0. DOCID:14411 SCORE: 0.00252984768488416
DOCNO: 3120317
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: L Levin L
AUTHOR: W Hryniuk W
AFFILIATION: London Regional Cancer Centre, Ontario, Canada.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: The application of dose intensity to problems in chemotherapy of ovarian and endometrial cancer.
PUBDATE: 19871201
An attempt was made using dose intensity to resolve some of the conflicting issues regarding chemotherapy in ovarian cancer and endometrial cancer. Analyses were done to determine if dose intensity correlates with outcome of first-line and salvage chemotherapy of advanced ovarian cancer and chemotherapy of advanced endometrial cancer. The concept of dose intensity was used to analyze the relative contributions of individual drugs, such as cyclophosphamide, hexamethylmelamine, Adriamycin (Adria Laboratories, Columbus, OH) and cisplatin to outcome, and to suggest how such drugs should be used in combination.


1. DOCID:14385 SCORE: 0.00252984250334933
DOCNO: 3567859
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: F Tanaka F
AUTHOR: K Yamaguchi K
AUTHOR: Y Urano Y
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Statistical analysis of the surgical materials of stomach cancer in Japan.
PUBDATE: 19870601
Two thousand three hundred seventy gastric cancers from 2173 patients for which surgical resections were performed at the Tokyo University Hospital from 1967 to 1985, were analyzed. Cancers were classified into diffuse adenocarcinomas, intestinal adenocarcinomas, and an unclassified group. The proportional rate of the intestinal type was higher in the old than in the young, and higher in men than in women. The reverse was true of the diffuse type. The intestinal-diffuse ratio had increased recently, especially in patients with early cancers and in patients in their 50s and 60s, which suggested the efficacy of early screening methods for gastric cancers.


2. DOCID:14469 SCORE: 0.00248597862416702
DOCNO: 3382204
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hyperthermia, Induced
QUALIFIER: therapy
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: I Fukuda I
AUTHOR: M Kameyama M
AUTHOR: T Iwanaga T
AUTHOR: O Doi O
AUTHOR: H Koyama H
AUTHOR: S Imaoka S
AUTHOR: H Furukawa H
AUTHOR: K Kodama K
AUTHOR: T Kabuto T
AUTHOR: O Ishikawa O
AFFILIATION: Dept. of Surgery, Center for Adult Diseases, Osaka.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Local chemo-hyperthermotherapy of recurrent rectal cancer]
PUBDATE: 19880401
Local radiofrequency hyperthermia combined with chemotherapy was performed on five patients with pelvic recurrence of rectal cancer. Relief of pain was obtained in all four patients with uncontrolled pelvic pain due to recurrent rectal cancer. In some patients, CEA levels of peripheral blood were decreased and tumor necrosis was proved histologically. These results suggest that this combined therapy may be useful for patients with pelvic recurrence of rectal cancer.


3. DOCID:14463 SCORE: 0.00248597368935091
DOCNO: 3734846
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: D Vugrin D
AUTHOR: L Hood L
AUTHOR: J Laszlo J
PUBTYPE: Journal Article
JOURNALTITLE: Journal of biological response modifiers.
COUNTRY: UNITED STATES
TITLE: A phase II trial of high-dose human lymphoblastoid alpha interferon in patients with advanced renal carcinoma.
PUBDATE: 19860801
Seventeen patients with metastatic renal cancer were treated with human lymphoblastoid cell-derived alpha interferon, 30 X 10(6) U/m2, which was given intravenously for 3 consecutive days of each week for 6 weeks. On the days of interferon treatment only, patients received prednisone, 15 mg t.i.d., in order to minimize toxicity. Of the 16 evaluable patients, one had a minor regression of disease, eight had stable metastatic disease, and seven progressed. Constitutional symptoms, such as fever, anorexia, and fatigue, were common. Debilitating degrees of malaise were a treatment-limiting factor.


4. DOCID:10851 SCORE: 0.00247862361326545
DOCNO: 3863969
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: T Fujimoto T
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Acute childhood leukemia: treatment results in children's cancer and leukemia group studies 1972-1981]
PUBDATE: 19850701
Controlled clinical trials of therapy for childhood acute leukemia are reviewed in the Children's Cancer & Leukemia Group Studies 1972-1981. The mortality of acute lymphocytic leukemia in children has been reduced about one-half in the past 10 years. Continued progress depends on maintaining our objective of curing all children and in conceiving and testing new ideas that might contribute to cure. Nowadays, the end result of most importance is long-term leukemia-free survival, i.e., the freedom from relapse after off therapy. Advances in the childhood leukemia have paved the way for encouraging progress in the management of the much more common malignancies that affects adults.


5. DOCID:10804 SCORE: 0.00247862193894951
DOCNO: 3967769
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Enkephalins
QUALIFIER: physiology
AUTHOR: N P Plotnikoff NP
AUTHOR: A J Murgo AJ
AUTHOR: G C Miller GC
AUTHOR: C N Corder CN
AUTHOR: R E Faith RE
PUBTYPE: Journal Article
JOURNALTITLE: Federation proceedings.
COUNTRY: UNITED STATES
TITLE: Enkephalins: immunomodulators.
PUBDATE: 19850101
Our original studies of the enkephalins were centered on behavioral stress and brain dopaminergic interactions. More recently we discovered the enkephalins to be immunomodulators as evidenced by their enhancement effects on lymphocyte blastogenesis in mice, increases in the sizes of the thymus or spleen in rodents, and prolongation of survival of BDF1 mice inoculated with attentuated L1210 cells. Finally, in studies of human blood samples from both normal volunteers and cancer patients, the enkephalins were demonstrated to stimulate active T cell rosettes and natural killer cell activities (in vitro). These studies support our hypothesis that, in stress, the enkephalins modulate the effects of steroid hormones on the immune system.


6. DOCID:13712 SCORE: 0.00244791951114946
DOCNO: 2958468
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ovarian Neoplasms
QUALIFIER: secondary
QUALIFIER: secondary
AUTHOR: C E de Metz CE
AUTHOR: A A Starreveld AA
AUTHOR: G D MacLean GD
AUTHOR: A R Turner AR
AFFILIATION: Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes.
COUNTRY: CANADA
TITLE: Cerebral metastases from epithelial ovarian carcinoma.
PUBDATE: 19870901
We describe four patients with epithelial ovarian carcinoma and cerebral metastases. Cerebral metastases are still an infrequent occurrence in this malignancy but, as treatment for ovarian cancer produces more long-term survivors, such uncommon patterns of spread may become more frequent. Part of a future successful cure for this disorder may require the recognition of the central nervous system as a potential sanctuary site for metastatic disease.


7. DOCID:13700 SCORE: 0.00244791885090149
DOCNO: 3768850
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: prevention & control
QUALIFIER: toxicity
AUTHOR: S De Flora S
AUTHOR: M Astengo M
AUTHOR: D Serra D
AUTHOR: C Bennicelli C
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: NETHERLANDS
TITLE: Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine.
PUBDATE: 19860901
The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NAC also significantly enhanced GSH S-transferase activity in liver preparations of the same animals. These data show that, under certain conditions, it is possible to prevent chemically induced cancer by increasing the levels of physiological trapping agents.


8. DOCID:11252 SCORE: 0.00241045651412164
DOCNO: 4079049
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radiotherapy Dosage
QUALIFIER: radiotherapy
AUTHOR: M Nakano M
AUTHOR: K Iida K
AUTHOR: S Sato S
AUTHOR: S Sakata S
AUTHOR: H Sueyama H
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Radiotherapy of carcinoma of the larynx--dose and function preservation]
PUBDATE: 19850901
Relationship between irradiated dose and function preservation of the larynx in patients of laryngeal carcinoma (T1-T3) treated with radiotherapy were analysed and discussed. Local control rate for T1 and T2 lesion was highest in the dose range of 65-70 Gy. But in T3 lesion, especially of supraglottic cancer, the dose range to obtain highest local tumor control rate is above 76 Gy and higher than in case of T1 and T2 lesions. Laryngeal edema was seen in patients who were delivered the dose of 80 Gy. But total laryngectomy could be avoided by conservative therapy. Necessity of induction chemotherapy for advanced cases was also discussed.


9. DOCID:11210 SCORE: 0.00241045204090611
DOCNO: 6565026
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Crisis Intervention
DESCRIPTOR: Psychotherapy, Group
QUALIFIER: psychology
AUTHOR: F A Youssef FA
PUBTYPE: Journal Article
JOURNALTITLE: Journal of advanced nursing.
COUNTRY: ENGLAND
TITLE: Crisis intervention: a group-therapy approach for hospitalized breast cancer patients.
PUBDATE: 19840501
The purpose of this study was to assess the effect of nursing intervention on the level of depression and the self-esteem of hospitalized breast cancer patients. The theoretical framework was based on crisis theory (Caplan 1964). The population of this study consisted of 18 female hospitalized breast cancer patients. Ten were in the control group and eight in the experimental group. Two self-administered instruments were selected for the pre- and post-testing of all clients. Nursing intervention was employed for the experimental group, over a 2-month period. The findings demonstrated that there was a change in the level of depression and improvement in self-esteem among the subjects in the experimental group after nursing intervention.


10. DOCID:10073 SCORE: 0.00237534306966253
DOCNO: 12264221
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Contraceptives, Oral
DESCRIPTOR: Follicle Stimulating Hormone
DESCRIPTOR: Gonadotropins, Pituitary
DESCRIPTOR: Hormones
DESCRIPTOR: Luteinizing Hormone
DESCRIPTOR: Progesterone Congeners
AUTHOR: M Detouef M
AUTHOR: F Kuttenn F
PUBTYPE: Journal Article
JOURNALTITLE: Contraception, fertilité, sexualité.
COUNTRY: FRANCE
TITLE: [Hyperestrogenic state under low-dose progestagen-only mini-pill (author's transl)]
PUBDATE: 19820601
The low-dose progestagen minipill exerts its contraceptive effect mostly by its action on the cervical mucus. However, in 50% of the cases, alterations of the gonadotropins FSH and LH secretion occur. A relative hyperestrogenic state ensues. This has been proved to be involved in the genesis of uterus and breast dystrophies. Consequently, this method of contraceptive should not be offered to patients with benign breast disease, endometrial or myometrial hyperplasia, in premenopausal women or those women with a hisotyr of dysovulation, and in women with a high risk of genital cancer. (author's)


11. DOCID:10033 SCORE: 0.00237533360167347
DOCNO: 4047668
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: S M Shapshay SM
AUTHOR: R L Hybels RL
PUBTYPE: Journal Article
JOURNALTITLE: Otolaryngologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Treatment of cancer of the larynx. Analysis of success and failure.
PUBDATE: 19850801
The treatment of patients with cancer of the larynx must consider the potential for multiple sites of origin and the possibility of regional metastasis. Treatment options must also address effects on the voice, deglutition, and the sphincteric function of the larynx which protects the lungs. Fortunately, our advanced techniques in surgery--reconstruction, radiotherapy, and endoscopic laser application--enable us to choose from and use these modalities in combination. Induction chemotherapy appears to be a promising, albeit unproved, adjuvant therapy. The oncologist dealing with cancer of the head and neck must select appropriate individualized therapy in a multidisciplinary environment.


12. DOCID:15652 SCORE: 0.00230236639640903
DOCNO: 2429765
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: blood
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: A Horwich A
AUTHOR: M J Peckham MJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Transient tumor marker elevation following chemotherapy for germ cell tumors of the testis.
PUBDATE: 19861101
A total of 22 adults with metastatic nonseminomatous germ cell tumor of the testis and raised pretreatment serum levels of the beta subunit of human chorionic gonadotropin (HCG) had serial monitoring of serum HCG by weekly assay following initiation of chemotherapy with bleomycin, etoposide, and cisplatin (BEP). A transient rise in HCG (the marker "surge") was detected in 9 patients (41%), of whom one relapsed. None of the other 13 patients have relapsed (follow-up, 24-60 months), and the BEP regimen overall leads to an 83.3% disease-free survival (Br J Cancer 47:613-619, 1983). The marker surge is not an adverse prognostic factor during initial chemotherapy.


13. DOCID:15466 SCORE: 0.00230097085840938
DOCNO: 12268267
OWNER: PIP
STATUS: MEDLINE
DESCRIPTOR: Cause of Death
DESCRIPTOR: Data Collection
DESCRIPTOR: Mortality
DESCRIPTOR: Neoplasms
DESCRIPTOR: Nutrition
DESCRIPTOR: Occupations
DESCRIPTOR: Smoking
DESCRIPTOR: Social Class
DESCRIPTOR: Socioeconomic Factors
AUTHOR: J P Lindsay JP
AUTHOR: G R Howe GR
PUBTYPE: Journal Article
JOURNALTITLE: Cahiers québécois de démographie / Association des démographes du Québec.
COUNTRY: CANADA
TITLE: [A system for monitoring cancer mortality]
PUBDATE: 19860401
"This paper reports the establishment of a system for monitoring cancer mortality of individuals forming approximately a 10 percent sample of the Canadian labour force. Computerized record linkage was used in conjunction with the Canadian mortality data base maintained by Statistics Canada to determine the mortality experience of the cohort between 1965 and 1979. Selected results are presented, some of which appear to indicate associations between the occupation and cause of death, and others of which seem likely to indicate the influence of lifestyle factors such as smoking and diet. Cancer mortality is also presented by social class." (SUMMARY IN ENG AND SPA)


14. DOCID:15401 SCORE: 0.00230095255159955
DOCNO: 2477896
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: A J Wieczorek AJ
AUTHOR: K Rhyner K
AFFILIATION: Medizinische Poliklinik, Departement für Innere Medizin, Universitätsspital Zürich.
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [A gene probe test for serum RNA proteolipid in neoplasia]
PUBDATE: 19890901
We describe for the first time the specific determination of a tumor associated nucleic acid found in 50 of 57 sera from cancer patients. The novel tumor marker "RNA-proteolipid" described by us contains an mRNA of about 10 kilobases. We have established a test to determine this RNA by hybridization. A cDNA was obtained by reversed transcription from RNA using serum from a patient with Hodgkin's lymphoma. The cDNA was then ligated into a M13 phage and cloned in Escherichia coli. The phage DNA was sulfonated chemically and hybridized to RNA from neoplastic sera which was immobilized on nylon. The bound DNA was detected by an immunoassay.