0. DOCID:7449 SCORE: 0.00311379487923719
DOCNO: 7026459
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: G Todd G
AUTHOR: C W Chan CW
AUTHOR: A J Cochran AJ
AUTHOR: R Kennedy R
AUTHOR: R M Mackie RM
AUTHOR: L J Morrison LJ
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: In vitro reaction of cancer patients and others to Bacillus Calmette-Gueérin.
PUBDATE: 19800901
We examined the in vitro reaction of leukocytes from 71 cancer patients and 121 control donors (disease-free individuals or patients with non-malignant non-debilitating conditions) against Bacillus Calmette-Guérin using a one-stage capillary leukocyte migration assay. The proportion of reactive cancer patients and control donors increased with increasing BCG concentration, but the proportion of patients who reacted was less than that of control donors at all concentrations of BCG. As cancer stage advanced and the volume of clinically detectable tumor increased, the proportion of reactive patients decreased. There was a small age-related decline in reactivity in the control population. The results of simultaneous in vitro tests and Mantoux reactions were concurrent in a majority of normal individuals so tested.


1. DOCID:7520 SCORE: 0.00300583861535427
DOCNO: 6992969
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
AUTHOR: H Ulfelder H
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The stilbestrol disorders in historical perspective.
PUBDATE: 19800601
In the late 1960's when a series of adolescent girls with adenocarcinoma of the vagina presented themselves to our hospital, we did not immediately suspect the cause. Previous experience with radical hysterectomy and with vaginal reconstruction had prepared us technically to treat them sucessfully. Then a clue to etiology from one mother's observation regarding DES as a pregnancy supportive medication was quickly and conclusively converted into fact by an investigation with case controls. Rapid expansion of our knowledge came about through information accumulated in a Registry, and untoward effects other than cancer soon came to notice as young asymptomatic women presented themselves for examination because of known fetal exposure. The dominant event is clearly recognizable ss teratogenic, resulting in anomalous development of the vagina and cervix. Although the appearance of clear cell adenocarcinoma in a small fraction of DES-daughters is a consequence, the role of DES in its carcinogenesis is still unproved.


2. DOCID:7805 SCORE: 0.00289937380942868
DOCNO: 7448715
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: J G Schenker JG
AUTHOR: J Tal J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Adenocarcinoma of the endometrium in Israel, 1960-1968.
PUBDATE: 19801201
Data gathered during an epidemiologic study of endometrial cancer in Israel are presented. In the nine-year period of this survey, 877 new cases of primary cancer of the endometrium were diagnosed, representing an incidence of 17.8/100,00 females over the age of 25. Two thirds of the patients were in the sixth and seventh decades of life at diagnosis of the tumor. Endometrial carcinoma was two to three times more prevalent in women of European-American origin than in those of Asian-African Background. In 85% of the patients, diagnosis was made while the disease was in Stage I. A strong correlation was found between endometrial cancer, diabetes (14%), hypertension (18%), and infertility (25%). The five-year survival rate in the present survey was 69.2%. Factors affecting prognosis are clinical stage of the disease at diagnosis, degree of myometrial invasion, tumor differentiation, age of the patient, and type of treatment.


3. DOCID:7700 SCORE: 0.00286919902464386
DOCNO: 6273014
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: blood
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: T Goffman T
AUTHOR: J Cantrell J
AUTHOR: P Schein P
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Unexplained increase in serum creatine kinase isoenzyme MB activity in a lung cancer patient.
PUBDATE: 19811201
In this case of mixed small cell--large cell cancer of the lung in an elderly woman, creatine kinase (EC 2.7.3.2) isoenzymes were assayed serially because of chest pain. The proportions of serum CK-BB and CK-MB isoenzyme activities were persistently above normal (CK-MB 10-18%, normal less than 5%). Electrocardiograms revealed no signs of ischemia or infarction. At autopsy no gross or microscopic infarction or inflammation of the heart was seen. There was also no infarction of smooth or skeletal muscle. The tumor was the probable source of most of the circulating CK-MB isoenzyme. Future cases may pose a similar diagnostic dilemma: differentiating creatine kinase that is present as a result of myocardial infarction from tumor-related CK-MB. Whether or not CK-MB assay could be useful in detecting tumors remains to be investigated.


4. DOCID:7816 SCORE: 0.00286100490329121
DOCNO: 264088
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: A Spira A
AUTHOR: P Lazar P
PUBTYPE: Journal Article
JOURNALTITLE: European journal of obstetrics, gynecology, and reproductive biology.
COUNTRY: NETHERLANDS
TITLE: Spontaneous abortions in sibship of children with congenital malformation or malignant disease.
PUBDATE: 19790401
Parents of 751 children affected by cancer/leukemia, congenital heart disease, strawberry nevus or mental retardation have been investigated with respect to their reproductive history and their exposure to risk factors for spontaneous abortion. Differences between the four groups were established for the number of children in the sibship, the proportion of multigravidae and the spontaneous abortion rate among these women. The greatest differences were observed in the two groups of malformed children compared with the other two groups, being as marked in those with a severe malformation (heart defect) as in those with a benign one (strawberry nevus). Taking known risk factors for spontaneous abortion into account did not explain the observed differences. An etiological hypothesis is put forward which takes account of the high proportion of quantitative abnormalities of the karyotype associated with congenital heart disease and spontaneous abortion.


5. DOCID:7258 SCORE: 0.00277596812354985
DOCNO: 7401828
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymphocytes
QUALIFIER: blood
QUALIFIER: mortality
AUTHOR: I J Check IJ
AUTHOR: R L Hunter RL
AUTHOR: B Lounsbury B
AUTHOR: K Rosenberg K
AUTHOR: G Matz G
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Prediction of survival in head and neck cancer based on leukocyte sedimentation in Ficoll-Hypaque gradients.
PUBDATE: 19800801
A battery of immunologic tests were performed on 42 patients with recurrent cancer of the head and neck whose median survival time was 6.8 months. Two tests correlated with survival: total white blood cell (WBC) count and the percentage of lymphoid cells (%LG) in the Ficoll-Hypaque gradient separated leukocyte fraction of blood. Patients with abnormally low values of %LB had a poor prognosis, as did patients who had greater than 8000 WBC count. Of the variation in %LG, 43% was due to the differences in differential WBC counts among the patients, with the remaining variation attributed to changes in the buoyant densities of the leukocytes. These data suggest that further study of the factors effecting buoyant density of cells may be clinically useful.


6. DOCID:6135 SCORE: 0.00258369489514029
DOCNO: 6939424
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: P L Nandi PL
AUTHOR: S C Tang SC
AUTHOR: C K Mok CK
AUTHOR: W T Lee WT
AUTHOR: G B Ong GB
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Pulmonary coin lesions: a ten-year review of 239 cases.
PUBDATE: 19810201
The results of a study of 239 resected solitary pulmonary nodules are presented; 66.5% of the resected nodules were malignant, and there were three patients with malignant coin lesions who were under 30 years of age. These findings confirm the generally accepted fact that most solitary pulmonary nodules must be resected if the presence of cancer is to be excluded. Transbronchial biopsy under biplane fluoroscopic guidance through a flexible bronchoscope may provide an effective alternative to early thoracotomy in the future, so that malignant nodules can be diagnosed before operation and patients with benign lesions are spared a thoracotomy.


7. DOCID:7223 SCORE: 0.00255422911683421
DOCNO: 221127
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: enzymology
AUTHOR: Y Miyagi Y
PUBTYPE: Journal Article
JOURNALTITLE: The Bulletin of Tokyo Medical and Dental University.
COUNTRY: JAPAN
TITLE: Guanosine 3', 5'-cyclic monophosphate level in plasma of patients with cancer and various diseases.
PUBDATE: 19790601
Guanosine 3'5'-cyclic monophosphate (cGMP) in the plasma of normal persons and patients with lung or breast cancer and other kinds of neoplasma or other diseases was determined using radioimmunoassay. In comparison with normal persons, significant elevation occurred in the cGMP in the plasma of patients with various kinds of cancer or renal insufficiency. The average cGMP values in the plasma of eight normal persons, 16 patients with lung cancer, 16 patients with breast cancer, five patients with oesophagus cancer, three patients with liver cancer, three patients with stomach cancer, ten patients with renal insufficiency and two patients with myocardial infarction, were respectively 3.46, 9.05, 5.39, 5.42, 7.33, 11.66, 19.55, and 8.0 pmol per ml of plasma. There was no elevation in the cGMP in the plasma of the patients with other diseases studied.


8. DOCID:7504 SCORE: 0.00252167974773631
DOCNO: 7285326
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: A M Dnistrian AM
AUTHOR: M K Schwartz MK
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Plasma lipid-bound sialic acid and carcinoembryonic antigen in cancer patients.
PUBDATE: 19811001
We evaluated lipid-bound sialic acid as a "marker" in cancer patients and assessed the individual and combined value of lipid-bound sialic acid and carcinoembryonic antigen determinations in these patients. Plasma was sampled from 62 normal subjects and 125 cancer patients. Lipid-bound sialic acid was determined by the resorcinol method after total lipid extraction and isolation of the sialolipid fraction from plasma. Neither marker was increased in many breast cancer patients. Carcinoembryonic antigen was increased more commonly and to a greater degree in colon cancer patients and seems to be the preferred marker. Both markers were increased in lung cancer patients and their combined evaluation improved the rate of detection. Lipid-bound sialic acid was increased in more patients with leukemias, lymphomas, Hodgkin's disease, and melanomas, suggesting that it may be a useful biochemical marker in these types of cancer.


9. DOCID:7553 SCORE: 0.00252167966563817
DOCNO: 626157
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: adverse effects
AUTHOR: I Savostin-Asling I
AUTHOR: S Silverman S
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of anatomy.
COUNTRY: UNITED STATES
TITLE: Effects of therapeutic radiation on microstructure of the human mandible.
PUBDATE: 19780201
Mandibular bone from eight patients who had received therapeutic radiation (6,000-7,200 rads) for intra-oral cancer was obtained at surgery (1 month to 9 years after radiation) and compared histologically with non-irradiated mandibular bone from five subjects. Measurements made on the internal remodeling process of cortical bone included the extent of internal surface and the fraction indicating resorption, and the proportions of osteones which were incomplete (less than 3/4 filled with matrix), complete, and plugged. Appreciable differences were observed in all parameters except plugged osteones. The findings suggested early cessation of osteogenesis, and somewhat later cessation of resopriton, without subsequent resumption of either process. The histologic appearance of the osteoblasts, osteoclasts, and osteones was in accord. Microfractures found in the irradiated bone were not seen to have healed. Radiation damage to the osteoprogenitor cells is postulated.


10. DOCID:5820 SCORE: 0.00250576079332654
DOCNO: 568617
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ozone
DESCRIPTOR: Veterinary Medicine
QUALIFIER: veterinary
QUALIFIER: etiology
AUTHOR: K E Kopecky KE
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the American Veterinary Medical Association.
COUNTRY: UNITED STATES
TITLE: Ozone depletion: implications for the veterinarian.
PUBDATE: 19780901
Man has inadvertently modified the stratosphere. There is a good possibility that the ozone layer is being depleted by the use of jet aircraft (SST), chlorofluoromethane propellants, and nitrogen fertilizers. Under unpolluted conditions, the production of ozone equals its destruction. By man's intervention, however, the destruction may exceed the production. The potential outcome is increased intensity of solar ultraviolet (280-400 nm) radiation and penetration to the earth's surface of previously absorbed wavelengths below about 280 nm. The increased ultraviolet radiation would increase the likelihood of skin cancer in man and ocular squamous cell carcinoma in cattle. The climate also might be modified, possibly in an undesirable way.


11. DOCID:7647 SCORE: 0.00246384273213482
DOCNO: 7274182
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: F W Sunderman FW
PUBTYPE: Journal Article
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Recent research on nickel carcinogenesis.
PUBDATE: 19810801
Research on nickel carcinogenesis from 1975 to March 1980 is reviewed. Epidemiological studies have strengthened the evidence that workers in nickel refineries have increased risks of cancers of the nasal cavities and lungs. Clinical investigations have resulted in improved diagnosis, classification, and management of cancers of respiratory organs in nickel refinery workers. Carcinogenicity tests have demonstrated the carcinogenicity of nickel subsulfide (alpha-Ni3S2) in rodents following administration by a variety of parenteral routes. Radiotracer studies and x-ray diffractometry have clarified the metabolism of alpha-Ni3S2 in rodents. In vitro exposures of mammalian cells to certain nickel compounds have been shown to inhibit cellular uptake of thymidine-3H, and to induce chromosomal aberrations, somatic mutations, and morphological transformation. Mutagenicity tests of nickel compounds in bacterial systems have consistently been negative. Ni(II) has beeb reported to impair the fidelity of viral and bacterial DNA polymerases for in vitro replication of synthetic nucleotide templates.


12. DOCID:6893 SCORE: 0.00245302295437098
DOCNO: 526543
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
AUTHOR: F Liautaud-Roger F
AUTHOR: P Coninx P
AUTHOR: M Pluot M
AUTHOR: C Pourny C
AUTHOR: J C Jardillier JC
PUBTYPE: Journal Article
JOURNALTITLE: Biomedicine / [publiée pour l'A.A.I.C.I.G.].
COUNTRY: FRANCE
TITLE: Simultaneous microscopic and biochemical findings in breast carcinoma. Preliminary results.
PUBDATE: 19791101
Intratumoral protein and glucose phosphate isomerase (GPI) content as well as median nuclear DNA amount were determined in breast carcinoma that could be classified by Bloom's grading. These data were analyzed in comparison with TNM classification. Higher protein contents have been displayed in T2 or N+ breast cancers than in T1 or N- tumors. Bloom's grading is strongly correlated to median nuclear DNA content and to some extent with protein and GPI amount. With these results, we have to think about the value of prognostic cytologic criteria. The relationship between intratumoral protein content and prognostic clinical or histological data requires our attention. This would seem to dictate a need for caution in expressing the results of some variables in function of protein content.


13. DOCID:6501 SCORE: 0.00244372907719608
DOCNO: 6893082
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antineoplastic Combined Chemotherapy Protocols
DESCRIPTOR: Conditioning (Psychology)
QUALIFIER: psychology
QUALIFIER: drug therapy
QUALIFIER: psychology
AUTHOR: R M Nesse RM
AUTHOR: T Carli T
AUTHOR: G C Curtis GC
AUTHOR: P D Kleinman PD
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Psychosomatic medicine.
COUNTRY: UNITED STATES
TITLE: Pretreatment nausea in cancer chemotherapy: a conditioned response?
PUBDATE: 19800101
Many patients receiving cancer chemotherapy become nauseated as they anticipate their treatments. We studied this phenomenon in eighteen cancer chemotherapy patients. The eight patients who reported pretreatment nausea had more extensive disease than the other patients and had received twice as much chemotherapy. In most cases pretreatment nausea developed only a after a number of months of treatment. Nausea was usually precipitated by the odor of the clinic and similar odors elsewhere also caused nausea. Patients continued to experience nausea during follow-up visits after treatment was completed. This syndrome of pretreatment nausea can be understood as a classically conditioned response. Clinical recommendations can be made on this basis.


14. DOCID:7910 SCORE: 0.00241422625828129
DOCNO: 41651
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: enzymology
AUTHOR: C H Lo CH
AUTHOR: D Kritchevsky D
PUBTYPE: Journal Article
JOURNALTITLE: Clinica chimica acta; international journal of clinical chemistry.
COUNTRY: NETHERLANDS
TITLE: Physical properties of human serum hexosaminidases A and B: studies in normal and cancer patients.
PUBDATE: 19790701
The major forms of human serum hexosaminidases A and B (Hex A and Hex B) were isolated from normal subjects and cancer patients using DEAE-cellulose. In normal serum, Hex A was heat-labile and had an apparent KM of 1.13 mM and Vmax of 0.51 mumol/ml/h; Hex B was heat-stable and had an apparent KM of 0.85 mM and Vmax of 0.22 mumol/ml/h. Both forms had the same pH optimum, at 4.3. Hex A and Hex B from the sera of cancer patients resembled their normal counterparts in heat stability, pH optimum, and apparent KM (1.07 mM for Hex A, 0.88 mM for Hex B). In contrast, the Vmax values for the cancer sera isozymes were greater than those of normal sera (0.70 and 0.40 mumol/ml/h for Hex A and Hex B, respectively).