0. DOCID:23222 SCORE: 0.00303995777126296
DOCNO: 9063491
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug therapy
AUTHOR: S Fujimoto S
AFFILIATION: Division of Chemotherapy, Chiba Cancer Center Research Institute.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Theory and actual attempts to establish an effective cancer chemotherapy]
PUBDATE: 19970201
In order to establish an effective cancer chemotherapy, theoretical analyses of chemoresistance factors in recurrent patients and possible approaches to curative chemotherapy were undertaken. Multidrug resistance of tumor cells in recurrent patients may hamper the development of new antitumor agents. Thus, we developed a new screening method (FACS method) which employs fresh clinical specimens. By this method, TAS-103 was found to be far more effective than 10 standard drugs and to be one of the most effective drugs among 20 or more new antitumor agents under study. Development of several effective drugs, such as TAS-103, might lead to a curative cancer chemotherapy.


1. DOCID:23755 SCORE: 0.00300387150739969
DOCNO: 7548841
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: metabolism
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: A Eastman A
AFFILIATION: Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: Survival factors, intracellular signal transduction, and the activation of endonucleases in apoptosis.
PUBDATE: 19950201
Cell survival is normally mediated by factors in the extracellular environment, whereas genetic changes that constitutively activate intracellular survival pathways often occur in cancer. It is suggested that a Ras/Raf/MAP kinase-dependent pathway is critical for cell survival. Apoptosis results from loss of these survival factors or deregulation of survival pathways. If protein kinase cascades mediate survival, then it is likely that phosphatases mediate apoptosis. Potential targets for dephosphorylation include regulators of ion homeostasis as these have been implicated in the regulation of endonucleases associated with apoptosis. Survival factors also modulate anticancer drug response and understanding these pathways may improve therapy.


2. DOCID:23195 SCORE: 0.00289261914319856
DOCNO: 8047476
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Advance Directives
DESCRIPTOR: Information Dissemination
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: D E Neumark DE
AFFILIATION: University of Pennsylvania School of Nursing, Philadelphia.
PUBTYPE: Journal Article
JOURNALTITLE: Oncology nursing forum.
COUNTRY: UNITED STATES
TITLE: Providing information about advance directives to patients in ambulatory care and their families.
PUBDATE: 19940501
PURPOSE/OBJECTIVES: To devise a teaching pamphlet on advance directives. DATA SOURCES: Published articles, professional publications, books. DATA SYNTHESIS: Content was designed to educate, increase awareness of the topic, and encourage dialogue among caregivers, patients, and families prior to the onset of a health crisis. The tool is written at a fifth-grade reading level. CONCLUSIONS: The booklet can achieve its goals. Dissemination strategies still are under discussion. IMPLICATIONS FOR NURSING PRACTICE: Helping patients and their families explore end-of-life decisions is vital to providing comprehensive care for patients with cancer. Tools such as this can facilitate that process.


3. DOCID:22935 SCORE: 0.00285577835815681
DOCNO: 7920740
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: standards
PUBTYPE: Guideline
PUBTYPE: Journal Article
PUBTYPE: Practice Guideline
JOURNALTITLE: Clinical practice guideline. Quick reference guide for clinicians.
COUNTRY: UNITED STATES
TITLE: High-quality mammography: information for referring providers. Agency for Health Care Policy and Research.
PUBDATE: 19941001
This Quick Reference Guide for Clinicians contains highlights from Quality Determinants of Mammography, Clinical Practice Guideline No. 13 of interest to health care providers who refer women for mammography. The Quality Determinants of Mammography Guideline Panel, a private-sector panel of health care professionals and consumers, developed the Guideline after comprehensively analyzing the research literature and current scientific knowledge concerning elements necessary for high-quality mammography. Specific recommendations are made in the following areas: Components of complete breast cancer screening; Responsibilities of women, mammography facilities,and referring providers as to screening and followup care; Communication of results; Limitations of mammography; Certification of mammography facilities.


4. DOCID:22626 SCORE: 0.00283517725218508
DOCNO: 9156943
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: J Rolski J
AUTHOR: M Pawlicki M
AUTHOR: T Zemełka T
AUTHOR: J Pernal J
AFFILIATION: Kliniki Chemioterapii Centrum Onkologii im. M. Skłodowskiej-Curie, Oddział w Krakowie.
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Results of tamoxifen treatment in patients with advanced breast cancer]
PUBDATE: 19961001
The results of advanced breast cancer therapy with tamoxifen have been evaluated. The objective response to the drug has been achieved in 32 (31.7%) patients, and a 2-year survival in 52% of cases. A correlation between the localization of lesions and response rate has been found. The best results have been achieved in localized lesions and lymph nodes metastases. Low toxicity of the drug enables achievement of results comparable to those seen in all types of the hormonal therapy, except androgens.


5. DOCID:21590 SCORE: 0.002746944177485
DOCNO: 8645029
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: metabolism
QUALIFIER: secondary
QUALIFIER: drug therapy
AUTHOR: H Tsuzuki H
AUTHOR: M Niki M
AUTHOR: H Ueda H
AUTHOR: H Abe H
AUTHOR: Y Kurosu Y
AFFILIATION: Dep. of Surgery, Yokohama Chuo Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Successful combination chemotherapy for a post-operative gastric cancer patient with multiple liver metastases and elevated CEA]
PUBDATE: 19960501
A 75-year-old male was admitted one year after surgery for advanced gastric cancer. He was diagnosed as having multiple liver metastases with elevated serum CEA level. Combination chemotherapy consisting of THP-ADM, MMC and 5'-DFUR was done in the outpatient clinic. As a result, both multiple metastatic liver tumors and serum CEA level showed a remarkable response.


6. DOCID:21565 SCORE: 0.00274694200548948
DOCNO: 7548353
AUTHOR: G Tibblin G
AUTHOR: M Eriksson M
AUTHOR: S Cnattingius S
AUTHOR: A Ekbom A
AFFILIATION: Department of Family Medicine,Uppsala University, Sweden.
PUBTYPE: Journal Article
JOURNALTITLE: Epidemiology (Cambridge, Mass.)
COUNTRY: UNITED STATES
TITLE: High birthweight as a predictor of prostate cancer risk.
PUBDATE: 19950701
In a follow-up study of a cohort of 50-year-old men who were born in 1913 and were living in Gothenburg, Sweden, we found an association between birthweight and prostate cancer. Of 366 men with known birthweight, there were 21 patients with prostate cancer. The incidence is about five times higher in the highest quartile of birthweight than in other birthweight groups. The findings indicate that aspects of the pre- and perinatal period may affect the risk of subsequent prostate cancer.


7. DOCID:23935 SCORE: 0.00249561578441918
DOCNO: 8707761
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: S K Kim SK
AUTHOR: G D Demetri GD
AFFILIATION: Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Chemotherapy and neutropenia.
PUBDATE: 19960401
Myelosuppression is the most common toxicity associated with the administration of dose-intensive cytotoxic chemotherapy. The basic understanding of neutrophil biology and the physiology of chemotherapy-induced neutropenia has advanced tremendously in the past 2 decades. Concordantly, the ability to reduce the morbidity associated with neutropenia has improved. Adjunctive cytokine and progenitor cell support of hematologic recovery after myelosuppressive therapy have proved to be models of translational research and have led to novel therapeutic initiatives for patients with cancer and hematologic malignancies. In this article, fundamental aspects of neutrophil production are discussed, and the clinical development of hematopoietic cytokines active on cells of the leukocyte lineages is presented.


8. DOCID:21337 SCORE: 0.00245915179319756
DOCNO: 7674982
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: microbiology
QUALIFIER: drug therapy
AUTHOR: K P Ng KP
AUTHOR: T S Soo-Hoo TS
AUTHOR: M T Koh MT
AUTHOR: P W Kwan PW
AFFILIATION: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Malaysia.
COUNTRY: MALAYSIA
TITLE: Disseminated Geotrichum infection.
PUBDATE: 19941201
Intensive chemotherapy has prolonged survival in cancer patients. Unfortunately it has also predisposed them to unusual infections because of their immunocompromised state. We report a case of fungal septicaemia caused by Geotrichum candidum, an imperfect yeast of low virulence in a young girl with acute lymphoblastic leukaemia. It was successfully treated with amphotericin B. The morphological characteristics of this fungus leading to its identification are described.


9. DOCID:23435 SCORE: 0.00220185846413177
DOCNO: 8599720
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: P S Smitt PS
AUTHOR: J B Posner JB
AFFILIATION: Dr Daniel den Hoed Kliniek, Department of Neuro-Oncology, Rotterdam, The Netherlands.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Baillière's clinical neurology.
COUNTRY: ENGLAND
TITLE: Paraneoplastic peripheral neuropathy.
PUBDATE: 19951101
Paraneoplastic peripheral neuropathies are not common. They are out-numbered by the far more common peripheral neuropathies that occur either as a direct result of the cancer (metastases) or its treatment (usually chemotherapy). Nevertheless, paraneoplastic peripheral neuropathies are important because they may be the first sign of an otherwise occult cancer and/or because they may substantially disable the patient even when the cancer itself is asymptomatic. Paraneoplastic disorders are sometimes marked by the presence of autoantibodies that react with proteins both in the underlying cancer and in the nervous system. Their discovery may lead to an early diagnosis and potential cure of the underlying cancer.


10. DOCID:21274 SCORE: 0.00211064896413165
DOCNO: 8907821
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: J A Edney JA
AFFILIATION: Department of Surgery, University of Nebraska Medical Center, USA.
PUBTYPE: Historical Article
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Nebraska medical journal.
COUNTRY: UNITED STATES
TITLE: Treatment options in surgical management of breast cancer.
PUBDATE: 19960301
The surgical approach to primary operable breast cancer has changed greatly within the past millenium. In the last 20 years collaborative patient trials have generated a wealth of valuable information that now allows us the opportunity to offer women a number of surgical options where before there was only one. The long awaited results of the chemoprevention trials will almost certainly change our surgical approach even further. Many questions regarding the management of breast cancer remain unanswered.


11. DOCID:23690 SCORE: 0.00207197848085523
DOCNO: 8187056
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Amplification
DESCRIPTOR: Genes, p53
DESCRIPTOR: Point Mutation
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: V Nigro V
AUTHOR: M Napolitano M
AUTHOR: C Abbondanza C
AUTHOR: N Medici N
AUTHOR: A A Puca AA
AUTHOR: M Schiavulli M
AUTHOR: I Armetta I
AUTHOR: B Moncharmont B
AUTHOR: G A Puca GA
AUTHOR: A M Molinari AM
AFFILIATION: Istituto di Patologia Generale e Oncologia, Facoltà di Medicina, Seconda Università degli Studi di Napoli, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: IRELAND
TITLE: A novel p53 mutant in human breast cancer revealed by multiple SSCP analysis.
PUBDATE: 19940401
DNA from tumor tissue and peripheral blood lymphocytes of primary breast cancer patients was screened for the presence of p53 mutations. In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT). This amino acid residue is highly conserved in many species, thus suggesting that such mutation plays an important role in the loss of wt-p53 function.


12. DOCID:22970 SCORE: 0.00204907576529783
DOCNO: 9054591
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Species Specificity
QUALIFIER: etiology
AUTHOR: J W Grisham JW
AFFILIATION: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Carcinogenesis.
COUNTRY: ENGLAND
TITLE: Interspecies comparison of liver carcinogenesis: implications for cancer risk assessment.
PUBDATE: 19970101
The morphology of hepatocellular carcinoma is similar among mice, rats and humans, and the cellular pathogenesis shows features that are both similar and divergent among these species. However, major elements of etiology, molecular pathogenesis, and natural history differ between humans and rodents. As a reflection of these species-determined differences, rodents appear to be neither highly sensitive nor highly specific surrogates for detecting agents that are potential causes of hepatocellular cancer in humans. Results of tests of chemical carcinogenicity in rodents are likely to include a significant number of both false-positive and false-negative risks for humans.


13. DOCID:23527 SCORE: 0.00199339770425728
DOCNO: 9033598
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: M G Reich MG
AUTHOR: D Razavi D
AFFILIATION: Service de médecine, centre Oscar-Lambret, Lille, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: FRANCE
TITLE: [Role of amphetamines in cancerology : a review of the literature]
PUBDATE: 19961101
The review of the literature shows that amphetamines (methylphenidate, dextroamphetamine) have been rarely used in the past, but have been recently introduced in the palliative treatment in oncology. They have stimulating, antidepressive and perhaps coanalgesic effects. They can alleviate sleepiness related to opiates analgesics which are given in chronic pain. Amphetamines may also be a therapeutic option, alone or in association with antidepressant drugs, in the pharmacological management of mood disorders unresponsive to tricyclics or selective serotonin reuptake inhibitors. These treatments are well-tolerated and are rapidly active. This treatment may improve the quality of life and comfort in cancer patients.


14. DOCID:21730 SCORE: 0.00198549339819509
DOCNO: 9410685
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: T Schlick T
AUTHOR: T Junginger T
AFFILIATION: Klinik für Allgemein- und Abdominalchirurgie, Johannes-Gutenberg-Universität Mainz.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY
TITLE: [Abrikossoff granular cell tumor: a rare tumor of the esophagus]
PUBDATE: 19970901
In the present case of a granular cell tumor an abdomino-thoracal resection of the esophagus was performed in a 41-year-old patient after preoperative diagnosis had suggested esophageal cancer. Granular cell tumors (Abrikossoff's tumor) of the esophagus are rather rare tumors of neuroectodermal benign histogenesis. Diagnosis can be obtained by endoscopic and histological study and immunohistochemical forceps biopsy. Because of the peculiar histological feature of the tumor, it can be mistaken for an squamous cell carcinoma.