0. DOCID:10589 SCORE: 0.00364350010497809
DOCNO: 7083243
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: S L Luedke SL
AUTHOR: D W Luedke DW
AUTHOR: P Petruska P
AUTHOR: G O Broun GO
AUTHOR: G Reed G
AUTHOR: J Leavitt J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Vindesine (VDS) monochemotherapy for non-small cell lung cancer: a report of 45 cases.
PUBDATE: 19820601
Fifty-three patients with non-small cell lung cancer were treated with vindesine. Of the 45 evaluable patients, 11 (24%) had a partial response. Responses were all evident within 6 weeks. Median duration of response was 8 weeks from documentation. Median survival was not improved significantly among responders (P less than 0.10, two-tailed test of significance). The most frequent toxic effect was leukopenia. The most troublesome toxic effect was peripheral neuropathy, with patients greater than 60 years old experiencing this more frequently.


1. DOCID:13869 SCORE: 0.0032781278055507
DOCNO: 3569806
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hematoporphyrin Photoradiation
DESCRIPTOR: Photochemotherapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: H Tajiri H
AUTHOR: N Daikuzono N
AUTHOR: S N Joffe SN
AUTHOR: Y Oguro Y
PUBTYPE: Journal Article
JOURNALTITLE: Gastrointestinal endoscopy.
COUNTRY: UNITED STATES
TITLE: Photoradiation therapy in early gastrointestinal cancer.
PUBDATE: 19870401
Endoscopic photodynamic therapy has been used in the treatment of 19 cases of upper gastrointestinal cancer of which six were superficial esophageal and 13 were early gastric cancer. Six patients subsequently underwent surgical resection. Residual tumors were found in the resected specimens of one esophageal carcinoma and in the two early gastric carcinomas. Technical problems resulted in one failure. Follow-up ranged from 4 months to 3 years and 11 months with no tumor recurrence in either the operated or unoperated patients. Other delivery systems are currently under investigation.


2. DOCID:15488 SCORE: 0.00315802025208877
DOCNO: 2677576
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: I B Voronetskiń≠ IB
AUTHOR: G A Zubovskiń≠ GA
AUTHOR: L I Smetanina LI
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [An ultrasonic study in the differential diagnosis of thyroid diseases]
PUBDATE: 19890901
The correlation of clinical, echo and morphological findings demonstrated ultrasound potentialities in the differential diagnosis of thyroid cancer. Ultrasound permitted the detection of nodes up to 3 cm in diameter. False-negative results were obtained in 6.5% of cases, there were no true false positive results. Adenomas are often characterized by mixed echogenicity of a node and hypoechogenic lining around it. Chronic nonspecific thyroid diseases are characterized by inhomogeneous echogenicity of the organ. Thyroid cancer is characterized by hypoechogenicity of a node with its inhomogeneous structure and irregular contours as if consisting of several nodules. The probability of malignancy grows with an increase in the number of these features combining in a particular patient.


3. DOCID:11637 SCORE: 0.00305272915122831
DOCNO: 7166678
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: prevention & control
AUTHOR: A J Silman AJ
AUTHOR: C M Locke CM
PUBTYPE: Journal Article
JOURNALTITLE: Journal of epidemiology and community health.
COUNTRY: ENGLAND
TITLE: Blood pressure distribution in responders and initial non-responders in a population screening study.
PUBDATE: 19821201
The distribution of diastolic blood pressure (DBP) was compared between those who responded to a first written request to attend at their general practitioner's surgery for screening for hypertension and those who need more intensive effort encouraging them to attend. After excluding 25% of the population whose current address could not be traced, 92% of the remainder were eventually seen and screened. There was no association between diastolic blood pressure and effort needed to bring the patient to screening, and this applied to all patients both with and without a history of hypertension. Thus it appears that unlike screening for cervical cancer, screening for hypertension may not selectively tend to miss the groups most at risk.


4. DOCID:11241 SCORE: 0.00298711970676645
DOCNO: 7155012
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Mapping
DESCRIPTOR: Gene Expression Regulation
QUALIFIER: genetics
QUALIFIER: analysis
QUALIFIER: genetics
AUTHOR: R L Hancock RL
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: IX. V-type position effect.
PUBDATE: 19821001
By the use of a simplistic concept of the structure of heterochromatin, one can derive a formulation for the mechanism by which the phenomenon of V-type position effect can repress genic activity. This notion would explain how the Bar locus and other position effect examples cause genic repression. The mechanism, when extended, may also explain the process of cancer induction by hereditary means. In its most concise form the theory states that heterochromatin has a stabilized structure through special proteins, such as phosphorylated species that allows it the capacity to induce new domains of a "pseudo-heterochromatic" conformation to juxta-positional euchromatic segments for short distances by virtue of electrostatic and hydrogen bond forces.


5. DOCID:15453 SCORE: 0.00298039960154456
DOCNO: 3531728
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: B A Morton BA
AUTHOR: J Scholes J
AUTHOR: J G Kral JG
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: An unusual presentation of colon cancer.
PUBDATE: 19861001
A rare case of asymptomatic cancer of the ascending colon presenting as a subcutaneous groin mass is reported. At the time of right hemicolectomy with resection of the groin mass there was no sign of incontinuity spread or lymph blockage. Sequential determination of carcinoembryonic antigen levels (CEA) in serum reflected the reduction in tumor mass after surgery as well as subsequent recurrences of disease in the groin and in the lung after 2 years. Immunoperoxidase staining of the primary tumor and the metastases showed strong positivity for CEA confirming the origin of the serum CEA. There have been no signs of liver involvement. The route of spread of this unusual metastasis is not known.


6. DOCID:10741 SCORE: 0.00292151640171727
DOCNO: 6539989
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: E Schmiedt E
AUTHOR: N Schmeller N
AUTHOR: P Mayer P
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Complications following external radiotherapy of prostate cancer. Case reports and overview of the literature]
PUBDATE: 19840501
Complications after definitive radiotherapy of prostatic cancer occur in 3 to 30% of cases. Most common is radiation injury of the urethra, the bladder or the rectum. Definitive radiation therapy of carcinoma of the prostata after staging lymphadenectomy has a considerable risk of lymphedema of the lower extremities. Two typical cases are used to illustrate the permanent damage done to the quality of life of the particular patient. The complication rate is decreased if only the prostate is irradiated without radiation of the regional lymphnodes. Interstitial radiation therapy using 125-Iodine-seeds yields comparable results with a tenfold decrease in the complication rate.


7. DOCID:11441 SCORE: 0.00286805491634913
DOCNO: 3982447
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: drug effects
QUALIFIER: toxicity
QUALIFIER: toxicity
AUTHOR: Y Shiloh Y
AUTHOR: E Tabor E
AUTHOR: Y Becker Y
PUBTYPE: Journal Article
JOURNALTITLE: Mutation research.
COUNTRY: NETHERLANDS
TITLE: Cells from patients with ataxia telangiectasia are abnormally sensitive to the cytotoxic effect of a tumor promoter, phorbol-12-myristate-13-acetate.
PUBDATE: 19850401
Fibroblast strains from 6 patients with ataxia telangiectasia (A-T) were found to be markedly hypersensitive to the cytotoxic action of the tumor promoter phorbol-12-myristate-13-acetate (PMA), their D37 values being 5 times lower than those of two normal controls. Two A-T heterozygous strains were slightly hypersensitive to PMA, while a third one showed normal sensitivity. It is concluded that the DNA lesion which is critical in A-T cells is an important component of the damage caused by PMA-induced free radicals and may play a role both in the tumor-promoting activity of PMA and the cancer proneness of A-T patients.


8. DOCID:14964 SCORE: 0.00277446935456295
DOCNO: 3019780
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
AUTHOR: D Flook D
AUTHOR: L E Hughes LE
AUTHOR: G T Williams GT
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
COUNTRY: ENGLAND
TITLE: Prolonged survival without treatment in a patient with primary hepatocellular carcinoma.
PUBDATE: 19860901
The proportion of primary hepatocellular carcinomas which are technically operable with hope of cure is small. Recommended therapy ranges from aggressive therapy to a nihilistic approach. There is little data available on the natural history of untreated tumours and we report such a case. A review of the literature regarding survival with primary hepatocellular carcinoma shows that the prognosis of patients with this tumour may vary considerably. Such variability has important implications for those involved in the design and interpretation of trials of treatment for hepatocellular cancer.


9. DOCID:15664 SCORE: 0.00273535396174871
DOCNO: 3709430
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: J Overnell J
PUBTYPE: Journal Article
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Occurrence of cadmium in crabs (Cancer pagurus) and the isolation and properties of cadmium metallothionein.
PUBDATE: 19860301
The occurrence of high cadmium levels in the digestive gland (hepatopancreas) of the crab Cancer pagurus is reviewed and its possible significance to human health is discussed. Previous attempts to isolate this cadmium in its native form are briefly reviewed and the present method used in this laboratory to isolate crab cadmium metallothionein is described. Quantitative amino acid analysis of the purified protein suggests that it has a total of 55 residues, including 19 Cys, and a molecular weight of approximately 5800. This yields an extinction coefficient at 220 nm for the protein in HCl, pH 1.5, of 50,000 and at 250 nm for the native cadmium protein in Tris-HCl, pH 8.4, of 92,000.


10. DOCID:10549 SCORE: 0.00267162483089036
DOCNO: 6088835
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lung Neoplasms
QUALIFIER: secondary
AUTHOR: H Ikegami H
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Characteristics and treatment of CNS metastases in lung cancer]
PUBDATE: 19840701
Frequency of CNS involvement in 407 non-resected and 227 resected lung cancer were 29 and 5% in small cell, 26 and 10% in adenocarcinoma, 23 and 18% in large cell, and 10 and 5% in squamous cell carcinoma. High risk factors overlapped with factors contributing long-term survival in small cell carcinoma. In resected adenocarcinoma, frequency was highest in poorly differentiated type. Differences were not significant in response rates of brain irradiation according to histologic type and to the dose ranging 3000 to 5000 rads. Survival time after the brain surgery was better than irradiation in patients whose primary lung tumor were resected and was worse in non-resected.


11. DOCID:15930 SCORE: 0.00266984703646198
DOCNO: 3012138
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: N Sakai N
AUTHOR: S Tanaka S
AUTHOR: T Ito T
AUTHOR: K Matsumura K
AUTHOR: T Takekoshi T
AUTHOR: H Ohshita H
AUTHOR: O Nonomura O
AUTHOR: M Kato M
AUTHOR: H Kachi H
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Primary diffused infiltrating (linitis plastica) type of colonic cancer--case report]
PUBDATE: 19860301
The primary diffused infiltrating type of colonic cancer is characteristically rare, and has a high rate of malignancy. A 54-year-old Japanese man was admitted to our hospital complaining of abdominal pain and decreased stools. Sigmoid colonic cancer was suspected as a result of the Ba-enema and colonic fiberscopy examination, but the biopsy results were negative. The sigmoid colon was resected extensively. Histopathologically, the cancer was diagnosed as being a signet ring-cell carcinoma of the sigmoid colon. Although the patient received postoperative chemotherapy, he died of carcinomata peritonitis 175 days after surgery.


12. DOCID:12847 SCORE: 0.00260864818920793
DOCNO: 3199807
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: isolation & purification
AUTHOR: K B Horwitz KB
AFFILIATION: University of Colorado Health Sciences Center, Denver, CO 80220.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of steroid biochemistry.
COUNTRY: ENGLAND
TITLE: Purification, monoclonal antibody production and structural analyses of human progesterone receptors.
PUBDATE: 19881001
Progesterone receptors (PR) from human breast cancer cells have been purified, and used as antigens to generate anti-PR monoclonal antibodies. Immunologic and in situ photoaffinity labeling methods were then used to study receptor structure, and we conclude that native human PR consist of two independent 8S receptors: one 8S subtype contains B-proteins (120,000 kDa) and the other contains A-proteins (94,000 kDa).


13. DOCID:9586 SCORE: 0.00258103484438081
DOCNO: 6807542
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: D L Trump DL
AUTHOR: S A Grossman SA
AUTHOR: G Thompson G
AUTHOR: K Murray K
AUTHOR: M Wharam M
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Treatment of neoplastic meningitis with intraventricular thiotepa and methotrexate.
PUBDATE: 19820701
Twenty-five patients with involvement of the meninges by disseminated cancers were treated weekly with intraventricular thiotepa (10 mg) and methotrexate (10 mg) and with radiation therapy. Twenty-two of the 25 patients were clinically improved or stable. Malignant cells were cleared from the cerebrospinal fluid in 76% of the patients. Myelosuppression was the dose-limiting toxic effect, and neurotoxicity occurred in three patients. Combination chemotherapy employing thiotepa and methotrexate is a safe and effective treatment for neoplastic meningitis.


14. DOCID:13996 SCORE: 0.00257247848221561
DOCNO: 3708251
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: radiography
AUTHOR: I H Gravelle IH
AUTHOR: J C Bulstrode JC
AUTHOR: R D Bulbrook RD
AUTHOR: D Y Wang DY
AUTHOR: D Allen D
AUTHOR: J L Hayward JL
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of radiology.
COUNTRY: ENGLAND
TITLE: A prospective study of mammographic parenchymal patterns and risk of breast cancer.
PUBDATE: 19860501
Breast parenchymal patterns have been assessed by the method of Wolfe in a prospective study in Guernsey. Women with P2 or DY grades had approximately four times the risk of developing breast cancer compared with those with N1 or P1 grades. Age, weight, parity and age at birth of first child are all related to the distribution of mammographic patterns. The combination of these variables with Wolfe grades may identify subsets of the population at very high risk.