0. DOCID:27375 SCORE: 0.00250476886451705
DOCNO: 10518048
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Fuzzy Logic
QUALIFIER: diagnosis
QUALIFIER: genetics
QUALIFIER: methods
AUTHOR: C A Pena-Reyes CA
AUTHOR: M Sipper M
AFFILIATION: Logic Systems Laboratory, Swiss Federal Institute of Technology, IN-Ecublens, CH-1015, Lausanne, Switzerland. carlos.pena@di.epfl.ch
PUBTYPE: Journal Article
JOURNALTITLE: Artificial intelligence in medicine.
COUNTRY: NETHERLANDS
TITLE: A fuzzy-genetic approach to breast cancer diagnosis.
PUBDATE: 19991001
The automatic diagnosis of breast cancer is an important, real-world medical problem. In this paper we focus on the Wisconsin breast cancer diagnosis (WBCD) problem, combining two methodologies-fuzzy systems and evolutionary algorithms-so as to automatically produce diagnostic systems. We find that our fuzzy-genetic approach produces systems exhibiting two prime characteristics: first, they attain high classification performance (the best shown to date), with the possibility of attributing a confidence measure to the output diagnosis; second, the resulting systems involve a few simple rules, and are therefore (human-) interpretable.


1. DOCID:26850 SCORE: 0.0023434620565713
DOCNO: 10921313
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: T Tada T
AUTHOR: F Kasumi F
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Characteristics of familial breast cancer]
PUBDATE: 20000701
We report the clinical characteristics of familial breast cancer families at our hospital in which the number of second-degree of breast cancer probands was more than 2. In our hospital, the incidence of onset at a young age was 21.9%, and bilateral breast cancer was 10.5%. These incident rates were significantly higher than sporadic breast cancer. The frequency of familial breast cancer in most Japanese hospitals was about 1.1%, but was 2.0% in our hospital. Familial breast cancer is a rare breast cancer, but the risk is high in breast cancer families. Therefore, it is necessary to follow up not only patients but the families.


2. DOCID:27310 SCORE: 0.00221574742557086
DOCNO: 9769121
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: embryology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H Bonkhoff H
AUTHOR: K Remberger K
AFFILIATION: Institute of Pathology, University of the Saarland, Homburg-Saar, Germany. patfix@med-rz.uni-sb.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Virchows Archiv : an international journal of pathology.
COUNTRY: GERMANY
TITLE: Morphogenetic concepts of normal and abnormal growth in the human prostate.
PUBDATE: 19980901
Benign prostatic hyperplasia (BPH) and prostate cancer are multifactorial disease processes, involving a growing number of biochemical, genetic and epigenetic factors. Their pathogenesis, however, remains poorly understood. The present review examines current morphogenetic concepts of normal and abnormal growth in the human prostate. This includes the role of basal cells in organogenesis and cancerogenesis, the impact of cell-matrix interactions, and the importance of cellular heterogeneity in tumour progression and hormone-insensitive growth. Knowledge of morphogenesis and morphology is required in any scientific approach to BPH and prostate cancer.


3. DOCID:27670 SCORE: 0.00212572989243258
DOCNO: 11847784
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adaptation, Psychological
QUALIFIER: ethnology
QUALIFIER: ethnology
QUALIFIER: ethnology
QUALIFIER: nursing
AUTHOR: L Chiu L
AFFILIATION: University of British Columbia, Vancouver, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: Nursing science quarterly.
COUNTRY: United States
TITLE: Transcending breast cancer, transcending death: a Taiwanese population.
PUBDATE: 20000101
This study explores transcendence as a lived experience through in-depth, face-to-face interviews of 15 Taiwanese women with breast cancer. A phenomenological research method and Leininger's culture care theory were employed to guide the study. Four themes emerged as characteristic of the current lifeworlds of the study participants. The four themes are giving meaning to suffering, liberating a clinging nature, opening to life and death, and healing with compassion. The findings reveal that the essential structure of transcendence is the capacity of a person to give meaning to suffering, liberate self from a clinging nature, open self to life and death, and heal self with compassion.


4. DOCID:26444 SCORE: 0.00211779921389843
DOCNO: 11503248
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: chemically induced
QUALIFIER: genetics
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: I Damps I
AUTHOR: E Jassem E
AUTHOR: A Siemińska A
AFFILIATION: Klinika Chorób Płuc i Gruźlicy Akademii Medycznej w Gdańsku.
PUBTYPE: Editorial
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: Poland
TITLE: [Molecular basis of carcinogenesis in lung cancer induced by cigarette smoking]
PUBDATE: 20010601
An association between cigarette smoking and lung cancer carcinogenesis is reviewed. It is highly possible, that "individual susceptibility" for tumor development exists and is related to polymorphic variants of genes encoding for enzymes, which are employed in metabolism of xenobiotic substances. The gathering of highly reactive molecules due to modified metabolic processes results in DNA adducts forming and increased tendency for mutations. Group of genes, responsible for proliferation, cell cycle arrest, apoptosis and DNA damage repair are frequently altered.


5. DOCID:26374 SCORE: 0.00211778312708998
DOCNO: 11422810
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: pathology
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: Z Jin Z
AUTHOR: G Tamura G
AUTHOR: M Satoh M
AUTHOR: T Meguro T
AUTHOR: T Miura T
AUTHOR: M Hayashi M
AUTHOR: M Osakabe M
AUTHOR: K Ohmura K
AUTHOR: S Ogata S
AUTHOR: Y Endoh Y
AUTHOR: T Motoyama T
AFFILIATION: Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Pathology international.
COUNTRY: Australia
TITLE: Absence of BAT-26 instability in gastric intestinal metaplasia.
PUBDATE: 20010601
BAT-26 instability, a sensitive marker for the high-frequency microsatellite instability (MSI-H) phenotype, was analyzed in samples of gastric cancer and in adjacent intestinal metaplastic mucosae. Although all MSI-H gastric cancer samples showed BAT-26 instability, as assessed using 12 dinucleotide microsatellite markers, BAT-26 instability was not found in the adjacent intestinal metaplastic mucosa in any of the samples.


6. DOCID:24956 SCORE: 0.00194002242530966
DOCNO: 9640065
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: K Iwaszkiewicz K
AFFILIATION: I Zakładu Radiologii Klinicznej AM w Warszawie.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Evaluation of the usefulness of stereotactic aspiration fine needle biopsy for breast neoplasm diagnosis in the preclinical stages]
PUBDATE: 19980301
Out of 6000 mammographies performed in the years 1991-1992, 61 patients have been qualified to stereotactic fine needle biopsies. Finally 50 stereotactic biopsies have been performed on 37 patients. In 6 cases (12%) cancer has been recognized. Stereotactic biopsy allows to recognize cancer in preclinical stages. In comparison with the surgical this method is less stressing for the patients and cheaper.


7. DOCID:24918 SCORE: 0.00194002168234137
DOCNO: 11905804
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: therapy
AUTHOR: F McCormick F
AFFILIATION: University of California San Francisco, Cancer Research Institute, 94115, USA. mccormick@cc.ucsf.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Cancer gene therapy: fringe or cutting edge?
PUBDATE: 20011101
Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the basis of its molecular characteristics. But although laboratory results have been extremely encouraging, many practical obstacles need to be overcome before gene therapy can fulfil its goals in the clinic. These issues are not trivial, but seem less formidable than the challenge of killing cancers selectively and rationally--a challenge that has been successfully addressed.


8. DOCID:25602 SCORE: 0.00193155648384655
DOCNO: 10878541
AUTHOR: G Jenster G
PUBTYPE: Comment
PUBTYPE: Editorial
JOURNALTITLE: The Journal of pathology.
COUNTRY: ENGLAND
TITLE: Ligand-independent activation of the androgen receptor in prostate cancer by growth factors and cytokines.
PUBDATE: 20000701
During the course of prostate cancer progression, cells convert from an androgen-dependent to an androgen-independent growth status. At this late stage, the role of the androgens testosterone and dihydrotestosterone and their nuclear receptor, the androgen receptor (AR), is unclear. Has the growth pathway, initiated by the AR, been bypassed in androgen-independent tumours? Mounting evidence suggests the opposite. Prostate cancer cells that have acquired the ability to survive and grow in a low androgen environment might be activating the AR pathway using growth factors, cytokines, and steroids other than androgens.


9. DOCID:26339 SCORE: 0.00192602277484081
DOCNO: 9864939
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: J H Payne JH
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hawaii medical journal.
COUNTRY: UNITED STATES
TITLE: Laparoscopic staging of malignant disease.
PUBDATE: 19981101
The earliest applications of laparoscopy were for diagnostic procedures. The goal was to make a diagnosis while sparing the patient a major, and often futile, operation. However, the view was limited and it was not possible to palpate organs or masses. The recent development of advanced laparoscopic techniques and ultrasound have improved our view and restored our "sense of touch". These innovations bring the goal of minimally invasive diagnosis and staging closer to reality. This paper reviews the current literature on the laparoscopic staging of cancer with an emphasis on patient selection, diagnostic accuracy, and the reduction in morbidity which can be achieved.


10. DOCID:25619 SCORE: 0.00189514687452276
DOCNO: 10542425
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Transformation, Neoplastic
DESCRIPTOR: MAP Kinase Signaling System
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: W E Miller WE
AUTHOR: N Raab-Traub N
AFFILIATION: Dept. of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Trends in microbiology.
COUNTRY: ENGLAND
TITLE: The EGFR as a target for viral oncoproteins.
PUBDATE: 19991101
The epidermal growth factor receptor (EGFR) is a potent stimulator of the mitogen-activated protein kinase (MAPK) signaling pathway. Chronic stimulation of the EGFR and of multiple steps in the MAPK signaling pathway is involved in the development of cancer. Several tumor viruses encode proteins that induce EGFR expression or stimulate EGFR-mediated signaling and are thus likely to play an important role in the transformation of virus-infected cells.


11. DOCID:27291 SCORE: 0.00186553487941078
DOCNO: 10418322
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Glucans
DESCRIPTOR: Xylans
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: A Hensel A
AUTHOR: K Meier K
AFFILIATION: Institut für Botanik und Pharmazeutische Biologie Erlangen, Friedrich-Alexander-Universität Erlangen, Germany. ahaensel@biologie.uni-erlangen.de
PUBTYPE: Journal Article
JOURNALTITLE: Planta medica.
COUNTRY: GERMANY
TITLE: Pectins and xyloglucans exhibit antimutagenic activities against nitroaromatic compounds.
PUBDATE: 19990601
Because a high daily consumption of polysaccharides-containing food is assessed to decrease the risk of cancer of the gastrointestinal system, different types of carbohydrates were investigated for their antimutagenic activity against different standard mutagens. Within the screening pronounced antimutagenic effects were found for xyloglucan and different pectins and pectin-like rhamnogalacturonans against 1-nitropyrene induced mutagenicity. Inhibition rates were dose-dependent and varied between 20 and 50%. Concerning the mode of action a direct interaction of the polymers with the cells is claimed, protecting the organisms from the mutagenic attack.


12. DOCID:27418 SCORE: 0.00174955735499497
DOCNO: 10730036
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: isolation & purification
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: diagnosis
QUALIFIER: etiology
QUALIFIER: isolation & purification
AUTHOR: R Uys R
AUTHOR: M F Cotton MF
AUTHOR: G Wessels G
AUTHOR: P B Hesseling PB
AUTHOR: R Bester R
AUTHOR: E Janse van Rensburg E
AFFILIATION: Department of Paediatrics and Child Health, University of Stellenbosch, Tygerberg, South Africa.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Journal of tropical pediatrics.
COUNTRY: ENGLAND
TITLE: Viral isolates during febrile neutropaenia in children with cancer.
PUBDATE: 20000201
We prospectively studied South African children with cancer for viral isolates during episodes of febrile neutropaenia. Viruses were found in seven (31.8 per cent) and bacteria in five (22.7 per cent) of 22 episodes. The most common isolate was the herpes simplex virus and the most common source was from nasopharyngeal aspirates. There was no dual detection of viral and bacterial isolates. This study emphasizes the important contribution of viruses to febrile neutropaenia.


13. DOCID:27001 SCORE: 0.00174538471015256
DOCNO: 10410154
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Protein Biosynthesis
QUALIFIER: complications
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: H Koshida H
AUTHOR: T Kametani T
AUTHOR: S Masuda S
AFFILIATION: Second Dept. of Internal Medicine, Kohseiren Takaoka Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of lung cancer with hypercalcemia and renal failure responsive to pamidronate]
PUBDATE: 19990501
A 46-year-old man was diagnosed as Stage IV lung cancer with neck lymph node and bilateral adrenal metastases. He was treated with seven courses of combined chemotherapy (CDDP + etoposide), until he showed extreme hypercalcemia and acute renal failure. The bisphosphonate, pamidronate with elcatonin and prednisolone dramatically lowered his serum calcium level and normalized his renal function. This is a representative case of humoral hypercalcemia of malignancy whose serum calcium could be safely and effectively controlled with pamidronate.


14. DOCID:26993 SCORE: 0.00174538136404164
DOCNO: 9646040
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Genetic
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: K Shannon K
AFFILIATION: Department of Pediatrics, University of California, San Francisco 94143, USA. kevins@itsa.ucsf.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Genetic predispositions and childhood cancer.
PUBDATE: 19980601
This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemia is used to illustrate some of the issues faced by molecular biologists and genetic epidemiologists in identifying and analyzing at-risk individuals. The problem of incomplete penetrance in cancer susceptibility is presented and potential models are discussed. The article concludes with a number of tentative conclusions from existing data and speculations for future studies.