz[a]anthracene (pancreas). The oncofoetal protein was identified by the use of specific xenogenic antitumour rabbit sera generated to the X-ray-induced neoplasm. In addition, the foetal protein was also found always to occur in the liver and lungs of those animals bearing the chemically induced tumours as well as in their serum. These results suggest the existence of a close relationship at the molecular level in the tumorigenic processes, even though induction is by apparently different mechanisms, for cancers arising in tissue or common embryonic origin.


14. DOCID:7164 SCORE: 0.00270244612933918
DOCNO: 7382008
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymph Node Excision
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: etiology
AUTHOR: W J Catalona WJ
AUTHOR: D Kadmon D
AUTHOR: D B Crane DB
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Effect of mini-dose heparin on lymphocele formation following extraperitoneal pelvic lymphadenectomy.
PUBDATE: 19800601
To evaluate the effect of mini-dose heparin therapy on lymphocele formation after extraperitoneal pelvic lymphadenectomy we reviewed the records of 38 patients undergoing this procedure for prostatic cancer during a 24-month period. All patients had a minimum of 6 months of followup. Lymphoceles occurred in 3 of 8 patients (38 per cent) receiving mini-dose heparin and prolonged lymph drainage occurred in 1 other patient (12 per cent). In contrast, only 1 of 30 patients (3 per cent) not receiving mini-dose heparin had a lymphocele and 1 (3 per cent) had prolonged lymph drainage. The results suggest that mini-dose heparin may delay clotting of lymph and, thus, may be associated with an increased incidence of lymphocele formation after extraperitoneal lymphadenectomy.